Özet:
Karkaç E, Surveillance of Staphylococcus aureus and vancomycin- resistant
enterococci carriage in peritoneal dialysis patients and evaluation of invasive
infections caused by these microorganisms. Eskişehir Osmangazi University
Faculty of Medicine,Medical Speciality Thesis in Department of
Clinical Bacteriology and Infection Diseases, Eskişehir, 2006. S.aureus
carriage has a key role on etiology and pathogenesis of infections. Nasal S.aureus
carriage is more prevelant in some patients groups. VRE has an important role in
nosocomial infections recently. We aimed to define nasal S.aureus carriage and
colonisation around catheter. We also aimed to define VRE carriage in stool and
association between S.aureus, VRE carriage and invasive infections.
Study was performed at the patients of Osmangazi University, unit of dialysis
between 01.10.2005 and 31.03.2006. Nasal S.aureus carriage and colonisation
around catheter, VRE carriage in stool were evaluated monthly. Invasive infections
and association between infections and carriage was investigated.
The number of patients followed by CAPD programme was 50 at the
beginning of the period. 15 of patients couldn’t completed the program.
At least one site of body S.aureus carriage were detected 28%, 17 % were
nasal carriers, 6 % were catheter site carriers, 6 % were carrier for both. 19
peritonitis attacks developed in 31% of patients. In these attacks, KNS,
Corynebacterium spp, and K.oxytoca were isolated.
In the patients who couldn’t complete the CAPD programme, at least one site
of body S.aureus carriage were detected 60%, 47% were nasal carriers, 7% were
catheter carriers, 7% were carriers for both . VRE was isolated at one patient. Ten
peritonitis attacks developed in 53% of patients. Tunnel infection was detected in
6% of them. CNS, A. faecalis, C.albicans were isolated in the peritonitis attacks.
P.aeruginosa was isolated in the tunnel infection. Eight patients in CAPD
programme couldn’t complete study because of catheter loss. They were passed to
haemodialysis. Catheter loss was related with peritonitis, tunnel infection, and
functional problems. Seven of them were carrier for S.aureus. Carriers had increased
risk for catheter loss (p≤0,05)
