2024-03-29T16:48:46Z
http://openaccess.ogu.edu.tr:8080/oai/request
oai:openaccess.ogu.edu.tr:11684/328
2016-03-03T01:00:06Z
com_11684_15
com_11684_2
col_11684_86
Çalışkan, Hakan
Tunca, Nihal
TR53734
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-03-02T10:12:47Z
2016-03-02T10:12:47Z
2008
2008-01-18
http://hdl.handle.net/11684/328
Bu çalışma, Haziran 2003 ile Temmuz 2005 tarihleri arasında Eskişehir ve çevresinde yakalanan 230 cerambycidae örneğine dayanmaktadır. Bu çalışmada beş alt familyaya ait (Prioninae, Lamiinae, Lepturinae, Spondydylinae, Cerambycinae) toplam 39 tür tespit edilmiştir.
Çalışma alanında tespit edilen türlerin tanımları ve teşhis anahtarları verilmiştir. Türlerin baş, anten, pronotum, scutellum, elytra, abdomen ve bacaklarına ait bazı karakteristik ayırt edici kısımların şekillen verilmiştir.
This study depends on 230 Cerambycidae samples found in Eskişehir and its surroundings between June 2003 and July 2005. In this study, 39 species belonging to five subfamilies (Prioninae, Laminaae, Lepturinae Spondydylinae, Cerambycinae) were found.
Species' which are determined in working area description determination keys are given. Relating to species head, antennae, pronotum, scutellum, elytra, abdomen and legs some characteristic distinguishing parts of shape are also given.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-03-02T10:09:08Z
No. of bitstreams: 1
201603011133.pdf: 11038772 bytes, checksum: ee079866676b6b483fd5a7b487e44610 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-03-02T10:12:47Z (GMT) No. of bitstreams: 1
201603011133.pdf: 11038772 bytes, checksum: ee079866676b6b483fd5a7b487e44610 (MD5)
Made available in DSpace on 2016-03-02T10:12:47Z (GMT). No. of bitstreams: 1
201603011133.pdf: 11038772 bytes, checksum: ee079866676b6b483fd5a7b487e44610 (MD5)
Previous issue date: 2008
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Cerambycidae Familyası
Coleoptera Familyası
Faunistik Çalışmalar
Eskişehir
Eskişehir ili cerambycidae (coleoptera) familyası faunası üzerine faunistik çalışmalar
masterThesis
ORIGINAL
201603011133.pdf
201603011133.pdf
application/pdf
11038772
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/328/1/201603011133.pdf
ee079866676b6b483fd5a7b487e44610
MD5
1
TEXT
201603011133.pdf.txt
201603011133.pdf.txt
text/plain
153
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/328/2/201603011133.pdf.txt
e99206507635dc5bc3598c6c73831d80
MD5
2
11684/328
oai:openaccess.ogu.edu.tr:11684/328
2016-03-03 03:00:06.093
Dspace@ESOGU
openaccess@ogu.edu.tr
oai:openaccess.ogu.edu.tr:11684/347
2016-03-25T01:00:10Z
com_11684_15
com_11684_2
col_11684_86
Uyanoğlu, Mustafa
Durmuş, Başak
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-03-24T09:07:07Z
2016-03-24T09:07:07Z
2015
2015-12-22
http://hdl.handle.net/11684/347
Yazar izni yok.
Karvakrol, Lamiaceae familyasının uçucu yağlarında bulunan bir bileşendir. Antihepatotoksik, hepatoprotektif özelliğinin yanında karaciğer rejenerasyonuna katkısının olduğu bilinmektedir. Karvakrolün, hücre proliferasyonu ve rejenerasyon mekanizması üzerine etkisi ile ilgili yapılan araştırmalar az sayıdadır. Bu nedenle çalışmamızda, sıçanlarda %70 parsiyal hepatektomi (PH) sonrası uyarılan karaciğer rejenerasyonuna IL-6/STAT3 ve MAPK yolakları üzerinden karvakrolün etkisi araştırılmıştır.
Çalışmamızda, ağırlıkları 250±30 gr olan 3 aylık erkek Wistar albino sıçanlardan her grupta n=6 olacak şekilde 6 grup oluşturulmuştur. Grup I ve II, Sham grupları; Grup III ve IV, 1mL %0,9 NaCl; Grup V ve VI ise 73 mg.kg-1 karvakrol verilen gruplardır. Grup III, IV, V ve VI hayvanlarına %68-70 PH yapılmıştır. Cerrahi işlemlerden 24 ve 48 saat sonra diseksiyon yapılmıştır. Serum örneklerinde Alanine Transaminase (ALT) enzim seviyeleri belirlenmiştir. Karaciğer rejenerasyon oranı hesaplanmıştır. Karaciğer kesitlerinde Hematoxylin ve Eosin (H&E) boyama ile histopatolojik analiz ve Proliferating Cell Nuclear Antigen (PCNA) immunhistokimya boyama ile proliferasyon değerlendirmeleri yapılmıştır. Karaciğerde, RT-PCR analizi ile IL-6/STAT3 ve MAPK yolaklarındaki bazı genlerin ifade düzeylerine ve Western Blot analizi ile bu genlerin protein ifadelerine bakılmıştır.
Çalışmamızdan elde edilen tüm veriler istatistiksel olarak değerlendirilip gruplar arasında karşılaştırılmıştır. Buna göre; PH’den 24 ve 48 saat sonra karvakrolün hepatosit çoğalması ve karaciğer rejenerasyonu üzerine olumlu etki gösterdiği saptanmıştır.
Carvacrol is a component in the essential oil of Lamiaceae family. Besides antihepatotoxic and hepatoprotective property is known that the contribution of liver regeneration. The research of related to the effects on cell proliferation and regeneration mechanism of carvacrol are merely. Therefore, in our study, 70% partial hepatectomy (PH) after liver regeneration in rats, induced IL-6/STAT3 and MAPK pathways through carvacrol effect was investigated.
In our study, 6 groups were created to be each group n = 6 with Wistar albino male rats weighted 250±30 gr and 3 month old. Group I and II, Sham operated; Group III and IV, 1ml 0.9% NaCl; The Group V and VI are the group that treated with 73 mg.kg-1 carvacrol. 68-70% PH was performed to Group III, IV, V, VI animals. Dissection was performed 24 and 48 after surgical procedure. Alanine transaminase (ALT) enzyme levels in serum samples were determined. The liver regeneration rate was calculated. In liver sections, evaluation of histopathological analysis by staining Hematoxylin and Eosin (H&E) and the proliferation by proliferating cell nuclear antigen (PCNA) immunohistochemical staining was performed. In the liver, certain genes expression in IL-6/STAT3and MAPK pathways with RT-PCR analysis and protein expression of these genes with Western blot analysis were measured.
All data obtained from this study were compared between groups were statistically evaluated. Accordingly; 24 and 48 hours after PH carvacrol on hepatocyte proliferation and liver regeneration was found to show a positive effect.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-03-22T13:32:18Z
No. of bitstreams: 1
10093122.pdf: 3665621 bytes, checksum: a5aa598c45a4510f839788926d8a9b88 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-03-24T09:07:07Z (GMT) No. of bitstreams: 1
10093122.pdf: 3665621 bytes, checksum: a5aa598c45a4510f839788926d8a9b88 (MD5)
Made available in DSpace on 2016-03-24T09:07:07Z (GMT). No. of bitstreams: 1
10093122.pdf: 3665621 bytes, checksum: a5aa598c45a4510f839788926d8a9b88 (MD5)
Previous issue date: 2015
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Karaciğer Rejenerasyonu
IL-6/STAT3 Yolağı
SOCS3
MAPK Yolağı
PCNA İndeksi
Liver Regeneration
IL-6/STAT3 Pathway
MAPK Pathway
PCNA Index
Verbascum exuberans hub.-mor. türünün in vivo antinosiseptif ve antiinflamatuvar etkilerinin araştırılması
doctoralThesis
ORIGINAL
10093122.pdf
10093122.pdf
application/pdf
3665621
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/347/1/10093122.pdf
a5aa598c45a4510f839788926d8a9b88
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/347/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
TEXT
10093122.pdf.txt
10093122.pdf.txt
text/plain
168828
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/347/3/10093122.pdf.txt
6b1fc3bf1fa3f99f4afc08a6b84b56b2
MD5
3
11684/347
oai:openaccess.ogu.edu.tr:11684/347
2016-03-25 03:00:10.512
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/383
2016-05-11T00:00:31Z
com_11684_15
com_11684_2
col_11684_86
Ayhancı, Adnan
Eyiiş, Esra
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-05-10T09:01:59Z
2016-05-10T09:01:59Z
2015
2015-12-22
http://hdl.handle.net/11684/383
Bu çalışma, Verbascum exuberans ekstresi (Vex)’nin antinosiseptif etkinliğini, bu
etkide serotonerjik, nitrerjik ve opiyoderjik yolaklar üzerindeki rolünü ve antiinflamatuvar
aktivitesini belirlemek üzere dizayn edilmiştir. Ekstrenin santral antinosiseptif etkinliği tail
clip, tail flick ve hot plate testleriyle, periferal antinosiseptif etkinliği ise asetik asit ile
oluşturulan writhing testiyle araştırılmıştır. Bu duruma ek olarak, Vex (250 mg/kg) LNAME
(100 mg/kg), siproheptadin (50 μg/kg) ve nalokson (1 mg/kg) ile kombine
edilmiştir. Karragenan ile oluşturulan arka ayak pençe ödem modeli Vex (250 mg/kg)’nin
antiinflamatuvar aktivitesinin belirlenmesinde kullanılmıştır. 250 mg/kg Vex % MPE
değerlerini sadece tail clip testinde arttırırken (p˂0,05), 500 mg/kg Vex % MPE
değerlerini tail clip, tail flick ve hot plate testlerinde arttırmamıştır (p˃0,05). Ekstrenin her
iki dozu asetik asit ile oluşturulan writhing testinde kıvranma sayılarını azaltmıştır
(p˂0,001). Vex ile kombine verilen L-NAME santral antinosiseptif testlerdeki % MPE
değerini sadece tail clip testinde arttırdığı görülmüştür (p<0,05). L-NAME ve nalokson
kombine gruplarında ekstrenin kıvranma sayılarını azalttığı (p<0,05), siproheptadin ile
kombine verilen grupta ise azaltmadığı belirlenmiştir (p>0,05). Çalışmamızda, Vex’nin
santral spinal düzeyde antinosiseptif etkili olduğu, santral supraspinal düzeyde
antinosiseptif etkili olmadığı ve Vex’nin periferal antinosiseptif etkili olduğu bulunmuştur.
Vex’nin periferal antinosiseptif etkide hem nitrerjik hem de opiyoderjik yolaklara aracılık
ettiği, serotonerjik yolağın aracılık etmediği görülmüştür. Ayrıca, Vex’nin santral spinal
düzeyde nitrerjik yolak üzerinden antinosiseptif etkiye aracılık ettiği belirlenmiştir. Vex,
karragenan ile oluşturulan inflamasyona karşı ödem miktarını TNF-α ve IL-1β düzeylerini
azaltarak inhibitör etki göstermiştir.
This study was designed to investigate the antinociceptive effects of Verbascum
exuberans extract (Vex) and the contribution of nitrergic, serotonergic and opioidergic
pathways of Vex, and the antiinflammatory activity of Vex. Tail clip, tail flick, and hot
plate tests were used to investigate the central antinociceptive effect and acetic acidinduced
writhing test was used to assess the pheripheral antinociceptive effect of Vex. In
addition, Vex (250 mg/kg) was combined with L-NAME (100 mg/kg), cyproheptadine (50
μg/kg), and naloxone (1 mg/kg). Carrageenan-induced hind paw edema model was used
for the assessment of antiinflammatory activity of Vex (250 mg/kg). Vex 250 mg/kg
increased MPE % solely in tail clip test (p<0.05), whereas Vex 500 mg/kg did not enhance
MPE % in tail clip, tail flick and hot plate tests (p>0.05). The combined use of Vex with LNAME
reduced the MPE % solely in tail clip test (p<0.05). Both doses of Vex decreased
the number of strechings in acetic acid-induced writhing test (p<0.001). The combined use
of Vex 250 mg/kg with L-NAME and naloxone decreased the number of strechings
(p<0.05), while cyproheptadine did not (p˃0.05). We suggest that Vex presents central
spinal but not central supraspinal antinociceptive effect and Vex shows peripheral
antinociceptive effect. The opioidergic and nitrergic pathways seem to mediate its
pheripheral antinociceptive effect of Vex while serotonergic pathway is not involved.
Besides, nitrergic pathway seems to mediate its central spinal antinociceptive activity of
Vex. Vex inhibits carrageenean-induced edema formation as a consequence of decreasing TNF-α and IL-1β levels.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-04-20T13:02:36Z
No. of bitstreams: 1
10085734.pdf: 2361909 bytes, checksum: d620caf1a1fe983b410b13770faa6d69 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-05-10T09:01:59Z (GMT) No. of bitstreams: 1
10085734.pdf: 2361909 bytes, checksum: d620caf1a1fe983b410b13770faa6d69 (MD5)
Made available in DSpace on 2016-05-10T09:01:59Z (GMT). No. of bitstreams: 1
10085734.pdf: 2361909 bytes, checksum: d620caf1a1fe983b410b13770faa6d69 (MD5)
Previous issue date: 2015
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Verbascum Exuberans
Scrophulariaceae
Antinosiseptif Etki
Antiinflamatuvar Etki
Antinociceptive Effect
Antiinflammatory Effect
Verbascum exuberans hub.-mor. türünün in vivo antinosiseptif ve antiinflamatuvar etkilerinin araştırılması
doctoralThesis
ORIGINAL
10085734.pdf
10085734.pdf
application/pdf
2361909
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/383/1/10085734.pdf
d620caf1a1fe983b410b13770faa6d69
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/383/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
TEXT
10085734.pdf.txt
10085734.pdf.txt
text/plain
225806
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/383/3/10085734.pdf.txt
54c614fb9ecb4089ef945aba2b60be24
MD5
3
11684/383
oai:openaccess.ogu.edu.tr:11684/383
2016-05-11 03:00:31.089
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/396
2016-05-11T00:00:10Z
com_11684_15
com_11684_2
col_11684_86
Canbek, Mediha
Danış, Seren
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-05-10T09:04:50Z
2016-05-10T09:04:50Z
2015
2015-12-22
http://hdl.handle.net/11684/396
Tez çalışmasında sıçanlarda deneysel olarak oluşturulan böbrek iskemi reperfüzyon hasarına karşı, antioksidan özelliğe sahip geraniolün koruyucu etkileri araştırıldı.
Deneysel çalışmada; herbirinde n=7 olmak üzere 28 adet Wistar albino cinsi erkek sıçanlar rastgele seçilerek 4 grup oluşturuldu. Grup I (Sham), Grup II (İ/R + Serum Fizyolojik), Grup III (50 mg/kg Geraniol + İ/R), Grup IV (100mg/kg Geraniol + İ/R) olarak belirlendi. Tüm gruplara ksilazin (10mg/kg) ve ketamin (70mg/kg) anestezisi altında sağ böbrek nefroktomisi yapıldı, 15 gün iyileşmeleri beklendi. Grup I ve II’ ye 2 ml SF, Grup III ve IV’ e sırasıyla 50 mg/kg ve 100 mg/kg geraniol tek doz halinde iskemiden bir saat önce intraperitonal olarak verildi. Grup I haricindeki gruplara 45 dakika iskemi ve 4 saat reperfüzyon uygulandı. Deney sonunda tüm sıçanlardan kan örnekleri ve böbrek dokuları alındı. Serum örneklerinde kanda üre nitrojen testi (BUN) ve kreatinin (CRE) değerlerine bakılırken, doku örneklerinde katalaz (CAT) ve süperoksit dismutaz (SOD) enzim aktiviteleri ölçüldü. Doku kesitleri H&E ile boyandı ve ışık mikroskobunda incelendi.
Çalışma sonuçlarına göre; Grup I ve Grup II’ nin serumda BUN ve CRE, doku örneklerinde CAT ve SOD değerleri karşılaştırıldığında Grup II’ de yükseldiği ve bunun sonucunda İ/R hasarının oluştuğu gözlendi. Geraniol uygulanan Grup III ve Grup IV’ ün değerlerinin Grup I’ e yaklaştığı gözlendi. Birbirine paralellik gösteren bu sonuçlar; 50 mg/kg’ lik geraniolün, 100 mg/kg’ lik geraniole göre daha etkili olduğunu destekler nitelikteydi.
Deney sonuçlarına göre; intraperitonal olarak uygulanan geraniolün böbrek iskemi reperfüzyon hasarına karşı koruyucu etkisi olduğunu gösterdi.
In this thesis study, the possible protective effects of geraniol, which is known to be an antioxidant, were investigated against experimentally induced short-term renal ischemia/ reperfusion (IR) injury in rats.
In this empirical study, 28 Wistar-albino type 28 male rats (n=7) were prepared. They were randomly separeted into 4 groups. The groups were determined as follows: Group I (Sham), Group II (IR), Group III (50 mg/kg Geraniol + IR), Group IV (100 mg/kg Geraniol + IR). Under anesthesia, the right kidney nephrectomy was performed in all groups by using ksilazin (10mg/kg) and ketamin (70mg/kg). The rats were allowed to recover for 15 days before they were subjected to IR injury. Then, 2 ml SF was injected to Group I and Group II; 50 mg/kg geraniol was injected to Group III and 100 mg/kg geraniol was injected to Group IV intraperitoneally one hour before ischemia. 45 minutes ischemia and 4 hours reperfusion were applied to all groups expect Group I. The dissection was performed in the Group I (without ischemia) after reperfusion. At the end of the experiment, Blood Urea Nitrogen (BUN), Creatinine (CRE) activities in the blood serum and the Catalase (CAT) and Superoxide dismutases (SOD) Hematoxylien & Eosine and investigated by light microscope.
At the end of the study, when Group I and Group II’s BUN and CRE values of the I/R injury were compared, it was determined that there had been an increase in Group II and as a result of this, I/R injury had been created. It was observed that as a result of the application of geraniol, the CAT and SOD activities approached the control values and prevented this, injury 50 mg/kg geraniol was thought to be more effective when compared to 100 mg/kg of geraniol.
The results obtained in the study showed that geraniol has a protective effect renal against renal I/R injury.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-04-22T09:03:19Z
No. of bitstreams: 1
10084836.pdf: 3165528 bytes, checksum: 791cd956339929bb749e719fb32756b5 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-05-10T09:04:50Z (GMT) No. of bitstreams: 1
10084836.pdf: 3165528 bytes, checksum: 791cd956339929bb749e719fb32756b5 (MD5)
Made available in DSpace on 2016-05-10T09:04:50Z (GMT). No. of bitstreams: 1
10084836.pdf: 3165528 bytes, checksum: 791cd956339929bb749e719fb32756b5 (MD5)
Previous issue date: 2015
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Serbest Radikal
Antioksidan
Geraniol
İskemi Reperfüzyon
Böbrek
Kidney
Ischemia/Reperfusion
Free Radical
Antioxidant
Sıçanlarda kısa süreli böbrek iskemi/reperfüzyon hasarına karşı geraniolün koruyucu etkisi
masterThesis
ORIGINAL
10084836.pdf
10084836.pdf
application/pdf
3165528
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/396/1/10084836.pdf
791cd956339929bb749e719fb32756b5
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/396/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
TEXT
10084836.pdf.txt
10084836.pdf.txt
text/plain
122440
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/396/3/10084836.pdf.txt
6cb032ba1539ff31c20d8c30419376d4
MD5
3
11684/396
oai:openaccess.ogu.edu.tr:11684/396
2016-05-11 03:00:10.14
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/382
2016-05-11T00:00:27Z
com_11684_15
com_11684_2
col_11684_86
İşcen, Cansu Filik
Malay, Dilek
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-05-10T09:01:44Z
2016-05-10T09:01:44Z
2015
2015-12-22
http://hdl.handle.net/11684/382
Antibiyotikler insan ve hayvan hastalıklarının iyileştirilmesinde kullanılan en başarılı ilaç grupları arasındadır. Ancak antibiyotiklerin büyük bir kısmı insanlarda tam metabolize olmamaları ya da kullanılmayan antibiyotiklerin alıcı ortama boşaltılması nedeniyle, antibiyotikler kentsel atıksularda bulunabilmektedir. Su ve atık sulardan antibiyotik gideriminde kullanılan yöntemler arasında anaerobik arıtım yöntemlerinin kullanımı artış göstermektedir.
Günümüzde anaerobik arıtma sistemleri orta ve yüksek derecede organik maddeler içeren atık sular için yaygın olarak kullanılmaktadır. Bu çalışmada farklı antibiyotik gruplarını içeren sentetik atık suların kesikli ve laboratuvar ölçekli yukarı akışlı dolgulu yatak reaktörde arıtımı, KOİ giderimi ve reaktördeki mikrobiyal çeşitliliğin araştırılması amaçlanmıştır. Çalışmada amfoterisin b, eritromisin, flukonazol, kanamisin, sefamezin tetrasikilin, vankomisin antibiyotikleri kullanılmıştır. Kesikli reaktör çalışmalarının istatistiksel optimizasyonu sonucu elde edilen veriler dikkate alınarak sürekli reaktörde arıtım süreci takip edilmiştir. Reaktör sürecinde antibiyotik konsantrasyonu, organik yükleme oranı, kimyasal oksijen ihtiyacı gibi işletim parametrelerinin organik madde giderim verimi üzerine etkileri değerlendirilmiştir. En yüksek KOİ giderimi 30 mg/l antibiyotik içeren atık suyun uygulandığı, hidrolitik alıkonma süresinin 96 saat ve Organik yükleme oranının 0,618 g KOİ l-1 gün-1 olduğu koşullarda gerçekleşmiştir. Çalışmada denenen tüm antibiyotik konsantrasyonlarında (10-100 mg/L) çıkış suyunun deşarj standartlarını sağlayacak düzeyde arıtıldığı belirlenmiştir. Ayrıca, uygulanan toksisite test sonucunda toksik olan giriş atık suyunun arıtım sonrasında toksik etkisinin kalmadığı bulunmuştur. Arıtımda rol alan mikrobiyal konsorsiyumun belirlenmesinde yeni nesil dizileme tekniği kullanılmıştır. Yeni nesil dizileme sonuçlarına göre, anaerobik çamurda 347 bakteri ve 26 arke üyesi tespit edilmiştir. Bakterilerden %19,56’ lik oranla Syntrophobacter spp. ve arkelerden %94,064 Methanosaeta spp. baskın türler olduğu ve arıtımda etkin oldukları tespit edilmiştir.
Antibiotics are among the most successful group of pharmaceuticals used for human and veterinary therapy. However, large amounts of antibiotics are released into municipal wastewater due to incomplete metabolism in humans or due to disposal of unused antibiotics. Anaerobic treatment systems increasingly used for removal of antibiotics from wastewater.
Today, anaerobic treatment systems commonly used for wastewater containing medium and high degree of organic matters. This study was carried out for the treatment of synthetic wastewater containing different antibiotic group in batch and laboratory scale up flow packed bed reactor; for removal of COD and for investigation of the microbial diversity in reactor. In this study, amphotericin b, erythromycin, fluconazole, kanamycin, cefamezin, tetracycline, vancomycin antibiotics were used. The treatment process was monitored based on the statistical optimisation data of the batch reactor studies. The effects of operating parameters such as wastewater concentration, organic loading rate: OLR, chemical oxygen demand: COD on organic matter removal efficiency was evaluated in the reactor process. The highest COD removal efficiencies were obtained for the use of waste water containing 30 mg/l antibiotic at 96 hour HRT and 0,618 g COD/day OLR. For all samples with different antibiotic concentrations (10-100 mg/l) the treated water was treated to provide the water discharge standards. According to the results of the toxicity test, it was found that the toxicity of the raw wastewater was eliminated after the treatment. Next generation sequencing was used for determining microbial diversity. According to next generation sequencing results, 347 bacteria and 26 archaea members have been detected in the anaeorobic sludge. Also, of the bacterial strain Syntrophobacter spp. (19.56%) and of the archea strain Methanosaeta spp. (94,064 %) was found to be effective in treatment.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-04-26T08:28:57Z
No. of bitstreams: 1
10067352.pdf: 2509132 bytes, checksum: 1b1e69a97d8d8d2335952bb1517f8940 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-05-10T09:01:44Z (GMT) No. of bitstreams: 1
10067352.pdf: 2509132 bytes, checksum: 1b1e69a97d8d8d2335952bb1517f8940 (MD5)
Made available in DSpace on 2016-05-10T09:01:44Z (GMT). No. of bitstreams: 1
10067352.pdf: 2509132 bytes, checksum: 1b1e69a97d8d8d2335952bb1517f8940 (MD5)
Previous issue date: 2015
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Anaerobik Arıtım
Kesikli Reaktör
Yukarı Akışlı Anaerobik Dolgulu Yatak Reaktör
Antibiyotik
Sentetik Atık Su
Yeni Nesil Dizileme
Anaerobic Treatment
Batch Reactor
Up Flow Packed Bed Reactor
Antibiotic
Synthetic Wastewater
Next Generation Sequencing
Farklı antibiyotik gruplarını içeren sentetik atıksuların anaerobik arıtımı ve mikrobiyal komünitenin belirlenmesi
masterThesis
TEXT
10067352.pdf.txt
10067352.pdf.txt
text/plain
201762
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/382/3/10067352.pdf.txt
7ac27f4c9d6b0b63211325a5624d4ec2
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/382/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10067352.pdf
10067352.pdf
application/pdf
2509132
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/382/1/10067352.pdf
1b1e69a97d8d8d2335952bb1517f8940
MD5
1
11684/382
oai:openaccess.ogu.edu.tr:11684/382
2016-05-11 03:00:27.497
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/404
2016-05-13T00:00:07Z
com_11684_15
com_11684_2
col_11684_86
Erkara, İsmühan Potoğlu
Kocaman, Beyza Güler
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-05-12T08:20:45Z
2016-05-12T08:20:45Z
2015
2015-12-22
http://hdl.handle.net/11684/404
Araştırma alanı Pazaryeri (Bilecik) ve çevresini kapsamaktadır. Araştırma bölgesi Davis (1965) kareleme sistemine göre A2 ve B2 kareleri içinde yer almaktadır. 2013-2014 yıllarında yapılan arazi çalışmalarında bölgeden toplam 2472 damarlı bitki örneği toplanmıştır. Toplanan örneklerin teşhisleri sonucunda araştırma bölgesinde; 60 familyaya ait 312 cins, 546 tür ve tür altı damarlı bitki taksonu tespit edilmiştir. Bu taksonların büyük taksonomik gruplara dağılımı ise şöyledir; 1 takson Pteridophyta, 4 takson Gymnospermae ve 71’i Monocotyledonae, 470’i Dicotyledonae olmak üzere 541’i Spermatophyta bölümüne aittir. Araştırma alanında içerdiği takson sayısına göre en büyük 5 familya sırasıyla Asteraceae 68 (% 12,45), Lamiaceae 49 (% 8.97), Fabaceae 48 (% 8,79), Apiaceae 34 (% 6,22) ve Brassicaceae 32 (% 5,86)’dir. Araştırma alanında en fazla tür ve türaltı takson içeren ilk 4 cins ise sırasıyla; Salvia 11 (% 2,01), Verbascum 9 (% 1,64), Ornithogalum ve Centaurea 7 (% 1,28)’dir. Alandaki bitki taksonlarının fitocoğrafik bölgelere dağılımı ise şöyledir; 67 takson ve % 12,27’lik oranla Akdeniz bölgesi elementleri 1. sırada yer almaktadır. Bunu 57 takson ve % 10,43’lük oran ile Avrupa-Sibirya bölgesi elementleri ve 48 takson % 8,79’luk oran ile İran-Turan fitocoğrafik bölgesi elementleri almaktadır. Çok bölgeli veya fitocoğrafik bölgesi bilinmeyen 374 taksonun oranı ise % 68.41 dir. Araştırma alanında 49 endemik takson belirlenmiştir. Buna göre böldeki endemizm oranı ise % 8,97’dir. Endemik Taksonların 1’i VU, 7’si NT ve 26’sı LC kategorisindedir. Floristik liste APG III sistemi esas alınarak düzenlenmiştir.
The research area includes Pazaryeri (Bilecik) and its enviroment, and it occurs in the A2 and B2 square according to the grid system of P.H. Davis. To investigate the flora, 2472 specimens have been collected during the field seasons of 2013- 2014. At the end of identifications of the specimens 546 taxa belonging to 60 families and 312 genera have been determined. These of 1 taxon Pteridophyta, 4 taxa Gymnospermae, 71 taxa Monocotyledoneae, 470 taxa Dicotyledonae and 541 taxa Spermatophyta division are included. Acording to the number of taxa, Asteraceae 68 (% 12,45), Lamiaceae 49 (% 8.97), Fabaceae 48 (% 8,79), Apiaceae 34 (% 6,22) and Brassicaceae 32 (% 5,86) are the five largest families. The four largest genera are Salvia 11 (% 2,01), Verbascum 9 (% 1,64), Ornithogalum and Centaurea 7 (% 1,28). Phytogeographical distribution of the taxa are Mediterranean 67 (12.27%) and Euro- Siberian 57 (10.43%) and Irano- Turanian 48 (8.79%) with their percentage of. Pluriregional or phytogeographically unknown taxa is 374 (68.41%). The number of endemic taxa are 49 and endemism rate is 8.97%. These of 1 taxa VU, 7 taxa NT and 26 taxa LC category are included. The floristic list follows the APG III system.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-05-12T08:04:58Z
No. of bitstreams: 1
10072822.pdf: 11249352 bytes, checksum: cc8c83df27797b036f0e1b244167015b (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-05-12T08:20:45Z (GMT) No. of bitstreams: 1
10072822.pdf: 11249352 bytes, checksum: cc8c83df27797b036f0e1b244167015b (MD5)
Made available in DSpace on 2016-05-12T08:20:45Z (GMT). No. of bitstreams: 1
10072822.pdf: 11249352 bytes, checksum: cc8c83df27797b036f0e1b244167015b (MD5)
Previous issue date: 2015
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Flora
Pazaryeri
Bilecik
Türkiye
Pazaryeri (Bilecik) ve çevresinin florası
masterThesis
ORIGINAL
10072822.pdf
10072822.pdf
application/pdf
11249352
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/404/1/10072822.pdf
cc8c83df27797b036f0e1b244167015b
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/404/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
TEXT
10072822.pdf.txt
10072822.pdf.txt
text/plain
126667
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/404/3/10072822.pdf.txt
b762ad4758ddfaae573974e56e92c75c
MD5
3
11684/404
oai:openaccess.ogu.edu.tr:11684/404
2016-05-13 03:00:07.737
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/410
2016-06-09T00:00:13Z
com_11684_15
com_11684_2
col_11684_86
Ayhancı, Adnan
Karasatı, Pınar
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-06-08T07:47:11Z
2016-06-08T07:47:11Z
2015
2015-12-22
http://hdl.handle.net/11684/410
Antikanser bir ilaç olan siklofosfamid (CP) ürotoksik etkilerinin yanı sıra kardiyotoksik etkilerede sahiptir ve bu durum klinik kullanımını sınırlamaktadır. CP’nin kardiyotoksitesi ürotoksiteyle kıyaslandığında daha az yaygındır ve şu ana kadar CP nedenli kardiyotoksisitenin mekanizmasını çalışmak için daha az önem verilmiştir. Serbest oksijen radikallerinin inflamasyon boyunca aşırı üretilmesi kalp hasarının nedenlerinden biridir.
Selenyum (Se) neredeyse bütün dokularda redoks durumlarında ve serbest oksijen radikallerinin düzenlenmesinde hayati rol oynamaktadır. Bu yüzden bu çalışmada CP kardiyotoksisitesi ve selenyumun olası koruyucu etkileri kalp dokusunda araştırıldı. 42 adet Sprague-Dawley sıçanı her grupta 7 hayvan olacak şekilde 6 gruba ayrıldı ve kontrol grubuna serum fizyolojik ve diğer sıçanlara 150 mg/kg CP, 0.5 ve 1 mg/kg Se, CP+0.5 ve CP+1 mg/kg Se intraperitonal (İp) olarak enjekte edildi. Sıçan serumlarından iskemi modifiye albumin (İMA), laktat dehidrogenaz (LDH) ve kreatin kinaz MB (CK-MB) ölçüldü ve kalp dokuları mikroskopta incelendi. CP verilen ratlarda kontrole göre, İMA ( %27) yükselirken, CP ile birlikte 0,5 ve 1 mg/kg Se verilen ratlarda İMA değerleri kontrole yaklaştı. CP uygulamasını takiben LDH (%73) CK-MB (%58) oranlarında arttı. Ancak Se uygulanmasından sonra bu değerler önemli oranda düştü dahası bu biyokimyasal sonuçlar mikroskobik gözlemlerle de desteklendi.
Sonuç olarak, bu çalışma CP nedenli kardiyotoksisitede Se’un sadece potansiyel terapötik etkinliğini değil aynı zamanda kalp fonksiyon bozukluğu ile ilgili serbest oksijen türlerinin giderilmesi bakımından da önem arz etmektedir.
The anticancer drug cyclophosphamide (CP) has cardiotoxic effects besides its urotoxicity, which both in turn limit its clinical utility. The cardiotoxicity of CP is less common compared to its urotoxicity, and not much importance has been given for the study of mechanism of CP-induced cardiotoxicity so far. Overproduction of reactive oxygen species (ROS) during inflammation is one of the reasons of the heart injury. Selenium (Se) play crucial roles in regulating ROS and redox status in nearly all tissues; therefore, in this study, the cardiotoxicity of CP and the possible protective effects of Se on rat heart were investigated.
Forty-two Sprague–Dawley rats were equally divided into six groups of seven rats each. The control group received saline, and other rats were injected with CP (150 mg/kg), Se (0.5 or 1 mg/kg), or CP+ Se intraperitoneally. Ischemia modified albumin (IMA), lactate dehydrogenase (LDH) and creatine kinase- MB (CK-MB) levels in serum of rats were measured, and heart tissues were examined under the microscope. CP-treated rats showed a increase of serum IMA levels (27% of control), while CP+Se (0.5 or 1 mg/kg) injected rats had IMA values close to the control group. LDH levels increased 73% and CK-MB levels increased 58% of controls following CP administration, which were significantly decreased after Se treatment. Furthermore, these biochemical results were supported by microscopical observations.
In conclusion, the present study not only points to the therapeutic potential of Se in CP-induced cardiotoxicity but also indicates a significant role for ROS and their relation to heart dysfunction.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-06-07T07:38:26Z
No. of bitstreams: 1
10092268.pdf: 1202671 bytes, checksum: 0028099dc9128dca62c2e6474289b2ae (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-06-08T07:47:11Z (GMT) No. of bitstreams: 1
10092268.pdf: 1202671 bytes, checksum: 0028099dc9128dca62c2e6474289b2ae (MD5)
Made available in DSpace on 2016-06-08T07:47:11Z (GMT). No. of bitstreams: 1
10092268.pdf: 1202671 bytes, checksum: 0028099dc9128dca62c2e6474289b2ae (MD5)
Previous issue date: 2015
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Siklofosfamid
Oksidatif Stres
Kardiyotoksisite
Selenyum
Sitoprotektivite
Sıçan
Cyclophosphamide
Oxidative Stres
Cardiotoxicity
Selenium
Cytoprotectivity
Rat
Sıçanlarda siklofosfamid nedenli kardiyotoksisitede oksidatif stres ve kalp hasarına karşı selenyumun koruyucu etkisi
masterThesis
TEXT
10092268.pdf.txt
10092268.pdf.txt
text/plain
129410
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/410/3/10092268.pdf.txt
4ccf8cca9c15f16108dbed6e6cf3a69d
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/410/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10092268.pdf
10092268.pdf
application/pdf
1202671
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/410/1/10092268.pdf
0028099dc9128dca62c2e6474289b2ae
MD5
1
11684/410
oai:openaccess.ogu.edu.tr:11684/410
2016-06-09 03:00:13.793
Dspace@ESOGU
openaccess@ogu.edu.tr
REFHSVRJTSBMSVNBTlNJCgpCdSBsaXNhbnPEsSBpbXphbGF5xLFwIGfDtm5kZXJlcmVrLCBnw7ZuZGVyaW5pemkgZMO8bnlhIMOnYXDEsW5kYSBiYXPEsWzEsSBoYWxkZSwgCmVsZWt0cm9uaWsgb3J0YW1kYSB2ZSBoZXJoYW5naSBiYXNrYSBiaXIga2FuYWxsYSB5ZW5pZGVuIG9sdcWfdHVybWFrLCAKw6dldmlyaXNpbmkgeWFwbWFrIChhxZ9hxJ/EsWRhIHRhbsSxbWxhbmTEscSfxLEgw7x6ZXJlKSB2ZS92ZXlhIGRhxJ/EsXRtYWsgacOnaW4gCkVza2nFn2VoaXIgT3NtYW5nYXppIMOcbml2ZXJzaXRlc2nigJluaW4gKEVTT0dVKSDDtnplbCBvbG1heWFuIGhha2xhcsSxbsSxIGthYnVsIGV0bWnFnyBvbHVyc3VudXouCgpFU09HVSwgZ8O2bmRlcmluaXppbiBpw6dlcmnEn2luaSBkZcSfaXN0aXJtZWRlbiBoZXJoYW5naSBiaXIgCm9ydGFtZGEgZmFya2zEsSBiacOnaW1sZXJkZSBrb3J1bWEgYW1hw6dsxLEgb2xhcmFrIMOnZXZpcmViaWxpci4gCsOWdGUgeWFuZGFuIEVTT0dVLCBnw7x2ZW5saWssIHllZGVrbGVtZSB2ZSBrb3J1bWEgYW1hY8SxeWxhIGJ1IGfDtm5kZXJpbmluIApiaXJkZW4gZmF6bGEga29weWFzxLFuxLEgZWxpbmRlIHR1dGFiaWxpci4gCgpHw7ZuZGVyaW5pbiBzaXplIGFpdCBvcmlqaW5hbCBiaXIgw6dhbGnFn21hIG9sZHXEn3VudSB2ZSBidSBsaXNhbnN0YSBiZWxpcnRpbGVuIApoYWtsYXLEsSBrYWJ1bCBldG1lIGhha2vEsW7EsXogb2xkdcSfdW51IGJlbGlydG1pxZ8gb2x1cnN1bnV6LiBBeW7EsSB6YW1hbmRhIGfDtm5kZXJpbml6aW4sIApiaWxkacSfaW5peiBrYWRhcsSxeWxhLCBraW1zZW5pbiDDtnpsdWsgaGFra8SxbsSxIMOnacSfbmVtZWRpxJ9pbmkgZGUgc3VubXXFnyBvbHVyc3VudXouCgpFxJ9lciBnw7ZuZGVyaSB0ZWxpZiBoYWtrxLFuYSBzYWhpcCBvbHVubWF5YW4gYmlyIG1hdGVyeWFsIGnDp2VyaXlvcnNhLCBvIHphbWFuIAp0ZWxpZiBoYWtrxLEgc2FoaWJpbmRlbiBidSBsaXNhbnMgaWNpbiBnZXJla2xpIG9sYW4gRVNPR1UgaGFrbGFyxLFuxLEga2FidWwgZXRtZWsgCmljaW4ga8Sxc8SxdHPEsXogaXppbiBhbGTEscSfxLFuxLF6xLEgdmUgYnUgdGFyeiDDvMOnw7xuY8O8IGtpxZ9pbGVyIHRhcmFmxLFuZGFuIHNhaGlwIG9sdW5hbiAKbWF0ZXJ5YWxsZXJpbiBnw7ZuZGVyaSBpw6dlcmnEn2kgdmV5YSBtZXRuaSBpw6dlcmlzaW5kZSBhw6dpa8OnYSB0YW7EsW1sYW5kxLHEn8SxbsSxIHZlIAprYWJ1bCBlZGlsZGnEn2luaSBzdW5hcnNpbml6LgoKRcSeRVIgR8OWTkRFUsSwIEVTT0dVIERJxZ5JTkRBIEJBxZ5LQSBCxLBSIEtVUlVMVcWeIFRBUkFGSU5EQU4gREVTVEVLTEVORU4gQsSwUiDDh0FMScWeTUFZQSAKREFZQUxJIMSwU0UsIEJVIFRBUlogQklSIEFOTEHFnk1BIFZFWUEgU8OWWkxFxZ5NRU7EsE4gR0VSRUtUxLBSRMSwxJ7EsCBExLDEnkVSIApaT1JVTkxVTFVLTEFSSSBZRVLEsE5FIEdFVMSwUkTEsMSexLBOxLBaxLAgU1VOQVJTSU5JWi4KCkVTT0dVIGlzbWluaXppIGfDtm5kZXJpbmluIHlhemFyxLEgdmV5YSBzYWhpYmkgb2xhcmFrIGHDp8Sxa8OnYSB0YW7EsW1sYXlhY2FrdMSxciB2ZSAKYnUgbGlzYW5zxLFuIGl6aW4gdmVyZGnEn2luaW4gZMSxxZ/EsW5kYSBoZXJoYW5naSBiaXIgZGXEn2nFn2lrbGlrIHlhcG1heWFjYWt0xLFyLgo=
oai:openaccess.ogu.edu.tr:11684/442
2016-06-21T00:00:19Z
com_11684_15
com_11684_2
col_11684_86
Çabuk, Ahmet
Yardımcı, Ezgi
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-06-20T11:55:24Z
2016-06-20T11:55:24Z
2015
2015-12-22
http://hdl.handle.net/11684/442
Bu çalışmada 2013-123 no’lu bilimsel araştırma projeleri kapsamında laboratuarımızda devam eden çalışmalarda aşırı ortam olarak yüksek sıcaklık değerine sahip Kütahya ili Simav ilçesinde bulunan Naşa ve Çitgöl Termal kaplıcasından elde edilen izolatların hücre dışı proteaz enzimi üretim belirlenmesi amaçlanmıştır. Proteolitik aktiviteleri bakımından taranan izolatlar spesifik enzim aktivitelerine göre değerlendirilmiş ve en yüksek aktiviteyi gösteren ve Ç2-1 olarak kodlanan izolat Geobacillus subterraneus Ç2-1 olarak tanılanmıştır.
Geobacillus subterraneus Ç2-1 izolatının proteaz üretim yeteneği üzerine çeşitli faktörlerin etkisi incelenmiş ve üretim ortamının optimizasyonu gerçekleştirilmiştir. Bu amaçla en uygun başlangıç pH değeri, karbon ve azot kaynakları ve bu kaynakların miktarları, inokulum miktarı, inkübasyon sıcaklığı ve süre değerleri Plackett- Burman Deney Tasarım Yöntemi kullanılarak belirlenmiştir. Ç2-1 izolatı için en yüksek proteaz aktivitesi karbon kaynağı olarak %1,49 glikoz, azot kaynağı olarak %0,26 maya özütü kullanıldığında ve %3,23’lük inokulum oranında, 75°C’de 168 saatlik inkübasyon sonucunda, pH 5,5’de gözlenmiştir. Belirlenen optimum koşullarda üretilen proteaz enziminin karakterizasyonu amacıyla yapılan çalışmalarda enzimin optimum reaksiyon sıcaklığı 95°C ve optimum reaksiyon pH değeri 8 olarak bulunmuştur.
In this study, determination of extracellular protease enzyme production by isolates obtained from Nasa and Citgol thermal springs (Kutahya, Simav) having high temperature value as extreme environment at the studies ongoing in our laboratories in the scope of 2013-123 scientific research Project was aimed. The isolates screened for proteolitic activity were investigated for spesific enzyme activities and Ç2-1 coded isolate exhibited higher protease enzyme activity and was identified Geobacillus subterraneus Ç2-1.
The effects of various factors on the abilities of protease production of Geobacillus subterraneus Ç2-1 isolate were investigated and the optimization of production medium was carried out. For this purpose, the optimum initial pH, carbon and nitrogen sources, the amounts of these sources, inoculum amount, incubation temperature, incubation time were defined using Plackett Burman experimental design. For Ç2-1 isolate, when 1.49% of glucose as carbon source, 0.26% of yeast extract as nitrogen source, 3.23% of inoculum amount, 75 °C of incubation temperature, 168 hours of incubation time, and pH 5.5 were used, the highest protease activity was provided. For the characterization studies of protease enzyme produced at determined optimum conditions, 95 °C of optimum reaction temperature and 8 of optimum reaction pH were found.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-06-16T08:02:24Z
No. of bitstreams: 1
10061829.pdf: 1531255 bytes, checksum: 9c49e433b89618dca61c95d3c29109be (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-06-20T11:55:24Z (GMT) No. of bitstreams: 1
10061829.pdf: 1531255 bytes, checksum: 9c49e433b89618dca61c95d3c29109be (MD5)
Made available in DSpace on 2016-06-20T11:55:24Z (GMT). No. of bitstreams: 1
10061829.pdf: 1531255 bytes, checksum: 9c49e433b89618dca61c95d3c29109be (MD5)
Previous issue date: 2015
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Proteaz Üretimi
Geobacillus Subterraneus
Geobacillus subterraneus ile proteaz üretimi
masterThesis
ORIGINAL
10061829.pdf
10061829.pdf
application/pdf
1531255
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/442/1/10061829.pdf
9c49e433b89618dca61c95d3c29109be
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/442/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
TEXT
10061829.pdf.txt
10061829.pdf.txt
text/plain
191234
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/442/3/10061829.pdf.txt
e14ee9745fa03b0abd72bf44e2f75f5c
MD5
3
11684/442
oai:openaccess.ogu.edu.tr:11684/442
2016-06-21 03:00:19.472
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/444
2016-06-21T00:00:06Z
com_11684_15
com_11684_2
col_11684_86
Ayhancı, Adnan
Acar, Özge
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-06-20T11:55:27Z
2016-06-20T11:55:27Z
2015
2015-12-22
http://hdl.handle.net/11684/444
Siklofosfamid (CP) klinikte kanser ve non-malignant hastalıkların tedavisinde yaygın olarak kullanılan, yüksek derecede etkili, alkilleyici sitotoksik bir ilaçtır. CP’nin antitümoral etkinliği yüksek dozda kullanılmasına bağlıdır. Ancak yüksek doz CP kullanımı bir veya birden fazla dokuda sitotoksisiteye neden olmaktadır. Selenyum (Se), güçlü antioksidan (AO) ve hücre koruyucu özellikleri olduğu bilinen, canlı organizmalar için esansiyel bir iz elementtir. Bu çalışmada CP nedenli hepatotoksisitenin önlenmesinde Se’un olası koruyucu etkisi araştırılmıştır.
Sprague-Dawley cinsi 42 adet erkek sıçan her grupta 7 hayvan olacak şekilde 6 gruba bölündü (kontrol, 150 mg/kg CP, 0.5 mg/kg Se, 1 mg/kg Se, 150+0.5 mg/kg CP+Se, 150+1 mg/kg CP+Se). Se’un karaciğerdeki koruyuculuk derecesini belirlemek için serum aspartat transaminaz (AST), alanin transaminaz (ALT) ve alkalen fosfataz (ALP) düzeyleri ölçüldü. Ayrıca karaciğer dokusu histolojik olarak da incelendi. Sadece CP uygulanan grupta serum AST (%226), ALT (%145) ve ALP (%88) değerlerinde artış gözlendi. CP ile birlikte verilen Se’un her iki dozu da serum AST, ALT ve ALP değerlerini önemli oranda azalttı (p<0.001). CP uygulanan grupta hepatositlerde sitoplazmada bulanıklaşma ve homojenite kaybı görüldü ancak CP ile birlikte verilen Se’un her iki dozu da bu hasarları önemli oranda azalttı. Bununla birlikte 1mg/kg Se CP nedenli karaciğer hasarının önlenmesinde 0.5 mg/kg Se’a göre daha etkili bir koruma sağladı.
Verilerimiz Se’un oldukça etkili bir AO ve hücre koruyucu olduğunu göstermektedir. Bu nedenle kemoterapi protokollerinde AO ilaçların yan etkilerinin azaltılmasında etkili bir aday olabilir.
Cyclophosphamide (CP) is a highly effective alkylating cytotistic drug widely used in the treatment of cancer and non-malignant diseases. The antitumoral efficiency of CP comes about when it is used in high doses. However, high doses of this drug have a tendency to result in cytotoxicity in more than one tissues. Selenium (Se), is known to have potent antioxidant (AO) and cytoprotective properties, is an essential trace element for living organisms. The present study aims to investigate the possile protective effect of Se on CP-induced hepatotoxicity.
A total of 42 male Spraque-Dawley rats were divided into 6 groups of 7 animals each (control, 150 mg/kg CP, 0.5 mg/kg Se, 1 mg/kg Se, 150+0.5 mg/kg CP+Se, 150+1 mg/kg CP+Se). In order to determine the protective effect of Se upon the liver, the levels of aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP), were determined. Furthermore, the liver tissues were analysed histologically. Only in the group treated with CP serum AST (%226), ALT (%145) and ALP (%88) were observed increase in value. Both doses of Se with CP in serum AST, ALT and ALP values decreased significantly (p<0.001). In the group treated with CP hepatocyte cytoplasm blurring and loss of homogeneity was observed but both doses of Se are provided with CP was also significantly reduces the damage. However, Se of 1 mg/kg was determined to be more effective in the prevention of liver damage than was Se of 0.5 mg/kg.
Our data suggest that Se is a highly effective AO substance with a cell-protecting effect. Therefore, Se could serve as effective agent that could lessen the adverse effects of anti-cancer drugs in the course of chemotherapy protocols.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-06-16T08:12:28Z
No. of bitstreams: 1
10075232.pdf: 999444 bytes, checksum: 8f1cc949bfa115373894dd92793352e0 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-06-20T11:55:27Z (GMT) No. of bitstreams: 1
10075232.pdf: 999444 bytes, checksum: 8f1cc949bfa115373894dd92793352e0 (MD5)
Made available in DSpace on 2016-06-20T11:55:27Z (GMT). No. of bitstreams: 1
10075232.pdf: 999444 bytes, checksum: 8f1cc949bfa115373894dd92793352e0 (MD5)
Previous issue date: 2015
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Siklofosfamid
Oksidatif Stres
Hepatotoksisite
Selenyum
Sitoprotektivite
Sıçan
Cyclophosphamide
Oxidative Stress
Hepatotoxicity
Selenium
Cytoprotectivity
Rat
Sıçanlarda siklofosfamid nedenli hepatotoksisitede oksidatif stres ve karaciğer hasarına karşı selenyumun koruyucu etkisi
masterThesis
TEXT
10075232.pdf.txt
10075232.pdf.txt
text/plain
155319
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/444/3/10075232.pdf.txt
b4295f82495c8bbbd822694890c5df00
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/444/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10075232.pdf
10075232.pdf
application/pdf
999444
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/444/1/10075232.pdf
8f1cc949bfa115373894dd92793352e0
MD5
1
11684/444
oai:openaccess.ogu.edu.tr:11684/444
2016-06-21 03:00:06.694
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/506
2016-07-14T00:00:13Z
com_11684_15
com_11684_2
col_11684_86
Ocak, Atila
Özgişi, Kurtuluş
TR168043
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-07-13T08:32:27Z
2016-07-13T08:32:27Z
2015
2015-12-22
http://hdl.handle.net/11684/506
Araştırma alanı Yunusemre (Eskişehir) ve çevresini kapsamaktadır. Davis’in kareleme sistemine göre araştırma alanının tamamı B3 karesinde yer almaktadır. Floranın belirlenmesi için 2012-2013 yılları arasında araştırma alanından 1900 örnek toplanmıştır. Toplanan bitki örnekleri herbaryum tekniklerine uygun olarak preslenip kurutulmuştur. Floristik liste hazırlanırken APG III sistemi izlenmiştir. Yapılan teşhisler sonucunda; 83 familya, 383 cins, 671 tür ve tür altı takson tespit edilmiştir. Araştırma alanındaki bitki taksonları fitocoğrafik bölgelerine göre; %20,72’si İran-Turan, %9,39'u Akdeniz ve %6,11’i Avrupa-Sibirya elementi olarak tespit edilmiştir. Çok bölgeli veya fitocoğrafik bölgesi bilinmeyenlerin oranı ise %63,77’dir. Endemizm oranı %17,59’dur. Tür ve tür altı seviyede 16 takson B3 karesi için yeni kayıttır.
The research area includes Yunusemre(Eskişehir) and its enviroment, and it occurs in the B3 square according to the grid system of P.H. Davis. To investigate the flora, 1900 specimens have been collected during the field seasons of 2012- 2013. The specimens have been prepared according to the relevant herbarium techniques. The floristic list follows the APG III. At the end of identifications of the specimens 671 taxa belonging to 383 genera (83 family) have been determined. Phytogeographical distribution of the taxa are Irano- Turanian (20.72%), Mediterranean (9.39%) and Euro- Siberian (6.11%) with their percentage of. Pluriregional or phytogeographically unknown taxa is 63.77%. The endemism ratio of the areas is 17.59%. Sixteen taxa are new record for the B3 square.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-13T08:09:38Z
No. of bitstreams: 1
10024786 .pdf: 26970489 bytes, checksum: 1c4771208f54df3d0fab11f28aeb04de (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-13T08:32:27Z (GMT) No. of bitstreams: 1
10024786 .pdf: 26970489 bytes, checksum: 1c4771208f54df3d0fab11f28aeb04de (MD5)
Made available in DSpace on 2016-07-13T08:32:27Z (GMT). No. of bitstreams: 1
10024786 .pdf: 26970489 bytes, checksum: 1c4771208f54df3d0fab11f28aeb04de (MD5)
Previous issue date: 2015
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Flora
Yunusemre
Eskişehir
Türkiye
Yunusemre (Eskişehir) ve çevresinin florası
masterThesis
TEXT
10024786 .pdf.txt
10024786 .pdf.txt
text/plain
229698
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/506/3/10024786+.pdf.txt
c74221ac56223db280a634ab997af87e
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/506/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10024786 .pdf
10024786 .pdf
application/pdf
26970489
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/506/1/10024786+.pdf
1c4771208f54df3d0fab11f28aeb04de
MD5
1
11684/506
oai:openaccess.ogu.edu.tr:11684/506
2016-07-14 03:00:13.849
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/525
2016-07-26T00:00:24Z
com_11684_15
com_11684_2
col_11684_86
Şentürk, Hakan
Yıldız, Fatma
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-07-25T12:54:06Z
2016-07-25T12:54:06Z
2015
2015
http://hdl.handle.net/11684/525
Bu tez çalışmasında sıçanlarda deneysel olarak oluşturulan böbrek iskemi/reperfüzyon (İ/R) hasarına karşı, antioksidan özelliği bilinen zeytin yaprağı ekstresinin olası koruyucu etkileri araştırılmıştır.
Bu çalışmada toplam 28 adet 3-4 aylık 200-250 gram ağırlığında Spraque-dawley cinsi erkek sıçanlar dört gruba ayrılmıştır (n=7). Grup I (Sham Grubu), Grup II (İR+SF), Grup III (İR + 100 mg/kg zeytin yaprağı ekstresi), Grup IV (İR + 200 mg/kg zeytin yaprağı ekstresi) olarak belirlenmiştir. Ksilazin (10 mg.kg-1) ve ketamin (70 mg.kg-1) anestezisi altında tüm gruplara sağ böbrek nefroktomisi yapılmıştır. Grup I’e laparotomi işlemi yapılmış ve ameliyat stresi sağlanmıştır. Sıçanlara oral (gavaj) olarak 15 gün boyunca günde bir kez olmak üzere serum fizyolojik (Grup I, II), ve zeytin yaprağı ekstresi (Grup III, IV) verilmiş ve bu gruptaki sıçanlara 45 dk iskemi 24 saat reperfüzyon işlemi uygulanmıştır. Deney sonunda kan serumunda BUN (Blood urea nitrogen), Kreatinin (CRE) ve Ürik asit (ÜAC) değerlerine, böbrek örneklerinde ise Süperoksit Dismutaz (SOD), Katalaz (CAT) ve Glutatyon Peroksidaz (Gpx) enzim aktivitelerine bakılmıştır. Çalışma sonunda Grup II’de BUN, CRE ve ÜAC değerlerinin arttığı görülmüş ve böbrek dokularına ait SOD, CAT ve Gpx enzim aktivitelerinde de Grup I’e göre artış görülmüştür. Zeytin yaprağı ekstresi uygulaması sonucunda SOD, CAT ve Gpx aktivitelerinin kontrol değerine yaklaşarak hasarı önlediği görülmüştür. Histolojik bulgularında bu sonuçları desteklediği görülmüştür.
Çalışmanın sonucunda, böbrek iskemi reperfüzyon hasarına karşı 200 mg/kg zeytin yaprağı ekstresinin, 100 mg/kg zeytin yaprağı ekstresine göre daha koruyucu etkili olduğu tespit edilmiştir.
In this thesis study, the possible protective effects of olive leaf extract, which is known to be an antioxidant, against experimentally-induced kidney ischemia/reperfusion (IR) injury in rats were investigated.
In the study, a total of 28 three to four month-old Spraque-dawley-type male rats, weighing between 200 and 250 grams, were separated into 4 groups (n=7). The groups were determined as follows: Group I (Sham Group), Group II (IR + normal saline), Group III (IR + 100 mg/kg olive leaf extract), Group IV (IR + 200 mg/kg olive leaf extract). Right nephrectomies were performed under xylazine (10 mg.kg-1) and ketamine (70 mg.kg-1) anaesthesia in all the groups of rats. The rats were given, orally (gavage) once a day for 15 days, either a saline serum (Groups I and II) or an olive leaf extract (Groups III and IV), and a 45-minute ischemia 24-hour reperfusion was performed on the rats in this group. At the end of the experiment, the BUN (Blood urea nitrogen), Creatinine (CRE) and Uric acid (UAC) values in the blood serum, and the superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) enzyme activities in the kidney samples were measured. At the end of the study, the BUN, CRE and UAC values in Group II were increased, and the SOD, CAT, and Gpx activities in the kidney samples also saw an increase when compared to Group I. As a result of the application of olive leaf extract, with the SOD, CAT and GPx activities approaching the control values, injury was found to have been prevented. The histological findings were seen to support these results.
Our results found that 200 mg/kg of olive leaf extract had a more protective effect against renal ischemic reperfusion injury when compared to 100 mg/kg of olive leaf extract.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-13T08:44:20Z
No. of bitstreams: 1
10027974.pdf: 3985322 bytes, checksum: fec0ffaad0deb83189249c567b7009fb (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-25T12:54:06Z (GMT) No. of bitstreams: 1
10027974.pdf: 3985322 bytes, checksum: fec0ffaad0deb83189249c567b7009fb (MD5)
Made available in DSpace on 2016-07-25T12:54:06Z (GMT). No. of bitstreams: 1
10027974.pdf: 3985322 bytes, checksum: fec0ffaad0deb83189249c567b7009fb (MD5)
Previous issue date: 2015
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Böbrek
İskemi/Reperfüzyon
Zeytin (Olea europaea L.) Yaprağı Ekstresi
Serbest Radikal
Kidney
Ischemia/Reperfusion
Olive (Olea europaea L.) Leaf Extract
Free Radical
Sıçan böbreğinde iskemi reperfüzyon ile oluşturulan oksidatif stres hasarına karşı zeytin (Olea europaea L.) yaprağı ekstresinin olası koruyucu etkileri
masterThesis
TEXT
10027974.pdf.txt
10027974.pdf.txt
text/plain
129519
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/525/3/10027974.pdf.txt
99206c4cd868a157543ea9d379b0e02f
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/525/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10027974.pdf
10027974.pdf
application/pdf
3985322
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/525/1/10027974.pdf
fec0ffaad0deb83189249c567b7009fb
MD5
1
11684/525
oai:openaccess.ogu.edu.tr:11684/525
2016-07-26 03:00:24.88
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/543
2016-07-26T00:00:41Z
com_11684_15
com_11684_2
col_11684_86
Vatan, Pınar Öztopcu
İnan, Emine
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-07-25T13:03:39Z
2016-07-25T13:03:39Z
2015
2015
http://hdl.handle.net/11684/543
Bu çalışmada, insan (T98G) ve sıçan glioma (C6) hücreleri üzerindeki protokatekuik asitin farklı dozlarının (0,5; 0,75; 1; 1,5; 2; 2,5; 3 ve 3,5 mM) hücre morfolojisi, çoğalması ve apoptotik-nekrotik etkileri zamana bağlı olarak incelenmiştir. Protokatekuik asitin hücre çoğalması üzerindeki etkileri 3-(4,5-Dimetiltriazol-2-il)-2,5 difeniltetrazolium bromid (MTT) ve nötral kırmızısı (NR) yöntemleriyle değerlendirilmiştir. Protokatekuik asitin, T98G hücrelerinde, hem hücre morfolojisi hem de çoğalması üzerinde herhangi bir etkisinin olmadığı belirlenmiştir (p>0,05). C6 hücrelerinde ise 24 saatte 2 mM, 48 saatte ise 1,5 mM dozundan itibaren hücre morfolojisi üzerinde değişikliklere neden olduğu gözlenmiştir. Hücre çoğalması üzerindeki baskılayıcı etkisi ise 24 saatte 2 mM (p<0,001); 48 saatte ise 1,5 mM (p<0,001) dozundan itibaren görülmeye başlanmıştır. MTT yöntemine göre 24 ve 48 saatteki IC50 değerleri sırasıyla 2,79 ve 1,84 mM, NR yöntemine göre ise 2,67 ve 1,79 mM olarak hesaplanmıştır. Seçilen protokatekuik asit dozlarının C6 hücreleri üzerinde doza ve zamana bağlı olarak anlamlı bir nekrotik etkiye neden olmazken (p>0,05), apoptotik etkiyi artırdığı belirlenmiştir (p<0,001). Elde edilen tüm veriler, tek yönlü varyans analizi (ANOVA) ve ardından Tukey’in çok yönlü karşılaştırma yöntemi ile istatistiksel olarak değerlendirilmiştir.
Sonuç olarak, protokatekuik asitin doza ve zamana bağlı olarak hücre morfolojisi, çoğalması ve apoptotik ve/veya nekrotik etkileri T98G ve C6 glioma hücreleri üzerinde ilk defa incelenmiştir. Protokatekuik asitin, doza ve zamana bağlı olarak T98G hücrelerinde, hem hücre morfolojisi hem de çoğalması üzerinde herhangi bir etkisinin olmadığı buna rağmen, C6 hücrelerinde hücre morfolojisini etkilediği, hücre çoğalmasını baskıladığı ve apoptotik etkiyi arttırdığı belirlenmiştir.
In this study, cell morphology, cell proliferation, apoptotic and necrotic effects of different doses of protocatechuic acid (0.5; 0.75; 1; 1.5; 2; 2.5; 3; 3.5 mM) on human (T98G) and rat glioma (C6) cells time dependent manner are investigated. The effects of protocatechuic acid on cell proliferation are evaluated with 3 - (4,5-Dimetiltriazol-2-yl) -2,5 diphenyltetrazolium bromide (MTT) and neutral red (NR) methods. It is determined that protocatechuic acid hasn't any effect on both morphological and proliferation on T98G cell (p>0.05). It is observed that protocatechuic acid cause cell morphological changes in C6 cells as beginning from dosage of 2 mM at 24 hr and 1.5 mM at 48 hr. Its effect on cell viability is observed as beginning from doses 2 mM at 24 hr (p<0.001) and 1.5 mM at 48 hr (p<0.001). While IC50 values are calculated as 2.79 and 1.84 mM for 24 and 48 hr respectively according to MTT method; these values are calculated as 2.67 and 1.79 mM according to NR method. It is observed that chosen doses of protocatechuic acid do not cause significantly any necrotic effect on C6 cells depending on dose and time(p>0.05); on the other hand, increase apoptotic effect (p<0.001). Obtained all data evaluated as statistically, with one way analysis of variance (ANOVA) and then Tukey’s multiple comparison tests.
As a result; cell morphology, cell proliferation, apoptotic and necrotic effects of protocatechuic acid by depending on doses and time are researched on T98G and C6 cell lines for the first time. Protocatechuic acid dose and time dependent in T98G cells, has no effect on cell morphology and also on the proliferation of cells any significantly, although on C6 cells, effects cell morphology, inhibits cell proliferation and increases apoptotic effects was determined.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-13T12:32:52Z
No. of bitstreams: 1
10029835.pdf: 1631100 bytes, checksum: a879f80769eb53477b9d9e5563e9316d (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-25T13:03:38Z (GMT) No. of bitstreams: 1
10029835.pdf: 1631100 bytes, checksum: a879f80769eb53477b9d9e5563e9316d (MD5)
Made available in DSpace on 2016-07-25T13:03:39Z (GMT). No. of bitstreams: 1
10029835.pdf: 1631100 bytes, checksum: a879f80769eb53477b9d9e5563e9316d (MD5)
Previous issue date: 2015
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Protokatekuik Asit
Glioma
Sitotoksisite
Apoptoz
Protocatechuic Acid
Cytotoxicity
Protokatekuik asitin hücre proliferasyonu ve apoptpz üzerindeki etkilerinin memeli hücre kültür yöntemiyle in vitro belirlenmesi
masterThesis
TEXT
10029835.pdf.txt
10029835.pdf.txt
text/plain
99492
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/543/3/10029835.pdf.txt
d1b47ca2cd3d3f062a1c2944e8828b0a
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/543/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10029835.pdf
10029835.pdf
application/pdf
1631100
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/543/1/10029835.pdf
a879f80769eb53477b9d9e5563e9316d
MD5
1
11684/543
oai:openaccess.ogu.edu.tr:11684/543
2016-07-26 03:00:41.469
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/526
2016-07-26T00:00:18Z
com_11684_15
com_11684_2
col_11684_86
Arslan, Naime
Korkmaz, Ertan Mahir
Kara, Deniz
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-07-25T12:54:19Z
2016-07-25T12:54:19Z
2015
2015
http://hdl.handle.net/11684/526
Bu çalışmada, Ponto-Caspien bir tür olan Potamothrix hammoniensis’in (Michaelsen, 1901) Türkiye’nin bazı doğal göllerindeki yayılışının ve filocoğrafyasının moleküler çalışmalarla ortaya konulması amaçlanmıştır. P. hammoniensis’in, Annelid’lerden başlayarak türe kadar tanımlanmasında yaklaşık 50’ye yakın morfolojik taksonomik karakter kullanılmaktadır. Türün filocoğrafik hikâyesi içinde yayılış bariyerleri ile ilişkili olarak progresif veya konservatif endemizm durumlarında da olduğu gibi allopatrik izolasyona bağlı olarak türleşme gösterebileceği öngörülmüştür.
2010-2013 yılları arasında Gala Gölü (Edirne), Büyük Akgöl (Adapazarı), Sapanca, Eğirdir Gölü (Isparta), Mogan Gölü (Ankara), Cernek Gölü (Samsun), Gölbaşı Gölü (Hatay) ve Nemrut Gölü (Bitlis)'nde yapılan arazi çalışmaları ile örnekler toplanmıştır. Potamothrix cinsine bağlı, morfolojik olarak P. hammoniensis’e çok benzeyen, ancak bugüne kadar tanımlanan P. hammoniensis türü taksonomik karakterlerinden alt tür veya tür kategorisinde farklılık gösteren, dolayısıyla da mevcut anahtarlara göre teşhisi yapılamayan örnekler tespit edilmiştir.
P. hammoniensis’in ülkemiz durgun sularındaki yayılışını temsil edebilecek, batıdan doğuya doğru yukarıda anılan göllerde coğrafik izolasyona bağlı olarak bu göllerde tespit edilen P. hammoniensis’e morfolojik olarak benzerlik gösteren üremede primer görevli olan bazı karakterler bakımından farklı olan örnekler moleküler veri setlerinden yararlanılarak varyasyon sınırları belirlenmiştir. Böylelikle türün, ülkemiz yayılış alanı içerisinde tek bir türle temsil edilmediği, Gala Gölü’nden tespit edilen örneklerin yeni tür olabileceği, Sapanca ve Eğirdir Gölleri’nden elde edilen örneklerin ise farklılaşma gösterdiği, ancak bu farklılaşmanın Gala Gölü örneklerindeki kadar yüksek oranda olmadığı tespit edilmiştir. Nemrut Gölü örneklerinin de farklılaşma oranın yüksek olduğu ve araştırılan tüm göllerdeki örneklerden farklı bir izolasyon süreci ve mekanizması geçirdiği sonucuna varılmıştır.
In this study, it is aimed that presents distribution and phylogeography of Potamothrix hammoniensis (Michaelsen, 1901) which is a Ponto-Caspian species in some natural lakes of Turkey with molecular studies. It is used almost 50 morphologic taxonomic characters for determination of P. hammoniensis becoming from Annelids. It is predicted that this species can show speciation depends on allopatric isolation as in also progressive or conservative endemism situations as related to distribution barriers in phylogeographic history of this species.
Oligochaeta samples were collected from Gala Lake (Edirne), Büyük Akgöl (Adapazarı), Sapanca, Eğirdir Lake (Isparta), Mogan Lake (Ankara), Cernek Lake (Samsun), Gölbaşı Lake (Hatay) and Nemrut Lake (Bitlis) between 2010-2013. These samples are belong to Potamothrix genus and look like P. hammoniensis as morphologically but differ from some taxonomic characters which are primary rolling in reproduction of P. hammoniensis determined until today at category of subpecies or species so could not identify according to current identification keys.
In this way, it is determined whether this species is represented with only one species in distribution area of our country or, samples determined in Gala Lake may be new species, samples in Sapanca Lake and Eğirdir Lake shown differentiation, however this differentiation is not high to samples in Gala Lake. Differentiation in Nemrut Lake samples also is high and it reach a conclusion that these samples have different isolation process and mechanism from all studied lakes samples.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-13T12:38:02Z
No. of bitstreams: 1
10029660.pdf: 4632447 bytes, checksum: 9163ff3e0abb661a8fc9f822bde44cc0 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-25T12:54:19Z (GMT) No. of bitstreams: 1
10029660.pdf: 4632447 bytes, checksum: 9163ff3e0abb661a8fc9f822bde44cc0 (MD5)
Made available in DSpace on 2016-07-25T12:54:19Z (GMT). No. of bitstreams: 1
10029660.pdf: 4632447 bytes, checksum: 9163ff3e0abb661a8fc9f822bde44cc0 (MD5)
Previous issue date: 2015
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Ponto-Caspien Tubificin
Potamothrix Hammoniensis
Coğrafik İzolasyon
Geographic Isolation
Türkiye’nin bazı tatlı su göllerinde yayılış gösteren ponto-caspien kökenli potamothrix hammoniensis’in (clitellata) filocoğrafyası ve coğrafik genetik analizi
masterThesis
TEXT
10029660.pdf.txt
10029660.pdf.txt
text/plain
133292
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/526/3/10029660.pdf.txt
f48100709f8601155495688273f38032
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/526/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10029660.pdf
10029660.pdf
application/pdf
4632447
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/526/1/10029660.pdf
9163ff3e0abb661a8fc9f822bde44cc0
MD5
1
11684/526
oai:openaccess.ogu.edu.tr:11684/526
2016-07-26 03:00:18.61
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/542
2016-07-26T00:00:58Z
com_11684_15
com_11684_2
col_11684_86
Emiroğlu, Özgür
Sülün, Şule
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-07-25T13:03:34Z
2016-07-25T13:03:34Z
2015
2015
http://hdl.handle.net/11684/542
Seydisuyu (Sakarya Havzası)’nda 2011 Nisan, 2013 Temmuz ayları arasında gerçekleştirilen bu çalışma ile elde edilen Squalius pursakensis populasyonunun bazı önemli biyoekolojik özellikleri ve habitat tercihleri belirlenmeye çalışılmıştır. Çalışma kapsamında Seydisuyu’ndan 1684 Squalius pursakensis bireyi toplanmıştır. Disekte edilen bu örneklerin boy, ağırlık ölçümleri yapılmış ve eşeyleri belirlenmiştir. Elde edilen materyalden yaş tayinleri kenar artışı analizi ile doğrulanarak gerçekleştirilmiştir. Yumurta sayımları ve pul çapı ölçümleri yapılmış, populasyonun çeşitli büyüme indisleri, boy ve ağırlık ilişkisi, üreme zamanı ve uzunluğu, cinsiyet oranı, cinsi olgunluğa erişme büyüklüğü, habitat seçimi, mevsimsel büyüme artışı ve kondüsyon faktörü hesaplanmıştır. Yaş tayinleri elde dilen balıkların 0 ile XIII yaşları arasında değiştiğini, en küçük birey 46 mm total boya, en büyük birey 445 mm total boya sahip olduğunu belirlemiştir. Ağırlık olarak en küçük bireyin 5 gr, en büyük bireyin ise 1263,5 gr olduğu belirlenmiştir. Kondüsyon değerleri sonbahar kış mevsimlerinde birbirine yakın değerlerdeyken ilkbahar ve yaz mevsiminde ciddi bir artış göstermiştir. Dişi erkek oranları ise 0,63:1 olarak tespit edilmiş ve cinsiyeti belirlenebilen 949 bireyin % 39’ unun dişi bireylerden % 61’ inin ise erkek bireylerden oluştuğunu tespit edilmiştir. Seydisuyu’nda, bütün bireyler için b değeri 3,2415, erkekler için b değeri 3,2067, dişiler için ise 3,2605 olarak saptanmış ve hepsinin pozitif allometrik büyüme gösterdiği tespit edilmiştir. Seydisuyu Havzası içinde yer alan farklı populasyonların büyüme oranları incelendiğinde Squalius pursakensis’in farklı çevresel faktörlere maruz kalma durumlarına göre büyümelerinde farklılıklar meydana geldiğini ancak genel olarak karşılaştırılan diğer durgun su (göl) populasyonlarından daha yavaş bir büyüme gösterdikleri tespit edilmiştir. Benzer şekilde incelenen populasyonların farklı üreme eforları, zamanları, fekondite ve cinsi olgunluğa erişme büyüklük değerlerine sahip oldukları bulunmuştur. Tespit edilen habitat tercihlerine bakıldığında bu türün gölge, ışık geçirgenliğinin çok olmadığı, bitkisel materyal ve odunsu madde oranı yüksek, akıntının az veya orta olduğu, ve substrat bakımından ufak taş ya da silt alanları tercih ettiği belirlenmiştir.
In the present study, some important bio-ecological features and habitat preferences of Squalius pursakensis caught from Seydisuyu between April 2011 and July 2013 were studied. During the study period, 1684 individuals were collected. Length, weight and sex of dissected fish specimens were determined. Age was determined from scales validated by marginal increment analysis. Fecundity, egg diameter distributions, various growth indices, length-weight relationship, spawning duration and time, sex ratio, size at maturity, habitat choices, seasonal growth increment and condition factor were calculated. Age determinations showed that age varied between 0 and XII. Minimum length and weight measured was 46 mm total length and 5 g., respectively while the maximum length and weight found was 445 mm and 1263.5 g, respectively. Condition values were similar in winter and fall whereas they increased in spring and summer months. Sex ratio was male biased; male ratio was 61% and female ratio was 39% for 949 individuals in total. b value of the length-weight relationship for all individuals was 3.2415. It was 3.2067 for males and 3.2605 for females, respectively and all suggested a positive allometry. Different populations examined in the Seydisuyu Basin indicated a variable growth rates and it was suggested that it can be attributed to different environmental factors that the populations were exposed however they had lower growth rates compared to other studies conducted on the species in the stagnant water bodies (reservoirs). Similarly, all analysed populations were found to have variable fecundity, size at maturity and spawning durations and efforts. Habitat preferences analyses suggested that the species preferred shadow, lower light intensity, plant and ligneous areas, lower or medium flow, small stones and silt.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-18T06:23:18Z
No. of bitstreams: 1
10030982.pdf: 4834562 bytes, checksum: 0c099eea3475934eeea5b4c8157ff727 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-25T13:03:34Z (GMT) No. of bitstreams: 1
10030982.pdf: 4834562 bytes, checksum: 0c099eea3475934eeea5b4c8157ff727 (MD5)
Made available in DSpace on 2016-07-25T13:03:34Z (GMT). No. of bitstreams: 1
10030982.pdf: 4834562 bytes, checksum: 0c099eea3475934eeea5b4c8157ff727 (MD5)
Previous issue date: 2015
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Squalius Pursakensis
Seydisuyu (Sakarya Havzası)
Büyüme
Üreme
Biyoekoloji
Growth
Reproduction
Bioecology
Endemik bir tatlı su balığı, Squalius pursakensis’in Seydisuyu (Sakarya Havzasaı)’ndaki biyo-ekolojik özelliklerinin incelenmesi
masterThesis
TEXT
10030982.pdf.txt
10030982.pdf.txt
text/plain
142072
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/542/3/10030982.pdf.txt
708441b91106611a201ee815b3fc1ff4
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/542/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10030982.pdf
10030982.pdf
application/pdf
4834562
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/542/1/10030982.pdf
0c099eea3475934eeea5b4c8157ff727
MD5
1
11684/542
oai:openaccess.ogu.edu.tr:11684/542
2016-07-26 03:00:58.674
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/519
2016-07-26T00:00:10Z
com_11684_15
com_11684_2
col_11684_86
Canbek, Mediha
Can, Senanur
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-07-25T12:52:48Z
2016-07-25T12:52:48Z
2014
2014
http://hdl.handle.net/11684/519
Bu tez çalışmasında sıçanlarda deneysel olarak oluşturulan uzun süreli böbrek iskemi/reperfüzyon (İR) hasarına karşı, antioksidan özelliği bilinen geraniolün olası koruyucu etkilerinin araştırılması hedeflenmiştir.
Çalışmada 28 adet 3-4 aylık Wistar-albino cinsi erkek sıçanlar kullanılmıştır (n=7). Bunlar rastgele seçimle 4 gruba ayrılmıştır. Grup I (Sham Grubu), Grup II (İR + Serum Fizyolojik), Grup III (İR + 50 mg/kg geraniol), Grup IV (İR + 100 mg/kg geraniol) olarak belirlenmiştir. Ksilazin (10 mg/kg) ve ketamin (70 mg/kg) anestezisi altında Grup I dışındaki tüm gruplara sağ böbrek nefroktomisi yapılmıştır. Grup II, III ve IV için iskemi süresi 60 dakika, reperfüzyon süresi ise 24 saat olarak belirlenmiştir. Grup I ve II’e serum fizyolojik (1 ml/kg), Grup III ve IV’e sırasıyla 50 mg/kg, 100 mg/kg dozlarındaki geraniol, serum fizyolojik içinde çözülerek intraperitonal enjeksiyon ile uygulanmıştır. Deney sonunda kan serumunda Üre (BUN), Kreatinin (CRE) aktivitelerine ve böbrek dokularında Katalaz (KAT), Glutatyon Peroksidaz (Gpx) ve Süperoksit dismütaz (SOD) enzim aktiviteleri ölçülmüştür. Doku kesitleri Hematoksilen&Eozin boyama yapılarak ışık mikroskobunda incelenmiştir.
Çalışma sonunda, gruplar arasında BUN ve CRE değerleri karşılaştırıldığında Grup II’nin diğer gruplara göre yükseldiği ve bunun sonucunda İ/R hasarının oluşturulduğu gözlenmiştir. Geraniol uygulaması sonucunda KAT, GPx ve SOD aktivitelerinin kontrol değerine yaklaşarak hasarı önlediği görülmüştür. Buna göre 100 mg/kg geraniol dozunun, 50 mg/kg geraniol dozuna göre daha etkili olduğu düşünülmüştür. Histolojik bulgular da bu sonuçları desteklemektedir.
Çalışma sonucunda elde edilen bulgular, böbrek İR hasarına karşı geraniolün koruyucu etki gösterdiğini ortaya koymuştur.
In this thesis study, the possible protective effects of geraniol, which is known to be an antioxidant, were investigated against experimentally induced long-term renal ischemia/reperfusion (IR) injury in rats.
In the study, three to four month old, Wistar-albino type 28 male rats were used (n=7). They were randomly separated into 4 groups. The groups were determined as follows: Group I (Sham Group), Group II (IR + normal saline), Group III (IR + 50 mg/kg geraniol), Group IV (IR + 100 mg/kg geraniol). Groups I and II were inoculated with normal saline (1 ml/kg) and Groups III and IV were inoculated with 50 mg/kg and 100 mg/kg of geraniol, injected intraperitoneally. Right nephrectomies were performed under xylazine (10 mg/kg) and ketamine (70 mg/kg) anesthesia in all group rats except Group I. For Groups II, III and IV, ischemia and reperfusion durations were determined to be 60 mins and 24 hours respectively. At the end of the experiment, Urea (BUN), Creatinine (CRE) activities in the blood serum and the catalase (CAT), glutathione peroxidase (Gpx) and Superoxide dismutases (SOD), enzyme activities in kidney tissue were measured. Histological sections were stained using Hematoxylien & Eosine and investigated by light microscope.
At the end of the study, when Group I and Group II’s BUN and CRE values of the I/R injury were compared, it was determined that there had been an increase in Group II and as a result of this, I/R injury had been created. It was observed that as a result of the application of geraniol, the CAT, GPx and SOD activities approached the control values and prevented this, injury 100 mg/kg geraniol was thought to be more effective when compared to 50 mg/kg of geraniol. Histological findings supported these results too.
The results obtained in the study showed that geraniol has a protective effect renal against renal I/R injury.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-21T08:24:11Z
No. of bitstreams: 1
10027977.pdf: 4119569 bytes, checksum: f45c347d23334661925bec39980dbd4a (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-25T12:52:48Z (GMT) No. of bitstreams: 1
10027977.pdf: 4119569 bytes, checksum: f45c347d23334661925bec39980dbd4a (MD5)
Made available in DSpace on 2016-07-25T12:52:48Z (GMT). No. of bitstreams: 1
10027977.pdf: 4119569 bytes, checksum: f45c347d23334661925bec39980dbd4a (MD5)
Previous issue date: 2014
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Böbrek
İskemi/Reperfüzyon
Geraniol
Serbest Radikal
Sıçan
Kidney
Ischemia/Reperfusion
Geraniol
Free Radical
Rat
Sıçanlarda uzun süreli böbrek iskemi / reperfüzyon hasarına karşı geraniol’ün koruyucu etkisi
masterThesis
TEXT
10027977.pdf.txt
10027977.pdf.txt
text/plain
153761
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/519/3/10027977.pdf.txt
90a5896f6af3a81ec27a5083245f9df6
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/519/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10027977.pdf
10027977.pdf
application/pdf
4119569
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/519/1/10027977.pdf
f45c347d23334661925bec39980dbd4a
MD5
1
11684/519
oai:openaccess.ogu.edu.tr:11684/519
2016-07-26 03:00:10.903
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/555
2016-07-26T00:00:11Z
com_11684_15
com_11684_2
col_11684_86
Savaroğlu, Filiz
Özçelik, Fatih
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-07-25T13:05:24Z
2016-07-25T13:05:24Z
2014
2014
http://hdl.handle.net/11684/555
Türkiye karayosunları için çeşitlilik merkezlerinden birisidir. Spor morfolojisi taksonomide yararlıdır. Bu çalışma yedi Grimmiaceae taksonunun spor morfolojisini içermektedir. Çalışmanın amacı Türkiye’ deki Grimmiaceae familyasının detaylı taksonomik, morfolojik ve ekolojik karakterizasyonu sağlamaktır.
Schistidium trichodon (Brid.) Poelt, S. confertum (Funck) Bruch & Schimp., Grimmia ovalis (Hedw.) Lindb., G. pulvinata (Hedw.) Sm., G. trichophylla Grev., G. dissimulata E.Maier ve G. decipiens (Schultz) Lindb. türlerinin sporları ışık ve taramalı elektron mikroskopları ile ilk kez çalışılmıştır. Tüm sporlarda apertür bölgesi bir leptomadan oluşmaktadır. Familyanın incelenen taksonlarının spor morfolojisi verrukat tiptir. Spor şekli prolat-sferoidaldir. Grimmiaceae familyasında spor boyutu 6 μm’ den 17 μm’ ye kadar değişkenlik göstermektedir.
Grimmiaceae familyasının spor duvarı sklerin ve intin içermektedir. Ekzin ve perin arasındaki ayırımı belirlemek oldukça güç olmaktadır. İncelenen türler kayacıl habitat tipine aittir. Bu çalışmada Grimmiaceae familyasının taksonomik ve ekolojik içerikleri spor morfolojisi tabanında tartışılmıştır.
Turkey is one of the main centres of diversity for the bryophytes. Spore morphology has been used in taxonomy. This study includes spore morphology of seven Grimmiaceae taxa. The aims of this study are to provide a detailed taxonomical, morphological and ecological characterization of family Grimmiaceae in Turkey.
The spores of Schistidium trichodon (Brid.) Poelt, S. confertum (Funck) Bruch & Schimp., Grimmia ovalis (Hedw.) Lindb., G. pulvinata (Hedw.) Sm., G. trichophylla Grev., G. dissimulata E.Maier ve G. decipiens (Schultz) Lindb. were examined by light and scanning electron microscopy for the first time. The apertural region forms from a leptoma in all spores. The spore morphology of the examined taxa of the family is verrucate type. The spore shape of all studied species is prolate-spheroid. Spore size ranges from 6 μm to 17 μm in the family of Grimmiaceae.
The spore wall of the family Grimmiaceae includes sclerine and intine. The examined species of mosses are belonged to saxicolous habitat type. The taxonomical and ecological implications of the family Grimmiaceae were discussed on the basis of their spore morphology.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-21T08:29:25Z
No. of bitstreams: 1
10027404.pdf: 2028096 bytes, checksum: b70ba1bf6fcd7e24927884f091a51db5 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-25T13:05:24Z (GMT) No. of bitstreams: 1
10027404.pdf: 2028096 bytes, checksum: b70ba1bf6fcd7e24927884f091a51db5 (MD5)
Made available in DSpace on 2016-07-25T13:05:24Z (GMT). No. of bitstreams: 1
10027404.pdf: 2028096 bytes, checksum: b70ba1bf6fcd7e24927884f091a51db5 (MD5)
Previous issue date: 2014
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Bryophyta
Grimmiaceae
Spor Morfolojisi
Işık Mikroskobu
Taramalı Elektron Mikroskop (SEM)
Türkiye
Bryophyta
Spore Morphology
Light Microscope
Scanning Electron Microscope (SEM)
Turkey
Türkiye karayosunu florasına ait bazı grimmiaceae arn. türlerinin spor morfolojilerinin incelenmesi
masterThesis
TEXT
10027404.pdf.txt
10027404.pdf.txt
text/plain
86607
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/555/3/10027404.pdf.txt
108da307d4a8102444738e1d93fba114
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/555/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10027404.pdf
10027404.pdf
application/pdf
2028096
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/555/1/10027404.pdf
b70ba1bf6fcd7e24927884f091a51db5
MD5
1
11684/555
oai:openaccess.ogu.edu.tr:11684/555
2016-07-26 03:00:11.719
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/556
2016-07-26T00:01:04Z
com_11684_15
com_11684_2
col_11684_86
Vatan Öztopcu, A. Pınar
Batır, Muhammet Burak
TR174902
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-07-25T13:05:30Z
2016-07-25T13:05:30Z
2014
2014
http://hdl.handle.net/11684/556
Toprakların ağır metaller ile kontaminasyonu ve burada gelişimlerini sürdürmek zorunda olan bitkilerde yüksek konsantrasyonlar da ağır metal birikimi görülür. Bu durum kontaminasyona sahip bölgelerde yetişen bitkilerin hücre ve dokularında toksik hasarlara neden olur. Ayrıca, bitkilerde ağır metal kontaminasyonu genotoksik etki göstererek DNA profilinde mutasyon benzeri değişimlere yol açar.
Bu çalışmada, kurşun (Pb) ve bakır (Cu) kontaminasyonunun enginar (Cynara scolymus L.) fideleri üzerindeki etkisi fizyolojik, biyokimyasal ve moleküler parametreler yardımıyla belirlenmesi amaçlamıştır. Kurşun ve bakır etkisi belirli konsantrasyonlarda enginar fidelerinin kök bölgelerinin uzunluğunda ve toplam çözünür protein miktarında düşüşe neden olmuştur. Moleküler parametrelerden biri olan PCR tabanlı RAPD parmak izi tarama yöntemi, ağır metal stresinin fideler üzerindeki genotoksik etkisinin incelenmesi için kullanılmıştır. Ekolojik ve genotoksik çalışmalarda RAPD yöntemi uygun bir biyobelirteç olarak bitkilerde kullanılmaktadır. RAPD analizi için, 17 farklı RAPD primerinin özgün polimorfik bant paternlerinden yararlanılmıştır. Farklı kurşun ve bakır konsantrasyonlarının kontaminasyonundan sonra kontrol fidelerine göre ağır metal stresi uygulanmış fidelerin RAPD profillerinde bant kazancı ve/veya kaybı gibi çeşitli değişiklikler gözlemlenmiştir. Sonuç olarak; kurşun ve bakır stresine maruz kalan enginar fidelerinin RAPD profillelerine göre yapılan değerlendirmede genomik kalıp stabilitesinin değiştiği görülmüştür.
Contamination of the soil with heavy metals and the plants which have to maintain their development in this contaminated area shows accumulation of heavy metals with high dose. This situtation causes toxic damage of plant cells and tissues, which is growth on contaminated area. On the other hand, contamination of plants with heavy metals could be shown genotoxic effect on DNA profile and cause damages like mutation.
In this study, the effects of lead (Pb) and copper (Cu) contamination on artichoke (Cynara scolymus L.) seedlings determined by physiological, biochemical and molecular parameters. Reduction of root growth and total soluble protein content in root of artichoke seedlings were observed with the under certain concentrations of lead and copper. For molecular research, PCR (Polymerase Chain Reaction) based RAPD fingerprinting techniques was used for investigate the genotoxic effects of metal stress on seedlings. İn ecologic and genotoxic study, RAPD method was used as a proper biomarker for plants. Unique polymorphic band patterns of 17 different RAPD primers was used for the RAPD analysis. After the contamination of various concentrations of lead and copper, there was a change in RAPD profiles observed as variations like increment and/or loss of bands of seedlings which is implemented to heavy metal stress compared to control seedlings. Consequently, genomic template stability had changed according to the RAPD profiles of seedlings under heavy metal stress.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-21T08:33:37Z
No. of bitstreams: 1
10027122.pdf: 1538819 bytes, checksum: f5efabe7bc962f128fb50541ca7c81af (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-25T13:05:30Z (GMT) No. of bitstreams: 1
10027122.pdf: 1538819 bytes, checksum: f5efabe7bc962f128fb50541ca7c81af (MD5)
Made available in DSpace on 2016-07-25T13:05:30Z (GMT). No. of bitstreams: 1
10027122.pdf: 1538819 bytes, checksum: f5efabe7bc962f128fb50541ca7c81af (MD5)
Previous issue date: 2014
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Enginar (Cynara scolymus L.)
Ağır Metal
RAPD
Genotoksisite
Kurşun (Pb) ve Bakır (Cu) ağır metal stresi uygulanan enginar (cynara scolymus L.) tohumlarının fidelerinde oluşan DNA değişikliklerinin belirlenmesi
masterThesis
TEXT
10027122.pdf.txt
10027122.pdf.txt
text/plain
98697
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/556/3/10027122.pdf.txt
0e0d486b20d95e8e60bf4fa33d10b7ec
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/556/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10027122.pdf
10027122.pdf
application/pdf
1538819
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/556/1/10027122.pdf
f5efabe7bc962f128fb50541ca7c81af
MD5
1
11684/556
oai:openaccess.ogu.edu.tr:11684/556
2016-07-26 03:01:04.661
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/520
2016-07-26T00:00:23Z
com_11684_15
com_11684_2
col_11684_86
Kunduhoğlu, Buket
Abanoz, Hilal Seval
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-07-25T12:52:59Z
2016-07-25T12:52:59Z
2014
2014
http://hdl.handle.net/11684/520
Bu çalıĢmada E. faecalis KT11‟in ürettiği bakteriyosinin kısmi karakterizasyonu yapılmıĢ ve üretim için optimum koĢullar belirlenmiĢtir. E. faecalis KT11‟den elde edilen kültür supernatanların pH‟ı 6,5 ayarlanmıĢ ve katalaz enzimi ile muamele edilmiĢtir, bu iĢlemler sonrasında aktivitesinde bir değiĢiklik olmamıĢtır. Daha sonra süpernatanlar bazı proteolitik enzimlerle (Tripsin, Pepsin, α-Kimotripsin, Proteaz, Proteinaz K) muamele edilmiĢ ve pepsin dıĢındaki tüm proteolitik enzimler, süpernatanların antimikrobiyal aktivitesini yitirmesine neden olmuĢtur. Bakteriyosinin yüksek sıcaklığa (121 °C‟de 30 dk) oldukça dirençli olduğu belirlenmiĢtir. Ayrıca bakteriyosinin aktivitesi, pH‟sı 2-11 olan ortamlarda değiĢmeden kalmıĢtır. Triton-X, Tween 80, üre, EDTA ve SDS gibi deterjanlar ve kloroform, propanol, metanol, etanol, hekzan, eter ve aseton gibi organik çözücülerle muamele sonrasında da aktivitesi değiĢmemiĢtir. Liyofilize süpernatandaki, amonyum sülfat çöktürmesi sonrasındaki ve diyalizattaki protein miktarı sırasıyla 328,7, 507,4 ve 498,8 μg/ml dir. Bakteriyosinin molekül ağırlığı 3,5-6,5 kDa arasındadır. Diyalizatın HPLC profili belirlenmiĢ ve 18, 20, 22, 26, 28 ve 30. dakikalarda toplanan fraksiyonlar antimikrobiyal aktivite göstermiĢtir. E. faecalis KT11‟in bakteriyosin üretmesi için optimum koĢullar; 40 °C (aerobik), pH=6, %4 inokulum ve 18 saattir. Ayrıca E. faecalis KT11 hücreleri, pH 2 ve 3‟ te; %0,3, %0,5 ve %1 safra tuzları varlığında; pH‟ı 3 ve 4 olan yapay mide sıvısında (3 mg/ml pepsin, 5 mg/ml NaCl) canlı kalabilmiĢtir. Buna ek olarak, E. faecalis KT11 kültür süpernatanlarının ve liyofilize süpernatanın oldukça yüksek bir antioksidan etkiye (DPPH inhibisyonu= %94-96) sahip olduğu da belirlenmiĢtir. Bu veriler E. faecalis KT11‟in probiyotik olarak kullanım potansiyelinin olduğunu göstermektedir.
In this study, partial characterization of bacteriocin produced by E. faecalis KT11 was done and optimum conditions for bacteriocin production were determined. The pH of culture supernatants were adjusted to 6,5 and treated with catalase enzyme, after these treatments their activity did not change. When supernatants were treated with some proteolytic enzymes (trypsin, pepsin, α-chemotrypsin, protease, Proteinase K), all enzymes except pepsin led to the loss of antimicrobial activity of supernatants. Bacteriocin was very heat stable (121 °C for 30 min). Activity of the bacteriocin did not change in the pH=2-11. Detergents such as Triton-X, Tween 80, urea, EDTA and SDS, and organic solvents such as chloroform, propanol, methanol, ethanol, hexane, ether, and acetone did not change the activity of the supernatants. Protein content of lyophilized supernatant, ammonium sulphate precipitate and dialysate were 328,7, 507,4 and 498,8 μg/ml, respectively. Molecular size of bacteriocin was between 3,5-6,5 kDa. HPLC fractions collected at 18, 20, 22, 26, 28 and 30 minutes showed antimicrobial activity. Optimum conditions were determined as; 40 °C (aerobic), pH=6, 4% inoculum and 18 hours, for the bacteriocin production by E. faecalis KT11. E. faecalis KT11 cells survived in pH 2 and 3; 0,3%, 0,5% and 1% bile salt; artificial gastric fluid at pH 3 and 4 (3 mg/ml pepsin, 5 mg/ml NaCl). In addition, it was determined that E. faecalis KT11 culture supernatants and lyophilized supernatant possess high antioxidant effect (inhibition of DPPH %=94-96). These data indicated that E. faecalis KT11 also has potential to be used as a probiotic.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-21T08:37:55Z
No. of bitstreams: 1
10026123.pdf: 1929645 bytes, checksum: 492fa0e4eb51c96ab4af055c87065582 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-25T12:52:59Z (GMT) No. of bitstreams: 1
10026123.pdf: 1929645 bytes, checksum: 492fa0e4eb51c96ab4af055c87065582 (MD5)
Made available in DSpace on 2016-07-25T12:52:59Z (GMT). No. of bitstreams: 1
10026123.pdf: 1929645 bytes, checksum: 492fa0e4eb51c96ab4af055c87065582 (MD5)
Previous issue date: 2014
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Bakteriyosin
Probiyotik
Laktik Asit Bakterileri
Enterococcus Faecalis
Bacteriocin
Probiotics Lactic Acid Bacteria
Enterococcus faecalis KT11’in probiyotik potansiyelinin belirlenmesi ve bakterriyosin üretimi üzerine çalışmalar
masterThesis
TEXT
10026123.pdf.txt
10026123.pdf.txt
text/plain
228569
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/520/3/10026123.pdf.txt
65b9cff823183c3cccd6d79515c8c149
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/520/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10026123.pdf
10026123.pdf
application/pdf
1929645
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/520/1/10026123.pdf
492fa0e4eb51c96ab4af055c87065582
MD5
1
11684/520
oai:openaccess.ogu.edu.tr:11684/520
2016-07-26 03:00:23.818
Dspace@ESOGU
openaccess@ogu.edu.tr
REFHSVRJTSBMSVNBTlNJCgpCdSBsaXNhbnPEsSBpbXphbGF5xLFwIGfDtm5kZXJlcmVrLCBnw7ZuZGVyaW5pemkgZMO8bnlhIMOnYXDEsW5kYSBiYXPEsWzEsSBoYWxkZSwgCmVsZWt0cm9uaWsgb3J0YW1kYSB2ZSBoZXJoYW5naSBiYXNrYSBiaXIga2FuYWxsYSB5ZW5pZGVuIG9sdcWfdHVybWFrLCAKw6dldmlyaXNpbmkgeWFwbWFrIChhxZ9hxJ/EsWRhIHRhbsSxbWxhbmTEscSfxLEgw7x6ZXJlKSB2ZS92ZXlhIGRhxJ/EsXRtYWsgacOnaW4gCkVza2nFn2VoaXIgT3NtYW5nYXppIMOcbml2ZXJzaXRlc2nigJluaW4gKEVTT0dVKSDDtnplbCBvbG1heWFuIGhha2xhcsSxbsSxIGthYnVsIGV0bWnFnyBvbHVyc3VudXouCgpFU09HVSwgZ8O2bmRlcmluaXppbiBpw6dlcmnEn2luaSBkZcSfaXN0aXJtZWRlbiBoZXJoYW5naSBiaXIgCm9ydGFtZGEgZmFya2zEsSBiacOnaW1sZXJkZSBrb3J1bWEgYW1hw6dsxLEgb2xhcmFrIMOnZXZpcmViaWxpci4gCsOWdGUgeWFuZGFuIEVTT0dVLCBnw7x2ZW5saWssIHllZGVrbGVtZSB2ZSBrb3J1bWEgYW1hY8SxeWxhIGJ1IGfDtm5kZXJpbmluIApiaXJkZW4gZmF6bGEga29weWFzxLFuxLEgZWxpbmRlIHR1dGFiaWxpci4gCgpHw7ZuZGVyaW5pbiBzaXplIGFpdCBvcmlqaW5hbCBiaXIgw6dhbGnFn21hIG9sZHXEn3VudSB2ZSBidSBsaXNhbnN0YSBiZWxpcnRpbGVuIApoYWtsYXLEsSBrYWJ1bCBldG1lIGhha2vEsW7EsXogb2xkdcSfdW51IGJlbGlydG1pxZ8gb2x1cnN1bnV6LiBBeW7EsSB6YW1hbmRhIGfDtm5kZXJpbml6aW4sIApiaWxkacSfaW5peiBrYWRhcsSxeWxhLCBraW1zZW5pbiDDtnpsdWsgaGFra8SxbsSxIMOnacSfbmVtZWRpxJ9pbmkgZGUgc3VubXXFnyBvbHVyc3VudXouCgpFxJ9lciBnw7ZuZGVyaSB0ZWxpZiBoYWtrxLFuYSBzYWhpcCBvbHVubWF5YW4gYmlyIG1hdGVyeWFsIGnDp2VyaXlvcnNhLCBvIHphbWFuIAp0ZWxpZiBoYWtrxLEgc2FoaWJpbmRlbiBidSBsaXNhbnMgaWNpbiBnZXJla2xpIG9sYW4gRVNPR1UgaGFrbGFyxLFuxLEga2FidWwgZXRtZWsgCmljaW4ga8Sxc8SxdHPEsXogaXppbiBhbGTEscSfxLFuxLF6xLEgdmUgYnUgdGFyeiDDvMOnw7xuY8O8IGtpxZ9pbGVyIHRhcmFmxLFuZGFuIHNhaGlwIG9sdW5hbiAKbWF0ZXJ5YWxsZXJpbiBnw7ZuZGVyaSBpw6dlcmnEn2kgdmV5YSBtZXRuaSBpw6dlcmlzaW5kZSBhw6dpa8OnYSB0YW7EsW1sYW5kxLHEn8SxbsSxIHZlIAprYWJ1bCBlZGlsZGnEn2luaSBzdW5hcnNpbml6LgoKRcSeRVIgR8OWTkRFUsSwIEVTT0dVIERJxZ5JTkRBIEJBxZ5LQSBCxLBSIEtVUlVMVcWeIFRBUkFGSU5EQU4gREVTVEVLTEVORU4gQsSwUiDDh0FMScWeTUFZQSAKREFZQUxJIMSwU0UsIEJVIFRBUlogQklSIEFOTEHFnk1BIFZFWUEgU8OWWkxFxZ5NRU7EsE4gR0VSRUtUxLBSRMSwxJ7EsCBExLDEnkVSIApaT1JVTkxVTFVLTEFSSSBZRVLEsE5FIEdFVMSwUkTEsMSexLBOxLBaxLAgU1VOQVJTSU5JWi4KCkVTT0dVIGlzbWluaXppIGfDtm5kZXJpbmluIHlhemFyxLEgdmV5YSBzYWhpYmkgb2xhcmFrIGHDp8Sxa8OnYSB0YW7EsW1sYXlhY2FrdMSxciB2ZSAKYnUgbGlzYW5zxLFuIGl6aW4gdmVyZGnEn2luaW4gZMSxxZ/EsW5kYSBoZXJoYW5naSBiaXIgZGXEn2nFn2lrbGlrIHlhcG1heWFjYWt0xLFyLgo=
oai:openaccess.ogu.edu.tr:11684/521
2016-07-26T00:00:21Z
com_11684_15
com_11684_2
col_11684_86
Çalışkan, Figen
İşçan, Arzu
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-07-25T12:53:07Z
2016-07-25T12:53:07Z
2013
2013
http://hdl.handle.net/11684/521
Akrep venomları yüksek ilgi ve özgünlük ile zar reseptörleri ve iyon kanallarını etkileyebilen memeli, böcek ve kabuklulara toksik olan peptidlerin kompleks karışımlarıdır. Akrep venomları ile son 50 yıldır yapılan biyokimyasal araştırmalar, özellikle bu araknidlerin neden olduğu insan zehirlenmelerinden sorumlu bileşenlerinin tanımlanmasını amaçlamaktadır. Mesobuthus gibbosus Türkiye'nin Karadeniz ve Doğu bölgeleri hariç halk sağlığı bakımından önemli olan akreplerden biridir. Venom salgısı akreplerin telson adı verilen ve kuyruğun en son segmentini oluşturan bölümde bulunan iğneden elde edilirAraştırmalarda kullanılan akrep venomları elektriksel uyarı metodu kullanılarak sağım yolu ile elde edilmektedir.
Akrepler UV ışığı altında verdikleri floresan yardımı ile gece Eskişehir’in Sarıcakaya bölgesinden toplanmıştır. Venom her ay olmak üzere akreplerden 2-3 dakika süresince 20V’luk elektriksel uyarı ile elde edilmiştir. Elektriksel uyarı uygulanmış telsonlar 3, 6, 9 ve 12 ay sonrasında çıkarılmış, uygulanmayan telsonlar ise kontrol olarak kullanılmıştır. Elektriksel uyarının zehir bezi yapısı üzerinde son derece etkili olduğu gözlemlenmiştir. Zehir bezlerinin hasarlı alanları ışık mikroskobu ve elektron mikroskobu ile incelenmiştir. Elektron mikrografları kontrolün venom bezlerinin sıkıca bir kas demeti tarafından sarılmış olduğunu göstermektedir. Ancak elektrik uyarıma maruz kalan telsonlarda kas demetlerinde deformasyon meydana gelerek şiddetli hasarlar oluştuğu ve venom’un kas demetleri arasına yayıldığı gözlemlenmiştir. Günümüze kadar araştırmacılar akreplerden venom toplanmasında birçok yol izlemişlerdir. Elektriksel uyarım ile sağım 1970 yılından beri kullanılan bir yöntemdir. Bu yöntem, herhangi bir kalıcı yaralanma ve ölüme sebep olmaması nedeni ile tercih edilmektedir. Ancak elde ettiğimiz sonuçlar, elektriksel uyarı yönteminin de dezavantajları olduğunu göstermektedir. Sonuç olarak uzun süren sağım süreçleri sonrasında venom üretilmekte ancak kasların zarar görmesi nedeniyle bazen iğneden akmamaktadır.
Scorpion venoms are complex mixtures of peptides that are toxic on mammalians, insects and crustaceans by interacting with membrane receptors and ion channels with high affinity and selectivity. Biochemical studies on scorpion venoms in the last 50 years, mainly aim the identification of the components responsible of human intoxication caused by these arachnids. Mesabuthus gibbosus are one of the important scorpions with public health except the Black Sea and the Eastern regions of Turkey. Venom secretion obtains from stinger which located on the last segment of the tail known as a telson. Scorpion venoms are used in research, obtained with milking method by using electrical stimulation. This study is focused on the determination of morphological structure by light microscope and ultrastructure by electron microscope of the scorpion venom glands of M.gibbosus during electrical stimulation. Scorpions were collected under the UV light at night from Sarıcakaya location of Eskisehir. The venom of the scorpion was obtained by electrical stimulation for every month at 20 V for 2-3 min. Then electrostimulation applied telsons were removed after 3.6.9. and 12 month and also unapplied telsons of scorpions used as a control.. We observed that electrostimulation were extremely effective on the venom gland structure. Damaged venom gland areas analysed and determined with the light microscope. Selected areas used for further investigation by electron microscopy. Electron micrographs showed that venom gland covered by several tightly muscle bundles on the control glands. However muscle bundles were deformed, severe damaged and the venom was spread among the muscle bundles of electrostimulation applied telsons.Up to date investigators have been practiced many ways of collecting venom from scorpions. Electrical stimulation has previously been used since 1970 to milk the scorpions. This method prefers due to allow not any permanent injuries and mortality. But our results show that electrostimulation method also has disadvantages. Here, we conclusion that after long term milking session venom still produce but sometimes not drop from the needle due to rupture of the muscle.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-21T09:01:50Z
No. of bitstreams: 1
10022391.pdf: 2455146 bytes, checksum: ccb0e5ae7c83cd36444c8e71bd0f1e1f (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-25T12:53:07Z (GMT) No. of bitstreams: 1
10022391.pdf: 2455146 bytes, checksum: ccb0e5ae7c83cd36444c8e71bd0f1e1f (MD5)
Made available in DSpace on 2016-07-25T12:53:07Z (GMT). No. of bitstreams: 1
10022391.pdf: 2455146 bytes, checksum: ccb0e5ae7c83cd36444c8e71bd0f1e1f (MD5)
Previous issue date: 2013
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Elektron Mikroskop
Mesabuthus Gibbosus
Elektrostimülasyon
Electron Microscopy
Elektrostimulation
Elektrostimulasyonun mesobuthus gibbosus akrep türüne ait venom bezi yapısı üzerindeki etkisinin ışık ve elektron mikroskobu ile araştırılması
masterThesis
TEXT
10022391.pdf.txt
10022391.pdf.txt
text/plain
96328
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/521/3/10022391.pdf.txt
0ef0be3d6440d9e6c5e4abe53ddf045c
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/521/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10022391.pdf
10022391.pdf
application/pdf
2455146
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/521/1/10022391.pdf
ccb0e5ae7c83cd36444c8e71bd0f1e1f
MD5
1
11684/521
oai:openaccess.ogu.edu.tr:11684/521
2016-07-26 03:00:21.515
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/564
2016-07-28T00:00:17Z
com_11684_15
com_11684_2
col_11684_86
İlhan, Semra
Özgök, Özden
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-07-27T12:39:40Z
2016-07-27T12:39:40Z
2014
2014
http://hdl.handle.net/11684/564
Bu çalışmanın amacı İzmir Çamaltı Tuzlası su örneklerinden mikrofungus
izolasyonu, sayımı, tanılanması ve Dematiaceae familyasına ait mikobiyotanın
belirlenmesidir. İzmir Çamaltı Tuzlası üzerinde belirlenen 4 farklı istasyondan
mevsimsel olarak toplamda 16 su örneği alınmıştır. Mikrofungus izolasyonu membran
filtrasyon yöntemi ile DRBC ve DRBC10 besiyerleri kullanılarak yapılmıştır.
DRBC besiyerinin kullanıldığı izolasyon petrilerinde ortalama koloni sayısı 15
kob/100ml, DRBC10 besiyerinde ise 24 kob/100ml olarak belirlenmiştir. İzole edilen
mikrofunguslar klasik ve moleküler teknikler kullanılarak tanılanmıştır. Sonuç olarak
10 farklı cinse ait olmak üzere toplamda 30 farklı tür belirlenmiştir. İzole edilen ve
tanılanan cinsler tür sayıları bakımından şu şekilde sıralanmaktadır: Cladosporium (10),
Alternaria (5), Stemphylium (5), Chaetomium (3), Arthrinium (2), Biscogniauxia (1),
Drechslera (1), Phomopsis (1), Pithomyces (1) ve Stachybotrys (1). DRBC üzerinde
göreceli bollukları yüksek cinsler Cladosporium (%52), Alternaria (%35), Chaetomium
(%6); DRBC10 üzerinde ise Alternaria (%50) ve Cladosporium (%47) olarak
belirlenmiştir.
Bu çalışma Çamaltı Tuzlası mikobiyotasının yüksek bir çeşitliliğe sahip
olduğunu ve izole edilen türlerin büyük bir kısmının hipersalin çevrelerin daimi üyeleri
olduğunu göstermektedir. Tuz gereksinimi açısından farklılık gösteren türlerin
izolasyonunda seçici bir besiyerinin kullanılması ile başarılı sonuçlar elde edilmiştir.
Mikrofungusların tanılanmasında klasik yöntemlerle birlikte moleküler tekniklerin
kullanımı, geleneksel yöntemlerin yetersiz kaldığı durumlarda tamamlayıcı olmuştur.
The aim of this study is to isolate, enumerate, identificate and determine
dematiaceous mycobiota from the İzmir Çamaltı Saltern water samples. From four
stations on the Çamaltı Saltern ponds, it were taken seasonally total of 16 water
samples. Microfungi isolation was performed by membrane filtration method using
DRBC and DRBC10 isolation mediums.
The average number of microfungi determined in water samples was 15
kob/100ml on DRBC and 24 kob/100ml on DRBC10. Microfungi isolated have been
identified using classical and molecular techniques. Consequently a total of 30 different
species determined belonging to 10 different genera. Isolated and identified genera in
the form are listed: Cladosporium (10), Alternaria (5), Stemphylium (5), Chaetomium
(3), Arthrinium (2), Biscogniauxia (1), Drechslera (1), Phomopsis (1), Pithomyces (1)
ve Stachybotrys (1). The relative abundance of these genera were obtained
Cladosporium (%52), Alternaria (%35), Chaetomium (%6) on DRBC, Alternaria (%50)
and Cladosporium (%47) on DRBC10.
This study indicate that mycobiota of the Çamaltı Saltern has a high diversity
and most of the isolated species are inhabitants of hypersaline environments. Successful
results are obtained by using a selective medium on the isolation of the species that have
different salt requirements. Using molecular techniques as well as conventional
techniques for identification of microfungi has been complemental when the
conventional techniques are inadequate.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-22T13:24:35Z
No. of bitstreams: 1
10043628.pdf: 23751734 bytes, checksum: 0b59fff8978e4fc6b0f2cf7785aeffab (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-07-27T12:39:40Z (GMT) No. of bitstreams: 1
10043628.pdf: 23751734 bytes, checksum: 0b59fff8978e4fc6b0f2cf7785aeffab (MD5)
Made available in DSpace on 2016-07-27T12:39:40Z (GMT). No. of bitstreams: 1
10043628.pdf: 23751734 bytes, checksum: 0b59fff8978e4fc6b0f2cf7785aeffab (MD5)
Previous issue date: 2014
eng
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Hipersalin
Halotolerant/Halofilik Mikrofungi
Dematiaceae
İzmir Çamaltı Tuzlası
Hypersaline Waters
Halotolerant/Halophilic Microfungi
İzmir Çamaltı Saltern
İzmir Çamaltı Tuzlası mikobiyotasının belirlenmesi (dematiaceae)
masterThesis
TEXT
10043628.pdf.txt
10043628.pdf.txt
text/plain
156962
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/564/3/10043628.pdf.txt
ddb0378f0e390bafdfec58f979d4eb58
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/564/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10043628.pdf
10043628.pdf
application/pdf
23751734
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/564/1/10043628.pdf
0b59fff8978e4fc6b0f2cf7785aeffab
MD5
1
11684/564
oai:openaccess.ogu.edu.tr:11684/564
2016-07-28 03:00:17.509
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/643
2016-08-16T00:00:20Z
com_11684_15
com_11684_2
col_11684_86
İlhan, Semra
İrdem, Emine
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-08-15T12:42:43Z
2016-08-15T12:42:43Z
2014
2014-05
http://hdl.handle.net/11684/643
Bu çalışmanın amacı İzmir Çamaltı Tuzlası su örneklerinden mikrofungus
izolasyonu, sayımı, tanılanması ve Moniliaceae familyasına ve teleomorflarına ait
mikobiyotanın belirlenmesidir. Çamaltı Tuzlasında belirlenen 4 farklı istasyondan
mevsimsel olarak toplamda 16 su örneği alınmıştır. Mikrofungus izolasyonunda
membran filtrasyon tekniği kullanılmıştır. İzolasyon besiyeri olarak DRBC ve
DRBC10 kullanılmıştır.
Su örneklerinden izole edilen ortalama mikrofungus sayısı DRBC’de 14
kob/100ml, DRBC10’da ise 28 kob/100ml olarak belirlenmiştir. İzole edilen
mikrofunguslar klasik ve moleküler teknikler kullanılarak 7 farklı cinse ait; Penicillium
(16), Aspergillus (11), Trichoderma (2), Fusarium (2), Eurotium (2), Emericella (1),
Acremonium (1) olmak üzere 35 farklı tür tanılanmıştır. Bu cinslerin DRBC besiyeri
üzerindeki sayım sonuçlarına göre göreceli bollukları Penicillium %47, Aspergillus
%42, Trichoderma ve Fusarium %4 olarak, DRBC10 besiyeri üzerindeki sayım
sonuçlarına göre göreceli bollukları ise Penicillium %49, Aspergillus %35 ve Eurotium
%15 olarak saptanmıştır.
Bu çalışma Çamaltı Tuzlası mikobiyotasının yüksek bir çeşitliliğe sahip
olduğunu ve izole edilen türlerin büyük bir kısmının tuzlu çevrelerin daimi üyeleri
olduğunu göstermektedir. Tuz gereksinimi açısından farklılık gösteren türlerin
izolasyonunda DRBC ve DRBC10 besiyerlerinin kullanılması ile başarılı sonuçlar elde
edilmiştir. Mikrofungus tanılanmasında klasik yöntemlerle birlikte moleküler
tekniklerin kullanılması klasik yöntemlerin yetersiz kaldığı durumlarda tamamlayıcı
olmuştur.
The aim of this study is to isolate, enumerate and identificate microfungi
(Moniliaceae family and their teleomorph) from the Çamaltı Saltern water samples.
From four stations in the Çamaltı Saltern ponds, it were taken seasonally total of 16
water samples. Microfungi isolation was performed by membrane filtration method.
DRBC and DRBC10 were used as isolation mediums.
The average number of microfungi in water samples was 14 kob/100 ml by
DRBC and 28 kob/100 ml by DRBC10. Microfungi isolated have been identified using
classical and molecular techniques, a total of 35 species belonging to 7 genera. Genera
isolated from Çamaltı Saltern water samples: Penicillium (16), Aspergillus (11),
Trichoderma (2), Fusarium (2), Eurotium (2), Emericella (1), Acremonium (1) in the
form are listed. The relative abundance of these genera obtained in DRBC is
Penicillium %47, Aspergillus %42, Trichoderma and Fusarium %4 and DRBC10 is
Penicillium %49, Aspergillus %35 and Eurotium %15.
This study notes that Çamaltı Saltern waters mycobiota has a high diversity and
most of the isolated species are inhabitants of hypersaline environments. Succesfull
results are obtained by using DRBC and DRBC10 on the isolation of the species that
have different salt requirements. Using molecular techniques as well as classical
techniques for idenfication of microfungus has been complemental when the classical
techniques are inadequate.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-08-10T13:26:47Z
No. of bitstreams: 1
10043811.pdf: 8481450 bytes, checksum: 964b92cc3655d8a15a123e2f15d66945 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-08-15T12:42:43Z (GMT) No. of bitstreams: 1
10043811.pdf: 8481450 bytes, checksum: 964b92cc3655d8a15a123e2f15d66945 (MD5)
Made available in DSpace on 2016-08-15T12:42:43Z (GMT). No. of bitstreams: 1
10043811.pdf: 8481450 bytes, checksum: 964b92cc3655d8a15a123e2f15d66945 (MD5)
Previous issue date: 2014
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Çamaltı Tuzlası
Mikrofungus
Hipersalin
Halotolerant
Halofilik
Çamaltı Saltern
Microfungi
Hypersaline
Halotolerant
Halophilic
İzmir Çamaltı Tuzlası mikobiyotasının belirlenmesi : (moniliaceae ve teleomorfları)
masterThesis
TEXT
10043811.pdf.txt
10043811.pdf.txt
text/plain
152662
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/643/3/10043811.pdf.txt
d01f57c5c120a299dfb482f439aec65b
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/643/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10043811.pdf
10043811.pdf
application/pdf
8481450
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/643/1/10043811.pdf
964b92cc3655d8a15a123e2f15d66945
MD5
1
11684/643
oai:openaccess.ogu.edu.tr:11684/643
2016-08-16 03:00:20.695
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/670
2016-11-03T01:00:26Z
com_11684_15
com_11684_2
col_11684_86
Ayhancı, Adnan
Çetik, Songül
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-11-02T07:20:27Z
2016-11-02T07:20:27Z
2014
2016-01-01
http://hdl.handle.net/11684/670
Bu çalışma kekik yağının başlıca bileşeni olan karvakrol (Car)’ ün Siklofosfamid (CP) nedenli kardiyotoksisiteye karşı muhtemel koruyucu etkisini araştırmak için planlandı. CP birçok neoplastik tümörlerin tedavisinde kullanılan değerli bir kemoterapötik ajandır. Kardiyotoksisite yoğun CP tedavisinde önemli bir doz sınırlayıcı faktördür. Deneysel çalışmamızda Sprague-Dawley cinsi sağlıklı, erkek sıçanlar her grupta 7 sıçan olacak şekilde 13 gruba bölündü (kontrol, zeytinyağı, 50-100-150 mg/kg CP grupları, 5 ve 10 mg/kg Car grupları, CP+5 Car ve CP+10 mg/kg Car grupları). Tüm enjeksiyonlar intraperitonal (i.p.) olarak yapıldı. Kontrol grubundaki sıçanlara 0.5 mL serum fizyolojik verildi. 5 ve 10 mg/kg Car verilen gruplarla 0.5 mL zeytinyağı verilen gruplara bu dozlar deney sonuna kadar verildi. CP ile birlikte Car verilen gruplarda Car uygulamasına CP uygulamasından 3 gün önce başlandı ve deney sonuna kadar devam edildi (6 gün). 4. gün hayvanlar tekrar tartıldı, CP dozları hesaplandı ve CP+Car birlikte verildi. Sadece CP verilen gruplarda CP uygulamasından üç gün sonra anestezi yapıldı. Böylece 4. ve 7. günlerde hayvanlardan anestezi altında intrakardiyak kan alımı yapıldıktan sonra kalpleri alındı. Kardiyotoksisiteyi belirlemek için serum kreatin kinaz-MB (CK-MB), alanin transaminaz (ALT), aspartat transaminaz (AST), laktat dehidrogenaz (LDH), malondialdehit (MDA), glutatyon (GSH), total oksidan seviyesi (TOS), total antioksidan seviyeleri (TAS) ve oksidatif stres indeksi (OSİ) düzeyleri ölçüldü. Rutin histolojik doku takibinden sonra alınan kalp dokusu kesitleri hemotoksilen - eozin boyasıyla boyanarak kalp dokusu histopatolojisi değerlendirildi. Sadece CP verilen gruplarda serum ALT, AST, LDH, MDA, CK-MB ve TOS düzeylerinin doz artışına paralel olarak yüksek bulunması CP nedenli kardiyotoksisitenin doza bağımlı olduğunu göstermektedir. Kalp dokusunda görülen kanama, inflamatuar hücre infiltrasyonu ve kas liflerinde ayrılmalar biyokimyasal bulgularımızı desteklemektedir. 5 ve 10 mg/kg Car’ ün bu dozlardaki CP toksisitesini önemli oranda azaltması CP nedenli kardiyotoksisitenin oksidatif ve nitrozatif strese bağlı olduğunu göstermektedir. Sonuç olarak Car varlığında kalp dokusundaki inflamasyonun ve lipid peroksidasyonunun azalması, GSH ve TAS düzeyinin artması bunu doğrulamaktadır. Çalışmamız CP nedenli kardiyotoksisitenin azaltılmasında veya önlenmesinde Car’ ün iyi bir aday olduğunu göstermektedir ancak bu konuda daha kapsamlı çalışmalar yapılmalıdır.
This study examined the possible protective effects of carvacrole (car) against cyclophosphamide (CP)-induced cardiotoxicity. CP which is used as a chemotherapeutic agent, is used to treat neoplastic tumors. In CP treatment, cardiotoxicity is a vital dose limiting factor. In this study, healthy, male Spraque-Dawley rats were seperated in 13 groups having 7 groups in each (control, 50-100-150 mg/kg CP groups, 0.5 mL olive oil, 5-10 mg/kg Car groups and CP+5 and CP+10 mg/kg Car groups). All injections were intraperitoneal (i.p.). 0.5 ml volume of serum physiologic (SF) was given to rats in the control group. 5 and 10 mg/kg car, and 0.5 mL olive oil were given to the groups until the end of the experiment. In the groups treated with CP+Car, before CP administration Car was given 3 days before and continued until the end of the experiment (6 day). 4. day the rats were weighed again, the doses of CP were calculated and CP+Car were injected. In alone CP-related groups, after 3 days of CP administration the animals were sacrificed. Therefore at 4. and 7. day of the experiment, intracardiac blood samples and hearts from all animals were taken under anesthesia. To determine the cardiotoxicity serum creatine kinase (CK-MB), alanine transaminase (ALT), aspartat transaminase (AST), lactate dehydrogenase (LDH), malondialdehyde (MDA), glutathione (GSH), total oxidant state (TOS), total antioxidant capacity (TAC) ve oxidative stress index (OSİ) levels were measured. After following the routine histological tissue, the section heart tissues were stained with hemotoxilen-eosine for evaluating the tissues histopatologically. Only in the CP groups the serum ALT, AST, LDH, MDA, CK-MB and TOS levels were high and parallel to the increase of the dose dependent in CP-induced cardiotoxicity. The hemorrhage, inflammatory cell infiltration and, the separation of the muscle fibers in heart tissue supported our biochemical data. Car of 5 and 10 mg/kg leading a vital decrease in CP toxicity and showed that it is related to oxidative and nitrosative stress in CP induced cardiotoxicity. As a matter of fact, car decreased the inflammation and lipid peroxidation in heart tissue and the increase of serum GSH and TAC levels confirms our data. Our study suggests car is a strong candidate in decreasing or preventing CP induced cardiotoxicity but there should be done further comprehensive studies.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-10-24T13:27:38Z
No. of bitstreams: 1
10030515.pdf: 4708711 bytes, checksum: f411ac0def7d85763658fc4e436c72a4 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-11-02T07:20:27Z (GMT) No. of bitstreams: 1
10030515.pdf: 4708711 bytes, checksum: f411ac0def7d85763658fc4e436c72a4 (MD5)
Made available in DSpace on 2016-11-02T07:20:27Z (GMT). No. of bitstreams: 1
10030515.pdf: 4708711 bytes, checksum: f411ac0def7d85763658fc4e436c72a4 (MD5)
Previous issue date: 2014
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Siklofosfamid
Oksidatif Stres
Kardiyotoksisite
Karvakrol
Antioksidan
Sıçan
Cyclophosphamide
Oxidative Stress
Cardiotoxicity
Carvacrole
Antioxidant
Rat
Sıçanlarda siklofosfamid nedenli kardiyotoksisitede oksidatif stres ve kalp hasarına karşı karvakrolün koruyucu etkisi
doctoralThesis
TEXT
10030515.pdf.txt
10030515.pdf.txt
text/plain
265081
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/670/3/10030515.pdf.txt
6683dff0f284a30c247e78aad546a534
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/670/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10030515.pdf
10030515.pdf
application/pdf
4708711
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/670/1/10030515.pdf
f411ac0def7d85763658fc4e436c72a4
MD5
1
11684/670
oai:openaccess.ogu.edu.tr:11684/670
2016-11-03 03:00:26.603
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/682
2016-11-10T01:00:19Z
com_11684_15
com_11684_2
col_11684_86
İlhan, Semra
İşcen, Cansu Filik
Akçal Çomoğlu, Burcu
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-11-09T13:38:48Z
2016-11-09T13:38:48Z
2014-08
2014
http://hdl.handle.net/11684/682
İlaç endüstrisi atık suları genel olarak yüksek organik yüke sahiptir ve günümüzde bu tip atık suların arıtımında anaerobik yöntemlerin kullanımı artış göstermektedir. Ancak anaerobik arıtımda rol alan mikroorganizmaların çeşitliliği ve ilişkileri hakkında bilgiye ihtiyaç vardır.
Bu çalışmada, kesikli anaerobik koşullarda istatistiksel optimizasyona dayalı olarak sürekli reaktörde ilaç atık sularının arıtım süreci izlenmiştir. Yukarı akışlı anaerobik dolgulu yatak reaktörde arıtım verimi ile mikrobiyal çeşitlilik arasındaki ilişkinin ortaya çıkarılması ve atık suya spesifik inokulum oluşturulması amaçlanmıştır. Reaktör sürecinde işletim parametrelerinin (atık su konsantrasyonu, hidrolik alıkonma süresi: HAS, organik yükleme oranı: OYO, kimyasal oksijen ihtiyacı: KOİ) organik madde giderim verimi üzerine etkileri değerlendirilmiştir. En yüksek KOİ giderimi %100 atık suyun uygulandığı, HAS 96 saat ve OYO 1,402 g KOİ l-1 gün-1 olduğu koşullarda gerçekleşmiştir. Bu koşullarda, ilaç atık suyunun oluşan mikrobiyal konsorsiyum tarafından deşarj standartlarını sağlayacak düzeyde arıtıldığı anlaşılmıştır. Ayrıca, uygulanan toksisite test sonucunda ham atık suyun toksisitesinin giderildiği belirlenmiştir. Arıtımda rol alan mikrobiyal konsorsiyumun belirlenmesinde klonlama, yüksek çözünürlükte erime eğrisi analizi, dizi analizi ve yeni nesil dizileme teknikleri kullanılmıştır. Mikrobiyal konsorsiyumdaki nitel ve nicel değişim ise floresan yerinde hibritleme yöntemi ile takip edilmiştir. Yeni nesil dizileme sonuçlarına göre, arıtımın en yüksek olduğu koşullarda 142 bakteri ve 8 arke üyesi tespit edilmiştir. Arıtımda bakteriyel aday divizyon OP8 ve Methanosaeta spp.'nin (%33,6’sı M. concilii) etkin olduğu belirlenmiştir.
In general, the pharmaceutical industry wastewater has a high organic load and using anaerobic treatment methods in this type of wastewater is increasing currently. However, information about the diversity of microorganisms involved in anaerobic treatment and their relationship is needed.
In this study, pharmaceutical industry wastewater treatment processes in continuous reactor based on the statistically optimization under batch anaerobic conditions was monitored. In up-flow anaerobic packed bed reactor, the detection of the relationship between treatment yield and microbial diversity and forming of wastewater specific inoculum is aimed. The effects of operating parameters (wastewater concentration, hydraulic retention time: HRT, organic loading rate: OLR, chemical oxygen demand: COD) on organic matter removal efficiency was evaluated in the reactor process. The highest COD removal efficiencies were obtained for 100% pharmaceutical industry wastewater at 4 days HRT and 1.402 g COD/day OLR. In these conditions, it is understood that the pharmaceutical wastewater was treated by the microbial consortium to provide a level of discharged standards. In addition, toxicity tests performed in the crude wastewater was determined to eliminate toxicity. Cloning, high resolution melting curve analysis and sequence analysis techniques and next generation sequencing was used for determining microbial diversity. Qualitative and quantitative changes in the microbial consortium was followed by fluorescence in situ hybridization. According to next generation sequencing results, 142 bacteria and 8 archaea members have been detected in the highest treatment conditions. Bacterial candidate division OP8 and Methanosaeta spp. (33.6% M. concilii) was found to be effective in treatment.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-11-02T10:23:46Z
No. of bitstreams: 1
10054431.pdf.pdf: 2617967 bytes, checksum: 1c6fb5d2bc22aee23d94fb0ed694d188 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-11-09T13:38:48Z (GMT) No. of bitstreams: 1
10054431.pdf.pdf: 2617967 bytes, checksum: 1c6fb5d2bc22aee23d94fb0ed694d188 (MD5)
Made available in DSpace on 2016-11-09T13:38:48Z (GMT). No. of bitstreams: 1
10054431.pdf.pdf: 2617967 bytes, checksum: 1c6fb5d2bc22aee23d94fb0ed694d188 (MD5)
Previous issue date: 2014-08
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Anaerobik Arıtım
Floresan Yerinde Hibritleme (FISH)
İlaç Sanayi Atık Suyu
Yeni Nesil Dizileme (NGS)
Yukarı Akışlı Anaerobik Dolgulu Yatak (YAAD) Reaktör
Anaerobic Treatment
Fluorescence in Situ Hybridization (FISH)
Next Generation Sequencing (NGS)
Pharmaceutical İndustry Wastewater
Upflow Anaerobic Packed Bed (UAPB) Reactor
İlaç sanayi atık sularının anaerobik arıtımı ve reaktördeki mikrobiyal çeşitliliğin araştırılması
doctoralThesis
TEXT
10054431.pdf.pdf.txt
10054431.pdf.pdf.txt
text/plain
191177
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/682/3/10054431.pdf.pdf.txt
053762898a3325994c95df21f2244305
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/682/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10054431.pdf.pdf
10054431.pdf.pdf
application/pdf
2617967
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/682/1/10054431.pdf.pdf
1c6fb5d2bc22aee23d94fb0ed694d188
MD5
1
11684/682
oai:openaccess.ogu.edu.tr:11684/682
2016-11-10 03:00:19.055
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/686
2016-11-10T01:00:25Z
com_11684_15
com_11684_2
col_11684_86
İlhan, Semra
Kocabıyık, Yaşar Erçin
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-11-09T13:38:57Z
2016-11-09T13:38:57Z
2014-02
2014
http://hdl.handle.net/11684/686
Bu çalışmanın amacı Tuz Gölü su ve toprak örneklerinden mikrofungus izolasyonu, sayımı ve tanımlanması ile fungal çeşitliliğin ortaya konması, fungal popülasyonun mevsimsel ve mekansal dağılımının belirlenmesidir. Tuz Gölü havzasında belirlenen üç istasyondan (Kayacık, Kaldırım ve Yavşan) 24 su ve 24 toprak olmak üzere mevsimsel olarak toplamda 48 örnek alınmıştır. Mikrofungus izolasyonunda su örnekleri için membran filtrasyon, toprak örnekleri için toprağı seyreltme yöntemi kullanılmıştır. İzolasyon besiyeri olarak DRBC ve DRBC17 kullanılmıştır.
Su örneklerinde ortalama mikrofungus sayısı DRBC’de 460 kob/100ml, DRBC17’de ise 126 kob/100ml; toprak örneklerinde ortalama mikrofungus sayısı DRBC’de 4575 kob/g kuru toprak, DRBC17’de ise 2875 kob/g kuru toprak olarak belirlenmiştir. Klasik ve moleküler teknikler kullanılarak toplamda 29 cinse ait 68 mikrofungus türü tanımlanmıştır.
Tuz Gölü su ve toprak örneklerinden sıklıkla izole edilen cinsler içerdikleri tür sayıları bakımından Penicillium (17), Aspergillus (7), Alternaria (6), Cladosporium (5) ve Eurotium (3) şeklinde sıralanmaktadır. Bunlardan başka Acremonium, Aporospora, Arthrinium, Beauveria, Botryotinia, Chaetomium, Chalastospora, Coniochaeta, Curvularia, Embellisia, Epicoccum, Leptospora, Mucor, Nigrospora, Phanerochaete, Phoma, Pithomyces, Pringsheimia, Rhizopus, Sordaria, Stemphylium, Tetracladium, Trichothecium ve Ulocladium cinslerine ait türlere daha az oranda rastlanmıştır. Aspergillus pseudodeflectus Türkiye için yeni kayıttır.
Biyoçeşitlilik indeksleri ile yapılan değerlendirmede Tuz Gölü suyunda fungal biyoçeşitliliğin toprağa oranla daha yüksek olduğu saptanmıştır. DRBC ve DRBC17 besiyerleri ile yapılan izolasyonlarda biyoçeşitlilik açısından önemli bir fark gözlenmese de, tuz gereksinimleri açısından farklılık gösteren türlerin izolasyonuna olanak sağlamıştır.
The aim of this study is to isolate, enumerate and identificate microfungi from the Tuz Gölü (Salt Lake) water and soil samples and so, to reveal of fungal diversity and to determine seasonal and spatial distribution of the fungal population. From three stations (Kayacık, Kaldırım and Yavşan) in the Tuz Lake basin, a total of 48 including 24 water and 24 soil samples were taken seasonally. Microfungi isolation was performed by membrane filtration and soil dilution method for water and soil samples, respectively. DRBC and DRBC17 were used as isolation media.
The average number of microfungi in water samples was 460 and 126 cfu/100 ml by DRBC and DRBC17. In the soil samples, the average number of microfungi were determined as 4575 and 2875 cfu/g dry soil in DRBC and DRBC17. A total of 68 species belonging to 29 genera have been identified using classical and molecular techniques.
Genera frequently isolated from Tuz Lake water and soil samples can be listed as: Penicillium (17), Aspergillus (7), Alternaria (6), Cladosporium (5) and Eurotium (3). Other than these, Acremonium, Aporospora, Arthrinium, Beauveria, Botryotinia, Chaetomium, Chalastospora, Coniochaeta, Curvularia, Embellisia, Epicoccum, Leptospora, Mucor, Nigrospora, Phanerochaete, Phoma, Pithomyces, Pringsheimia, Rhizopus, Sordaria, Stemphylium, Tetracladium, Trichothecium and Ulocladium genera was found at a lower rate. Aspergillus pseudodeflectus is new record for Turkey.
According to biodiversity indexes, the fungal biodiversity in the Salt Lake water was found to be higher than in the soil. Although significant difference in terms of diversity were not observed, DRBC and DRBC17 medium has led to the isolation of species which differ in salt requirements.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-11-02T10:43:30Z
No. of bitstreams: 1
10032590.pdf: 1934631 bytes, checksum: 0748b659d36a7f67c89ad1b890c88063 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-11-09T13:38:57Z (GMT) No. of bitstreams: 1
10032590.pdf: 1934631 bytes, checksum: 0748b659d36a7f67c89ad1b890c88063 (MD5)
Made available in DSpace on 2016-11-09T13:38:57Z (GMT). No. of bitstreams: 1
10032590.pdf: 1934631 bytes, checksum: 0748b659d36a7f67c89ad1b890c88063 (MD5)
Previous issue date: 2014-02
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Tuz Gölü
Mikrofungus
Biyoçeşitlilik
Halotolerant/Halofilik
Microfungi
Biodiversity
Halotolerant/Halophilic
Tuz gölü mikrofungus çeşitliliğinin belirlenmesi
doctoralThesis
TEXT
10032590.pdf.txt
10032590.pdf.txt
text/plain
218032
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/686/3/10032590.pdf.txt
5f7b15cf55177c9c014f1432175a679b
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/686/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10032590.pdf
10032590.pdf
application/pdf
1934631
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/686/1/10032590.pdf
0748b659d36a7f67c89ad1b890c88063
MD5
1
11684/686
oai:openaccess.ogu.edu.tr:11684/686
2016-11-10 03:00:25.316
Dspace@ESOGU
openaccess@ogu.edu.tr
REFHSVRJTSBMSVNBTlNJCgpCdSBsaXNhbnPEsSBpbXphbGF5xLFwIGfDtm5kZXJlcmVrLCBnw7ZuZGVyaW5pemkgZMO8bnlhIMOnYXDEsW5kYSBiYXPEsWzEsSBoYWxkZSwgCmVsZWt0cm9uaWsgb3J0YW1kYSB2ZSBoZXJoYW5naSBiYXNrYSBiaXIga2FuYWxsYSB5ZW5pZGVuIG9sdcWfdHVybWFrLCAKw6dldmlyaXNpbmkgeWFwbWFrIChhxZ9hxJ/EsWRhIHRhbsSxbWxhbmTEscSfxLEgw7x6ZXJlKSB2ZS92ZXlhIGRhxJ/EsXRtYWsgacOnaW4gCkVza2nFn2VoaXIgT3NtYW5nYXppIMOcbml2ZXJzaXRlc2nigJluaW4gKEVTT0dVKSDDtnplbCBvbG1heWFuIGhha2xhcsSxbsSxIGthYnVsIGV0bWnFnyBvbHVyc3VudXouCgpFU09HVSwgZ8O2bmRlcmluaXppbiBpw6dlcmnEn2luaSBkZcSfaXN0aXJtZWRlbiBoZXJoYW5naSBiaXIgCm9ydGFtZGEgZmFya2zEsSBiacOnaW1sZXJkZSBrb3J1bWEgYW1hw6dsxLEgb2xhcmFrIMOnZXZpcmViaWxpci4gCsOWdGUgeWFuZGFuIEVTT0dVLCBnw7x2ZW5saWssIHllZGVrbGVtZSB2ZSBrb3J1bWEgYW1hY8SxeWxhIGJ1IGfDtm5kZXJpbmluIApiaXJkZW4gZmF6bGEga29weWFzxLFuxLEgZWxpbmRlIHR1dGFiaWxpci4gCgpHw7ZuZGVyaW5pbiBzaXplIGFpdCBvcmlqaW5hbCBiaXIgw6dhbGnFn21hIG9sZHXEn3VudSB2ZSBidSBsaXNhbnN0YSBiZWxpcnRpbGVuIApoYWtsYXLEsSBrYWJ1bCBldG1lIGhha2vEsW7EsXogb2xkdcSfdW51IGJlbGlydG1pxZ8gb2x1cnN1bnV6LiBBeW7EsSB6YW1hbmRhIGfDtm5kZXJpbml6aW4sIApiaWxkacSfaW5peiBrYWRhcsSxeWxhLCBraW1zZW5pbiDDtnpsdWsgaGFra8SxbsSxIMOnacSfbmVtZWRpxJ9pbmkgZGUgc3VubXXFnyBvbHVyc3VudXouCgpFxJ9lciBnw7ZuZGVyaSB0ZWxpZiBoYWtrxLFuYSBzYWhpcCBvbHVubWF5YW4gYmlyIG1hdGVyeWFsIGnDp2VyaXlvcnNhLCBvIHphbWFuIAp0ZWxpZiBoYWtrxLEgc2FoaWJpbmRlbiBidSBsaXNhbnMgaWNpbiBnZXJla2xpIG9sYW4gRVNPR1UgaGFrbGFyxLFuxLEga2FidWwgZXRtZWsgCmljaW4ga8Sxc8SxdHPEsXogaXppbiBhbGTEscSfxLFuxLF6xLEgdmUgYnUgdGFyeiDDvMOnw7xuY8O8IGtpxZ9pbGVyIHRhcmFmxLFuZGFuIHNhaGlwIG9sdW5hbiAKbWF0ZXJ5YWxsZXJpbiBnw7ZuZGVyaSBpw6dlcmnEn2kgdmV5YSBtZXRuaSBpw6dlcmlzaW5kZSBhw6dpa8OnYSB0YW7EsW1sYW5kxLHEn8SxbsSxIHZlIAprYWJ1bCBlZGlsZGnEn2luaSBzdW5hcnNpbml6LgoKRcSeRVIgR8OWTkRFUsSwIEVTT0dVIERJxZ5JTkRBIEJBxZ5LQSBCxLBSIEtVUlVMVcWeIFRBUkFGSU5EQU4gREVTVEVLTEVORU4gQsSwUiDDh0FMScWeTUFZQSAKREFZQUxJIMSwU0UsIEJVIFRBUlogQklSIEFOTEHFnk1BIFZFWUEgU8OWWkxFxZ5NRU7EsE4gR0VSRUtUxLBSRMSwxJ7EsCBExLDEnkVSIApaT1JVTkxVTFVLTEFSSSBZRVLEsE5FIEdFVMSwUkTEsMSexLBOxLBaxLAgU1VOQVJTSU5JWi4KCkVTT0dVIGlzbWluaXppIGfDtm5kZXJpbmluIHlhemFyxLEgdmV5YSBzYWhpYmkgb2xhcmFrIGHDp8Sxa8OnYSB0YW7EsW1sYXlhY2FrdMSxciB2ZSAKYnUgbGlzYW5zxLFuIGl6aW4gdmVyZGnEn2luaW4gZMSxxZ/EsW5kYSBoZXJoYW5naSBiaXIgZGXEn2nFn2lrbGlrIHlhcG1heWFjYWt0xLFyLgo=
oai:openaccess.ogu.edu.tr:11684/716
2016-12-01T01:00:14Z
com_11684_15
com_11684_2
col_11684_86
Ataşlar, Ebru
Türk, Ayşen Özdemir
Koç, Şeref Nur
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-11-30T08:03:21Z
2016-11-30T08:03:21Z
2012-10
2012
http://hdl.handle.net/11684/716
Bu çalışma Barla Dağı (Isparta) liken florasını belirlemek amacıyla yapılmıştır. Nisan 2008-Aralık 2010 tarihleri arasında 54 lokaliteden toplanan liken örneklerin teşhisleri sonucu 209 liken ve 12 likenikol mantar olmak üzere toplam 221 takson tespit edilmiştir. Bu taksonların deskripsiyonları, çalışma alanı, ekolojik özellikleri, Türkiye ve dünyadaki yayılışları verilmiştir. Protoblastenia terricola (Anzi) Lynge liken türü ve likenikol mantar olan Zwackhiomyces dispersus (J. Lahm ex Körb.) Triebel & Grube Türkiye için yeni kayıt olduğu tespit edilmiştir. Çalışma alanından teşhis edilen liken türlerinde 88’ Isparta için, 215’i Barla Dağıiçin yeni kayıttır.
The aim of this study is determinated of the lichen flora of Barla Mountain (Isparta). The lichen specimens collected from 54 localities between years April 2008 and December 2010. After determination of the collected samples, 209 lichens and 12 lichenicolous fungi (totally 221 taxa) were identified. It was reported that descriptions, ecological features of these taxa and their distributions in Turkey and the world. The lichen Protoblastenia terricola (Anzi) Lynge and the lichenicolous fungus Zwackhiomyces dispersus (J. Lahm ex Körb.) Triebel & Grube were determinated as new record for Turkey. 215 lichen taxa are also new records for Barla and 88 lichen taxa for Isparta Provinces.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-11-29T07:06:35Z
No. of bitstreams: 1
10006813.pdf.pdf: 5854379 bytes, checksum: 94441df4fce31e518f93fd92aaa66851 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-11-30T08:03:21Z (GMT) No. of bitstreams: 1
10006813.pdf.pdf: 5854379 bytes, checksum: 94441df4fce31e518f93fd92aaa66851 (MD5)
Made available in DSpace on 2016-11-30T08:03:21Z (GMT). No. of bitstreams: 1
10006813.pdf.pdf: 5854379 bytes, checksum: 94441df4fce31e518f93fd92aaa66851 (MD5)
Previous issue date: 2012-10
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Liken
Flora
Barla Dağı
Isparta
Türkiye
Lichen
Barla Mountain
Barla Dağı (Isparta) liken florası
doctoralThesis
TEXT
10006813.pdf.pdf.txt
10006813.pdf.pdf.txt
text/plain
754368
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/716/3/10006813.pdf.pdf.txt
ccf1e82727fb127c6ac435980ae24a02
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/716/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10006813.pdf.pdf
10006813.pdf.pdf
application/pdf
5854379
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/716/1/10006813.pdf.pdf
94441df4fce31e518f93fd92aaa66851
MD5
1
11684/716
oai:openaccess.ogu.edu.tr:11684/716
2016-12-01 03:00:14.711
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/751
2016-12-07T01:00:26Z
com_11684_15
com_11684_2
col_11684_86
Yamaç, Mustafa
Bayburt, Cansu
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-12-06T07:26:05Z
2016-12-06T07:26:05Z
2013-02
2013
http://hdl.handle.net/11684/751
Bu çalışmanın amacı, yeni ve yerel ligninolitik enzim kaynağı makrofungus izolatlarının bulunması ve çevresel bir kirlilik etmeni olan tekstil endüstrisi atık sularının gideriminde kullanım potansiyellerinin belirlenmesidir.
Bu amaçla ülkemizden izole edilen 40 adet Basidiomyecetes izolatı, ligninolitik enzim üretimi ve boyar madde giderim kapasiteleri açısından taranmış, başarılı bulunan OBCC 1047 ve OBCC 3501 kodlu izolatlar bir sonraki aşamalarda kullanılmak üzere seçilmiştir. Seçilen izolatların, 3 farklı kültür (statik, derin ve katı faz) sisteminde, farklı lignoselülozik atıklar (portakal kabuğu atığı, çay atığı, buğday kepeği) varlığında büyümeleri sırasında lakkaz, MnP ve LiP enzimlerinin varlığı incelenmiştir. OBCC 1047 izolatında ölçümü yapılan enzimlerin varlığına rastlanamazken, OBCC 3501 kodlu makrofungusun her üç enzimi değişik oranlarda ürettiği ve en iyi enzim üretiminin inkübasyonun 11. gününde katı faz kültür yöntemiyle çay atığında 114.5 U/L lakkaz, 438.1 U/L MnP, 15.9 U/L LiP olduğu belirlenmiştir. Moleküler bazlı tekniklere dayanılarak OBCC 3501 izolatı NCBI veritabanından % 98 benzerlik oranı ile Polyporus arcularius olarak tanılanmıştır.
Polyporus arcularius ham kültür filtratıyla, RBBR, remazol black, cibacron blue 3R, amaranth, kristal viyole, malaşit yeşili boyar maddelerinde in vitro giderim çalışması gerçekleştirilmiş, renk giderimi sırasıyla % 62, 8, 80, 20, 57, 37 olarak ölçülürken, ortama HBT mediatörünün ilavesiyle bu oranlar % 92, 82, 100, 100, 87, 100‟e yükseltilmiştir. Boyar madde gideriminde sorumlu olduğu belirlenen MnP enziminin, DMP oksidasyonu sırasında optimum pH ve sıcaklık değerleri 4.8 ve 40 oC olarak belirlenirken, bu koşullarda enzimin Km ve Vmax değerleri sırasıyla 1.37 mM ve 0.135 mM/sn olarak belirlenmiştir.
Amonyum sülfat çöktürmesi ile konsantre edilen ham enzim çözeltisi sodyum alginat boncuklarına immobilize edilmiştir. İmmobilize enzim boncuklarının immersiyon tip reaktörde (3.5 L hacim) yapay atık boyar madde giderim kapasitesi araştırılmış ve 24 saat sonunda % 88 renk giderimi ölçülürken, yapay boyar madde karışımının toksisitesinde % 80 azalma meydana gelmiştir.
The aim of the present study was to discover new and local macrofungi producing ligninolytic enzymes and to determine decolorization capacity of crude culture filtrates of these isolates.
Ligninolytic enzyme producing ability of fourty Basidiomycetes isolates was investigated. Isolates OBCC 1047 and OBCC 3501 were selected further studies. Laccase, manganase peroxidase (MnP) and lignin peroxidase (LiP) production capacity of these isolates were investigated under different culture conditions such as static, submerged and solid state and lignocellulosic agro-wastes (orange peel, tea waste, wheat bran). While OBCC 3501 produced all the enzymes, no enzyme activity was detected for OBCC 1047. Maximum enzyme activities were obtained on tea wastes as 114 U/L laccase, 438.1 U/L MnP, 15.9 U/L LiP under solid state fermentation on the day 11th. The isolate OBCC 3501 was identified Polyporus arcularius with 98 % similarity ratio.
In vitro Remazol Brilliant Blue R (RBBR), remazol black, cibacron blue 3R, amaranth, crystal violet, malachite gren dyes decolorization capacity of crude enzymes from Polyporus arcularius was determined as 62, 8, 80, 20, 57 and 37 % respectively. The decolorization values were 92, 82, 100, 100, 87 and 100 % in HBT containing reaction media, respectively. Mnp was the ezyme responsible for dye decolorization. Kinetic properties of MnP against DMP (Dimethoxy phenol) were found optimum pH 4.8, optimum temperature 40 oC, 1.37 mM Km and 0.135 mM/sn Vmax.
The concantrated crude enzyme extract was immobilised into Ca-alginat beads and dye decolorization capacity of these beads invastigated in the immersion reactor (3.5 L). The decolorization ratio obtained after 24 h was 88 %. Also, the toxicity of the dye mixture decrease at the rate of 80 %.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-06T07:09:10Z
No. of bitstreams: 1
462522.pdf.pdf: 3518152 bytes, checksum: 7837a9a1b45cf89c4e854955241c3590 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-06T07:26:05Z (GMT) No. of bitstreams: 1
462522.pdf.pdf: 3518152 bytes, checksum: 7837a9a1b45cf89c4e854955241c3590 (MD5)
Made available in DSpace on 2016-12-06T07:26:05Z (GMT). No. of bitstreams: 1
462522.pdf.pdf: 3518152 bytes, checksum: 7837a9a1b45cf89c4e854955241c3590 (MD5)
Previous issue date: 2013-02
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Polyporus Arcularius
Ligninolitik Enzimler
Boyar Madde Renk Giderimi
İmmersiyon Reaktör
Ligninolytic Enzymes
Dye Degradation
İmmersion Reactor
Farklı kültür ve atık tipleri ile indüklenen makrofungus ligninolitik enzimleri ile boyar madde renk giderimi ve reaktör uygulaması
masterThesis
TEXT
462522.pdf.pdf.txt
462522.pdf.pdf.txt
text/plain
258209
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/751/3/462522.pdf.pdf.txt
c3d86fa4d2d096b0056369ee468d8397
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/751/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
462522.pdf.pdf
462522.pdf.pdf
application/pdf
3518152
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/751/1/462522.pdf.pdf
7837a9a1b45cf89c4e854955241c3590
MD5
1
11684/751
oai:openaccess.ogu.edu.tr:11684/751
2016-12-07 03:00:26.175
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/794
2016-12-15T01:00:19Z
com_11684_15
com_11684_2
col_11684_86
Canbek, Mediha
Özen, Ahmet
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-12-14T06:56:43Z
2016-12-14T06:56:43Z
2013-04
2013
http://hdl.handle.net/11684/794
Bu çalışmada, bor bileşiklerinden B2O3’ün sıçanlarda %70 parsiyel hepatektomi sonrası indüklenen karaciğer rejenerasyonu üzerindeki apoptotik etkileri ortaya konmuştur.
Bor, çok hücreli canlılar için iç dengenin sağlanmasında görev alan önemli bir elementtir. Herhangi bir hasar karşısında yanıt oluşturma yeteneğine sahip olan bor, hücre çoğalmasını baskılayıcı bir etkiye de sahiptir. Bu amaçla Wistar albino türü erkek sıçanlar kullanılarak n=7 olacak şekilde 6 grup oluşturuldu. Sham kontrol grubu olan Grup I ve II’ye sadece laparoktomi yapılırken, diğer 4 grup hayvana ayrı ayrı %70 parsiyel hepatektomi işleminden hemen sonra tek doz serum fizyolojik ve 1,8 g.kg-1 B2O3 intraperitonel enjeksiyonları yapılmıştır. Cerrahi işlemlerden 3 ve 6 saat sonra diseksiyonları yapılıp karaciğer ağırlık indeksi hesaplandı. Tüm gruplardan histolojik, RT-PCR ve QPCR incelemeleri için karaciğer doku örnekleri alındı. RT-PCR ve QPCR analizinde NF-κB ve kaspaz-3 gen ve protein ifade düzeylerine bakıldı. Grup V ve VI hayvanlarından alınan örneklerde NF-κB gen ve protein ifadeleri incelendiğinde azaldığı; kaspaz-3 gen ve protein ifadelerinin ise anlamlı şekilde arttığı gözlenmiştir. Ayrıca B2O3’ ün karaciğerde apoptotik etkisi TUNEL analizi ile de desteklenmiştir.
Bu çalışma intraperitonel olarak uygulanan B2O3’ün, parsiyal hepatektomiden 6 saat sonra hepatosit proliferasyonunu inhibe ederek apoptozu indüklediğini göstermiştir.
In this study, the apoptotic effects of boron compound B2O3 on induced liver regeneration after 70% partial hepatectomy in rats have been revealed.
Boron is an important element for multicellular organisims to provide homeostasis. Against any damage boron has the ability to form a response and shows cell growth inhibitory effect. For this purpose, Wistar albino male rats were divided into 6 with groups, n = 7. Laparoctomy was applied to sham control group, Group I and II to the other 4 groups of animals a single dose of saline and 1,8 g.kg-1 B2O3 was immediately injected intraperitoneally after 70% partial hepatectomy. 3 and 6 hours after the surgical procedures, liver mass index was calculated. For histological, RT-PCR and QPCR for analysis liver tissue samples were taken from all groups. RT-PCR and QPCR analysis of nuclear factor-κB (NF-κB) and caspase-3 gene and protein expression levels were determined. Group V and VI of the samples taken from the animals examined NF-kB gene and protein expressions were decreased; however caspase-3 gene and protein expressions were significantly increased. In addition, B2O3's apoptotic effect was supported by the TUNEL analysis in the liver.
This study has shown that intraperitoneally applied B2O3 induced apoptosis by inhibiting hepatocytes proliferation after 6 hour of partial heaptectomy.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-12T07:05:55Z
No. of bitstreams: 1
10000933.pdf: 2301403 bytes, checksum: 77333072277f6cdbd8e3e253869ed95e (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-14T06:56:43Z (GMT) No. of bitstreams: 1
10000933.pdf: 2301403 bytes, checksum: 77333072277f6cdbd8e3e253869ed95e (MD5)
Made available in DSpace on 2016-12-14T06:56:43Z (GMT). No. of bitstreams: 1
10000933.pdf: 2301403 bytes, checksum: 77333072277f6cdbd8e3e253869ed95e (MD5)
Previous issue date: 2013-04
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Parsiyal Hepatektomi
Borik Anhidrit
Apoptoz
Kaspaz-3
NF-κB
Partial Hepatectomy
Boric Anhydride
Apoptosis
Caspase 3
NF-κB
Sıçan karaciğerinde parsiyal hepatektomi sonrası borik anhidrit (B2O3) ile apoptozun indüklenmesi
doctoralThesis
TEXT
10000933.pdf.txt
10000933.pdf.txt
text/plain
130087
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/794/3/10000933.pdf.txt
f0c5e30aa7295b01c98d6b49333b9192
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/794/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10000933.pdf
10000933.pdf
application/pdf
2301403
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/794/1/10000933.pdf
77333072277f6cdbd8e3e253869ed95e
MD5
1
11684/794
oai:openaccess.ogu.edu.tr:11684/794
2016-12-15 03:00:19.547
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/782
2016-12-15T01:00:30Z
com_11684_15
com_11684_2
col_11684_86
Canbek, Mediha
Emeksiz, Harika
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-12-14T06:55:33Z
2016-12-14T06:55:33Z
2013-05
2013
http://hdl.handle.net/11684/782
Çevremizde biyolojik aktiviteleri henüz bilinmeyen çok sayıda sentetik kimyasal madde bulunmaktadır. Bu kimyasalların mutajenik potansiyellerinin ortaya konması gerekmektedir. Çünkü mutajen olduğu saptanan birçok bileşiğin aynı zamanda kanserojen olduğu bilinmektedir. Bu da insan sağlığı açısından son derece önemlidir.
Bu çalışmada yeni sentezlenen 2 farklı benzotiyazol türevi olan N-(4-benzotiyazol-2-il)-2-metoksifenil)-2-(4-klorofenoksi) asetamit ile N-(4-(benzotiyazol-2-il)-3-klorofenil)-2-(4-klorofeniltiyo) asetamit’ in Umu test sistemi ile genotoksik potansiyelleri çalışıldı. Benzotiyazol türevi bileşiklerin 5 ayrı dozu (10, 100, 1000, 2500 ve 5000 μg/ml) DMSO (Dimetilsülfoksit) da çözülerek hazırlandı. Bu dozlar test organizması olarak kullanılan Salmonalla thyphimurium NM 2009 ve NM 3009 suşları ile sınandı ve verdiği enzim aktivitesi değerleri pozitif mutajen olarak kullanılan 4NQO (4-Nitrokinolin-1-oksit) ile karşılaştırıldı.
Elde ettiğimiz verilere göre; N-(4-benzotiyazol-2-il)-2-metoksifenil)-2-(4-klorofenoksi) asetamit türevinde direkt mutajenik etki görülmedi. N-(4-(benzotiyazol-2-il)-3-klorofenil)-2-(4-klorofeniltiyo) asetamit türevinde ise pozitif mutajenle karlılaştırıldığında anlamlı bir artış görüldü. Bu benzotiyazol türevi orta dereceli mutajen olarak belirlendi.
Around us, there are many synthetic chemical substances of which biological activities are not known. These chemicals’ mutagenic potentials should be exhibited. Because, many compounds that were identified as mutagen are known to be carcinogenic.
In this study, genotoxic potentials of N-(4-benzothiazole-2-yl)-2-methoxyphenyl)-2-(4-chlorophenoxy) acetamite and N-(4-(benzothiazole-2-yl)-3-chlorophenyl)-2-(4-chlorophenylthio) acetamite, that are recently synthesised 2 different benzotiazol derivative, are studied via Umu test system. 5 different doses (10, 100, 1000, 2500 and 5000 μg/ml) of benzotiazol derivative compounds were prepared by solving in DMSO (Dimetilsulfoxide). These doses were tested via Salmonalla thyphimurium NM 2009 and NM 3009 strains which are used as test organisms, and enzyme activity values obtained were compared with 4NQO (4-nitroquinoline-1-oxide) that is used as positive mutagen.
According to the values we’ve obtained, there weren’t seen a direct mutagenic effect on N-(4-benzothiazole-2-yl)-2-methoxyphenyl)-2-(4-chlorophenoxy) acetamite derivative. As for N-(4-(benzothiazole-2-yl)-3-chlorophenyl)-2-(4-chlorophenylthio) acetamite derivative, a significant increase was observed compared to positive mutagen. We observed this benzotiazol derivative as a moderate mutagen.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-13T06:44:44Z
No. of bitstreams: 1
10002085.pdf: 1041915 bytes, checksum: 4e728cac3a9ac03439fa38a443b0f694 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-14T06:55:33Z (GMT) No. of bitstreams: 1
10002085.pdf: 1041915 bytes, checksum: 4e728cac3a9ac03439fa38a443b0f694 (MD5)
Made available in DSpace on 2016-12-14T06:55:33Z (GMT). No. of bitstreams: 1
10002085.pdf: 1041915 bytes, checksum: 4e728cac3a9ac03439fa38a443b0f694 (MD5)
Previous issue date: 2013-05
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
SOS/Umu-testi
SOS Cevabı
Mutajenite
Benzotiyazol Türevleri
SOS/Umu-assay
SOS Response
Mutagenicitiy
Benzothiazole Derivatives
Bazı benzotiyazol türevlerinin mutajenik aktivitelerinin umu test sistemi ile belirlenmesi
masterThesis
TEXT
10002085.pdf.txt
10002085.pdf.txt
text/plain
126779
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/782/3/10002085.pdf.txt
01ce7d96341503603bc61011b9a7ebe3
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/782/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10002085.pdf
10002085.pdf
application/pdf
1041915
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/782/1/10002085.pdf
4e728cac3a9ac03439fa38a443b0f694
MD5
1
11684/782
oai:openaccess.ogu.edu.tr:11684/782
2016-12-15 03:00:30.238
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/783
2016-12-15T01:00:31Z
com_11684_15
com_11684_2
col_11684_86
Canbek, Mediha
Yerlikaya, Azmi
Ceyhan, Emre
TR170878
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-12-14T06:55:35Z
2016-12-14T06:55:35Z
2013-06
2013
http://hdl.handle.net/11684/783
Parsiyal hepatektomi sonrası karaciğer rejenerasyonunda kilit bir role sahip olan NF-κB, rejenerasyon, apoptozis ve genlerin regülasyonunda görev alan dimerik bir transkripsiyon faktörüdür. Doğada bulunan çok sayıda bitkisel materyal tamamlayıcı tıp tarafından çeşitli hastalıkların tedavisinde ilaç olarak kullanılmaktadır. Bunlardan biriside geranioldür ve karaciğer rejenerasyonu üzerine in vivo etkisi ile ilgili araştırmalar bulunmamaktadır. Bu sebeple çalışmamızda, geraniolün Wistar albino türü erkek sıçanlarda %70 parsiyal hepatektomi sonrası karaciğer rejenerasyonu üzerine etkilerini in vivo olarak ortaya koymayı amaçlandık ve n=6 olacak şekilde 8 grup oluşturuldu. Grup I ve grup II sham kontrol grubu iken, diğer 6 grup hayvana parsiyel hepatektomi işleminden hemen sonra tek doz serum fizyolojik, silymarin ve geraniolün intraperitonal enjeksiyonu tek tek yapıldı. Cerrahi işlemlerden 24 ve 48 saat sonra karaciğer kütle endeksi hesaplandı. RT-PCR ve Western Blot analizlerinde NF-κB, TNF-α ve IL-6 gen ekspresyon düzeylerine ve protein miktarlarına bakıldı. Ayrıca ısı şok proteinlerinden HSP27 ve HSP60’ın Western blot yöntemiyle gruplardaki ekspresyon düzeylerine bakıldı.
Elde ettiğimiz verilere göre intraperitoneal olarak verilen geraniolün karaciğer rejenerasyon oranını artırma sürecinde anlamlı bir role sahip olduğunu ve karaciğeri koruduğu histolojik bilgilerle ve HSP protein miktar analizleriyle ortaya konuldu.
NF-κB is a dimeric transcription factor, involved in the regulation of regeneration and apoptosis genes, and has a key role liver regeneration after partial hepatectomy. Complementary medicine is used as a medicine to treat various diseases obtained from a large number of plants, which were found in nature. One of them is geraniol, and there are as yet no studies about its in vivo effects on liver regeneration. For this reason, we aimed to determine in our study, the effects of geraniol on liver regeneration in Wistar albino male rats after 70% partial hepatectomy in vivo and 8 groups with n = 6 were formed. Group I and Group II are the sham control groups while a single dose of saline, silymarin or geraniol was injected intraperitonally to the other 6 groups immediately after partial hepatectomy. Liver mass index was calculated at 24 and 48 hours after surgical procedures. RT-PCR and Western blot analysis of NF-κB, TNF-α and IL-6 gene expression levels and the amounts of protein were measured. Moreover, the expression levels of the heat shock proteins HSP27 and HSP60 protein amounts by Western blot analysis groups were examined.
According to the data obtained, it was found that geraniol has a significant role in increasing the process of liver regeneration when given intraperitoneally and it was also revealed to protect the liver by analysis of histological information and of HSP protein amount.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-13T06:49:33Z
No. of bitstreams: 1
10002840.pdf: 3369863 bytes, checksum: 9601b06bc618ed325ef5963f2f413206 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-14T06:55:35Z (GMT) No. of bitstreams: 1
10002840.pdf: 3369863 bytes, checksum: 9601b06bc618ed325ef5963f2f413206 (MD5)
Made available in DSpace on 2016-12-14T06:55:35Z (GMT). No. of bitstreams: 1
10002840.pdf: 3369863 bytes, checksum: 9601b06bc618ed325ef5963f2f413206 (MD5)
Previous issue date: 2013-06
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Geraniol
NF-κB
HSP
Hepatektom
Hepatectomy
Sıçanlarda parsiyel hepatektomi sonrası karaciğer rejenerasyonuna geraniolün etkisinin NF-KB yolağı üzerinden belirlenmesi
doctoralThesis
TEXT
10002840.pdf.txt
10002840.pdf.txt
text/plain
145477
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/783/3/10002840.pdf.txt
fa0bcdd3ac7c268458c02285086d54d8
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/783/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10002840.pdf
10002840.pdf
application/pdf
3369863
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/783/1/10002840.pdf
9601b06bc618ed325ef5963f2f413206
MD5
1
11684/783
oai:openaccess.ogu.edu.tr:11684/783
2016-12-15 03:00:31.104
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/785
2016-12-15T01:00:20Z
com_11684_15
com_11684_2
col_11684_86
Çabuk, Ahmet
Çelikdemir, Meltem
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-12-14T06:55:40Z
2016-12-14T06:55:40Z
2012-12
2012
http://hdl.handle.net/11684/785
Sürfektanlar yapılarında hem hidrofilik hem de hidrofobik yapılar içeren, su/yağ ya da hava/su arasındaki gibi yüzey ve yüzeyler arası gerilimi düşüren yüzey aktif maddelerdir. Biyosürfektanlar yapısal olarak geniş çeşitlilik gösteren ve mikroorganizmalar tarafından sentezlenen yüzey aktif moleküllerdir.
Sunulan tez çalışması kapsamında Eskişehir sanayi bölgesinde hidrokarbon kirliliği bulunan topraklardan 70 adet mikroorganizma izole edilmiş ve33 biyosürfektan üretici izolat olduğu belirlenmiştir. Etkin üretici 5 izolat için mineral tuz ortamında gerçekleşen inkübasyon sonunda örneklerin yüzey gerilimi ölçümleri yapılmış ve 71,1 mN/m yüzey gerilimindeki saf su kontrolüne göre 33,6 mN/m olarak ölçülen yüzey gerilimi değeri ile D1 kodlu izolat etkin üretici olarak seçilmiştir.
Etkin üretici izolat ile biyosürfektan üretimi için besiyeri bileşenleri ve inkübasyon koşulları optimizasyonu yapılmıştır. Mineral tuz ortamı içeriği için belirlenen optimum karbon kaynağı glikoz derişimi 20g/L, azot kaynağı NH4Cl ve azot miktarı 25 g/L,etkin C:N oranı 2:2,5 (w/w) olarak belirlenmiştir. İnkübasyon koşulları için 150 r.p.m. çalkalama hızı, besiyeri pH’ı 6, 40˚C inkübasyon sıcaklığı ve 48 saat inkübasyon süresi olarak belirlenmiştir. Üretilen biyosürfektan kloroform metanol karışımı (2:1) ile ekstrakte edilmiş -55’de liyofilize edilmiştir. Üretilen biyosürfektanın karakterizasyonu aşamasında, kritik misel konsantrasyonu 2 g/L, misel çapı 200 nm ve izoelektrik noktası pH 6 değerinde belirlenmiştir. Biyosürfektan üretici izolat 16S rRNA sekans analizi sonuçlarına göre %99 benzerlik oranı ile Gordonia amicalis olarak belirlenmiştir.
Surfactants are amphipatic molecules with both hydrophilic and hydrophobic moieties which are the partition preferentially at the interface between fluid phases such as oil/water or air/water interfaces. Biosurfactants are structurally diverse group of surface active molecules synthesized by microorganisms.
In this study, samples of oil contaminated soil were aseptically collected from industrial area in Eskisehir province of Turkey. Seventy microorganisms isolated from these soil samples. Thirty three isolates were able to produce surface active compounds when grown in minimal salt medium.
Five isolates were determined as more effective biosurfactant producer. These isolates were grown in mineral salt medium and according to their surface tensions results and according to controls of pure water with 71 mN/m surface tensionD1 was selected the most effective strain with 33.6 mN/m against to distilated water control.
The strain with highest biosurfactant activity was chosen for identification and optimization of the culture medium and the incubation conditions and characterization of biosurfactant. Effects of medium composition and culture conditions on biosurfactant production were investigated and optimum conditions were determined; when mineral salt medium was used as culture medium, glucose (20g/l) as carbon source; NH4Cl (25g/l) nitrogen source; medium pH 6; incubation temperature; 40C; agitation rate 150 r.p.m.; incubation time of 48 hours. Produced biosurfactant was extracted from cell free culture broth by chloroform-methanol method (2:1) and lyophilized at -55C. This surfactants characteristic properties were 2-4g/L critical micelle concentration, micelle size 200 nm, isoelectric point pH 6 as measured at charactherization prosess and producer isolate was identified. When 16S rRNA analysis was carried out, this bacterium was shown that it was a close relative with %96 smilarity ratio of Gordonia amicalis species.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-14T06:06:47Z
No. of bitstreams: 1
10002797.pdf: 2148809 bytes, checksum: 200940b8741b49843a394800b48ded34 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-14T06:55:40Z (GMT) No. of bitstreams: 1
10002797.pdf: 2148809 bytes, checksum: 200940b8741b49843a394800b48ded34 (MD5)
Made available in DSpace on 2016-12-14T06:55:40Z (GMT). No. of bitstreams: 1
10002797.pdf: 2148809 bytes, checksum: 200940b8741b49843a394800b48ded34 (MD5)
Previous issue date: 2012-12
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Biyosürfektan
Gordonia Amicalis
Drop Collapse
du Nouy Ring Yöntem
Gordonia Amicalis
Drop-Collapse
du Nouy Ring Method
Hidrokarbon kirliliği bulunan topraklardan izole edilen mikroorganizmalar ile biyosürfektan üretimi
masterThesis
TEXT
10002797.pdf.txt
10002797.pdf.txt
text/plain
206508
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/785/3/10002797.pdf.txt
48db45dde92140e799011da997b0e961
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/785/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10002797.pdf
10002797.pdf
application/pdf
2148809
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/785/1/10002797.pdf
200940b8741b49843a394800b48ded34
MD5
1
11684/785
oai:openaccess.ogu.edu.tr:11684/785
2016-12-15 03:00:20.704
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/786
2016-12-15T01:00:33Z
com_11684_15
com_11684_2
col_11684_86
Çabuk, Ahmet
Şam, Mesut
Cengiz, Gürhan
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-12-14T06:55:44Z
2016-12-14T06:55:44Z
2013-09
2013
http://hdl.handle.net/11684/786
Bu çalışmada tekstil endüstrisinde kullanılan, Reaktif Mavi 13 (RM13), Reaktif
Sarı 85 (RS85) ve Reaktif Viyole 1 (RV1) gibi tekstil boyar maddelerinin renk
giderimleri için manyetik hale getirilmiş Trametes versicolor biyokütlesinin
kullanılabilirliği araştırılmıştır. Optimizasyon çalışmaları sonucunda manyetik Trametes
versicolor biyokütlesi RM13 için %98,30, RS85 için %96,02 ve RV1 için %98,56 renk
giderimi sağlanmıştır.
FT-IR analizi, bazı biyomoleküllerin piklerindeki değişimler söz konusu boyar
maddelerin biyosorpsiyondan sorumlu gruplar olabileceklerini düşündürmektedir.
Ayrıca yapılan toksisite testinde; RM13 boyar maddesinin 15. dakika EC50 değeri renk
giderimi öncesi %5, renk giderimi sonrası bu değer %100; RS85 boyar maddesinin 15.
dakika EC50 değeri renk giderimi öncesi %6, renk giderimi sonrası bu değer %80; RV1
boyar maddesinin 15. dakikada EC50 değerleri renk giderimi öncesi %6, renk giderimi
sonrasında ise %100 bulunmuştur. Toksisitedeki bu değişim bize biyosorbent ile
muamele edilmiş boyar maddelerin önemli ölçüde toksisitesinin azaldığını göstermiştir.
Uygulanan izoterm modellerine göre her üç boyar maddenin adsorpsiyonunun da
Langmuir izoterm modeline uygun olduğu anlaşılmıştır. Deneylerden elde edilen veriler
ışığında yalancı ikinci dereceden kinetik yaklaşım modelinin daha uygun olduğu
gözlemlenmiştir. Taramalı elektron mikroskobu ve manyetik kuvvet mikroskobu ile
biyosorpsiyon işlemi sonrası doğal biyokütle ile manyetik biyokütle yüzeylerindeki
farklılıklar görüntülenmiş; manyetik hale getirilmiş biyosorbentin yüzeyinde pürüzlerin
arttığı ve dolayısı ile daha geniş bir yüzey alanının elde edildiği düşünülebilir. Yapılan
EDX analizleri manyetik hale getirmek üzere yüzeye Fe3O4 kaplanması ile yüzeydeki
Fe miktarının önemli düzeyde arttığı görülmektedir. Boyar maddeler ile temas eden
manyetik biyokütlelerdeki C miktarındaki azalma, boyar maddelerin C ile bir
kompleksleşme oluşturabileceğini düşündürmektedir. Sonuç olarak elde edilen veriler
ışığında seçilen boyar maddeler için toksisitedeki azalma ve uygulama kolaylığı ile
başarılı olarak nitelendirilebilecek sonuçlar doğrultusunda çevresel uygulamalar için de
önemli bir biyosorbent geliştirildiği söylenebilir.
In this study, usability of magnetically modified T. versicolor biomass for
removal of textile dyestuffs such as Reactive Blue 13 (RB13), Reactive Yellow 85
(RY85) and Reactive Violet 1 (RV1) has been investigated. At the end of optimization
studies, magnetic T. versicolor biomass obtained 98.30%, 96.02% and 98.56% of color
removal for RB13, RY85 and RV1, respectively.
FTIR analysis obtained that the changes of some biomolecules peaks are
responsible from biosorption. Additionally, for the toxicity test at the end of 15 minutes,
EC50 values for RM13 before and after dye removal are 5% and 100%, for RY85 before
and after dye removal are 6% and 80%, for RV1 before and after dye removal are 6%
and 100%, respectively. The changes on the toxicity showed that the toxicity of
dyestuffs decreased after treatment with biosorbents. According to applied isotherm
models, adsorptions of all dyestuffs fitted to the Langmuir isotherm model. The results
of experiments show that the pseudo-second order kinetic model is the most proper
model for biosorption. Scanning electron microscope and magnetic force microscope
images showed that differences between natural biomass and magnetic biomass
occurred. It is considered that larger surface area is obtained because of increasing the
rough nesses on the surface of the magnetic biosorbent. As a result of EDX analyses,
the Fe3O4 coating for making magnetic caused the increase Fe amount on the surface.
Decrease of carbon amount of magnetic biomass showed that a complexation may be
between dyestuffs and carbon.. As a result of this study, we may say that an important
biosorbent with decreasing the toxicity and ease of application has been developed.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-14T06:15:46Z
No. of bitstreams: 1
10020935.pdf: 9523743 bytes, checksum: 9f7ac043ac73c3258844f5c8ec8da69a (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-14T06:55:44Z (GMT) No. of bitstreams: 1
10020935.pdf: 9523743 bytes, checksum: 9f7ac043ac73c3258844f5c8ec8da69a (MD5)
Made available in DSpace on 2016-12-14T06:55:44Z (GMT). No. of bitstreams: 1
10020935.pdf: 9523743 bytes, checksum: 9f7ac043ac73c3258844f5c8ec8da69a (MD5)
Previous issue date: 2013-09
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Biyosorpsiyon
Nanopartikül Fe3O4
Trametes Versicolor
Biosorption
Nanoparticle Fe3O4
Trametes Versicolor
Manyetik trametes versicolor biyokütlesi ile boyar madde giderimi
masterThesis
TEXT
10020935.pdf.txt
10020935.pdf.txt
text/plain
251640
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/786/3/10020935.pdf.txt
2e70793f4f6caca767a67bfac6cb8019
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/786/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10020935.pdf
10020935.pdf
application/pdf
9523743
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/786/1/10020935.pdf
9f7ac043ac73c3258844f5c8ec8da69a
MD5
1
11684/786
oai:openaccess.ogu.edu.tr:11684/786
2016-12-15 03:00:33.047
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/777
2016-12-15T01:00:49Z
com_11684_15
com_11684_2
col_11684_86
İlhan, Semra
Cantürk, Zerrin
TR18172
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-12-14T06:55:19Z
2016-12-14T06:55:19Z
2013-07
2013
http://hdl.handle.net/11684/777
Günümüz yaşam şartlarıyla baş etmeye yardımcı olabilecek ve oluşan hastalıkların tedavisinde kullanılmak üzere yeni, doğal ve etkili maddelere olan gereksinim gün geçtikçe artmaktadır. Bu amaçla yaygın olarak kullanılan bitkisel kaynakların yanında mikroorganizmalar da oldukça önemli kaynaklardır. Yeni metabolitlerin keşfi amacıyla son zamanlarda ekstrem ortamlarda yaşayan mikroorganizmalardan olan mikrofunguslar da bu alanda önemli bir yere sahiptir. Tez kapsamında, Tuz Gölü’nde izole edilen Aspergillus ve Penicillium cinslerine ait 124 izolatın serbest radikal süpürücü etkisi DPPH yöntemiyle taranmış ve %80’nin üzerinde inhibisyon gösteren sekiz izolat seçilmiştir. Folin-Ciocalteu yöntemi ile bu izolatların toplam fenolik madde miktarları 62-82 mg/GA arasında bulunmuştur. MTT yöntemi ile A. terreus AZC1 ve P. flavigenum PZC1 özütlerinin, A549, MCF7, Caco-2 hücre hatları üzerinde sitotoksik etkilerinin olduğu belirlenmiştir. Üç kanser hücre hattına ilaveten 3T3 hücre hattı üzerinde aynı özütlerin antiproliferatif etkisi ise Xcelligence gerçek zamanlı hücre analiz sistemiyle çalışılmıştır. Xcelligence’dan elde edilen IC50 değerleri A549 96,7 μg/ml, MCF7’de 33,4 μg/ml, Caco-2’de 43,4 μg/ml ve 3T3 de ise 97,3 μg/ml bulunmuştur. Kanser hücre hatları üzerinde etkili bulunan A. terreus AZC1 ve P. flavigenum PZC1 özütlerinin bileşiminde bulunan fenolik asitler YBSK ile, uçucu özelliğe sahip metabolitleri ise GK-KS ile belirlenmiştir. P.flavigenum PZC1 özütü kolon kromatografisiyle saflaştırılarak elde edilen M3 metaboliti iki kanser hücre hattına yüksek sitotoksik etki gösterirken sağlıklı hücre hattı olan 3T3 hücre hattı üzerindeki antiproliferatif etkisi oldukça azdır. M3 metabolitinin GK-KS de belirlenen ve NMR ile desteklenen sonuçlarına göre 2,4 ditert-butylfenol yapısında olduğu düşünülmektedir. M3 metaboliti bu açıdan anti-kanser ilaçlarında aranan bir özellikte olup bu nedenle de yeni bir anti-kanser ilaç olma yolunda araştırmaya değer önemli bir potansiyele sahiptir. Bu metaboliti üreten Penicillium flavigenum Türkiye için yeni kayıttır.
Need for new, natural and effective drugs which help to cope with hard life conditions and to use in the treatments of illnesses is increasing day by day. For this purpose, in addition to the commonly used plants, microorganisms are also quite important resources. Recently microorganisms living in extreme conditions altereted attention to discover new metabolites, and microfungi are also significant in this area. In this study the free radical scaveging effect of 124 isolates belonging to Aspergillus and Penicillium genus isolated from Tuz Gölü (Salt Lake), Turkey, was scanned by using DPPH method, and eight isolates showing over 80% inhibition were selected. Total phenolic content drug quantities of these isolates were found between 62 and 82 mg/g GA by using folin-ciocalteu spectrophotometric method. The cytotoxic effects of A. terreus AZC1 ve P. flavigenum PZC1 extracts on A549, MCF7, Caco-2 cell lines were measured by MTT. The antiproliferative effect of the same extracts on 3T3 cell line was studied with real time by the Xcelligence system. IC50 values were found as for 96,7; 33,4; 43,4 and 97,3 μg/ml for A549, MCF7, Caco-2 and 3T3 respectively with Xcelligence system. Phenolic acids existing in the extracts of A. terreus AZC1 and P. flavigenum PZC1 which are effective on the cancer cell lines were determined via HPLC, and the volatile metabolites were detected via GC-MS. P. flavigenum PZC1 extract was subjected by column chromatography, and M3 metabolite was purified. It showed high cytotoxic effect on two cancer cell lines; whereas, its antiproliferative effect of it on 3T3 cell line, which was a healthy one, was so weak. NMR and GC-MS results are of the structure of metabolite M3 is thought to be 2,4-di-tert butylphenol. M3 metabolite has a feature looked for anti-cancer drugs, so it is worth to be searched as a new candidate for anti-cancer drugs because of its crucial potential. Penicillium flavigenum is the first record for Turkey.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-14T06:35:26Z
No. of bitstreams: 1
10012127.pdf: 3842100 bytes, checksum: 2669bf083d57c4945e5ba8cab96e2a6a (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-14T06:55:19Z (GMT) No. of bitstreams: 1
10012127.pdf: 3842100 bytes, checksum: 2669bf083d57c4945e5ba8cab96e2a6a (MD5)
Made available in DSpace on 2016-12-14T06:55:19Z (GMT). No. of bitstreams: 1
10012127.pdf: 3842100 bytes, checksum: 2669bf083d57c4945e5ba8cab96e2a6a (MD5)
Previous issue date: 2013-07
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Kanser Hücre Hattı
Penicillium Flavigenum
Xcelligence Sistemi
Tuz Gölü
Cancer Cell Line
Penicillium Flavigenum
Xcelligence System
Tuz Lake
Tuz Gölü’nden izole edilen aspergillus ve penicillium cinsi türlere ait metabolitlerin antioksidan ve anti-proliferatif etkilerinin belirlenmesi
doctoralThesis
TEXT
10012127.pdf.txt
10012127.pdf.txt
text/plain
200155
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/777/3/10012127.pdf.txt
1ffdaae869cb9d936e88866b18b49512
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/777/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10012127.pdf
10012127.pdf
application/pdf
3842100
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/777/1/10012127.pdf
2669bf083d57c4945e5ba8cab96e2a6a
MD5
1
11684/777
oai:openaccess.ogu.edu.tr:11684/777
2016-12-15 03:00:49.909
Dspace@ESOGU
openaccess@ogu.edu.tr
REFHSVRJTSBMSVNBTlNJCgpCdSBsaXNhbnPEsSBpbXphbGF5xLFwIGfDtm5kZXJlcmVrLCBnw7ZuZGVyaW5pemkgZMO8bnlhIMOnYXDEsW5kYSBiYXPEsWzEsSBoYWxkZSwgCmVsZWt0cm9uaWsgb3J0YW1kYSB2ZSBoZXJoYW5naSBiYXNrYSBiaXIga2FuYWxsYSB5ZW5pZGVuIG9sdcWfdHVybWFrLCAKw6dldmlyaXNpbmkgeWFwbWFrIChhxZ9hxJ/EsWRhIHRhbsSxbWxhbmTEscSfxLEgw7x6ZXJlKSB2ZS92ZXlhIGRhxJ/EsXRtYWsgacOnaW4gCkVza2nFn2VoaXIgT3NtYW5nYXppIMOcbml2ZXJzaXRlc2nigJluaW4gKEVTT0dVKSDDtnplbCBvbG1heWFuIGhha2xhcsSxbsSxIGthYnVsIGV0bWnFnyBvbHVyc3VudXouCgpFU09HVSwgZ8O2bmRlcmluaXppbiBpw6dlcmnEn2luaSBkZcSfaXN0aXJtZWRlbiBoZXJoYW5naSBiaXIgCm9ydGFtZGEgZmFya2zEsSBiacOnaW1sZXJkZSBrb3J1bWEgYW1hw6dsxLEgb2xhcmFrIMOnZXZpcmViaWxpci4gCsOWdGUgeWFuZGFuIEVTT0dVLCBnw7x2ZW5saWssIHllZGVrbGVtZSB2ZSBrb3J1bWEgYW1hY8SxeWxhIGJ1IGfDtm5kZXJpbmluIApiaXJkZW4gZmF6bGEga29weWFzxLFuxLEgZWxpbmRlIHR1dGFiaWxpci4gCgpHw7ZuZGVyaW5pbiBzaXplIGFpdCBvcmlqaW5hbCBiaXIgw6dhbGnFn21hIG9sZHXEn3VudSB2ZSBidSBsaXNhbnN0YSBiZWxpcnRpbGVuIApoYWtsYXLEsSBrYWJ1bCBldG1lIGhha2vEsW7EsXogb2xkdcSfdW51IGJlbGlydG1pxZ8gb2x1cnN1bnV6LiBBeW7EsSB6YW1hbmRhIGfDtm5kZXJpbml6aW4sIApiaWxkacSfaW5peiBrYWRhcsSxeWxhLCBraW1zZW5pbiDDtnpsdWsgaGFra8SxbsSxIMOnacSfbmVtZWRpxJ9pbmkgZGUgc3VubXXFnyBvbHVyc3VudXouCgpFxJ9lciBnw7ZuZGVyaSB0ZWxpZiBoYWtrxLFuYSBzYWhpcCBvbHVubWF5YW4gYmlyIG1hdGVyeWFsIGnDp2VyaXlvcnNhLCBvIHphbWFuIAp0ZWxpZiBoYWtrxLEgc2FoaWJpbmRlbiBidSBsaXNhbnMgaWNpbiBnZXJla2xpIG9sYW4gRVNPR1UgaGFrbGFyxLFuxLEga2FidWwgZXRtZWsgCmljaW4ga8Sxc8SxdHPEsXogaXppbiBhbGTEscSfxLFuxLF6xLEgdmUgYnUgdGFyeiDDvMOnw7xuY8O8IGtpxZ9pbGVyIHRhcmFmxLFuZGFuIHNhaGlwIG9sdW5hbiAKbWF0ZXJ5YWxsZXJpbiBnw7ZuZGVyaSBpw6dlcmnEn2kgdmV5YSBtZXRuaSBpw6dlcmlzaW5kZSBhw6dpa8OnYSB0YW7EsW1sYW5kxLHEn8SxbsSxIHZlIAprYWJ1bCBlZGlsZGnEn2luaSBzdW5hcnNpbml6LgoKRcSeRVIgR8OWTkRFUsSwIEVTT0dVIERJxZ5JTkRBIEJBxZ5LQSBCxLBSIEtVUlVMVcWeIFRBUkFGSU5EQU4gREVTVEVLTEVORU4gQsSwUiDDh0FMScWeTUFZQSAKREFZQUxJIMSwU0UsIEJVIFRBUlogQklSIEFOTEHFnk1BIFZFWUEgU8OWWkxFxZ5NRU7EsE4gR0VSRUtUxLBSRMSwxJ7EsCBExLDEnkVSIApaT1JVTkxVTFVLTEFSSSBZRVLEsE5FIEdFVMSwUkTEsMSexLBOxLBaxLAgU1VOQVJTSU5JWi4KCkVTT0dVIGlzbWluaXppIGfDtm5kZXJpbmluIHlhemFyxLEgdmV5YSBzYWhpYmkgb2xhcmFrIGHDp8Sxa8OnYSB0YW7EsW1sYXlhY2FrdMSxciB2ZSAKYnUgbGlzYW5zxLFuIGl6aW4gdmVyZGnEn2luaW4gZMSxxZ/EsW5kYSBoZXJoYW5naSBiaXIgZGXEn2nFn2lrbGlrIHlhcG1heWFjYWt0xLFyLgo=
oai:openaccess.ogu.edu.tr:11684/917
2017-01-17T01:00:30Z
com_11684_15
com_11684_2
col_11684_86
Şirin, Ümit
Küçükkaykı, Ebru Ceren
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-01-16T08:16:06Z
2017-01-16T08:16:06Z
2013-06
2013
http://hdl.handle.net/11684/917
Bu çalışmada, Mayıs 2012-Nisan 2013 ayları arasında, Türkmen Dağları’ndaki (Eskişehir-Kütahya) Carabidae tür çeşitliliğinin yükseklik, mevsim ve temel çevresel etmenlere bağlı olarak değişimi araştırılmıştır. Çalışmada, bölgede 5 altfamilya ve 13 cinse ait 32 yer böceği türünün yaşadığı tespit edilmiştir. Bu türlerden 3 tanesinin (Leistus (Pogonophorus) montanus Stephens, 1827, Bembidion (Philochthus) aeneum Germar, 1824 ve Trechus (Trechus) subnotatus Dejean, 1831) ülkemiz faunası için yeni kayıt olduğu belirlenmiştir. Bununla birlikte 28 tür Eskişehir'den ilk kez rapor edilmektedir. Türlerin yükseklik ile ilişkisi araştırılmış, yükseklik faktörünün türlerin çeşitliliği üzerine birinci derecede etken olmadığı ancak bazı türlerin belirli yükseklik tercihi olduğu belirlenmiştir. Türlerin tespit edildiği habitatlar benzerlik (Jaccard, Sorensen) ve çeşitlilik (Simpson, Shannon-Wiener) açısından farklı indeksler ile karşılaştırılmıştır. Çeşitlilik bakımından en yüksek değere sahip olan alanın, tür sayısı bakımından ilk sırayı alan (Açık Karaçam ormanı özelliği gösteren) 3. çalışma alanının değil, (dere yatağı özelliği gösteren) 2. çalışma alanı olduğu belirlenmiştir. Benzerlik sonuçlarına göre; karışık ağaç vejetasyonuna sahip 9. çalışma alanı, dağ zirvesinde bulunan ve açık karaçam orman alanı olan 10. çalışma alanı % 75’lik oran ile en benzer alanları oluşturmaktadır. Bazı türlerin belirli habitatlara özelleştiği belirlenmiş, en çok tür özelleşmesi görülen alanların nemli habitatlar ve orman alanları olduğu tespit edilmiştir. Türlerin çeşitliliğine etki edeceği düşünülen çevresel faktörler ölçülmüş, Canonical Correspondence Analizi (CCA) sonucunda bölgede yer böceklerinin tür çeşitliliği üzerine en etkili olan çevresel faktörün “nem” faktörü olduğu belirlenmiştir.
In this study, Carabidae species relationship with altitude, season and environmental factors has investigated on Türkmen Mountain (Eskişehir-Kütahya) between May 2012- April 2013. Total of 32 species, belonging to 13 genus and 5 subfamily has collected and 3 of them (Leistus (Pogonophorus) montanus Stephens, 1827, Bembidion (Philochthus) aeneum Germar, 1824 and Trechus (Trechus) subnotatus Dejean, 1831) has determined as new record for Turkish fauna. However, 28 species were reported from Eskişehir for the first time. Species relationship with altitude has researched and it was determined that altitude factor is not a primary factor on species diversity but some species has an altitude preference. Habitats has compared with similarity (Jaccard, Sorensen) and diversity (Simpson, Shannon-Wiener) indexes. It is determined that the area with highest value in terms of diversity was not the 3rd study area (open pine forest) which has the highest species number, but the 2nd area (stream bed). According to similarity index the most similar habitats in terms of ground beetles communities were 9th area (mixed forest vegetation) and 10th area (open pine forest) with 75% percentage. Some species have habitat specialization, the most area specialization was seen on moist habitat and pine forest habitats. CCA indicates that most effective environmental variable on the ground beetle species is “moist” factor.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-19T06:36:24Z
No. of bitstreams: 1
10008875.pdf: 3360897 bytes, checksum: e5e267e3445056c06251f8eb2d09d6a9 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-01-16T08:16:06Z (GMT) No. of bitstreams: 1
10008875.pdf: 3360897 bytes, checksum: e5e267e3445056c06251f8eb2d09d6a9 (MD5)
Made available in DSpace on 2017-01-16T08:16:06Z (GMT). No. of bitstreams: 1
10008875.pdf: 3360897 bytes, checksum: e5e267e3445056c06251f8eb2d09d6a9 (MD5)
Previous issue date: 2013-06
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Yer Böcekleri
Carabidae
Türkmen Dağları
Biyoçeşitlilik
Fauna
Ground Beetles
Türkmen Mountain
Biodiversity
Fauna
Türkmen dağları (Eskişehir-Kütahya) yer böcekleri (Coleoptera : Carabidae)’nin fenolojileri ve vertikal tür çeşitliliğinin araştırılması
masterThesis
TEXT
10008875.pdf.txt
10008875.pdf.txt
text/plain
140224
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/917/3/10008875.pdf.txt
698b687498fc1ed3ea19ce427d5e3732
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/917/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10008875.pdf
10008875.pdf
application/pdf
3360897
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/917/1/10008875.pdf
e5e267e3445056c06251f8eb2d09d6a9
MD5
1
11684/917
oai:openaccess.ogu.edu.tr:11684/917
2017-01-17 03:00:30.072
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/844
2016-12-31T01:00:25Z
com_11684_15
com_11684_2
col_11684_86
Erkara, İsmühan Potoğlu
Yaylacı, Ömer Koray
TR234066
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-12-30T10:31:52Z
2016-12-30T10:31:52Z
2013-10
2013
http://hdl.handle.net/11684/844
Araştırma alanı Günyüzü (Eskişehir) ve çevresini kapsamaktadır. Damarlı bitkiler için Davis’in kareleme sistemine göre araştırma alanının tamamı B3 karesinde karayosunları için Henderson’ın kareleme sistemine göre ise B7 karesi içerisinde yer almaktadır. Floranın belirlenmesi için 2011-2013 yılları arasında araştırma alanından 2430 damarlı bitki örneği ve 100 zarf karayosunu örneği toplanmıştır. Toplanan bitki örnekleri herbaryum tekniklerine uygun olarak preslenip kurutulmuştur. Floristik liste hazırlanırken APG III sistemi kullanılmıştır. Yapılan tayinler sonucunda; 82 familya, 404 cins, 803 tür ve tür altı damarlı bitki taksonu ve 9 familya ya ait 12 cins ve bunlara bağlı 24 karayosunu taksonu tespit edilmiştir. Araştırma alanındaki damarlı bitki taksonları fitocoğrafik bölgelerine göre; % 20,67’si İran-Turan, % 10,09’u Akdeniz ve % 6,48’i Avrupa-Sibirya elementi olarak tespit edilmiştir. Çok bölgeli veya fitocoğrafik bölgesi bilinmeyenlerin oranı ise % 62,76’dır. Endemizm oranı % 19,55’tir.
This study has carried out Günyüzü (Eskişehir) and environs. For the vascular plants according to Davis’ grid system the research area situated in B3 square and for mosses according to Henderson’ grid system the research area situated in B7 square. To determinate the flora of research area, 2430 vascular plant samples and 100 envelopes mosses samples have collected between 2011-2013. Collected plant specimens have pressed and dried in accordance with the herbarium techniques. APG III system has used in the preparation of the floristic list. As a result of the assignments of collected samples, 803 taxa belonging to 404 genera and 82 families of vascular plans and 24 moss taxa belonging to 9 genera and 9 families have been identified. According to the phytogeographic regions of the vascular plant taxa on research area, Iranian-Turanian with a ratio of 20.68%, Mediterranean with a ratio of 10.08%, European-Siberian with a ratio of 6.48%. Multi-zone or phytogeographical region of unknown rate is of 62.76%. Endemism rate of these are 19.55%.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-20T06:24:11Z
No. of bitstreams: 1
10020668.pdf: 34786937 bytes, checksum: 8805c52a8ea3231f8e6ae80931ebc077 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-30T10:31:52Z (GMT) No. of bitstreams: 1
10020668.pdf: 34786937 bytes, checksum: 8805c52a8ea3231f8e6ae80931ebc077 (MD5)
Made available in DSpace on 2016-12-30T10:31:52Z (GMT). No. of bitstreams: 1
10020668.pdf: 34786937 bytes, checksum: 8805c52a8ea3231f8e6ae80931ebc077 (MD5)
Previous issue date: 2013-10
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Flora
Günyüzü
Eskişehir
Türkiye
Günyüzü (Eskişehir) ve çevresinin florası
masterThesis
TEXT
10020668.pdf.txt
10020668.pdf.txt
text/plain
280168
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/844/3/10020668.pdf.txt
89f907097a535848a0df128a71a86669
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/844/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10020668.pdf
10020668.pdf
application/pdf
34786937
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/844/1/10020668.pdf
8805c52a8ea3231f8e6ae80931ebc077
MD5
1
11684/844
oai:openaccess.ogu.edu.tr:11684/844
2016-12-31 03:00:25.034
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/845
2016-12-31T01:00:31Z
com_11684_15
com_11684_2
col_11684_86
Çabuk, Ahmet
Aytar, Pınar
TR54867
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-12-30T10:31:54Z
2016-12-30T10:31:54Z
2012-12
2012
http://hdl.handle.net/11684/845
Biyoteknolojik potansiyele sahip yeni mikroorganizmalara kaynak olabileceğinden dolayı asidik ortamlarda bulunan mikroorganizmaları belirlemek ekolojik ve pratik açıdan önemlidir. Bu tez çalışmasının öncelikli hedefi asidik maden drenajı (AMD) gibi asidik sularda yaşayan asidofilik mikroorganizmaların çeşitliliğinin belirlenmesidir. Ülkemizde asidik çevrelerdeki mikrobiyal çeşitlilik hakkında çok az bilgi bulunmaktadır. Balıkesir ve Çanakkale’de bulunan Balya ve Çan asidik maden drenajları olarak adlandırılan sabit pH değerine sahip bu çevrelerdeki mikrobiyal komünite, fluoresan in situ hibridizasyon, denatüre edici jel elektroforezi, terminal restriksiyon uzunluk polimorfizmi gibi moleküler yaklaşımlar ve klasik mikrobiyal (kültürel) tekniklerin kombinasyonu ile değerlendirilmiştir. Bu çalışmanın sonucunda, Balya AMD’den Acidithiobacillus ferrivorans, Acidithiobacillus sp., 2 farklı Ferrimicrobium sp., Actinobacterium sp., Acidiphilium sp., ve Acidobacteriaceae familyasına ait bir bakteri şeklinde 7 ve Çan AMD’den Leptospirillum sp., Acidobacteriaceae familyasına ait bir bakteri, Acidiphilium sp. ve kültüre edilmemiş bir bakteri şeklinde 4 tür izole edilmiştir.
Balya AMD’den elde edilen izolatlardan, kükürt ve demir metabolizmasına sahip bir suş olan, At. ferrivorans’ın biyodesülfürizasyon kapasitesi çalışılmıştır. Desülfürizasyon optimizasyon deneyleri Taguchi yöntemi ile gerçekleştirilmiştir. pH, inokulum miktarı, pulp yoğunluğu, kömür partikül boyutu ve inkübasyon süresinin değerlendirildiği optimizasyon deneylerinde belirlenen koşullar; sırası ile 2,5; %2, %1, 500+212 μm, 15 gün olmuş ve %30 toplam kükürt giderim verimi elde edilmiştir. Biyodesülfürizasyondan sonra kömür yüzeyindeki değişimler taramalı elektron mikroskobu (SEM) ve FTIR analizi ile değerlendirilmiştir. Özellikle SEM analizi pirit kristallerine bakterinin yaptığı atağı göstermektedir, bu kristaller işlem görmemiş kömür kristalleri ile karşılaştırıldığında açık bir şekilde korozyon ve deformasyona uğradıkları görülmüştür. Bununla birlikte redoks potansiyeli ile Fe+2 ölçümleri, kükürt oksidasyonunun yanısıra ferro demirin yükseltgenmesi ve ferrik demir indirgenmesi reaksiyonlarının varlığını göstermiştir.
Determining the microorganisms present in the acidic environments has ecological and practical importance, being a source of new microorganisms with biotechnological potential. The first aim of the thesis study is determining the biodiversity of acidophilic prokaryotes living in acidic waters, such as acidic mine drainage. Very little is known about microbiological diversities of acidic environments at Turkey. Microbial communities in extreme acidic environments with a rather constant acidic pH, acidic mine drainages of Çan and Balya, at Çanakkale and Balıkesir were investigated a combination of classical microbiology (cultivation techniques) and molecular biology approaches including fluorescent in situ hybridisation, denaturing gradient gel electrophoresis, terminal restriction fragment length polymorphism, examined microbiological diversity and found the correlation between the approaches. As the result of this study, seven strains such as Acidithiobacillus ferrivorans, Acidithiobacillus sp., two different Ferrimicrobium sp., Actinobacterium sp., Acidiphilium sp., and a bacterium belonging to Acidobacteriaceae were isolated from Balya AMD, and four strains including Leptospirillum sp., a bacterium belonging to Acidobacteriaceae, Acidiphilium sp. and uncultured bacterium were isolated Çan AMD.
The biodesulphurization capability of a strain having sulphur and iron metabolism isolated from acidic mine drainage of Balya (Turkey) was studied. When molecular identification was carried out, this bacterium was shown that it was a strain of At. ferrivorans. Desulphurization optimization experiments were performed by Taguchi’s method. The optimum conditions for these parameters have found to be pH 2.5, 2% of inoculum amount, 1% of pulp density, 500212 μm of particle size, and 15 days of incubation period. The obtained yields were about 30% in removal of total sulphur. Scanning electron microscope (SEM) and FTIR analysis also indicated a modification of coal surface after biodesulphurization. Especially, SEM analysis showed that the attack of bacterium on pyrite crystals and there was clear corrosion and deformation on the pyrite surface compared to untreated coal. Besides, the redox potential and Fe+2 measurement demonstrated that sulphur oxidation was coupled with ferrous iron oxidation and ferric iron reduction.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-20T06:29:43Z
No. of bitstreams: 1
458716.pdf: 5941675 bytes, checksum: 4724de72436b067d703f472e6ccfcc95 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-30T10:31:54Z (GMT) No. of bitstreams: 1
458716.pdf: 5941675 bytes, checksum: 4724de72436b067d703f472e6ccfcc95 (MD5)
Made available in DSpace on 2016-12-30T10:31:54Z (GMT). No. of bitstreams: 1
458716.pdf: 5941675 bytes, checksum: 4724de72436b067d703f472e6ccfcc95 (MD5)
Previous issue date: 2012-12
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Asidofil
Asidik Maden Drenajı
Biyodesülfürizasyon
Acidophile
Acidic Mine Drainage
Biodesulphurization
Aşırı asidik ortamlarda prokaryotik çeşitliliğin geleneksel ve moleküler yöntemlerle belirlenmesi ve biyodesülfürizasyonda kullanılabilirliği
doctoralThesis
TEXT
458716.pdf.txt
458716.pdf.txt
text/plain
454073
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/845/3/458716.pdf.txt
5e5ed827825657c1dd5f60863b113443
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/845/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
458716.pdf
458716.pdf
application/pdf
5941675
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/845/1/458716.pdf
4724de72436b067d703f472e6ccfcc95
MD5
1
11684/845
oai:openaccess.ogu.edu.tr:11684/845
2016-12-31 03:00:31.656
Dspace@ESOGU
openaccess@ogu.edu.tr
REFHSVRJTSBMSVNBTlNJCgpCdSBsaXNhbnPEsSBpbXphbGF5xLFwIGfDtm5kZXJlcmVrLCBnw7ZuZGVyaW5pemkgZMO8bnlhIMOnYXDEsW5kYSBiYXPEsWzEsSBoYWxkZSwgCmVsZWt0cm9uaWsgb3J0YW1kYSB2ZSBoZXJoYW5naSBiYXNrYSBiaXIga2FuYWxsYSB5ZW5pZGVuIG9sdcWfdHVybWFrLCAKw6dldmlyaXNpbmkgeWFwbWFrIChhxZ9hxJ/EsWRhIHRhbsSxbWxhbmTEscSfxLEgw7x6ZXJlKSB2ZS92ZXlhIGRhxJ/EsXRtYWsgacOnaW4gCkVza2nFn2VoaXIgT3NtYW5nYXppIMOcbml2ZXJzaXRlc2nigJluaW4gKEVTT0dVKSDDtnplbCBvbG1heWFuIGhha2xhcsSxbsSxIGthYnVsIGV0bWnFnyBvbHVyc3VudXouCgpFU09HVSwgZ8O2bmRlcmluaXppbiBpw6dlcmnEn2luaSBkZcSfaXN0aXJtZWRlbiBoZXJoYW5naSBiaXIgCm9ydGFtZGEgZmFya2zEsSBiacOnaW1sZXJkZSBrb3J1bWEgYW1hw6dsxLEgb2xhcmFrIMOnZXZpcmViaWxpci4gCsOWdGUgeWFuZGFuIEVTT0dVLCBnw7x2ZW5saWssIHllZGVrbGVtZSB2ZSBrb3J1bWEgYW1hY8SxeWxhIGJ1IGfDtm5kZXJpbmluIApiaXJkZW4gZmF6bGEga29weWFzxLFuxLEgZWxpbmRlIHR1dGFiaWxpci4gCgpHw7ZuZGVyaW5pbiBzaXplIGFpdCBvcmlqaW5hbCBiaXIgw6dhbGnFn21hIG9sZHXEn3VudSB2ZSBidSBsaXNhbnN0YSBiZWxpcnRpbGVuIApoYWtsYXLEsSBrYWJ1bCBldG1lIGhha2vEsW7EsXogb2xkdcSfdW51IGJlbGlydG1pxZ8gb2x1cnN1bnV6LiBBeW7EsSB6YW1hbmRhIGfDtm5kZXJpbml6aW4sIApiaWxkacSfaW5peiBrYWRhcsSxeWxhLCBraW1zZW5pbiDDtnpsdWsgaGFra8SxbsSxIMOnacSfbmVtZWRpxJ9pbmkgZGUgc3VubXXFnyBvbHVyc3VudXouCgpFxJ9lciBnw7ZuZGVyaSB0ZWxpZiBoYWtrxLFuYSBzYWhpcCBvbHVubWF5YW4gYmlyIG1hdGVyeWFsIGnDp2VyaXlvcnNhLCBvIHphbWFuIAp0ZWxpZiBoYWtrxLEgc2FoaWJpbmRlbiBidSBsaXNhbnMgaWNpbiBnZXJla2xpIG9sYW4gRVNPR1UgaGFrbGFyxLFuxLEga2FidWwgZXRtZWsgCmljaW4ga8Sxc8SxdHPEsXogaXppbiBhbGTEscSfxLFuxLF6xLEgdmUgYnUgdGFyeiDDvMOnw7xuY8O8IGtpxZ9pbGVyIHRhcmFmxLFuZGFuIHNhaGlwIG9sdW5hbiAKbWF0ZXJ5YWxsZXJpbiBnw7ZuZGVyaSBpw6dlcmnEn2kgdmV5YSBtZXRuaSBpw6dlcmlzaW5kZSBhw6dpa8OnYSB0YW7EsW1sYW5kxLHEn8SxbsSxIHZlIAprYWJ1bCBlZGlsZGnEn2luaSBzdW5hcnNpbml6LgoKRcSeRVIgR8OWTkRFUsSwIEVTT0dVIERJxZ5JTkRBIEJBxZ5LQSBCxLBSIEtVUlVMVcWeIFRBUkFGSU5EQU4gREVTVEVLTEVORU4gQsSwUiDDh0FMScWeTUFZQSAKREFZQUxJIMSwU0UsIEJVIFRBUlogQklSIEFOTEHFnk1BIFZFWUEgU8OWWkxFxZ5NRU7EsE4gR0VSRUtUxLBSRMSwxJ7EsCBExLDEnkVSIApaT1JVTkxVTFVLTEFSSSBZRVLEsE5FIEdFVMSwUkTEsMSexLBOxLBaxLAgU1VOQVJTSU5JWi4KCkVTT0dVIGlzbWluaXppIGfDtm5kZXJpbmluIHlhemFyxLEgdmV5YSBzYWhpYmkgb2xhcmFrIGHDp8Sxa8OnYSB0YW7EsW1sYXlhY2FrdMSxciB2ZSAKYnUgbGlzYW5zxLFuIGl6aW4gdmVyZGnEn2luaW4gZMSxxZ/EsW5kYSBoZXJoYW5naSBiaXIgZGXEn2nFn2lrbGlrIHlhcG1heWFjYWt0xLFyLgo=
oai:openaccess.ogu.edu.tr:11684/879
2017-01-05T01:00:15Z
com_11684_15
com_11684_2
col_11684_86
İlhan, Semra
Gürsu, Bükay Yenice
TR126767
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-01-04T06:12:41Z
2017-01-04T06:12:41Z
2013-08
2013
http://hdl.handle.net/11684/879
Bu çalışmada hipersalin çevrelerden mikrofungus izolasyonu ve bu fungusların
Alkol Dehidrogenaz (ADH) enzimi açısından taranması amaçlanmıştır. İlaveten seçilen
verimli izolatlardan klonlama çalışmaları yapılarak endüstriyel üretime geçişi
sağlayacak verilerin ortaya konması hedeflenmiştir.
Bu amaçla, Tuz Gölü’nden alınan su örneklerinden mikrofungus izolasyonu
gerçekleştirilmiştir. Mikrofunguslar diagnostik literatürler kullanılarak geleneksel
yöntemler ile cins seviyesinde tanımlanmıştır. Dokuz cinse (Alternaria, Aspergillus,
Cladosporium, Emericella, Eurotium, Penicillium, Scopulariopsis, Stemphylium ve
Ulocladium) ait toplam 51 mikrofungus izole edilmiştir. İzolatların büyük bir kısmının
sırasıyla Cladosporium, Penicillium, Alternaria ve Aspergillus cinslerine ait olduğu
belirlenmiştir.
38 izolat için ADH enzim aktivitesi taraması yapılmıştır. En yüksek aktivite
saptanan 8 izolatın ITS (içsel transkrip ayırıcı) bölgeleri dizilenerek moleküler
yöntemlerle tanımlamaları yapılmıştır. En yüksek spesifik aktivite sırasıyla
Cladosporium macrocarpum (5776), Eurotium niveoglacum (5778), Aspergillus
versicolor (T55), A. niger (5800), C. sphaerospermum (5821), C. cladosporioides
(5794), Penicillium chrysogenum (5797) ve E. amstelodami (5810) türlerinde
saptanmıştır. Bu türler için spesifik enzim aktivitesi 3,21-5,93 U/mg arasında
değişmektedir.
Alkol dehidrogenaz gen bölgesi klonlama çalışmaları için E. amstelodami, P.
chrysogenum ve A. niger seçilmiştir. pJET1.2/blunt vektör klonlama plazmidi olarak
kullanılmış ve bakteryal transformansyon için E. coli EZ kompotent hücreleri ile
çalışılmıştır. Söz konusu gen bölgesinden farklı gen bölgelerinin klonlanması üzerine
enzim varlığını ortaya koymak için A. niger (5800) izolat özütüne amonyum sülfatla
çöktürme ve diyaliz yöntemleri uygulanmıştır. Enzim spesifik aktivitesi ham özüte göre
yaklaşık 20 kat artmıştır. Hücre özütü diyalizatında proteinlerin varlığının ve
profillerinin ortaya konması için SDS-PAGE ve HPLC yönteminden faydalanılmıştır.
In this study, focused on isolation of microfungi from hipersaline environment
and screening of their ADH activity. In addition, intended to reveal of the data for
provide the progression to the industrial production by cloning studies on selected
active isolates.
For this purpose, microfungi were isolated from Tuz Gölü water samples. The
microfungi were identified at genus level according to traditional identification
literatures. Totally 51 microfungi was isolated relating to nine genera (Alternaria,
Aspergillus, Cladosporium, Emericella, Eurotium, Penicillium, Scopulariopsis,
Stemphylium and Ulocladium). Respectively isolates determined belonged to genera
order of Cladosporium, Penicillium, Alternaria ve Aspergillus.
ADH enzyme activity screening was carried out for 38 isolates. Eight isolates
with the highest activity were identified by molecular methods with sequencing of
internal transcribe spacer (ITS) regions. The highest specific activity determined on the
following species; Cladosporium macrocarpum (5776), Eurotium niveoglacum (5778),
Eurotium niveoglacum (5778), Aspergillus versicolor (t55), A. niger (5800), C.
sphaerospermum (5821), C. cladosporioides (5794), ), Penicillium chrysogenum (5797)
ve E. amstelodami (5810). Specific enzyme activity of these species ranged from 3.21
to 5.93 U / mg.
E. amstelodami, P. chrysogenum ve A. niger were selected for cloning studies.
pJET1.2/blunt vector was used as a cloning plasmid and for bacterial transformation
were studied with E. coli EZ competent cells. Due to cloning of different gene regions
instead of interested gene, ammonium sulfate precipitation and dialysis methods applied
to extract of A. niger (5800) for establish the presence of the enzyme. Enzyme specific
activity increased approximately 20-fold compared to the crude extract. SDS-PAGE ve
HPLC method was used to indicate the presence of proteins and protein profiles in
dialyzed cell extract.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-22T06:02:17Z
No. of bitstreams: 1
10019095.pdf: 3421436 bytes, checksum: 341ccfa7845fdcbe10dbb7bae5dda72e (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-01-04T06:12:41Z (GMT) No. of bitstreams: 1
10019095.pdf: 3421436 bytes, checksum: 341ccfa7845fdcbe10dbb7bae5dda72e (MD5)
Made available in DSpace on 2017-01-04T06:12:41Z (GMT). No. of bitstreams: 1
10019095.pdf: 3421436 bytes, checksum: 341ccfa7845fdcbe10dbb7bae5dda72e (MD5)
Previous issue date: 2013-08
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Tuz Gölü
Halotolerant-Halofilik Fungus- Alkol Dehidrogenaz
Halotolerant-halophilic Fungi
Alcohol Dehydrogenase
Tuz Gölü’nden izole edilen mikrofungusların tanımlanması, alkol dehidrogenaz enzimi açısından taranması ve klonlama çalışmaları
doctoralThesis
TEXT
10019095.pdf.txt
10019095.pdf.txt
text/plain
141171
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/879/3/10019095.pdf.txt
6e5e70b2f0807d0f94bbf2f3127c14ce
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/879/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10019095.pdf
10019095.pdf
application/pdf
3421436
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/879/1/10019095.pdf
341ccfa7845fdcbe10dbb7bae5dda72e
MD5
1
11684/879
oai:openaccess.ogu.edu.tr:11684/879
2017-01-05 03:00:15.858
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/814
2016-12-31T01:00:33Z
com_11684_15
com_11684_2
col_11684_86
Ocak, Atilla
Karayer, Aykut
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2016-12-30T07:02:23Z
2016-12-30T07:02:23Z
2013-01
2013
http://hdl.handle.net/11684/814
Çalışma alanımız; Kırka ilçesi maden isletmesi etrafı tarım alanları ve
çevresindeki Akin, Yarbasan, Fethiye köylerinden 2011-2012 yılları arasında toplanan
topraklar da ve Hordeum vulgare F., Triticum aestivum, F., Phaseolus vulgaris F.,
Cucurbita pepo F., Lactuca sativa F., Cicer arietinum F., Beta vulgaris F., Solanum
tuberosum F., Solanum melongena F., Allium cepa F., Medicago sativa F. bitkilerinde
kök, gövde, yaprak ve çiçek aksamları üzerinde çalışılarak Potasyum (K), Kalsiyum
(Ca), Magnezyum (Mg), Demir (Fe), Mangan (Mn), Bor (B), Çinko (Zn), Bakır (Cu),
Alüminyum (Al), Kursun (Pb), Krom (Cr), Sodyum (Na), Silisyum (Si), Arsenik (As),
Nikel (Ni) ve Kadmiyum (Cd) gibi elementlerinin analizleri yapılmıştır.
Kırka isletmesinde maden çıkarma işlemi nedeniyle açılan yataklardan ve
çalışılmış ocaklardan dolayı yüzey akısı ile bor taşınmaktadır. Yeraltı sularına da
taşınan bor, toprak ve sularda düşük olduğu halde bitkilerin bu elemente karsı hassas
olmaları ve toprakta biriken borun yıkanamamasından dolayı bitkilere zararlı
olabilmektedir. Bor elementinin tüm bitkilerde kök, gövde ve yaprakta birikimlerinin
yaz aylarında ciddi verim ve ürün kalitesinde kayıplara yol açabilecek seviyelerde
çıkması çevresel sorun boyutunda değerlendirilmiştir.
Diğer elementlerden kalsiyum, magnezyum, arseniğin olması gereken
değerlerden yüksek olusu bu elementlerin birbiriyle de ilişkileri göz önüne alındığında
üreticilerin yetiştirecekleri ürün seçimlerinde bor kadar bu elementlere dayanıklı türleri
seçmeleri dikkate almaları gerektiği diğer bir husustur.
The soil samples collected from agriculture area which is near mine concern in
Kırka and Akin, Yarbasa, Fethiye villages in between 2011-2012 years. Also root,
stem, leaf, flower part of Hordeum vulgare F., Triticum aestivum, F., Phaseolus
vulgaris F., Cucurbita pepo F., Lactuca sativa F., Cicer arietinum F., Beta vulgaris F.,
Solanum tuberosum F., Solanum melongena F., Allium cepa F., Medicago sativa F.
plants were invastigated. The soil and plants samples were analized for fundemantal
elements such as potassium (K), calsium (Ca), magnesium (Mg), iron (Fe), mangane
(Mn), boron (Br), zinc (Zn), copper (Cu), aluminium (Al), plumbo (Pb), crome (Cr),
natrium (Na), silisium (Si), arsenic (As), nickel (Ni), cadmium (Cd).
Boron (Br) can be transport by a result of mining process or runoff from mine
bed in Kırka. It also can be exist in groundwater and it is hazardous for plants because
of sensitivity of plants against this element and hard to rewash by plants. It has found a
enviromental problem that the product quality can be effected negative because of too
much boron accumulation in root, stem and leaf part of plants in summer time.
We also determined high level of calsium, magnesium and arsenic far from it
had too be. We can say that the farmer in this area has to be consider this results and we
recommended to pick resistant plants against this elements as much as boron.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-22T06:17:41Z
No. of bitstreams: 1
464355.pdf: 1721954 bytes, checksum: 0363b8c2e9623b99765f8a5b56b9a489 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2016-12-30T07:02:23Z (GMT) No. of bitstreams: 1
464355.pdf: 1721954 bytes, checksum: 0363b8c2e9623b99765f8a5b56b9a489 (MD5)
Made available in DSpace on 2016-12-30T07:02:23Z (GMT). No. of bitstreams: 1
464355.pdf: 1721954 bytes, checksum: 0363b8c2e9623b99765f8a5b56b9a489 (MD5)
Previous issue date: 2013-01
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Bor
Kırka
Tarım Bitkileri
Boron
Agricultural Plants
Kırka (Eskişehir) ve çevresindeki bazı tarım alanlarındaki topraklarda ve bitkilerde ağır metal içeriklerinin belirlenmesi
masterThesis
TEXT
464355.pdf.txt
464355.pdf.txt
text/plain
178618
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/814/3/464355.pdf.txt
4d44e3e021bd73caae65110c2f95450a
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/814/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
464355.pdf
464355.pdf
application/pdf
1721954
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/814/1/464355.pdf
0363b8c2e9623b99765f8a5b56b9a489
MD5
1
11684/814
oai:openaccess.ogu.edu.tr:11684/814
2016-12-31 03:00:33.43
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/932
2017-01-25T01:00:15Z
com_11684_15
com_11684_2
col_11684_86
Yamaç, Mustafa
Kunduhoğlu, Buket
Özkan, Cem
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-01-24T06:47:45Z
2017-01-24T06:47:45Z
2013-10
2013
http://hdl.handle.net/11684/932
Bu çalışmada, yırtıcı kuşlardan elde edilen laktik asit bakterilerinin (LAB’ nin) bakteriyosin benzeri madde (BBM) üretim potansiyeli konu alınmıştır. LAB izolasyonu için ükemizde dağılım gösteren Kara Akbaba, Şah Kartal, Kızıl Şahin, Atmaca ve Delice gibi önemli yırtıcı kuş türlerinin ağız, kloak ve dışkılarından örnekler alınmıştır. Elde edilen LAB izolatlarının antimikrobiyal aktiviteleri test bakterilerine karşı agar sandviç ve agar kuyu yöntemleri ile belirlenmiştir. Aktiviteleri belirlenen LAB suşlarının virülans faktörleri taranmış ve virülant suşlar elenmiştir. Seçilen izolat geleneksel ve moleküler yöntemler ile Enterococcus faecium olarak isimlendirilmiştir.
Enterococcus faecium’ tarafından üretilen BBM’ nin 15 dakikada 45 - 100˚C de, 30 dakikada 45 – 90 ˚C de ve 2 – 11 pH değerlerinde 24 saat stabil kaldığı belirlenmiştir. Ayrıca, proteolitik enzimler, organik çözücüler, bazı deterjanlar ve kimyasallarla muamele edildiğinde aktivitesinin değişmediği belirlenmiştir. Üretilen BBM liyofilize edilerek 4 – 25 ˚C de raf ömrü araştırılmış, kısmi bir aktivite kaybına karşın aktivitenin 75 gün korunduğu belirlenmiştir.
BBM nin kısmi karakterizasyonu için amonyum sülfat çöktürmesi ve diyaliz yapılarak elde edilen konsantre süpernatan SDS-PAGE elektroforezde yürütülmüş ve antimikrobiyal aktivitesi belirlenmiştir. Antimikrobiyal aktivite sonuçları ile jelde elde edilen bantlar karşılaştırılmıştır.
Son olarak Enterococcus faecium’ un maksimum verimle BBM üretebilmesi için çevresel ve besinsel koşullar optimize edilmiştir. Elde edilen veriler karıştırmalı tank reaktöründe BBM üretimi için kullanılmıştır.
In this study, has been subject to potential for production substance BLS by lactic acid bacteria obtained from birds of prey. Mouth, cloaca and feces samples were taken from major types of birds of prey distributed in our country such as Kara Akbaba, Şah Kartal, Kızıl Şahin, Atmaca ve Delice for the isolation of LAB. Antimicrobial activity of obtained from LAB isolates against test bacteria were determined by agar sandwiches and agar well methods. LAB strains which identified activities were scanned virulence factors and virulent strains were eliminated. The selected isolate named as Enterococcus faecium with conventional and molecular methods.
BLS produced by Enterococcus faecium was determined to be stable for 24 hours in 15 minutes (45-100 ˚C) and 30 minutes (45 - 90 ˚C) at pH (2-11) values. Additionally, when treated with some of detergents, proteolytic enzymes, organic solvents, and chemicals, the activity was determined to unchanged. It was determined to preserve for 75 days against a partial loss of activity and the shelf life was investigated at 4-25 ˚C. As lyophilized of producing BLS. The concentrated supernatant which obtained by dialysis and ammonium sulfate precipitation for partial characterization of BLS was conducted at SDS-PAGE electrophoresis and antimicrobial activity were determined. Antimicrobial activity results were compared with bands obtained from the gel.
Finally, to produced BLS with maximum efficiency of Enterococcus faecium were optimized to environmental and nutritional conditions. The resulting data was used for the production of BLS in stirred tank reactor.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2017-01-04T06:27:50Z
No. of bitstreams: 1
10019729.pdf: 1917645 bytes, checksum: 8e7151c82a75683a5a4f9f1ea1137aed (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-01-24T06:47:45Z (GMT) No. of bitstreams: 1
10019729.pdf: 1917645 bytes, checksum: 8e7151c82a75683a5a4f9f1ea1137aed (MD5)
Made available in DSpace on 2017-01-24T06:47:45Z (GMT). No. of bitstreams: 1
10019729.pdf: 1917645 bytes, checksum: 8e7151c82a75683a5a4f9f1ea1137aed (MD5)
Previous issue date: 2013-10
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Laktik Asit Bakterisi
Bakteriyosin
Yırtıcı Kuş
Optimizasyon
Lactic acid Bacteria
Bacteriocin
Birds of Prey
Optimization
Çeşitli yırtıcı kuşlardan izole edilen laktik asit bakterileri’nin bakteriyosin benzeri madde üretim yeteneklerinin belirlenmesi ve üretim koşullarının optimizasyonu
masterThesis
TEXT
10019729.pdf.txt
10019729.pdf.txt
text/plain
193455
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/932/3/10019729.pdf.txt
a2959d4e562da2bef5eee4f847ee6d40
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/932/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10019729.pdf
10019729.pdf
application/pdf
1917645
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/932/1/10019729.pdf
8e7151c82a75683a5a4f9f1ea1137aed
MD5
1
11684/932
oai:openaccess.ogu.edu.tr:11684/932
2017-01-25 03:00:15.955
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/896
2017-01-11T01:00:36Z
com_11684_15
com_11684_2
col_11684_86
Yamaç, Mustafa
Doğan, Bilal
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-01-10T06:52:23Z
2017-01-10T06:52:23Z
2013-10
2013
http://hdl.handle.net/11684/896
Günümüzde tarımsal üretim veriminin düşmesinin yanı sıra hızla artan nüfus dünya genelinde olduğu gibi ülkemizde de besin ve beslenme sorununu beraberinde getirmektedir. Bu sebeple bitkisel kaynaklardan mümkün olduğu kadar fazla verim elde edilmesi zorunluluğu doğmaktadır. Bitki gelişim düzenleyicileri (BGD) bu sorun için alternatif bir çözüm olarak düşünülmektedir.
Çalışmada Eskişehir Osmangazi Üniversitesi Fen Edebiyat Fakültesi Biyoloji Bölümü Fungikültür Laboratuvarı’ nda dikaryotik misel formunda saklanan Basidiomycetes kültür koleksiyonunun BGD üretim potansiyellerinin belirlenmesi, üretim koşullarının optimizasyonu ve pilot çapta üretimi amaçlanmıştır.
Bu amaçla 103 adet Basidiomyecetes izolatı, BGD üretim kapasiteleri açısından taranmış, başarılı bulunan Pleurotus eryngii (Hakkari) izolatı sonraki aşamalarda kullanılmak üzere seçilmiştir.
Pleurotus eryngii (Hakkari) izolatının 3 farklı kültür sisteminde (derin kültür, statik kültür ve katı faz kültür sisemi), BGD üretimi incelenmiştir. En iyi BGD üretimi inkübasyonun 18. gününde derin kültür yönteminde GA için 4438.67, ABA için 436.95 ve IAA için 54.32 mg/l olarak belirlenmiştir.
BGD üretim koşullarının optimizasyonu için Plackett-Burman deney tasarımı (PB) ve cevap yüzey yöntemi kullanılmıştır. İstatistiksel deney tasarımı ile BGD üretiminin optimizasyonu aşamasında belirlenen en uygun üretim koşulları, ölçek büyütme uygulanarak reaktör boyutunda araştırılmıştır. Reaktör koşullarında BGD üretim değerleri GA, ABA ve IAA için sırasıyla 10545, 872,32 ve 60,48 mg/l olarak belirlenmiştir. Sonuç olarak, GA, ABA ve IAA üretim değerleri, başlangıç değerlerine göre sırası ile 4,1, 3,4 ve 2,3 kat arttırılmıştır.
Nowadays, decline in the efficiency of agricultural production as well as the rapidly growing population in our country as it is throughout the world brings about the problem of food and nutrition. These situation causes reveal the necessity of obtaining as possible as greater efficiency from plant sources. Plant growth hormones (PGH) could be accepted as an alternative solution for this problem.
In this context, aims of the suggested study are to determine of their potential to produce plant growth hormones of fungal cultures stored as dicaryotic mycelium form in Basidiomycetes culture collection of Eskisehir Osmangazi University, Faculty of Arts and Sciences, Department of Biology, Fungiculture Laboratory, to optimize of production conditions, and to produce in pilot scale.
Therefore 103 Basidiomycetes isolates were invastigated the ability of producing plant growth hormones capacity. Isolate Pleurotus eryngii (Hakkari) was found successful and choosen for next experiments.
Plant growth hormones producing capacity of Pleurotus eryngii (Hakkari) isolate measured while mushroom growing on different culture type (static, submerged and solid state). Maximum plant growth hormones production noted respectively GA; 4438.67, ABA; 436.95 and IAA; 54.32 mg/l with submerged fermentation on day 18th.
Plackett-Burman experimental design and response surface method were used for optimization of plant growth hormones production conditions. The determined optimum conditions was investigated in stirred tank reactor scale to produce PGH in higher volume and reached the results, GA; 10545, ABA; 872.32 and IAA; 60.48 mg/l. Finally, production amounts of GA, ABA and IAA were increased respectively 4.1, 3,4 and 2.3 fold.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2017-01-04T06:58:35Z
No. of bitstreams: 1
10019684.pdf: 2382962 bytes, checksum: bfaebd278693018d64c7d14e98e117ea (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-01-10T06:52:23Z (GMT) No. of bitstreams: 1
10019684.pdf: 2382962 bytes, checksum: bfaebd278693018d64c7d14e98e117ea (MD5)
Made available in DSpace on 2017-01-10T06:52:23Z (GMT). No. of bitstreams: 1
10019684.pdf: 2382962 bytes, checksum: bfaebd278693018d64c7d14e98e117ea (MD5)
Previous issue date: 2013-10
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Pleurotus Eryngii
Gibberellik Asit
Absisik Asit
İndol Asetik Asit
Optimizasyon
Reaktör
Pleurotus Eryngii
Gibberellic Acid
Abscisic Acid
Indole Acetic Acid
Optimization
Reactor
Basidiomycetes türlerinin gibberellik asit, absisik asit ve indol asetik asit üretimi açısından taranması, üretim koşullarının optimizasyonu ve reaktör çapında üretimi
masterThesis
TEXT
10019684.pdf.txt
10019684.pdf.txt
text/plain
130362
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/896/3/10019684.pdf.txt
62f989865655410b12a5b2e3b740a8ac
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/896/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10019684.pdf
10019684.pdf
application/pdf
2382962
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/896/1/10019684.pdf
bfaebd278693018d64c7d14e98e117ea
MD5
1
11684/896
oai:openaccess.ogu.edu.tr:11684/896
2017-01-11 03:00:36.49
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/901
2017-01-11T01:00:14Z
com_11684_15
com_11684_2
col_11684_86
Ocak, Atilla
Kolata, Filiz Eğin
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-01-10T06:52:46Z
2017-01-10T06:52:46Z
2013-01
2013
http://hdl.handle.net/11684/901
Bu çalışmada 107 km uzunluğundaki Seyitgazi Kırka beldesinden çıkarak,
Doğançayır, Mahmudiye ve Çiftelerden Sakarya Nehrine dökülen Seydisuyu’ nda
belirlenen 7 lokalitede doğal olarak yetişen Heracleum sphondlylium L., Salix cinera L.,
Urtica dioica L., Rumex crispus L. bitkileri toplanmıştır.
Bu bitkilerin kök, gövde, yaprak ve çiçek kısımları üzerinde çalışılarak
Potasyum (K), Kalsiyum (Ca), Magnezyum (Mg), Demir (Fe), Mangan (Mn), Bor (B),
Çinko (Zn), Bakır (Cu), Alüminyum (Al), Kurşun (Pb), Krom (Cr), Sodyum (Na),
Silisyum (Si), Arsenik (As), Nikel (Ni) ve Kadmiyum (Cd) yararlı elementlerinin
analizleri yapılmıştır. Bu elementler bitkiler için genel olarak düşük derişimlerde
gerekli, yüksek derişimlerde ise toksik etkiye sahiptirler.
Çalışma alanımız, bor madeninin çıktığı ve jeolojik yapısı itibariyle Seydisuyuna
karışımın fazla olduğu önemli alanlardan biridir. Bu nedenle bitki bor birikim
parametrelerinin bilinmesi ve izlenmesi, özellikle toprak ve sulardaki düzeyleri ile
reaksiyonlarının belirlenmesi bölgedeki kirlik düzeyinin değerlendirilmesi açı����������ından
önem arz etmektedir.
Elementlerin kuru bitki minimum ve maksimum değerlerini karşılaş����������ırdığı����������ızda;
Cd, Mn, Ca elementleri belirlenen sınır değerlerinin çok üzerinde, Fe ve Zn elementleri
belirtilen sınır değerler arasında, Cu elementi sınır değerlerin altında bulunmuştur.
Analizi yapılan Mg, Al, Pb, Cr, Ar, K, Na, Si elementlerinin bitkilerimizdeki miktarları
belirlenmiştir. Araştırma bitkilerinde en fazla B elementi birikimi Sancar köyü,
Yazıdere köyü, Hamidiye köprüsü, Mahmudiye-Çifteler arası lokalitelerde gözlenmiş
ve bu bitkilerin tüm kısımlarının bor toksisitesine dayanıklı olduğu belirlenmiştir
In 7 different localities the plants Heracleum sphondlylium L., Salix cinera L.,
Urtica dioica L., Rumex crispus L., were taken from a 107 km distance situated in
Seyitgazi K��rka district, flowing into Sakarya River from Do��ançay��r, Mahmudiye and
Çifteler, determinated in Seydisuyu, have been gathered in this work.
The root, shaft, leaf and flower parts of the plants were analysed for the useful
elements; Potassium (K), Calcium (Ca), Magnesium (Mg), Iron (Fe), Manganesse (Mn),
Boron (B), Zinc (Zn), Copper (Cu), Aluminium(Al), Lead (Pb), Chrome (Cr), Sodium
(Na), Silicium (Si), Arsenic (As), Nickel (Ni), Cadmium (Cd). Those elements are
generally needed by the plants in a low concentration, while they have toxic effects if
they are highly concentrated.
Our study has an important place in the literature, because it contains a mixture
of the Seydisuyu River and a Boron mine. Due to this reason, the plants’ Boron
deposition parameters must be known and observed, especially their level in the soil and
waters and its reactions must be known. Furthermore it is important to evaluate the level
of dustiness in the area.
When we compared the minimum and maximum value of the dry plants, we
found that the determined limit values of the elements Cd, Mn and Ca were very high,
while the value of the elements “Fe and Zn” were of medium height and the value of the
element Cu were low. The quantitiy of the analysed elements Mg, Al, Pb, Cr, Ar, K, Na
and Si in our plants has determined. In our studied plants mostly B element deposit was
monitored around the localities of Sancar Köyü, Yaz��dere Köyü, Hamidiye Köprüsü and
Mahmudiye-Çifteler, and in those plants the toxicity tolerance towards Boron was
found to be very high in all parts of the plants.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2017-01-05T06:45:01Z
No. of bitstreams: 1
10000982.pdf: 8579325 bytes, checksum: 03af5650ea68704eb0869b918e01f38f (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-01-10T06:52:46Z (GMT) No. of bitstreams: 1
10000982.pdf: 8579325 bytes, checksum: 03af5650ea68704eb0869b918e01f38f (MD5)
Made available in DSpace on 2017-01-10T06:52:46Z (GMT). No. of bitstreams: 1
10000982.pdf: 8579325 bytes, checksum: 03af5650ea68704eb0869b918e01f38f (MD5)
Previous issue date: 2013-01
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Seydisuyu (Eskişehir)
Kırka
Bor
H. Sphondlylium L.
S. Cinera L.
U. Dioica L.
R. Crispus L.
Boron
Seydisuyu (Eskişehir) yakın çevresinde yetişen bazı yabani bitkilerde başta bor olmak üzere bazı elementlerin birikim düzeylerinin belirlenmesi
masterThesis
TEXT
10000982.pdf.txt
10000982.pdf.txt
text/plain
223294
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/901/3/10000982.pdf.txt
28f29996cf19ab1c43facbd85f438084
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/901/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10000982.pdf
10000982.pdf
application/pdf
8579325
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/901/1/10000982.pdf
03af5650ea68704eb0869b918e01f38f
MD5
1
11684/901
oai:openaccess.ogu.edu.tr:11684/901
2017-01-11 03:00:14.567
Dspace@ESOGU
openaccess@ogu.edu.tr
REFHSVRJTSBMSVNBTlNJCgpCdSBsaXNhbnPEsSBpbXphbGF5xLFwIGfDtm5kZXJlcmVrLCBnw7ZuZGVyaW5pemkgZMO8bnlhIMOnYXDEsW5kYSBiYXPEsWzEsSBoYWxkZSwgCmVsZWt0cm9uaWsgb3J0YW1kYSB2ZSBoZXJoYW5naSBiYXNrYSBiaXIga2FuYWxsYSB5ZW5pZGVuIG9sdcWfdHVybWFrLCAKw6dldmlyaXNpbmkgeWFwbWFrIChhxZ9hxJ/EsWRhIHRhbsSxbWxhbmTEscSfxLEgw7x6ZXJlKSB2ZS92ZXlhIGRhxJ/EsXRtYWsgacOnaW4gCkVza2nFn2VoaXIgT3NtYW5nYXppIMOcbml2ZXJzaXRlc2nigJluaW4gKEVTT0dVKSDDtnplbCBvbG1heWFuIGhha2xhcsSxbsSxIGthYnVsIGV0bWnFnyBvbHVyc3VudXouCgpFU09HVSwgZ8O2bmRlcmluaXppbiBpw6dlcmnEn2luaSBkZcSfaXN0aXJtZWRlbiBoZXJoYW5naSBiaXIgCm9ydGFtZGEgZmFya2zEsSBiacOnaW1sZXJkZSBrb3J1bWEgYW1hw6dsxLEgb2xhcmFrIMOnZXZpcmViaWxpci4gCsOWdGUgeWFuZGFuIEVTT0dVLCBnw7x2ZW5saWssIHllZGVrbGVtZSB2ZSBrb3J1bWEgYW1hY8SxeWxhIGJ1IGfDtm5kZXJpbmluIApiaXJkZW4gZmF6bGEga29weWFzxLFuxLEgZWxpbmRlIHR1dGFiaWxpci4gCgpHw7ZuZGVyaW5pbiBzaXplIGFpdCBvcmlqaW5hbCBiaXIgw6dhbGnFn21hIG9sZHXEn3VudSB2ZSBidSBsaXNhbnN0YSBiZWxpcnRpbGVuIApoYWtsYXLEsSBrYWJ1bCBldG1lIGhha2vEsW7EsXogb2xkdcSfdW51IGJlbGlydG1pxZ8gb2x1cnN1bnV6LiBBeW7EsSB6YW1hbmRhIGfDtm5kZXJpbml6aW4sIApiaWxkacSfaW5peiBrYWRhcsSxeWxhLCBraW1zZW5pbiDDtnpsdWsgaGFra8SxbsSxIMOnacSfbmVtZWRpxJ9pbmkgZGUgc3VubXXFnyBvbHVyc3VudXouCgpFxJ9lciBnw7ZuZGVyaSB0ZWxpZiBoYWtrxLFuYSBzYWhpcCBvbHVubWF5YW4gYmlyIG1hdGVyeWFsIGnDp2VyaXlvcnNhLCBvIHphbWFuIAp0ZWxpZiBoYWtrxLEgc2FoaWJpbmRlbiBidSBsaXNhbnMgaWNpbiBnZXJla2xpIG9sYW4gRVNPR1UgaGFrbGFyxLFuxLEga2FidWwgZXRtZWsgCmljaW4ga8Sxc8SxdHPEsXogaXppbiBhbGTEscSfxLFuxLF6xLEgdmUgYnUgdGFyeiDDvMOnw7xuY8O8IGtpxZ9pbGVyIHRhcmFmxLFuZGFuIHNhaGlwIG9sdW5hbiAKbWF0ZXJ5YWxsZXJpbiBnw7ZuZGVyaSBpw6dlcmnEn2kgdmV5YSBtZXRuaSBpw6dlcmlzaW5kZSBhw6dpa8OnYSB0YW7EsW1sYW5kxLHEn8SxbsSxIHZlIAprYWJ1bCBlZGlsZGnEn2luaSBzdW5hcnNpbml6LgoKRcSeRVIgR8OWTkRFUsSwIEVTT0dVIERJxZ5JTkRBIEJBxZ5LQSBCxLBSIEtVUlVMVcWeIFRBUkFGSU5EQU4gREVTVEVLTEVORU4gQsSwUiDDh0FMScWeTUFZQSAKREFZQUxJIMSwU0UsIEJVIFRBUlogQklSIEFOTEHFnk1BIFZFWUEgU8OWWkxFxZ5NRU7EsE4gR0VSRUtUxLBSRMSwxJ7EsCBExLDEnkVSIApaT1JVTkxVTFVLTEFSSSBZRVLEsE5FIEdFVMSwUkTEsMSexLBOxLBaxLAgU1VOQVJTSU5JWi4KCkVTT0dVIGlzbWluaXppIGfDtm5kZXJpbmluIHlhemFyxLEgdmV5YSBzYWhpYmkgb2xhcmFrIGHDp8Sxa8OnYSB0YW7EsW1sYXlhY2FrdMSxciB2ZSAKYnUgbGlzYW5zxLFuIGl6aW4gdmVyZGnEn2luaW4gZMSxxZ/EsW5kYSBoZXJoYW5naSBiaXIgZGXEn2nFn2lrbGlrIHlhcG1heWFjYWt0xLFyLgo=
oai:openaccess.ogu.edu.tr:11684/999
2017-03-28T00:00:20Z
com_11684_15
com_11684_2
col_11684_86
İlhan, Semra
İşcen, Cansu Filik
Temur, Banu Oben
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-03-27T06:34:27Z
2017-03-27T06:34:27Z
2012-08
2012
http://hdl.handle.net/11684/999
Günümüzde hızlı bir artış gösteren endüstriyel gelişme, çevre sorunlarının ortaya
çıkmasına ve tüm canlıları olumsuz yönde etkilenmesine neden olmuştur. Özellikle
endüstrilerden kaynaklanan atıksular bu sorunları oluşturan en büyük etkendir. Bu
sebeple son yıllarda endüstriyel atık suların arıtılması ile ilgili çalışmalar yoğunluk
kazanmış ve farklı yöntemler geliştirilmiştir. Kullanılacak arıtma yönteminin yüksek
verimde arıtım sağlamasıyla beraber ekonomik olarak da uygun olması gerekmektedir.
Bu çalışmada tekstil endüstrisinde kullanılan 3 azo boya (Burazol Yellow ED-
2G, Burazol Black ED ve Burazol Orange ED-2R) içeren sentetik atıksuyunun ardışık
anaerobik- aerobik sürekli sistemde arıtımı amaçlanmıştır.
Sürekli sistemde Yukarı Akışlı Anaerobik Dolgulu Yatak Reaktör (YADYR) ve
Sürekli Karıştırmalı Tank Reaktör (SKTR) ardışık olarak kullanılmıştır. Reaktör 0,01-
0,15 g/l arasında değişen konsantrasyonlarda azo boya karışımı içeren sentetik atık su
ile 177 gün boyunca beslenmiştir. Sürekli çalışmalar sırasında anaerobik prosesde en
yüksek renk giderimi 50 mg/l’de %83,1 olarak bulunmuştur. En yüksek KOİ giderimi
ise 100 mg/l’de %97,3 olarak bulunmuştur. Aerobik prosesde en yüksek renk giderimi
100mg/l’de %81,7 olarak bulunmuştur. En yüksek KOİ giderimi ise 100 mg/l’de %97,5
olarak bulunmuştur. Anaerobik safhada oluşan aromatik aminler nedeniyle artan
toksisite düzeyi ardışık aerobik prosesle azalmıştır. Elde edilen sonuçlar anaerobikaerobik
arıtım sonucunda azo boyaların indirgendiğini göstermektedir.
Recently, industrial development which is increasing fast gave rise to
environment problems and had negative impact on all living organisms. Particularly
waste waters which are originated from industries are the biggest factor of that issue.
For that reason studies about treating industrial waste waters have been increasing and
different methods were developed. The using treathment method must afford high
efficiency and also should be avaible economically.
This study focused on the treatment of mixed three azo dyes, Burazol Yellow
ED-2G, Burazol Black ED ve Burazol Orange ED-2R, using a sequential anaerobicaerobic
system.
In continuous system, up-flow anaerobic packed bed reactor (YADYR) and stirred
tank reactor (SKTR) was used as sequential. From 0,01-0,15 g/l with varying
concentrations of containing a mixture of azo dyes were used as the synthetic
wastewater. As a result of cnstant researches the highest colour reduction is found as
%83,1 in 50 ppm of 16,5 mg/l colour concentration. And the highest KOİ reduction is
found as %97,5 in 100 ppm of 33 mg/l colour concentration. Effects of operating
parameters on removal of colour an COD were evaluated. With the sequential
anaerobic-aerobic treatment system; color and chemical oxygen demands (COD) of
synthetic textiles wastewater largely fixed by the anaerobic process. The rising level of
toxicity due to the becoming of aromatic amines in the anaerobic stage decreased by
the sequential aerobic process. According to the obtained results at the end of
the anaerobic-aerobic treatment shows that the azo dyes are reduced.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2017-02-02T06:57:44Z
No. of bitstreams: 1
443187.pdf: 1407944 bytes, checksum: 01b2b157d00e01f79940d7fd573fbf1d (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-03-27T06:34:27Z (GMT) No. of bitstreams: 1
443187.pdf: 1407944 bytes, checksum: 01b2b157d00e01f79940d7fd573fbf1d (MD5)
Made available in DSpace on 2017-03-27T06:34:27Z (GMT). No. of bitstreams: 1
443187.pdf: 1407944 bytes, checksum: 01b2b157d00e01f79940d7fd573fbf1d (MD5)
Previous issue date: 2012-08
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Azo Boyalar
Renk Giderimi
Anaerobik Dolgulu Yatak Reaktör
Sürekli Karıştırmalı Tank Reaktör
Azo Dyes
Decolorization
Up-flow Anaerobic Packed bed Reactor
Stirred Tank Reactor
Sentetik tekstil atık sularının anaerobik- aerobik ardışık sistemde arıtımı
masterThesis
TEXT
443187.pdf.txt
443187.pdf.txt
text/plain
82107
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/999/3/443187.pdf.txt
4213afdad81f6f1c14503196bd04a77a
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/999/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
443187.pdf
443187.pdf
application/pdf
1407944
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/999/1/443187.pdf
01b2b157d00e01f79940d7fd573fbf1d
MD5
1
11684/999
oai:openaccess.ogu.edu.tr:11684/999
2017-03-28 03:00:20.793
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1034
2017-06-06T00:00:27Z
com_11684_15
com_11684_2
col_11684_86
Arslan, Naime
Kökçü, Cansev Akkan
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-06-05T06:36:58Z
2017-06-05T06:36:58Z
2016-06
2016
http://hdl.handle.net/11684/1034
Sapanca Gölü’nün ekolojik kalitesinin, biyolojik parametrelerden
makroomurgasızlar kullanılarak, Su Çerçeve Direktifi doğrultusunda belirlenmesi amacıyla,
Haziran 2011-Aralık 2013 tarihleri arasında 9 istasyondan mevsimsel periyotlarla örnekler
(15121 birey) toplanmış, aynı zamanda bazı çevresel parametreler de (pH, sıcaklık,
çözünmüş oksijen -in situ-, Biyolojik oksijen ihtiyacı, Amonyum ve Nitrat azotu)
ölçülmüştür. Araştırma sonucunda Sapanca Gölü’nden 13 Gastropoda, 20 Oligochaeta ve 38
Chironomidae taksonu olmak üzere toplam 79 takson tespit edilmiştir. Sapanca Gölü
zoobentozunun % 39,24’ünü Oligochaeta, %22,72’sini Gastropoda, %15,17’sini Copepoda,
% 10,68’ini Bivalvia, % 8,86’sını Chironomidae oluşturmaktadır. Gölün dominant taksonu
%29,06’lık baskınlıkla Potamothrix hammoniensis (Clitellata)’dir. Bunu sırayla; % 16,71
oranı ile Borysthenia naticina (Gastropoda), % 6,19 oranı ile Limnodrilus hoffmeisteri
(Clitellata), % 2,12 oranı ile Einfeldia carbonaria (Chironomidae) takip etmektedir.
BMWP (Biological Monitoring Working Party Score) ve ASPT (Avarage Score Per
Taxon) biyotik indeksleri ile Dominansi, Shannon-Wiener, Simpson, Evenness ve Margalef
çeşitlilik indeksleri kullanılmıştır. BMWP biyotik indeks sonucuna göre, 2. ve 4. istasyonlar
kirlenmiş, diğer bütün istasyonlar IV. kalite (kirlenmiş ve etki altında), ASPT sonuçlarına
göre ise tüm istasyonlar ağır derecede kirli olarak tespit edilmiştir. Shannon-Wiener çeşitlilik
indeksinin 0,27-1,25 arasında değiştiği tespit edilmiştir. Hem çevresel parametreler hem de
biyotik indekslere göre Sapanca Gölü mezotrof göl olarak belirlenmiştir. Ayrıca gölde
Ponto-Caspien türlerden Potamothrix hammoniensis, Lithoglyphus naticoides ve Fagotia
esperi’nin tespit edilmiş olması Sapanca Gölü ile Tuna nehri faunasının güney koridoru ile
bağlantılı olduğunu göstermektedir.
Samples were collected from 9 stations seasonally between June 2011-December
2013 for evaluation ecological quality of Sapanca Lake by using macroinvertebrate from
biological parameters according to Water Framework Directive. In addition, some
environmenteal variables (pH, temperature, dissolved oxygen,) were measured in situ and
NO3⎯N, NH4-N and Biological Oxygen Demand were measured in laboratory.
Consequently, Totally 79 taxa were identified in Sapanca Lake (13 of them belong to
Gastropoda, 20 of them belong to Oligochaeta and 38 of them belong to Chironomidae). The
zoobenthos samples from Lake Sapanca were contained the following invertebrate groups:
Oligochaeta (39.24%), Gastropoda (22.72%), Bivalvia (10.68%) and Chironomidae larvae
(8.86%). Potamothrix hammoniensis belong to Clitellata was the dominant zoobenthic
species (29.06%) of the total benthic fauna followed by gastropod Borysthenia naticina
(16.71%), clitellat Limnodrilus hoffmeisteri 6.19% and chironomid Einfeldia carbonaria
(2.12%).
Biotic indices (BMWP-Biological Monitoring Working Party Score and ASPTAvarage
Score Per Taxon) and diversity indices were used (Dominancy, Shannon-Wiener,
Simpson, Evenness and Margalef). According to results of BMWP, 2. and 4. station were
determined as heavily polluted while the other stations were determined IV. quality (polluted
or impacted). ASPT values were determined polluted at all stations. The values of Shannon-
Wiener Diversity Index were varied between 0.27 and 1.25. Sapanca Lake is determined as
mesotrophic according to both biotic indices and environmental parameters. Potamothrix
hammoniensis, Lithoglyphus naticoides and Fagotia esperi, to which the population in Lake
Sapanca can be attributed emphasizes the Danubian relationship of the Lake Sapanca
invertebrates fauna.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2017-05-23T06:50:39Z
No. of bitstreams: 1
10124993.pdf: 3664143 bytes, checksum: ddd38c0339429fc4e8b10fbcc9548735 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-06-05T06:36:58Z (GMT) No. of bitstreams: 1
10124993.pdf: 3664143 bytes, checksum: ddd38c0339429fc4e8b10fbcc9548735 (MD5)
Made available in DSpace on 2017-06-05T06:36:58Z (GMT). No. of bitstreams: 1
10124993.pdf: 3664143 bytes, checksum: ddd38c0339429fc4e8b10fbcc9548735 (MD5)
Previous issue date: 2016-06
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Sapanca Gölü
BMWP
ASPT
SÇD
Makrozoobentoz
Sapanca Lake
Macrozoobenthos
Sapanca gölü ekolojik kalitesinin makroomurgasızlara dayalı olarak su çerçeve direktifi (SÇD) doğrultusunda değerlendirilmesi
doctoralThesis
TEXT
10124993.pdf.txt
10124993.pdf.txt
text/plain
414727
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1034/3/10124993.pdf.txt
db980b06050ba1f87f0659eec617f3c3
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1034/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10124993.pdf
10124993.pdf
application/pdf
3664143
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1034/1/10124993.pdf
ddd38c0339429fc4e8b10fbcc9548735
MD5
1
11684/1034
oai:openaccess.ogu.edu.tr:11684/1034
2017-06-06 03:00:27.899
Dspace@ESOGU
openaccess@ogu.edu.tr
REFHSVRJTSBMSVNBTlNJCgpCdSBsaXNhbnPEsSBpbXphbGF5xLFwIGfDtm5kZXJlcmVrLCBnw7ZuZGVyaW5pemkgZMO8bnlhIMOnYXDEsW5kYSBiYXPEsWzEsSBoYWxkZSwgCmVsZWt0cm9uaWsgb3J0YW1kYSB2ZSBoZXJoYW5naSBiYXNrYSBiaXIga2FuYWxsYSB5ZW5pZGVuIG9sdcWfdHVybWFrLCAKw6dldmlyaXNpbmkgeWFwbWFrIChhxZ9hxJ/EsWRhIHRhbsSxbWxhbmTEscSfxLEgw7x6ZXJlKSB2ZS92ZXlhIGRhxJ/EsXRtYWsgacOnaW4gCkVza2nFn2VoaXIgT3NtYW5nYXppIMOcbml2ZXJzaXRlc2nigJluaW4gKEVTT0dVKSDDtnplbCBvbG1heWFuIGhha2xhcsSxbsSxIGthYnVsIGV0bWnFnyBvbHVyc3VudXouCgpFU09HVSwgZ8O2bmRlcmluaXppbiBpw6dlcmnEn2luaSBkZcSfaXN0aXJtZWRlbiBoZXJoYW5naSBiaXIgCm9ydGFtZGEgZmFya2zEsSBiacOnaW1sZXJkZSBrb3J1bWEgYW1hw6dsxLEgb2xhcmFrIMOnZXZpcmViaWxpci4gCsOWdGUgeWFuZGFuIEVTT0dVLCBnw7x2ZW5saWssIHllZGVrbGVtZSB2ZSBrb3J1bWEgYW1hY8SxeWxhIGJ1IGfDtm5kZXJpbmluIApiaXJkZW4gZmF6bGEga29weWFzxLFuxLEgZWxpbmRlIHR1dGFiaWxpci4gCgpHw7ZuZGVyaW5pbiBzaXplIGFpdCBvcmlqaW5hbCBiaXIgw6dhbGnFn21hIG9sZHXEn3VudSB2ZSBidSBsaXNhbnN0YSBiZWxpcnRpbGVuIApoYWtsYXLEsSBrYWJ1bCBldG1lIGhha2vEsW7EsXogb2xkdcSfdW51IGJlbGlydG1pxZ8gb2x1cnN1bnV6LiBBeW7EsSB6YW1hbmRhIGfDtm5kZXJpbml6aW4sIApiaWxkacSfaW5peiBrYWRhcsSxeWxhLCBraW1zZW5pbiDDtnpsdWsgaGFra8SxbsSxIMOnacSfbmVtZWRpxJ9pbmkgZGUgc3VubXXFnyBvbHVyc3VudXouCgpFxJ9lciBnw7ZuZGVyaSB0ZWxpZiBoYWtrxLFuYSBzYWhpcCBvbHVubWF5YW4gYmlyIG1hdGVyeWFsIGnDp2VyaXlvcnNhLCBvIHphbWFuIAp0ZWxpZiBoYWtrxLEgc2FoaWJpbmRlbiBidSBsaXNhbnMgaWNpbiBnZXJla2xpIG9sYW4gRVNPR1UgaGFrbGFyxLFuxLEga2FidWwgZXRtZWsgCmljaW4ga8Sxc8SxdHPEsXogaXppbiBhbGTEscSfxLFuxLF6xLEgdmUgYnUgdGFyeiDDvMOnw7xuY8O8IGtpxZ9pbGVyIHRhcmFmxLFuZGFuIHNhaGlwIG9sdW5hbiAKbWF0ZXJ5YWxsZXJpbiBnw7ZuZGVyaSBpw6dlcmnEn2kgdmV5YSBtZXRuaSBpw6dlcmlzaW5kZSBhw6dpa8OnYSB0YW7EsW1sYW5kxLHEn8SxbsSxIHZlIAprYWJ1bCBlZGlsZGnEn2luaSBzdW5hcnNpbml6LgoKRcSeRVIgR8OWTkRFUsSwIEVTT0dVIERJxZ5JTkRBIEJBxZ5LQSBCxLBSIEtVUlVMVcWeIFRBUkFGSU5EQU4gREVTVEVLTEVORU4gQsSwUiDDh0FMScWeTUFZQSAKREFZQUxJIMSwU0UsIEJVIFRBUlogQklSIEFOTEHFnk1BIFZFWUEgU8OWWkxFxZ5NRU7EsE4gR0VSRUtUxLBSRMSwxJ7EsCBExLDEnkVSIApaT1JVTkxVTFVLTEFSSSBZRVLEsE5FIEdFVMSwUkTEsMSexLBOxLBaxLAgU1VOQVJTSU5JWi4KCkVTT0dVIGlzbWluaXppIGfDtm5kZXJpbmluIHlhemFyxLEgdmV5YSBzYWhpYmkgb2xhcmFrIGHDp8Sxa8OnYSB0YW7EsW1sYXlhY2FrdMSxciB2ZSAKYnUgbGlzYW5zxLFuIGl6aW4gdmVyZGnEn2luaW4gZMSxxZ/EsW5kYSBoZXJoYW5naSBiaXIgZGXEn2nFn2lrbGlrIHlhcG1heWFjYWt0xLFyLgo=
oai:openaccess.ogu.edu.tr:11684/1035
2017-06-06T00:00:29Z
com_11684_15
com_11684_2
col_11684_86
Çalışkan, Hakan
Aydınlı, Hülya Aksoy
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-06-05T06:37:05Z
2017-06-05T06:37:05Z
2016-06
2016
http://hdl.handle.net/11684/1035
Bu çalışmada larva yara tedavisinde en yaygın kullanılan Lucilia sericata türü ile
uygulamada yeni olan L. cuprina türünün laboratuvar koşullarında yetiştirilmeleri, yaşam
süreleri, farklı sıcaklık-nem değerlerinde, farklı besin miktarı ve besin tiplerinde
beslenmeleri, gelişimleri ve üreme değerleri, farklı sterilantlara olan dirençleri, diyapoza
girme sıcaklıklarının belirlenerek iki türde karşılaştırılması hedeflenmiştir. Bu kapsamda
aynı koşullarda aynı zaman diliminde bırakılan iki türe ait yumurtaların açılma oranları,
larvaların gelişimleri, beslenme miktarları, pupaya giriş-çıkış zamanları, erginlerin üreme
potansiyelleri incelenmiştir.
Çalışma sonucunda L. cuprina türünün L. sericata türünden düşük sıcaklık ve nem
koşullarına daha toleranslı olduğu, aynı koşullarda daha fazla döl verdiği, 25
o
C-36
o
C
sıcaklık aralığında larval gelişimini daha erken tamamladığı, her iki türde yüksek verimde
üreme için optimum sıcaklık koşullarının 32
o
C-34
o
C, nem koşullarının %65 olduğu,
sterilantlarda %0,05 lik konsantrasyon ve 1 dakikalık uygulamanın iki tür içinde yeterli
olduğu, yumurta sterilizasyonunda NaClO sterilantının HCl sterilantından kullanıma daha
uygun olduğu belirlenmiştir.
In this study it is aimed to determine and compare the laboratory cultivating
conditions, life expectancy, types and amount of nutrition as well nutrition in different
temperature-humidity conditions, development and reproductive values, resistance against
different sterilants and diapauses entering temperatures of two different larvae of which
Lucilia sericata is widely and L. cuprina newly used in larvae wound treatment. In this
manner, hatching rates of eggs of above mentioned larvae left contemporaneously under the
same laboratory conditions as well as the development, nutrition quantities, timing of entry
into and exit from pupae of larvae, additionally the reproductive potential of adults were
examined.
In the study results, L. cuprina was found to be tolerant to low temperature and
humidity conditions more than L. sericata, with more offspring under the same conditions
and early completed larval development under 25
o
C-36
o
C temperature range. Also, it was
found that conditions for highly efficient reproduction for both of species were temperatures
between 32oC-34oC and 65% humidity. Additionally, sterilization for 1-minute in 0,05%
sterilant concentration was determined as sufficient for both of species. Moreover, the use
of NaClO sterilants was found more convenient than that of HCl sterilants for egg
sterilization.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2017-05-23T07:52:40Z
No. of bitstreams: 1
10128945.pdf: 6627665 bytes, checksum: 1241decdfb4d4dc6b0d32c3ceadf7518 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-06-05T06:37:05Z (GMT) No. of bitstreams: 1
10128945.pdf: 6627665 bytes, checksum: 1241decdfb4d4dc6b0d32c3ceadf7518 (MD5)
Made available in DSpace on 2017-06-05T06:37:05Z (GMT). No. of bitstreams: 1
10128945.pdf: 6627665 bytes, checksum: 1241decdfb4d4dc6b0d32c3ceadf7518 (MD5)
Previous issue date: 2016-06
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Calliphoridae
Larva Yara Tedavisi
Lucilia Sericata
L.cuprina
Larvae Wound Treatment
Larva yara tedavisinde kullanılan lucilia sericata (Meigen, 1826) ve lucilia cuprina (Wiedemann, 1830) (Diptera:calliphoridae)’nın gelişim ve beslenme farklılıklarının belirlenmesi
doctoralThesis
TEXT
10128945.pdf.txt
10128945.pdf.txt
text/plain
296632
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1035/3/10128945.pdf.txt
ef7c3c6a456604461094c5b42a67f7ea
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1035/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10128945.pdf
10128945.pdf
application/pdf
6627665
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1035/1/10128945.pdf
1241decdfb4d4dc6b0d32c3ceadf7518
MD5
1
11684/1035
oai:openaccess.ogu.edu.tr:11684/1035
2017-06-06 03:00:29.8
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1120
2017-11-17T01:01:38Z
com_11684_15
com_11684_2
col_11684_86
Çalışkan, Figen
Kamaoğlu, Ayşegül
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-11-16T11:59:39Z
2017-11-16T11:59:39Z
2014-02
2017
http://hdl.handle.net/11684/1120
Calchas nordmanni yakın zamana kadar Artvin-Erzurum çevresinde endemik olduğu sanılan fakat son zamanlardaki çalışmalarla Türkiye’nin bir çok bölgesinde ve bazı Yunan adalarında bulunduğu ortaya çıkan Iuridae familyasına ait bir akrep türüdür. Günümüzde antibiyotiklere direnç kazanan bakterilerin neden olduğu enfeksiyonların önemli halk sağlığı problemlerinden birisi olduğu bilinmektedir. Bu çalışma; akrep venomunun antibakteriyal etkinliğinin belirlenmesi üzerine odaklanmıştır.
Bu amaçla, seçilen klinik önemi olan bakterilere karşı ham venomun antibakteriyal etkinliği belirlenmiştir. Ardından; yüksek performans sıvı kromatografisinde fraksiyonlarınmıştır. Bu fraksiyonların Salmonella typhimirium, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus vulgaris, Staphylococcus aureus, Bacillus cereus, Bacillus subtilis ve Micrococcus luteus bakterileri üzerinde agar difüzyon yöntemi kullanılarak antibakteriyal aktiviteleri araştırılmıştır. En geniş inhibisyon zonuna sahip olan Bacillus cereus’a ait çalışmalar bir adım daha ileri taşınmış ve yüksek performans sıvı kromatografisinde yeniden fraksiyonlanarak etkin peptid/peptidler bulunmaya çalışılmıştır. Aktivitesi belirlenen pikler arasında en geniş inhibisyon zonuna sahip olan 21.3 dakika alıkonma süreli fraksiyon olmuştur. Bu fraksiyon Trici-Tricine jel elektroforezinde yürütülmüş ve molekül ağırlığının 3,4 kDa ile 6,2 kDa arasında olduğu belirlenmiştir.
Bu çalışma, Calchas nordmanni venomunun elektroforetik profilini ve seçilen bakterilere karşı antibakteriyal etkili bileşenlerin varlığını ilk kez bildirmektedir. Elde edilen sonuçların yeni antibiyotiklerin tasarımında yardımcı olması beklenmektedir.
Calchas nordmanni that was thought to be endemic to Artvin-Erzurum region till recent studies claimed that it also exists in lots of regions in Turkey and some Greek Islands, is a species of scorpion from Iuridae family. Nowadays, it is known that infections, which are caused by antibiotic resistant bacteria, are one of the serious public health problems. Because the new antibacterial molecules to control these bacteria are required all over the world, this study is focused to define the antibacterial activity of scorpion’s venom. For this purpose, crude venom’s antibacterial activity against clinically impostatnt bacteria was determined. Then they were separated to one minute fractions by high performance liquid chromatography. The antibacterial activities of these fractions on Salmonella typhimirium, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus vulgaris, Staphylococcus aureus, Bacillus cereus, Bacillus subtilis and Micrococcus luteus bacteria were determined by using agar diffusion method. The studies on Bacillus cereus, that has the widest inhibition zone, were researched one step more and they were studied to find the active peptides peak by peak fractionation on high performance liquid chromatography. The fraction which has 21.3 minutes retention time, was the peak, that has the widest inhibition zone, between the peaks which activities have been determined. This fraction was analyzed by Trici-Tricine gel electrophoresis and its molecular weights determined between 3.4 and 6.2 kDa. This study declares the electrophoretic profile of Calchas nordmanni's venom and the presence of antibacterial active components against to chosen bacterias, to the world literatures for the first time.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2017-11-09T08:10:19Z
No. of bitstreams: 1
10143246.pdf: 2020634 bytes, checksum: 4bffc3b4de33a2a96ccc9975006bf0d6 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-11-16T11:59:39Z (GMT) No. of bitstreams: 1
10143246.pdf: 2020634 bytes, checksum: 4bffc3b4de33a2a96ccc9975006bf0d6 (MD5)
Made available in DSpace on 2017-11-16T11:59:39Z (GMT). No. of bitstreams: 1
10143246.pdf: 2020634 bytes, checksum: 4bffc3b4de33a2a96ccc9975006bf0d6 (MD5)
Previous issue date: 2014-02
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Calchas Nordmanni
Akrep
Venom
Antibakteriyal Aktivite
Scorpion
Antibacterial Activity
Calchas nordmanni venomunda bulunan peptidlerin antibakteriyal aktivitesinin araştırılması
masterThesis
TEXT
10143246.pdf.txt
10143246.pdf.txt
text/plain
97445
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1120/3/10143246.pdf.txt
cc0ff65a42c6661a093cd23a6ce91dc6
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1120/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10143246.pdf
10143246.pdf
application/pdf
2020634
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1120/1/10143246.pdf
4bffc3b4de33a2a96ccc9975006bf0d6
MD5
1
11684/1120
oai:openaccess.ogu.edu.tr:11684/1120
2017-11-17 03:01:38.085
Dspace@ESOGU
openaccess@ogu.edu.tr
REFHSVRJTSBMSVNBTlNJCgpCdSBsaXNhbnPEsSBpbXphbGF5xLFwIGfDtm5kZXJlcmVrLCBnw7ZuZGVyaW5pemkgZMO8bnlhIMOnYXDEsW5kYSBiYXPEsWzEsSBoYWxkZSwgCmVsZWt0cm9uaWsgb3J0YW1kYSB2ZSBoZXJoYW5naSBiYXNrYSBiaXIga2FuYWxsYSB5ZW5pZGVuIG9sdcWfdHVybWFrLCAKw6dldmlyaXNpbmkgeWFwbWFrIChhxZ9hxJ/EsWRhIHRhbsSxbWxhbmTEscSfxLEgw7x6ZXJlKSB2ZS92ZXlhIGRhxJ/EsXRtYWsgacOnaW4gCkVza2nFn2VoaXIgT3NtYW5nYXppIMOcbml2ZXJzaXRlc2nigJluaW4gKEVTT0dVKSDDtnplbCBvbG1heWFuIGhha2xhcsSxbsSxIGthYnVsIGV0bWnFnyBvbHVyc3VudXouCgpFU09HVSwgZ8O2bmRlcmluaXppbiBpw6dlcmnEn2luaSBkZcSfaXN0aXJtZWRlbiBoZXJoYW5naSBiaXIgCm9ydGFtZGEgZmFya2zEsSBiacOnaW1sZXJkZSBrb3J1bWEgYW1hw6dsxLEgb2xhcmFrIMOnZXZpcmViaWxpci4gCsOWdGUgeWFuZGFuIEVTT0dVLCBnw7x2ZW5saWssIHllZGVrbGVtZSB2ZSBrb3J1bWEgYW1hY8SxeWxhIGJ1IGfDtm5kZXJpbmluIApiaXJkZW4gZmF6bGEga29weWFzxLFuxLEgZWxpbmRlIHR1dGFiaWxpci4gCgpHw7ZuZGVyaW5pbiBzaXplIGFpdCBvcmlqaW5hbCBiaXIgw6dhbGnFn21hIG9sZHXEn3VudSB2ZSBidSBsaXNhbnN0YSBiZWxpcnRpbGVuIApoYWtsYXLEsSBrYWJ1bCBldG1lIGhha2vEsW7EsXogb2xkdcSfdW51IGJlbGlydG1pxZ8gb2x1cnN1bnV6LiBBeW7EsSB6YW1hbmRhIGfDtm5kZXJpbml6aW4sIApiaWxkacSfaW5peiBrYWRhcsSxeWxhLCBraW1zZW5pbiDDtnpsdWsgaGFra8SxbsSxIMOnacSfbmVtZWRpxJ9pbmkgZGUgc3VubXXFnyBvbHVyc3VudXouCgpFxJ9lciBnw7ZuZGVyaSB0ZWxpZiBoYWtrxLFuYSBzYWhpcCBvbHVubWF5YW4gYmlyIG1hdGVyeWFsIGnDp2VyaXlvcnNhLCBvIHphbWFuIAp0ZWxpZiBoYWtrxLEgc2FoaWJpbmRlbiBidSBsaXNhbnMgaWNpbiBnZXJla2xpIG9sYW4gRVNPR1UgaGFrbGFyxLFuxLEga2FidWwgZXRtZWsgCmljaW4ga8Sxc8SxdHPEsXogaXppbiBhbGTEscSfxLFuxLF6xLEgdmUgYnUgdGFyeiDDvMOnw7xuY8O8IGtpxZ9pbGVyIHRhcmFmxLFuZGFuIHNhaGlwIG9sdW5hbiAKbWF0ZXJ5YWxsZXJpbiBnw7ZuZGVyaSBpw6dlcmnEn2kgdmV5YSBtZXRuaSBpw6dlcmlzaW5kZSBhw6dpa8OnYSB0YW7EsW1sYW5kxLHEn8SxbsSxIHZlIAprYWJ1bCBlZGlsZGnEn2luaSBzdW5hcnNpbml6LgoKRcSeRVIgR8OWTkRFUsSwIEVTT0dVIERJxZ5JTkRBIEJBxZ5LQSBCxLBSIEtVUlVMVcWeIFRBUkFGSU5EQU4gREVTVEVLTEVORU4gQsSwUiDDh0FMScWeTUFZQSAKREFZQUxJIMSwU0UsIEJVIFRBUlogQklSIEFOTEHFnk1BIFZFWUEgU8OWWkxFxZ5NRU7EsE4gR0VSRUtUxLBSRMSwxJ7EsCBExLDEnkVSIApaT1JVTkxVTFVLTEFSSSBZRVLEsE5FIEdFVMSwUkTEsMSexLBOxLBaxLAgU1VOQVJTSU5JWi4KCkVTT0dVIGlzbWluaXppIGfDtm5kZXJpbmluIHlhemFyxLEgdmV5YSBzYWhpYmkgb2xhcmFrIGHDp8Sxa8OnYSB0YW7EsW1sYXlhY2FrdMSxciB2ZSAKYnUgbGlzYW5zxLFuIGl6aW4gdmVyZGnEn2luaW4gZMSxxZ/EsW5kYSBoZXJoYW5naSBiaXIgZGXEn2nFn2lrbGlrIHlhcG1heWFjYWt0xLFyLgo=
oai:openaccess.ogu.edu.tr:11684/1130
2017-11-16T12:00:05Z
com_11684_15
com_11684_2
col_11684_86
Çabuk, Ahmet
Toptaş, Yağmur
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-11-16T12:00:05Z
2017-11-16T12:00:05Z
2016-11
2016
http://hdl.handle.net/11684/1130
Asidofilik mikroorganizmalar aşırı pH değerlerine adaptasyonları, metabolik
çeşitlilikleri ve biyomadencilik uygulamalarda kullanabilir olmaları nedeniyle oldukça ilgi
çekicidirler. Ülkemizde de işletilen veya terk edilmiş madenlerin oluşturdukları asit maden
drenajları bu mikroorganizmaların önemli habitatlarındandır. Bu ilgi çekici habitatların
mikrobiyal çeşitliliğini belirlemek amacıyla yapılan çalışmalar ülkemizde oldukça
sınırlıdır. Asidofil mikroorganizmaları tanımlamanın yanısıra, onlarla yapılacak
biyoteknolojik uygulama çalışmaları da kimyasal uygulamalara karşı her geçen gün önem
kazanmaktadır.
İzmir Beydağ-Halıköy bölgesinde bulunun, hedef mikroorganizmalar için uygun
komposizyona ve pH değerine sahip su numuneleri Mart 2014 ve Haziran 2015
tarihlerinde alınmıştır. Yapılan kültüre bağlı kommünite analizi çalışmalarında farklı besi
ortamlarında bakteriler izole edilmiştir. Kültürden bağımsız kommünite analizi
çalışmalarında ayrıca arkelerin varlığı belirlenmiş, 16S klonlama ve denatüre edici jel
elektroforezi deneyleri ile de kommünitedeki prokaryotik asidofillerin çeşitliliği
belirlenmiştir. Laboratuvar koşullarında kültüre edilebilen üç farklı mikroorganizma ile
sentetik AMD biyoremediasyonu, kurşun-çinko cevheri ve pirit biyooksidasyonu ve
Çayırhan (Ankara) bölgesi linyitlerine biyodesülfürizasyon uygulamaları yapılmıştır.
Sentetik AMD biyoremediasyon çalışmalarında mikroorganizmaların metalleri
çözünürlüğünde etkili oldukları, özellikle YT-5 kodlu izolatın Pb-Zn cevherinde kurşun
çözünürlüğü üç kat arttırdığı belirlenmiştir. Bu izolatların biyomadencilik uygulama
alanlarında potansiyelleri ortaya koyulmuştur.
Acidophilic microorganisms are very interesting because of their adaptability to
extreme pH values, their metabolic diversity, and their ability to be used in biomining
applications. The acid mine drainages operated in also our country or abandoned mines are
important habitats of these microorganisms. Studies to determine the microbial diversity in
these attractive habitats are very limited in our country. In addition to identifying
acidophile microorganisms, the biotechnological application studies to be carried out with
them have gained importance day by day towards chemical applications.
The water samples were taken from İzmir Beydag-Halıköy area in March 2014 and
in July 2015, which have low pH and appropriate composition for target acidophilic
microorganisms. Culture dependent community analysis indicated that bacteria have been
isolated from different media. Culture independent community analysis showed to be
defined availability of archaea. Besides, diversity of prokaryotic acidophiles in community
were determined through 16S cloning and denaturing gel electrophoresis. Applications
including synthetic AMD bioremediation, lead-zinc ore and pyrite biooxidation and
biodesulfurization of lignites of Çayırhan (Ankara) region were carried out with three
different microorganisms which can be cultured under laboratory conditions. In synthetic
AMD bioremediation studies, microorganisms were found to be effective in the solubility
of metals, especially YT-5 encoded isolate, which increased the lead solubility by three
times in Pb-Zn ore. The potentials of these isolates in biomining applications have been
demonstrated.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2017-11-13T07:29:18Z
No. of bitstreams: 1
10136404.pdf: 76703930 bytes, checksum: f519ccef57fa5e31b531c2820b7c0ac8 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-11-16T12:00:05Z (GMT) No. of bitstreams: 1
10136404.pdf: 76703930 bytes, checksum: f519ccef57fa5e31b531c2820b7c0ac8 (MD5)
Made available in DSpace on 2017-11-16T12:00:05Z (GMT). No. of bitstreams: 1
10136404.pdf: 76703930 bytes, checksum: f519ccef57fa5e31b531c2820b7c0ac8 (MD5)
Previous issue date: 2016-11
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Prokaryot Çeşitlilik
Asidofiller
Biyomadencilik
Prokaryotic Diversity
Acidophiles
Biomining
Asidofil mikrobiyal çeşitliliğinin belirlenmesi ve biyomadencilik uygulamalarında kullanılabilirlikleri
doctoralThesis
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1130/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10136404.pdf
10136404.pdf
application/pdf
76703930
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1130/1/10136404.pdf
f519ccef57fa5e31b531c2820b7c0ac8
MD5
1
11684/1130
oai:openaccess.ogu.edu.tr:11684/1130
2017-11-16 14:00:05.214
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1167
2017-12-11T07:04:08Z
com_11684_15
com_11684_2
col_11684_86
Erkara, İsmuhan Potoğlu
Çolak, Hasibe
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-12-11T07:04:08Z
2017-12-11T07:04:08Z
2016-11
2016
http://hdl.handle.net/11684/1167
Eskişehir ’in park ve bahçelerinde bulunan ağaç ve çalıların polen morfolojilerini
belirlemek amacıyla yapılan bu çalışmada, 2013-2016 yıllarında toplanan Aceraceae,
Anacardiaceae, Apocynaceae, Berberidaceae, Betulaceae, Bignoniaceae, Buddleiaceae,
Caprifoliaceae, Cistaceae, Cornaceae, Cupressaceae, Ebenaceae, Elaeagnaceae, Fabaceae,
Hippocastanaceae, Juglandaceae, Lamiaceae, Malvaceae, Moraceae, Myrtaceae,
Nyctaginaceae, Oleaceae, Onagraceae, Philadelphaceae, Pinaceae, Platanaceae,
Punicaceae, Rosaceae, Rutaceae, Salicaceae, Sapindaceae, Scrophulariaceae,
Simaroubaceae, Solanaceae, Tamaricaceae, Taxaceae ve Tiliaceae familyalarına ait
toplam 136 tür ve türaltı taksonun tanımlamaları yapılmış, fotoğrafları çekilmiştir.
Çiçeklenme döneminde alınan anterlerden polenler ayıklanmış polen morfolojileri
Wodehouse, Erdtman ve SEM yöntemleriyle tespit edilmiş, ışık ve taramalı elektron
mikroskopları ile çalışılmış ve polenlerin şekilleri, büyüklükleri, apertür özellikleri, ayrıca
skulptür ve strüktür özellikleri belirlenmiştir. Polenlerin ölçümleri 80i Nikon marka ışık
mikroskobunda gerçekleştirilmiş ve fotoğrafları çekilmiştir. Ayrıca Jeol 5600 LV marka
SEM cihazı ile de elektron fotoğrafları görüntülenmiştir.
Sonuç olarak bu çalışmada Eskişehir’deki park ve bahçelerde bulunan ağaç ve
çalılardan 136 tür ve türaltı taksonun polen morfolojisi ortaya konulmuştur.
The aim of this study determine to pollen morphology of trees and shrubs which found in
the center of Eskişehir's parks and gardens. Aceraceae, Anacardiaceae, Apocynaceae,
Berberidaceae, Betulaceae, Bignoniaceae, Buddleiaceae, Caprifoliaceae, Cistaceae,
Cornaceae, Cupressaceae, Ebenaceae, Elaeagnaceae, Fabaceae, Hippocastanaceae,
Juglandaceae, Lamiaceae, Malvaceae, Moraceae, Myrtaceae, Nyctaginaceae, Oleaceae,
Onagraceae, Philadelphaceae, Pinaceae, Platanaceae, Punicaceae, Rosaceae, Rutaceae,
Salicaceae, Sapindaceae, Scrophulariaceae, Simaroubaceae, Solanaceae, Tamaricaceae,
Taxaceae and Tiliaceae families were collected between 2013-2016 years from parks and
gardens of Eskişehir. Total of 136 taxa photos were taken.
Pollen morphology determined by Wodehouse, Erdtman ve SEM methods. In this
study, it has been studied by light and scanning electron microscopes and shape of pollen
size, aperture properties also sculpture and specified structural features. Pollens were
measured and their photos were taken using 80i Nikon light photomicroscope. Moreover
the device is also illustrated by SEM (Jeol 5600 LV) electron photographs.
As a result, in this study 136 taxa pollen morphology of the bushes and trees which
found in parks and gardens in Eskişehir has been demonstrated.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2017-11-22T06:41:52Z
No. of bitstreams: 1
HASİBE ÇOLAK DOKTORA TEZ 10131319.pdf: 69638945 bytes, checksum: 93bc0154b02bde793d84e3127cecbc5a (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-12-11T07:04:08Z (GMT) No. of bitstreams: 1
HASİBE ÇOLAK DOKTORA TEZ 10131319.pdf: 69638945 bytes, checksum: 93bc0154b02bde793d84e3127cecbc5a (MD5)
Made available in DSpace on 2017-12-11T07:04:08Z (GMT). No. of bitstreams: 1
HASİBE ÇOLAK DOKTORA TEZ 10131319.pdf: 69638945 bytes, checksum: 93bc0154b02bde793d84e3127cecbc5a (MD5)
Previous issue date: 2016-11
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Eskişehir
Ağaçlar ve Çalılar
Polen Morfolojisi
Bushes and Trees
Pollen Morphology
Eskişehir il merkezindeki park ve bahçelerde bulunan ağaç ve çalıların polen morfolojisi
doctoralThesis
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1167/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
HASİBE ÇOLAK DOKTORA TEZ 10131319.pdf
HASİBE ÇOLAK DOKTORA TEZ 10131319.pdf
application/pdf
69638945
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1167/1/HAS%C4%B0BE+%C3%87OLAK+DOKTORA+TEZ+10131319.pdf
93bc0154b02bde793d84e3127cecbc5a
MD5
1
11684/1167
oai:openaccess.ogu.edu.tr:11684/1167
2017-12-11 09:04:08.263
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1168
2017-12-12T01:00:21Z
com_11684_15
com_11684_2
col_11684_86
Çabuk, Ahmet
Gedikli, Serap
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-12-11T07:04:11Z
2017-12-11T07:04:11Z
2016-08
2016
http://hdl.handle.net/11684/1168
Termofilik ve hipertermofilik gibi ekstremofilik mikroorganizmalar hem
biyoçeşitlilik hem de evrimsel süreç açısından oldukça ilgi çekicidirler. Ülkemiz jeolojik
yapısından dolayı pek çok sıcak su kaynağına sahiptir. Ancak bu kaynakların
mikrobiyolojik profillerini hem bakteriler hem de arkeler açısından belirleyen kapsamlı bir
çalışma açısından eksikliklerin olduğu bilinmektedir. Bu organizmalar yüksek
sıcaklıklarda hızlı ve verimli bir şekilde cereyan eden endüstriyel ve biyoteknolojik
süreçlerde önemli avantajlar sağlar. Yeni mikrobiyal suşların izolasyonu, yeni bileşiklerin
ve yol izlerinin identifikasyonu, hücresel bileşenlerin moleküler ve biyokimyasal
karakterizasyonu ile olası potansiyel de giderek artmaktadır. Kütahya-Simav’da bulunan
Naşa ve Çitgöl Termal Kaplıcalarından Mayıs 2011 ve Ekim 2012 aylarında alınan su
örneklerinin mikrobiyal çeşitliliği hem kültüre bağımlı hem de flueresens in situ
hibridizasyon, denature edici jel elektroforezi, 16S klon kütüphanesi oluşturma teknikleri
kullanılarak kültürden bağımsız olarak çalışılmıştır. Kültüre bağımlı yapılan çalışmalar
sonunda Mayıs 2011’de alınan su örneklerinden Geobacillus subterraneus, Geobacillus
stearothermophilus ve Geobacillus thermoleovarans, Ekim 2012’de alınan su
örneklerinden ise Geobacillus kaustophilus, Geobacillus thermoleovarans ve Geobacillus
thermoparaffinivorans, Geobacillus sp ve Thermus thermophilus türleri izole edilmiştir.
Kültürden bağımsız olarak yapılan çalışmalar sonunda Naşa termal kaplıcasında arke
varlığı belirlenmiştir. Elde edilen bu izolatlardan termal kararlılığa sahip bir PHB üreticisi
seçmek için tarama çalışması yapılmıştır. Seçilen Ç4-2 kodlu Geobacillus kaustophilus ile
Box-Behnken deneysel tasarım yöntemi kullanılarak optimizasyon çalışmaları yapılmış ve
% 8,66 verime ulaşılmıştır. Elde edilen PHB’nin FTIR, NMR, TG/DTA ve vizkozite
analizleri yapılarak karakterizasyonu gerçekleştirilmiştir. TG/DTA sonucuna göre 600
°C’de %14.3 oranında bozunmadan kalan sıcaklığa dayanıklı PHB üretilmiştir.
Extremophilic microorganisms as well as thermophilic and hyperthermophilic are
quite interesting in terms of biodiversity and the evolutionary process. Due to the
geological structure of our country which has a lot of thermal resource. In fact, it is the first
country in Europe and the seventh in the world in the way of the geothermal potential.
However, it is well known that a lack of the extensive study about determining of
microbiological profiles of these resources including both bacteria and archaea. These
organisms have important advantages in biotechnological and industrial processes which
occur efficiently at high temperatures. Recently, extremophile studies have focused on
either these microorganisms own or potential biotechnological applications. Possible
potential increases day by day when identification of new compounds and pathways,
molecular and biochemical characterization of cellular components have carried out.
Microbial diversity of water samples, taken from Naşa and Çitgöl thermal spring in
Kütahya-Simav in May 2011 and in October 2012, has been investigated a combination of
classical microbiology (cultivation techniques) and molecular biology approaches (culture
dependent techniques) including fluorescent in situ hybridization (FISH), denaturing
gradient gel electrophoresis (DGGE) and clone libraries with amplified 16S rRNA. In the
result of studies depend on cultivation techniques, Geobacillus subterraneus, Geobacillus
stearothermophilus ve Geobacillus thermoleovarans were isolated from water samples
which were taken on May 2011 and also Geobacillus kaustophilus, Geobacillus
thermoleovarans, Geobacillus thermoparaffinivorans, Geobacillus sp and Thermus
thermophilus were isolated from water samples taken in October 2012. The presence of
Archaea was determined as a result of studies carried out with culture dependent methods.
The scanning studies were performed to choose an isolate which is a producer of PHB
with thermal stability. Box-Behnken experimental design was used for optimizing studies
by using Geobacillus kaustophilus selected isolate coding Ç4-2. The yield was to be 8,66
% as a result of optimization. The characterization of obtained PHB was performed by
doing analyses including FTIR, NMR, TG/DTA and viscosity. PHB, which was thermal
resistant and remained 14,3 % without decomposition at 600 °C, was produced according
to the result of TG/DTA.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2017-11-22T06:46:21Z
No. of bitstreams: 1
10131268.pdf: 21522656 bytes, checksum: dc9442927eefbf30ab77460266e414b1 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-12-11T07:04:11Z (GMT) No. of bitstreams: 1
10131268.pdf: 21522656 bytes, checksum: dc9442927eefbf30ab77460266e414b1 (MD5)
Made available in DSpace on 2017-12-11T07:04:11Z (GMT). No. of bitstreams: 1
10131268.pdf: 21522656 bytes, checksum: dc9442927eefbf30ab77460266e414b1 (MD5)
Previous issue date: 2016-08
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Mikrobiyal Çeşitlilik
Termofil Mikroorganizmalar
PHB
Microbial Diversity
Thermophile Microorganisms
Sıcak su kaynaklarından termofilik mikroorganizmaların izolasyonu, identifikasyonu ve poli-ß-hidroksibütirat üretim yeteneklerinin belirlenmesi
doctoralThesis
TEXT
10131268.pdf.txt
10131268.pdf.txt
text/plain
367926
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1168/3/10131268.pdf.txt
56a83709cffe70b5f22d94f89ac7ace8
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1168/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10131268.pdf
10131268.pdf
application/pdf
21522656
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1168/1/10131268.pdf
dc9442927eefbf30ab77460266e414b1
MD5
1
11684/1168
oai:openaccess.ogu.edu.tr:11684/1168
2017-12-12 03:00:21.507
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1169
2017-12-12T01:00:23Z
com_11684_15
com_11684_2
col_11684_86
Ocak, Atila
Sezer, Okan
TR125361
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-12-11T07:04:14Z
2017-12-11T07:04:14Z
2016-10
2016
http://hdl.handle.net/11684/1169
Çalışma alanı Eskişehir, Afyon ve Kütahya illeri sınırları içerisinde yer alan
"Dağlık Frigya" bölgesini kapsamaktadır. Davis’in kareleme sistemine göre araştırma
alanının tamamı B3 karesinde yer almaktadır. Çalışma alanının floristik çeşitliliğini
belirlemek amacıyla 2012-2015 yılları arasında bölgeden 855 taksona ait 2214 bitki örneği
toplanmıştır. Toplanan bitki örnekleri herbaryum tekniklerine uygun olarak preslenip
kurutulmuştur. Floristik liste hazırlanırken APG III sistemi izlenmiştir. Yapılan teşhisler
sonucunda; 80 familya, 388 cins, 855 tür ve tür altı takson tespit edilmiştir. Araştırma
alanındaki bitki taksonları fitocoğrafik bölgelerine göre; % 15,67’si İran-Turan, % 11,58'i
Akdeniz ve % 13,10’u Avrupa-Sibirya elementi olarak tespit edilmiştir. Çok bölgeli veya
fitocoğrafik bölgesi bilinmeyenlerin oranı ise % 59,65’dir. Araştırma alanı sınırları
içerisinde tespit edilen endemik takson sayısı 103 olup endemizm oranı % 12,05’dir.
Araştırma alanında takson sayısı bakımından en büyük familya 107 takson ile Asteraceae,
en büyük cins ise 16 takson ile Astragalus cinsidir.
The study area includes ''Dağlık Frigya'' region which is in the borders of Eskişehir,
Afyon ve Kütahya provinces. According to the grid system of Davis, the whole part of the
study area is in the B3 square. With the aim of defining the floristic diversity of the study
area, 2214 plant samples belonging to 855 taxa were collected from the area between the
years of 2012-2015. Collected plant samples were pressed and dried according to the
herbarium techniques. While preparing the floristic list, APG III system was applied. At
the end of the study, 80 families, 388 genera and 855 species and subspecies taxa were
identified. According to the phytogeographic regions, plant taxa in the study area were
defined as 15,67 % Irano-Turanian, 11,58 % Mediterrenean and 13,10 % Euro-Siberian.
The ratio of more regional or unknown fitogeographgic ones is 59,65 %. The endemic taxa
number identified from study area is 103 and its endemism ratio is 12,05 %. The biggest
family in the study area is Asteraceae with 107 taxa. The biggest genus is Astragalus with
16 taxa.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2017-11-22T06:55:05Z
No. of bitstreams: 1
10131235.pdf: 25256503 bytes, checksum: be7d6bec7d625d17925d24bff3232f0e (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-12-11T07:04:14Z (GMT) No. of bitstreams: 1
10131235.pdf: 25256503 bytes, checksum: be7d6bec7d625d17925d24bff3232f0e (MD5)
Made available in DSpace on 2017-12-11T07:04:14Z (GMT). No. of bitstreams: 1
10131235.pdf: 25256503 bytes, checksum: be7d6bec7d625d17925d24bff3232f0e (MD5)
Previous issue date: 2016-10
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Flora
Frigya
Eskişehir
Kütahya
Afyon
Phrygia
Frigya vadisi florası
doctoralThesis
TEXT
10131235.pdf.txt
10131235.pdf.txt
text/plain
248423
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1169/3/10131235.pdf.txt
b39af65768e071c61b5a84f8e8840093
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1169/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10131235.pdf
10131235.pdf
application/pdf
25256503
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1169/1/10131235.pdf
be7d6bec7d625d17925d24bff3232f0e
MD5
1
11684/1169
oai:openaccess.ogu.edu.tr:11684/1169
2017-12-12 03:00:23.729
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1188
2017-12-12T01:00:29Z
com_11684_15
com_11684_2
col_11684_86
Vatan, Ayşe Pınar Öztopcu
Yıldız, Merve
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-12-11T07:05:03Z
2017-12-11T07:05:03Z
2016-05
2016
http://hdl.handle.net/11684/1188
Kanser hücrelerinde sfingolipid metabolizmasının ikincil habercilerinden olan
seramid molekülünün miktarındaki artışın hücre bölünmesini durdurduğu ve apoptozun
indüklenmesinde rol oynadığı daha önce yapılan çalışmalarla farklı hücre hatlarında
gösterilmiştir. Seranib-2 seramidaz enzim inhibitörü olarak sentezlenen hücrede seramid
miktarında artışa neden olan bir ajandır.
Çalışmada ilk olarak seranib-2’nin ve pozitif kontrol olarak seçilen karboplatinin 1,
5, 10, 25, 50, 75 ve 100 μM dozlarının hücre çoğalması üzerindeki etkileri MTT
yöntemiyle araştırılmıştır. Seranib-2’nin A549 hücrelerinde 24 ve 48 saatteki IC50 değerleri
sırasıyla, 22 ve 18 μM; H460 hücrelerinde ise 8 ve 3 μM olarak hesaplanmıştır.
Karboplatinin ise sadece H460 hücrelerinde 48 saatlik uygulamasında IC50 değeri 55 μM
olarak hesaplanmıştır. Ardından her iki hücre hattında da seranib-2 ve karboplatin dozları
1:1 oranında kombine olarak uygulanmıştır. A549 hücrelerinde 24 saatte tüm dozlarda
antogonistik etki, 48 saatte 1 ve 5 μM dozları dışında kalan diğer dozlarda sinerjistik etki
görülmüştür. H460 hücrelerinde ise 24 saatte 10 ve 25 μM dozlarında sinerjistik etki
görülürken, diğer dozlarda ve 48 saat uygulamalarında antogonistik etki gözlenmiştir.
Seçilen seranib-2 dozlarının her iki hücrede DNA fragmentasyonunu arttığı, apoptotik
fragmentasyonun nekrotik olana kıyasla daha fazla olduğu belirlenmiştir. H460
hücrelerinde seramidaz enzimin doza bağlı olarak seranib-2 tarafından baskılandığı ELISA
yöntemiyle belirlenmiştir. Son olarak seçilen seranib-2 dozlarının her iki hücre hattında da
apoptotik süreçle ilgili CASP3, CASP9 ve BAX genlerinin ifadesini artırırken, BCL-2
geninin ifadesini azalttığı gözlenmiştir.
Sonuç olarak; seranib-2 dozlarının KHDAK hücre hatlarında hücre canlılığını doza
ve zamana bağlı olarak azalttığı ve apoptozu indüklediği, karboplatin ile birlikte kombine
denendiğinde oluşturduğu antagonistik/sinerjistik etkileşim ilk kez tespit edilmiştir.
The increasing amount of ceramide, the secondary messenger molecule of
sphingolipid metabolism, has been shown to play role in stopping cell division and
inducing apoptosis in cancer cell lines by various studies. Ceranib-2 is an inhibitory agent
which inhibits ceramidase activation and causes an increase in the amount of ceramide in
cells.
In our research, first we investigated the antiproliferative effects of 1, 5, 10, 25, 50,
75 and 100 μM doses of ceranib-2 and carboplatin which is choosen as a positive control
by MTT assay. The IC50 values of ceranib-2 for 24 and 48 h are; 22 and 18 μM on A549
cells respectively, 8 and 3 μM on H460 cells respectively. However carboplatin has an
inhibitory effect (IC50= 55 μM) only on H460 cells by 48 h application. Then both
compound were applied in 1:1 ratio for each drug doses as combination on both cell lines.
In combination therapy, antagonistic effect at all doses in 24 h, synergistic effect at all
doses except 1 and 5 μM for 48 h was observed in A549 cells. In H460 cells, synergism
only at 10 and 25 μM for 24 h and antagonism for the rest of dose applications was
observed for 24 and 48 h. Selected ceranib-2 doses have increased DNA fragmentation on
both cell lines, apoptotic was greater than necrotic fragmentation. The inhibition of
ceramidase enzyme activity by ceranib-2 in H460 cells was determined by ELISA assay.
Finally, it is observed that the expression of apoptotic process related genes; CASP3,
CASP9 and BAX were increased while BCL-2 was reduced by selected doses of ceranib-2
in both cell lines.
As a result, the inhibition effects on cell viability and apoptosis of ceranib-2 doses
in a dose and time depended manner in NSCLC cell lines was determined for the first time.
Also the antagonistic/synergistic interactions by combination with carboplatin were
identified for the first time.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2017-11-28T08:37:29Z
No. of bitstreams: 1
10114199.pdf.pdf: 1174828 bytes, checksum: e459134e537e7f6070addd5d77565e8e (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-12-11T07:05:03Z (GMT) No. of bitstreams: 1
10114199.pdf.pdf: 1174828 bytes, checksum: e459134e537e7f6070addd5d77565e8e (MD5)
Made available in DSpace on 2017-12-11T07:05:03Z (GMT). No. of bitstreams: 1
10114199.pdf.pdf: 1174828 bytes, checksum: e459134e537e7f6070addd5d77565e8e (MD5)
Previous issue date: 2016-05
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Seranib-2
Seramidaz İnhibitörleri
Sitotoksisite
Apoptoz
Kombine Tedavi
Ceranib-2
Ceramidase İnhibitors
Cytotoxicity
Apoptosis
Combined Therapy
Seranib-2’nin akciğer kanseri hücre dizileri üzerindeki sitotoksik ve apoptptik etkilerinin belirlenmesi
masterThesis
TEXT
10114199.pdf.pdf.txt
10114199.pdf.pdf.txt
text/plain
130697
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1188/3/10114199.pdf.pdf.txt
56924b930087d0e8765c7ad9beed8536
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1188/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10114199.pdf.pdf
10114199.pdf.pdf
application/pdf
1174828
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1188/1/10114199.pdf.pdf
e459134e537e7f6070addd5d77565e8e
MD5
1
11684/1188
oai:openaccess.ogu.edu.tr:11684/1188
2017-12-12 03:00:29.539
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1194
2017-12-12T01:00:30Z
com_11684_15
com_11684_2
col_11684_86
Vatan, Ayşe Pınar Öztopcu
Pak, Fulya
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-12-11T07:05:43Z
2017-12-11T07:05:43Z
2016-06
2016
http://hdl.handle.net/11684/1194
Primer beyin tümörlerinin büyük bir kısmı glial kaynaklıdır ve bunların en tehlikeli türü glioblastoma multiforme (GBM)’dir. Kemoterapide kullanılan ilaçların az sayıda olması ve kullanılan ilaçlara karşı kanserli hücrelerin direnç geliştirmesi tedaviyi oldukça zorlaştırmaktadır. Fisetin, bitkilerde yaygın olarak bulunan doğal bir flavonoid çeşitidir. Yapılan araştırmalarda çeşitli kanser hücrelerinin çoğalmasını baskıladığı ve farklı mekanizmalarla apoptotik hücre ölümüne neden olduğu belirlenmiştir.
Çalışmada ilk olarak 1, 50, 100, 200, 300, 400 ve 500 μM fisetin dozlarının T98G hücre morfolojisi üzerindeki etkileri ters ışık mikroskobu ile belirlenirken, hücre çoğalması üzerindeki etkileri MTT yöntemi ile incelenmiştir. 24 ve 48 saatteki IC50 değerleri sırasıyla, 93 ve 75 μM olarak hesaplanmıştır. Fisetinin normal hücreler üzerindeki morfolojik ve sitotoksik etkilerini belirlemek ve T98G hücreleri ile karşılaştırmak için BEAS-2B hücreleri kullanılmıştır. 24 ve 48 saatteki IC50 değerleri sırasıyla 270 ve 90 μM olarak hesaplanmıştır. Seçilen fisetin dozlarının her iki hücrede de, apoptotik fragmentasyonu nekrotik orana kıyasla daha fazla arttırdığı belirlenmiştir. T98G hücrelerinde 25 ve 50 μM fisetin dozlarının apoptozla ilgili KASPAZ 3, 9, 8 ve BAX genlerinin ifadesini artırırken, BCL-2 ve SURVIVIN genlerinin ifadesini azalttığı gözlenmiştir. BEAS-2B hücrelerinde ise KASPAZ 3, 9, 8, BAX, BCL-2 ve SURVIVIN genlerinin ifadesini 50 μM dozunda arttırırken, 100 ve 200 μM dozlarında azalttığı tespit edilmiştir. Ayrıca fisetinin T98G hücrelerinde yarattığı morfolojik değişiklikler TEM mikroskobuyla incelenmiştir.
Çalışmada, fisetinin glioma hücrelerinde doza ve zamana sitotoksik ve apoptotik bir etkiye sahip olduğu ilk kez belirlenmiştir. Ayrıca normal hücreler ile karşılaştırıldığında fisetinin sitotoksik ve apoptotik etkilerinin glioma hücrelerinde daha güçlü olduğu tespit edilmiştir. Çalışma sonuçlarının fisetinin ileride glioma tedavisinde kullanılabilir bir ilaç olarak geliştirilmesinde yapılacak olan in vivo ve in vitro çalışmalara öncülük edeceğini düşünmekteyiz.
A large number of primary brain tumors are glial tumors and glioblastoma multiforme (GBM) is the most dangerous group of them. Cancer cells which develop resistance to chemotherapy drugs and a small number of used drugs cause difficulties on cancer therapy. Fisetin is a natural flavonoid. Previous studies have been reported that fisetin inhibit proliferation and induce apoptosis in several cancer types.
In our research, first we investigated the antiproliferative and morphology effects of 1, 50, 100, 200, 300, 400 and 500 μM doses of fisetin by inverted light microscope and MTT assay. The IC50 values of fisetin for 24 and 48 h are; 93 and 75 μM on T98G cells respectively. After BEAS-2B cells used to compare with morphological and T98G cells to the cytotoxic effects on normal cells of the fisetin. The IC50 values of fisetin for 24 and 48 h are; 270 and 90 μM on T98G cells respectively. Selected fisetin doses have increased DNA fragmentation on both cell lines, apoptotic was greater than necrotic fragmentation. We observed that the expression of apoptotic process related genes; CASPASE 3, 9, 8, BAX were increased while BCL-2 and survivin was reduced by selected doses of 25 and 50 μM fisetin in T98G cell lines. We observed that the expression of genes; CASPASE 3, 9, 8, BAX, BCL-2 and SURVIVIN were increase the dose of 50 μM, it was found to decrease from 100 and 200 μM doses of fisetin in BEAS-2B cell line. Finally, it is observed that alterations of T98G cell morphology treated with fisetin by transmission electron microscopy (TEM).
Consequently, depending on dose and time of fisetin in T98G cells were determined first to be stronger cytotoxic and apoptotic effects than normal cells. The results in the treatment of glioma cancer, we believe that it will lead to in vivo and in vitro studies, which will be held in the future.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2017-11-29T06:48:56Z
No. of bitstreams: 1
10114201.pdf: 2028643 bytes, checksum: 7f04f73d58f8ca4be84f317baf9ca3d5 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-12-11T07:05:43Z (GMT) No. of bitstreams: 1
10114201.pdf: 2028643 bytes, checksum: 7f04f73d58f8ca4be84f317baf9ca3d5 (MD5)
Made available in DSpace on 2017-12-11T07:05:43Z (GMT). No. of bitstreams: 1
10114201.pdf: 2028643 bytes, checksum: 7f04f73d58f8ca4be84f317baf9ca3d5 (MD5)
Previous issue date: 2016-06
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Glioma
Fisetin
Sitotoksisite
Apoptoz
RT-PCR
Cytotoxicity
Apoptosis
Fisetin’in hücre çoğalması ve apoptpz üzerindeki etkisinin insan glioblastoma multiforme (T98G) hücre dizisinde araştırılması
masterThesis
TEXT
10114201.pdf.txt
10114201.pdf.txt
text/plain
149883
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1194/3/10114201.pdf.txt
5e380d05b8d0794d0eee49f0952aa620
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1194/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10114201.pdf
10114201.pdf
application/pdf
2028643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1194/1/10114201.pdf
7f04f73d58f8ca4be84f317baf9ca3d5
MD5
1
11684/1194
oai:openaccess.ogu.edu.tr:11684/1194
2017-12-12 03:00:30.686
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1207
2017-12-12T01:00:54Z
com_11684_15
com_11684_2
col_11684_86
Emiroğlu, Özgür
Aksu, Sadi
TR193571
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-12-11T07:09:59Z
2017-12-11T07:09:59Z
2016-06
2016
http://hdl.handle.net/11684/1207
Bu çalışma ile Nilüfer Çayı balık faunası belirlenmiştir. Ayrıca balıkların dağılımları, yoğunlukları ve ekolojik şartları ortaya koyulmuştur. Haziran 2014 – Kasım 2015 tarihleri arasında yapılan arazi çalışmaları yapılmıştır. Nilüfer Çayı’nda 7 familyaya ait (Cobitidae, Cyprinidae, Nemacheilidae, Esocidae, Gobidae, Salmonidae, Siluridae) Cobitis vardarensis Karaman, 1928, Alburnoides manyasensis Turan, Ekmekçi, Kaya&Güçlü, 2013, Barbus niluferensis Turan, Kottelat&Ekmekçi, 2009, Barbus oligolepis Battalgil, 1941, Caopeta tinca (Heckel, 1843), Carassius gibelio (Bloch, 1782), Cyprinus carpio Linnaeus, 1758, Petroleuciscus borysthenicus (Kessler, 1859), Rhodeus amarus (Bloch, 1782), Scardinus erythrophthalmus (Linnaeus, 1758), Squalius cii (Richardson, 1857), Vimba vimba (Linnaeus, 1758), Oxynoemacheilus sp., Esox lucius Linnaeus, 1758, Neogobius fluviatilis (Pallas, 1814), Salmo coruhensis Turan, Kottelat & Engin, 2010, Salmo rizeensis Turan, Kottelat & Engin, 2010, Silurus glanis Linnaeus, 1758 türleri tespit edilmiştir. İstasyonların fiziko-kimyasal ölçümleri yapılmıştır. Shannon-Weiner çeşitlilik indeksine göre tür çeşitliliği ve CPUE (birim çabaya düşen av miktarı) belirlenmiştir.
Nilüfer River fish fauna have been identified by this study. In addition, the distribution of fish density and ecological conditions were demonstrated. June 2014 - fieldwork conducted between November 2015 carried out. Of 7 families in Nilüfer Stream (Cobitidae, Cyprinidae, Nemacheilus, Esocidae, Gobiida to, Salmonidae, Siluridae) Cobitis vardarensis Karaman, 1928, Alburnoides manyasensis Turan, Ekmekçi, Kaya&Güçlü, 2013, Barbus niluferensis Turan, Kottelat&Ekmekçi, 2009, Barbus oligolepis Battalgil, 1941, Caopeta tinca (Heckel, 1843), Carassius gibelio (Bloch, 1782), Cyprinus carpio Linnaeus, 1758, Petroleuciscus borysthenicus (Kessler, 1859), Rhodeus amarus (Bloch, 1782), Scardinus erythrophthalmus (Linnaeus, 1758), Squalius cii (Richardson, 1857), Vimba vimba (Linnaeus, 1758), Oxynoemacheilus sp., Esox lucius Linnaeus, 1758, Neogobius fluviatilis (Pallas, 1814), Salmo coruhensis Turan, Kottelat & Engin, 2010, Salmo rizeensis Turan, Kottelat & Engin, 2010, Silurus glanis Linnaeus, 1758species have been identified. Station of physico-chemical have been measured. Species diversity by the Shannon-Weiner diversity index and CPUE (catch per unit effort ) was calculated.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2017-11-30T12:45:24Z
No. of bitstreams: 1
10120990.pdf: 6640525 bytes, checksum: 8e43dd52af80a762ace462a18a799f7f (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-12-11T07:09:59Z (GMT) No. of bitstreams: 1
10120990.pdf: 6640525 bytes, checksum: 8e43dd52af80a762ace462a18a799f7f (MD5)
Made available in DSpace on 2017-12-11T07:09:59Z (GMT). No. of bitstreams: 1
10120990.pdf: 6640525 bytes, checksum: 8e43dd52af80a762ace462a18a799f7f (MD5)
Previous issue date: 2016-06
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Nilüfer Çayı
Balık Faunası
Shannon-Weiner
CPUE
Sistematik
Akarsu
Uludağ
Bursa
Türkiye
Nilüfer Stream
Fish Fauna
Systematics
Rivers
Turkey
Nilüfer çayı balık faunası
doctoralThesis
TEXT
10120990.pdf.txt
10120990.pdf.txt
text/plain
218078
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1207/3/10120990.pdf.txt
142ec23d6363bba27b728074f3377eb2
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1207/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10120990.pdf
10120990.pdf
application/pdf
6640525
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1207/1/10120990.pdf
8e43dd52af80a762ace462a18a799f7f
MD5
1
11684/1207
oai:openaccess.ogu.edu.tr:11684/1207
2017-12-12 03:00:54.832
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1214
2017-12-12T01:01:09Z
com_11684_15
com_11684_2
col_11684_86
Ocak, Atilla
Öztürk, Derviş
TR14849
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-12-11T07:10:20Z
2017-12-11T07:10:20Z
2016-06
2016
http://hdl.handle.net/11684/1214
Araştırma alanı Eskişehir sınırları içerisinde yer alan jipsli ve marnlı toprakların bulunduğu alanları kapsamaktadır. Davis’in kareleme sistemine göre araştırma alanının büyük bir bölümü B3 karesinde yer almaktadır. Floranın belirlenmesi için 2012-2015 yılları arasında araştırma alanından 1750 örnek toplanmıştır. Floristik liste hazırlanırken APG III sistemi izlenmiştir. Yapılan teşhisler sonucunda; 72 familyaya ait 354 cins, 673 tür ve toplam 738 takson tespit edilmiştir. Teşhisi yapılan bitki örneklerinden 738 takson Spermatophyta divizyosuna aittir. Alandaki toplam taksonların 42’si (% 5.6) Akdeniz elementi, 152’si (% 20.6) İran-Turan elementi, 38’i (% 5.1) Avrupa-Sibirya elementi, 1,’i (% 0.1) Karadeniz elementi, 27’si (% 3.6) D. Akdeniz elementi ve 478’i (% 64.7) çok bölgeli veya fitocoğrafik bölgesi bilinmeyen taksonlardır. Araştırma alanında 129 (% 17.5) endemik takson bulunmuştur.
Vejetasyon Braun-Blanquet (1932) metoduna göre araştırılmış olup 7 bitki birliği tanımlanmıştır. Tespit edilen birlik bilim dünyası için yenidir. Birlikler ve bağlı oldukları üst birimler aşağıdaki gibidir:
Sınıf: Astragalo-Brometea (Quezel, 1973)
Ordo: Onobrychido armenae-Thymetalia leucostomi Akman, Ketenoglu, Quézel
Alyans: Artragalo karamasici- Gypsophilion eriocalycis Quézel et Demirörs 1984
1.Birlik: Saponario kotschyii-Aethionemetum dumani ass. nova
2.Birlik: Salvio wiedemannii-Artemidetum campestrii ass. nova
3.Birlik: Anthemido gypsicolae-Centauredetum niveae ass. nova
4.Birlik: Hedysario pestalozzae- Convolvuletum phrygiae ass. nova
5.Birlik: Paronychio caricae- Convolvuletum pulvinatii ass. nova
6.Birlik: Lino cariensae- Fumanetum paphlagonicae ass. nova
7.Birlik: Gypsophilo viscosae-Thymetum longicaulii ass. nova
The investigation area covers gypsum and marl soils reside in the border of Eskisehir. It occurs in the B3 square according to the grid system of P.H. Davis. To investigate the flora, 1750 specimens have been collected during the field seasons of 2012- 2015. The specimens have been prepared according to the relevant herbarium techniques. The floristic list follows the APG III. At the end of identifications of the specimens 738 taxa belonging to 354 genera (72 family) have been determined. Phytogeographical distribution of the taxa are Irano- Turanian (20.6%), Mediterranean (5.36%), East Mediterranean (3.6 %) and Euro- Siberian (5.1 %) with their percentage of. Pluriregional or phytogeographically unknown taxa is 64.7 %. The endemism ratio of the areas is 17.5 %. One taxa are new record for the B3 square.
The vegetation of the area was studied according to Braun-Blanquet approach and classified into 7 associations. All associations are new for science. Associations and their higher units are as follows:
Class: Astragalo-Brometea (Quezel, 1973)
Order: Onobrychido armenae-Thymetalia leucostomi Akman, Ketenoglu, Quézel
Alliance: Artragalo karamasici- Gypsophilion eriocalycis Quézel et Demirörs 1984
1.Association: Saponario kotschyii-Aethionemetum dumani ass. nova
2. Association: Salvio wiedemannii-Artemidetum campestrii ass. nova
3. Association: Anthemido gypsicolae-Centauredetum niveae ass. nova
4. Association: Hedysario pestalozzae- Convolvuletum phrygiae ass. nova
5. Association: Paronychio caricae- Convolvuletum pulvinatii ass. nova
6. Association: Lino cariensae- Fumanetum paphlagonicae ass. nova
7. Association: Gypsophilo viscosae-Thymetum longicaulii ass. nova
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2017-12-01T07:32:12Z
No. of bitstreams: 1
10121966.pdf: 4641942 bytes, checksum: 6921e64c64693f54efcf1612a8991b64 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-12-11T07:10:20Z (GMT) No. of bitstreams: 1
10121966.pdf: 4641942 bytes, checksum: 6921e64c64693f54efcf1612a8991b64 (MD5)
Made available in DSpace on 2017-12-11T07:10:20Z (GMT). No. of bitstreams: 1
10121966.pdf: 4641942 bytes, checksum: 6921e64c64693f54efcf1612a8991b64 (MD5)
Previous issue date: 2016-06
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Jips
Marn
Flora
Vejetasyon
Eskişehir
Türkiye
Gypsum
Marl
Vegetation
Eskişehir’deki jipsli ve marnlı toprakların flora ve vejetasyonu
doctoralThesis
TEXT
10121966.pdf.txt
10121966.pdf.txt
text/plain
376028
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1214/3/10121966.pdf.txt
2de5a64300123f584971b610e78f4ee0
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1214/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10121966.pdf
10121966.pdf
application/pdf
4641942
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1214/1/10121966.pdf
6921e64c64693f54efcf1612a8991b64
MD5
1
11684/1214
oai:openaccess.ogu.edu.tr:11684/1214
2017-12-12 03:01:09.318
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1237
2017-12-12T01:01:01Z
com_11684_15
com_11684_2
col_11684_86
Ayhancı, Adnan
Heybeli, Nilhan
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-12-11T07:11:39Z
2017-12-11T07:11:39Z
2015-12
2015
http://hdl.handle.net/11684/1237
Siklofosfamid (CP) klinikte kanser ve non-malignant hastalıkların tedavisinde yaygın olarak kullanılan alkilleyici sitotoksik bir ilaçtır. CP‟nin antitümoral etkinliği yüksek dozda kullanılabilmesine bağlıdır. Ancak yüksek doz CP kan ve kemik iliği toksisitesine neden olmaktadır. CP‟ye bağlı hematoksisite, kan dokusunda lipit peroksidasyonunun artışıyla yakın ilişkilidir. Bu çalışmada deneysel olarak oluşturulmuş hematoksisitede, vücudumuzdaki antioksidan enzimlerin ana bileşeni olan ve aynı zamanda antioksidan özellikleri bilinen Selenyum‟un (Se) kan ve kemik iliği üzerindeki olası koruyucu etkilerini saptamak amaçlandı. Çalışmamızda, 3 aylık Spraque-Dawley cinsi 42 adet erkek sıçan her grupta 7 hayvan olacak şekilde 6 gruba ayrılmıştır (kontrol; 150 mg/kg CP; 0.5 mg/kg Se; 1 mg/kg Se; 150+0.5 mg/kg CP+Se; 150+1 mg/kg CP+Se). CP ile birlikte Se verilen gruplarda Se uygulamasına CP uygulamasından 5 gün önce başlandı ve deney sonuna kadar devam edildi (6 gün). CP uygulaması ise hayvanlar anestezi edilmeden 24 saat önce tek doz olarak uygulandı. Böylece 7. Günde hayvanlardan anestezi altında intrakardiyak kan alımı yapıldıktan sonra sıçanların femurlarından kemik iliği dikkatlice alındı. Periferik kan hücreleri ve kemik iliği çekirdekli hücreleri kan sayım cihazında sayıldı. İntraperitoneal CP uygulaması kontrole göre lökosit (%317), trombosit (%36) ve kemik iliği çekirdekli hücre sayısını (%481) oldukça azalttı. CP ile birlikte 0.5 ve 1 mg/kg Se verilen deney gruplarındaki lökosit, trombosit ve kemik iliği çekirdekli hücre sayılarının CP verilen gruptakilere göre önemli bir oranda arttığı görüldü (p<0.001). CP nedenli miyelosupresyon ve hematoksisitenin önlenmesinde 1 mg/kg Se, 0.5 mg/kg Se‟a göre daha koruyucu olmuştur. Verilerimiz Se dozunun belirli oranlarda değiştirilmesiyle artan CP dozuna karşı daha güçlü bir koruyucu etkinliğin sağlanabileceğini düşündürmektedir. CP nedenli hematoksisitenin önlenmesinde Se‟un farklı dozlarını içeren çalışmaların yapılması gerektiğini düşünmekteyiz.
Cyclophosphamide (CP) is an alkylating cytotoxic drug that is commonly used in the treatment of cancer and non-malignant diseases. High therapeutic doses of CP have antitumoral activity. On the other hand, high doses of CP cause blood and bone marrow toxicity due to the increase in lipid peroxidation. Aim of this thesis is to find out the protective role of antioxidant Selenium (Se) against blood and bone marrow toxicity in an experimentally induced haematoxicity model. For this purpose, we used 3 months old, 42 male Spraque-Dawley rats and divided them into 6 groups so that each group contains 7 animals (control; 150 mg/kg CP; 0.5 mg/kg Se; 1 mg/kg Se; 150+0.5 mg/kg CP+Se; 150+1 mg/kg CP+Se). Se injections started 5 days before the CP injections and carried on till the end of the experiment (6th day) for the groups to which CP was administrated together with Se. CP was administered as a single dose before anesthesia. Therefore on the 7th day, blood was taken with cardiac puncture and bone marrow was taken by flushing the femur. Peripheral blood cells and bone marrow nucleated cells were counted on a cell counter. Intraperitoneal CP injection was found to reduce the number of leukocytes by 317%, thrombocyte by 36% and bone marrow nucleated cells by 481% compaed to the control group. In the groups where CP was given after 0.5 and 1 mg/kg Se, numbers of leukocyte, thrombocyte and bone marrow nucleated cells were significantly increased compared to the group to which CP was given alone (p<0.001). Results show that 1 mg/kg Se has a better protection than 0.5 mg/kg against CP related myelosuppression and haematoxicity. These results also implies that the dose of Se could be adjusted according to an increase in CP dose in order to gain a stronger protective effect. We believe there is a need of further studies in which different doses of Se will be used against CP related haematoxicity.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2017-12-06T06:22:45Z
No. of bitstreams: 1
10095927.pdf: 1080146 bytes, checksum: 2460cd52477c8f0331702ef89a6754c6 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-12-11T07:11:39Z (GMT) No. of bitstreams: 1
10095927.pdf: 1080146 bytes, checksum: 2460cd52477c8f0331702ef89a6754c6 (MD5)
Made available in DSpace on 2017-12-11T07:11:39Z (GMT). No. of bitstreams: 1
10095927.pdf: 1080146 bytes, checksum: 2460cd52477c8f0331702ef89a6754c6 (MD5)
Previous issue date: 2015-12
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Siklofosfamid
Hematoksisite
Selenyum
Sitoprotektivite
Sıçan
Cyclophosphamide
Haematoxicity
Selenium
Cytoprotectivity
Rat
Kemoterapi nedenli miyelosüpresyon üzerine selenyum’un hematoprotektif etkisi
masterThesis
TEXT
10095927.pdf.txt
10095927.pdf.txt
text/plain
103992
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1237/3/10095927.pdf.txt
6d1a3011c17e1c7025752d361c7959f1
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1237/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10095927.pdf
10095927.pdf
application/pdf
1080146
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1237/1/10095927.pdf
2460cd52477c8f0331702ef89a6754c6
MD5
1
11684/1237
oai:openaccess.ogu.edu.tr:11684/1237
2017-12-12 03:01:01.024
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1232
2017-12-11T07:11:10Z
com_11684_15
com_11684_2
col_11684_86
İlhan, Semra
Demirel, Rasime
Kayış, Orkun
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2017-12-11T07:11:10Z
2017-12-11T07:11:10Z
2015-11
2015
http://hdl.handle.net/11684/1232
Bu çalışmanın amacı, İzmir Çamaltı Tuzlası’ndan elde edilmiş, morfolojik ve
moleküler yöntemler ile tanımlanmış olan 48 farklı mikrofungus izolatının
karakterizasyonunun yapılmasıdır. Çalışmada 13 Penicillium, 13 Aspergillus, 7
Cladosporium, 3 Alternaria, 2 Trichoderma, 2 Chaetomium ve birer Fusarium,
Acremonium, Biscogniauxia, Phomopsis ve Arthrinium türü incelenmiştir.
Çalışmada izolatların farklı kültür koşullarındaki koloni morfolojisindeki özellikleri
incelenmiştir. Bu amaçla % 8, 16 ve 24 NaCl derişimi ve 17, 27 ve 37 ºC’de inkübasyon
sıcaklığı uygulanmıştır. İncelenen her bir izolat için söz konusu koşulların cins ve tür
seviyesinde ayrım yapılmasında potansiyel sahibi olduğu belirlenmiştir.
Çalışma kapsamında incelenen izolatların kimyasal karakterizasyonu için ince
tabaka kromatografisi ile sekonder metabolit profilleri incelenmiştir. İlaveten aflatoksin ve
okratoksin A üretme yetenekleri belirlenmiştir. Metabolit üretimi için mikrofunguslar
Yeast Ekstrakt Sukroz Agar ortamında geliştirilmiş ve CAMAG HP-TLC kullanılarak 365
nm’de değerlendirilmiştir. Söz konusu 48 izolatın aflatoksin ve okratoksin A üretmediği,
Rf 0,36 – 2,02 arasında değişen en az 2 en fazla 10 farklı metabolite sahip oldukları
belirlenmiştir.
İzolatların DPPH yöntemi ile serbest radikal süpürücü etkileri de değerlendirilerek
% inhibisyonları belirlenmiştir. En yüksek aktivite % 65 inhibisyon ile Aspergillus
clavatus belirlemiş olup Cladosporium cladosporioides (%60) tarafından takip edilmiştir.
Sonuç olarak elde edilen tüm karakterizasyon verileri ile incelenen izolatların
morfolojik ve kimyasal özelliklerine ait geniş bir veri tabanı oluşturmuştur. Böylece temel
düzeyde bir kültür koleksiyonu oluşturulmuş olmasıyla birlikte geliştirilmesi için ilave
çalışmalara ihtiyaç duyulmaktadır.
Aim of this study is characterization of 48 different microfungal isolates that were
isolated and identified with molecular methods from Çamaltı/İzmir. Totally, 13 isolates
belong to Penicillium, 13 Aspergillus, 7 Cladosporium, 3 Alternaria, 2 Trichoderma, 2
Chaetomium and 1 isolate belong to Fusarium, Acremonium, Biscogniauxia, Phomopsis
and Arthrinium genera have been determined.
Properties of colonial morphology have been investigated under the different
cultural conditions. For this of aim, 8%, 16%, 24% NaCl concentrations and 17, 27, 37 ºC
incubation temperatures have been used. For each isolates, used cultural conditions showed
a potential for distribution at genus and species level.
Thin layer chromatography has been used for chemical characterization of
investigated isolates. In addition, aflatoxins and ochratoxin A producing properties have
been analyzed. For producing metabolites, microfungi have inoculated Yeast Extract
Sucrose Agar and evaluated under 365 nm with HP-TLC (CAMAG). As a result, it was
determined that all of the isolates do not produce to investigated mycotoxins and produced
to 2 – 10 different metabolites between 0.36 – 2.02 RF values.
Antioxidant activity potential of all isolates have been evaluated as inhibition
percentage. Aspergillus clavatus was determined as the best isolate with 65% inhibition
and was followed by Cladosporium cladosporioides (60%).
As a result of the study, a wide range database has been obtained about
morphological and chemical properties of isolates. Thus, the basic culture collection have
established but, the further studies needs to enlarge this collection.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2017-12-07T08:12:42Z
No. of bitstreams: 1
10096047.pdf: 620197690 bytes, checksum: 140070769d2f167df0707c1cfc552007 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2017-12-11T07:11:10Z (GMT) No. of bitstreams: 1
10096047.pdf: 620197690 bytes, checksum: 140070769d2f167df0707c1cfc552007 (MD5)
Made available in DSpace on 2017-12-11T07:11:10Z (GMT). No. of bitstreams: 1
10096047.pdf: 620197690 bytes, checksum: 140070769d2f167df0707c1cfc552007 (MD5)
Previous issue date: 2015-11
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Mikrofungus
Karakterizasyon
Kemotaksonomi
Tuzla
Microfungus
Characterization
Chemotaxonomy
Saltern
Çamaltı tuzlasından izole edilen mikrofungusların karakterizasyonu
masterThesis
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1232/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10096047.pdf
10096047.pdf
application/pdf
620197690
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1232/1/10096047.pdf
140070769d2f167df0707c1cfc552007
MD5
1
11684/1232
oai:openaccess.ogu.edu.tr:11684/1232
2017-12-11 09:11:10.425
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1419
2018-04-04T00:00:22Z
com_11684_15
com_11684_2
col_11684_86
Çalışkan, Figen
Atlıakın, Neslihan
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2018-04-03T06:45:41Z
2018-04-03T06:45:41Z
2012-10
2012
http://hdl.handle.net/11684/1419
Androctonus crassicauda Doğu Anadolu Bölgesi ve Güneydolu Anadolu
Bölgesi’nde yaygın olarak bulunan Buthidae familyasına ait bir akrep türüdür.
Androctonus crassicauda taş altlarında, harabeler, ev, ahır gibi insana yakın yerlerde
yaşaması ile ülkemizde akrep zehirlenmelerine neden olan türler arasında ilk sırayı
almaktadır. Bu çalışma Androctonus crassicauda akrebinde bulunan proteolitik
enzimlerin araştırılması ve polivalent akrep antivenomunun, venomun proteolitik
aktivitesine olan etkisinin araştırılması üzerine odaklanmıştır.
Bu amaçla Androctonus crassicauda ham venomu yüksek performans sıvı
kromatografisi kullanılarak bileşenlerine ayrılmıştır. Ham venoma ait fraksiyonların
proteolitik aktiviteleri sodyum dodesil sülfat poliakrilamid jel elektroforezinde
zimogram yöntemiyle belirlenmiştir. Proteolitik aktivite çalışmalarında substrat olarak
jelatin ve kazein kullanılmıştır. Farklı dozlarda antivenomla karıştırılmış ham
venomdan oluşan örnekler ile gerçekleştirilen elektroforez çalışmalarında antivenomun,
ham venomda bulunan jelatinolitik etkili peptidlerin aktivitesini inhibe ettiği
belirlenmiştir. Antivenomun ham venoma ait fraksiyonlarda ise jelatinolitik aktiviteyi
kısmen etkilediği belirlenmiştir.
Androctonus crassicauda is a scorpion species from the family Buthidae, which
can be extensively found in the East and South East Regions of Anatolia. Because of
the Androctonus crassicauda species share the same habitats with humans, such places
as under stones, ruins, houses and barns, it has been placed to the top of the scorpion
envenomation in our country. This study is focused on the investigation of the
proteolytic activity of peptides from the venom of a scorpion Androctonus crassicauda
and Androctonus crassicauda polivalent antivenom effects proteolytic activity of
Androctonus crassicauda scorpion venom.
To this end, crude venom compenents of Androctonus crassicauda seperated
using High Performance Liquid Chromatography. Proteolytic activities of the fraction
that belong to crude venom were identified with sodium dodeciyl sulphate
polyacrylamide gel electroforesis zymogram methods. Different two substrate were
used at the studies. The substrates are gelatin and casein. Studies carried out with the
samples that mixed various doses of antivenom and also the samples belong to crude
venom. And according to identified the peptides that have to gelatinolitic effect in
venom were inhibited by antivenom. Antivenom partly impress to gelatinolytic activity
on fractions belong to crude venom.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2018-03-30T06:32:37Z
No. of bitstreams: 1
448645.pdf: 41313591 bytes, checksum: 39544dc5a382ef86801cc4d787729a67 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2018-04-03T06:45:41Z (GMT) No. of bitstreams: 1
448645.pdf: 41313591 bytes, checksum: 39544dc5a382ef86801cc4d787729a67 (MD5)
Made available in DSpace on 2018-04-03T06:45:41Z (GMT). No. of bitstreams: 1
448645.pdf: 41313591 bytes, checksum: 39544dc5a382ef86801cc4d787729a67 (MD5)
Previous issue date: 2012-10
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Androctonus Crassicauda
Akrep
Venom
Antivenom
Proteolitik Aktivite
Scorpion
Androctonus crassicauda venomunda bulunan peptidlerin proteolitik aktivitesinin araştırılması ve antivenomun antiproteolitik etkisinin belirlenmesi
masterThesis
TEXT
448645.pdf.txt
448645.pdf.txt
text/plain
150057
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1419/3/448645.pdf.txt
3f103c5fab1a3288624fe467006cfe73
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1419/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
448645.pdf
448645.pdf
application/pdf
41313591
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1419/1/448645.pdf
39544dc5a382ef86801cc4d787729a67
MD5
1
11684/1419
oai:openaccess.ogu.edu.tr:11684/1419
2018-04-04 03:00:22.366
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1539
2018-06-09T00:00:54Z
com_11684_15
com_11684_2
col_11684_86
Yılmaz, Cenap
Zurnacı, Murat
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2018-06-08T05:28:22Z
2018-06-08T05:28:22Z
2017-04
2017
http://hdl.handle.net/11684/1539
Cactaceae familyasına ait Opuntia cinsi içinde yer alan Dikenli incir (Opuntia ficus-indica L.), ülkemizde Akdeniz Bölgesine özgü bitkiler içinde yer almaktadır. Türkiye'de dikenli incir genellikle Mersin, Adana, Osmaniye, Hatay, Antalya ile Güney Ege sahillerinde doğal olarak yetişmektedir. Bu bölgelerde doğal olarak yetişen dikenli incir yaz aylarında toplanarak yerel pazarlarda satılmaktadır. Ülkemizde dikenli incir üretim miktarı konusunda resmi istatistiklere göre bilgi bulunmamaktadır. Bu çalışmanın amacı, Akdeniz bölgesinde yer alan Mersin, Adana, Osmaniye ve Hatay illerinden selekte edilen dikenli incir (Opuntia ficus-indica L.) genotiplerinin tür içi çeşitliliğinin morfolojik ve moleküler olarak belirlemektir. Bu çalışma ile 2014 yılında Mersin, Adana, Hatay ve Osmaniye illerinden selekte edilen toplam 40 dikenli incir genotipi pomolojik ve moleküler olarak incelenmiştir. Çalışmada 13 pomolojik özellik incelenmiştir. Sonuçta meyve pomolojik karakterlerinin geniş bir dağılım gösterdiği tespit edilmiştir. Moleküler analizler neticesinde 19 RAPD primerinden toplam 137 bant elde edilmiştir. Bu bantlardan 112 tanesi polimorfik bulunmuştur ve polimorfizm oranı % 81,75 olarak tespit edilmiştir. Dikenli incir genotipleri arasındaki farklılığın yüksek seviyede (0,61-0,93) olduğu saptanmıştır.
Prickly pear (Opuntia ficus-indica L.) belongs to Opuntia geneous of Cactaceae family. Prickly pear is naturally grown in Mediterranean region of Turkey particularly in Adana, Mersin, Osmaniye, Hatay, Antalya and southern Aegean. It is sold and consumed in summer time at local markets. There is no statistical data of production and consumption amounts of prickly pear in Turkey. The aim of the determination of morphological and molecular biodiversity of prickly pear (Opuntia ficus-indica L.) genetic resources in Eastern Mediterranean Region. In this project, 40 prickly pear genotypes were selected in Eastern Mediterranean Region have been examined as pomological and molecular DNA properties. It weas determined that fruit pomological propeties showed wide diversity. Nineteen RAPD primers generated a total of 137 reproducible bands; 81.75% of which were polymorphic. It was determined that there was a high genetic difference (0.61-0.93 genetic similarity) among 40 prickly pear genotypes.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2018-05-09T06:58:42Z
No. of bitstreams: 1
10149495.pdf: 2641540 bytes, checksum: ad937837d402ad0d2271818391933368 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2018-06-08T05:28:22Z (GMT) No. of bitstreams: 1
10149495.pdf: 2641540 bytes, checksum: ad937837d402ad0d2271818391933368 (MD5)
Made available in DSpace on 2018-06-08T05:28:22Z (GMT). No. of bitstreams: 1
10149495.pdf: 2641540 bytes, checksum: ad937837d402ad0d2271818391933368 (MD5)
Previous issue date: 2017-04
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Dikenli İncir
Opuntia Ficus İndica
Doğu Akdeniz Bölgesi
Seleksiyon
Pomoloji
RAPD
Prickly Pear
Eastern Mediterranean Region
Selection
Pomology
Doğu Akdeniz Bölgesinde dikenli incir (opuntia ficus-indica [L.] mill.) tür içi çeiştliliğinin morfolojik ve moleküler olarak incelenmesi
masterThesis
TEXT
10149495.pdf.txt
10149495.pdf.txt
text/plain
128097
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1539/3/10149495.pdf.txt
f5e355d6d5b87e822d64d034f120f7f3
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1539/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10149495.pdf
10149495.pdf
application/pdf
2641540
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1539/1/10149495.pdf
ad937837d402ad0d2271818391933368
MD5
1
11684/1539
oai:openaccess.ogu.edu.tr:11684/1539
2018-06-09 03:00:54.306
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1634
2019-01-31T01:06:32Z
com_11684_15
com_11684_2
col_11684_86
Canbek, Mediha
Akçalı, Kamil Can
Berber, Burak
TR262541
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2019-01-30T08:19:01Z
2019-01-30T08:19:01Z
2017-05
2017
http://hdl.handle.net/11684/1634
Karaciğer kendini onarabilme yeteneği ile vücuttaki diğer tüm organlardan daha fazla avantaja sahiptir. Çeşitli nedenlerle zarar görmesi durumunda, fonksiyonel kütlesini tamamlama yönünde replikasyon ve proliferasyona başlayabilir. Karaciğer loblarının bir kısmının cerrahi olarak çıkarılması parsiyal hepatektomi-(PHx) ve hepatositlerin virüs ya da kimyasallardan zarar görmesi gibi durumlarda hepatosit replikasyonunun arttığı bilinmektedir.
Replikasyon ve proliferasyon yanıtı bir takım sinyal yolakları ile gerçekleşmektedir. PI3K/Akt/mTOR yolağının; hücre büyümesi, proliferasyon, hayatta kalım, farklılaşma ve hücre iskeleti değişiminin düzenlenmesi gibi birçok fonksiyonu vardır. %70’ lik parsiyel hepatektomi sonrası PI3K/Akt/mTOR aktive olur ve hepatositlerin artışını sağlar. Son yıllarda; kanser veya metabolik bozukluklar gibi pek çok hastalık PI3K/Akt/mTOR yolağının anormal aktivitesi ile ilişkilendirilmiştir. Diyet takviyelerinin geliştirilmesi, belirli populasyon gruplarında beslenme yoluyla hastalıkların önlenmesi ya da başlangıcının geciktirilmesine yardımcı olabilir. İnsan sağlağını etkileyen fitokimyasalların etkisinin PI3K/Akt/mTOR yolağı üzerinden belirlenmesi; bu yolak üzerinde moleküler etki mekanizmasının daha iyi anlaşılmasını sağlayacaktır. Safran (Crocus sativus L.)’ın antioksidan, anti-enflamatuar, anti-aterosklerotik, nöro-koruyucu ve yüksek yağlı diyet-kaynaklı insülin direncini önlemesi vb. etkileri bilinmektedir.
Çalışmamızda; 15 gün boyunca sıçanlara gavaj yöntemiyle 100 mg/kg safran diyeti uygulanmıştır. Diyet sonunda % 70’lik parsiyel hepatektomi işlemi ile hepatositlerin proliferasyonu uyarılmıştır. Bu işlemler ile safran’ in 0-6-12 ve 24. saatlerde hepatosit proliferasyonuna etkisi; PI3K/Akt/mTOR yolağı üzerinden belirlenmiştir.
Elde edilen bulgulara göre safran’ın karaciğeri koruduğu, proliferasyonu arttırıcı etkisinin olduğu tespit edilmiştir. Safran’ın PI3K/Akt/mTOR yolağı üzerindeki etkisinin belirlenmesi; karaciğer hastalıklarında (örn; obezite, tip 2 diabet, kanser gibi) safran tedavisi çalışmalarına temel oluşturacaktır.
Liver repair itself by its ability to have more advantages than any other organ in the body. In case of damage to the liver due to various reasons, replication and proliferation towards completing the functional mass start. Surgical removal of a portion of the liver lobe, known as partial hepatektomi- (PHx) and hepatocyte damage from viruses or chemicals, cause an increase in hepatocyte replication.
Replication and proliferation response is realized by a number of signaling pathways. PI3K/Akt/mTOR pathway has many functions; such as cell growth, proliferation, survival, differentiation, and the regulation of cytoskeletal changes. After 70% partial hepatectomy PI3K/Akt/mTOR is activated and allows the growth of hepatocytes. In recent years; many diseases such as cancer or metabolic disorders PI3K/Akt/mTOR pathway has been associated with abnormal activity. The development of dietary supplements that can help prevent or delay the onset of nutrition-related diseases in specific population groups. Identification ofeffects of PHxytochemicals over the identifying PI3K/Akt/mTOR pathway that affect human health; will provide a better understanding of the molecular mechanism of action. Saffron (Crocus sativus L); antioxidant, anti-inflammatory, anti-atherosclerotic, neuroprotective and preventing high-fat diet-induced insulin resistance (and so on.) effects are known.
In our study; by gavage method to rats for 15 days of 100 mg/kg diet saffron have been applied. At the end of the diet, have been stimulate hepatocyte proliferation by 70% partial hepatectomy process. These procedures with saffron 0-6-12 and 24 hours effect on hepatocyte proliferation; PI3K/Akt/mTOR pathway have been determined through the pathway.
According to our results; we determine that saffron has protective and proliferative effect on liver. Determination of saffron effects on PI3K/Akt/mTOR pathway liver disease (e.g. obesity, type 2 diabetes, cancer) will form the basis of the saffron treatment studies.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2018-06-11T11:27:49Z
No. of bitstreams: 1
10150079.pdf: 2028991 bytes, checksum: f9d18ea1e86c09c20ad9ae3c4e326ecb (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2019-01-30T08:19:01Z (GMT) No. of bitstreams: 1
10150079.pdf: 2028991 bytes, checksum: f9d18ea1e86c09c20ad9ae3c4e326ecb (MD5)
Made available in DSpace on 2019-01-30T08:19:01Z (GMT). No. of bitstreams: 1
10150079.pdf: 2028991 bytes, checksum: f9d18ea1e86c09c20ad9ae3c4e326ecb (MD5)
Previous issue date: 2017-05
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Karaciğer Rejenerasyonu
PI3K/Akt/mTOR Yolağı
Safran
Liver Regeneration
PI3K/Akt/mTOR Pathway
Saffron
Safran’in parsiyel hepatektomi sonrası karaciğer rejenerasyonuna etkisinin PI3K/AKT/mTOR sinyal yolağı üzerinden belirlenmesi
masterThesis
TEXT
10150079.pdf.txt
10150079.pdf.txt
text/plain
125265
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1634/3/10150079.pdf.txt
a3163e64b0e87d6ac4e4c5326c8b57b8
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1634/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10150079.pdf
10150079.pdf
application/pdf
2028991
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1634/1/10150079.pdf
f9d18ea1e86c09c20ad9ae3c4e326ecb
MD5
1
11684/1634
oai:openaccess.ogu.edu.tr:11684/1634
2019-01-31 03:06:32.932
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1639
2019-01-31T01:07:12Z
com_11684_15
com_11684_2
col_11684_86
Canbek, Mediha
Yılmaz, Işıl Tan
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2019-01-30T08:19:14Z
2019-01-30T08:19:14Z
2017-04
2017
http://hdl.handle.net/11684/1639
Bu tez çalışmasında sıçanlarda deneysel olarak oluşturulan kısa süreli böbrek iskemi/reperfüzyon (İ/R)’ una bağlı karaciğer hasarına karşı antioksidan özelliği bilinen geraniol’ ün olası koruyucu etkilerinin araştırılması hedeflenmiştir.
Çalışmada 28 adet 3-4 aylık erkek Wistar albino sıçanlar kullanılmıştır (n=7). Rastgele seçimle, Grup I (Sham Grubu), Grup II (İ/R + Serum Fizyolojik), Grup III (İ/R + 50 mg/kg Geraniol), Grup IV (İ/R + 100 mg/kg Geraniol) olmak üzere 4 grup oluşturulmuştur. Ksilazin (10 mg/kg) ve ketamin (70 mg/kg) anestezisi altında tüm gruplara sağ böbrek nefroktomi işlemi uygulanmıştır. Grup I haricindeki gruplara 45 dakika iskemi ve 4 saat reperfüzyon uygulanmıştır. Grup I ve II’ ye 2 mL serum fizyolojik (SF), Grup III ve IV’ e sırasıyla 50 mg/kg, 100 mg/kg geraniol tek doz halinde iskemiden 1 saat önce intraperitonal olarak enjekte edilmiştir. Deney sonunda kan serumunda alanin aminotransferaz (ALT), aspartat aminotransferaz (AST) aktiviteleri ve karaciğer dokularında katalaz (CAT), süperoksit dismutaz (SOD) ve glutatyon peroksidaz (Gpx) enzim aktiviteleri ölçülmüştür. Doku kesitleri H&E ile boyanmış ve ışık mikroskobunda incelenmiştir. Çalışma sonuçlarına göre; Grup I ve Grup II’ nin serumda ALT ve AST, doku örneklerinde CAT, SOD ve Gpx değerleri karşılaştırıldığında Grup II’ de Grup I’ e göre serum ALT ve AST değerlerinin ve karaciğer dokusuna ait SOD, Gpx aktivitelerinin arttığı, CAT aktivitesinin azaldığı görülmüştür. Grup III ve IV’ ün SOD ve Gpx aktiviteleri Grup II’ ye göre azalırken; CAT aktiviteleri artış göstermiştir. Histopatolojik olarak Grup II karaciğer dokusunda yoğun vakuolizasyon, ileri derece nekroz, yoğun nüklear infiltrasyon ve kanama gözlenirken, Grup IV’ te bu bulgulara rastlanmamıştır. Deneysel çalışmamızın histolojik bulguları biyokimyasal analizleri desteklemektedir.
Çalışma sonuçları, intraperitonal olarak uygulanan geraniol’ ün 100 mg/kg dozunun böbrek İ/R hasarından etkilenen karaciğer üzerinde koruyucu etkisi olduğunu göstermiştir.
In this thesis study, the possible protective effects of geraniol, which is known to be an atioxidant, were investigated against liver injury induced by experimentally short-term renal ischemia/reperfusion (I/R) injury in rats.
In the study, three to four month old, Wistar-albino type 28 rats were used (n=7). Four groups were designed randomly that Group I (Sham Group), Group II (I/R+normal saline), Group III (I/R+ 50 mg/kg geraniol), Group IV (I/R+ 100 mg/kg geraniol). Right nephrectomies were performed under xylazine (10 mg/kg) and ketamine (70 mg/kg) anesthesia in all group rats. Then, 2 mL physiological saline solution was injected to Group I and Group II; 50 mg/kg geraniol was injected to Group III and 100 mg/kg geraniol was injected to Group IV intraperitoneally one hour before ischemia. 45 minutes ischemia and 4 hours reperfsion were applied to all groups expect Group I. At the end of the experiment, ALT, AST activites in the blood serum and the Catalase (CAT), Superoxide dismutases (SOD) and Glutathione peroxidase (Gpx), enzime activities in liver tissue were measured. Histological sections were stained using Hematoxylien & Eosine and investigated by light microscope. According to the study results, when Group I and Group II’ s ALT and AST values were compared in serum and CAT, SOD, Gpx in tissue samples, belonging to Group II’ s serum ALT and AST value and SOD, Gpx activity increased and CAT activity decreased in liver tissue. While Group III and IV’ s SOD and Gpx activities decreased, CAT activity increased compared to Group II. Although histopathologically, in Group II the liver tissue was shown that intense vakuolization, advenced necrozis, intense nuclear infiltrasyon and congestion, this findings was not found in Group IV. Biochemical analyzes have supported by histological findings of our experimental study.
The results of this study have demonstrated that geraniol (100 mg/kg i.p.) prevents distant organ injury because of renal I/R injury.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2018-07-09T07:48:29Z
No. of bitstreams: 1
10144536.pdf.pdf: 2949599 bytes, checksum: 6a42f1d2ec5fe208717e56df7e4ad11f (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2019-01-30T08:19:14Z (GMT) No. of bitstreams: 1
10144536.pdf.pdf: 2949599 bytes, checksum: 6a42f1d2ec5fe208717e56df7e4ad11f (MD5)
Made available in DSpace on 2019-01-30T08:19:14Z (GMT). No. of bitstreams: 1
10144536.pdf.pdf: 2949599 bytes, checksum: 6a42f1d2ec5fe208717e56df7e4ad11f (MD5)
Previous issue date: 2017-04
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Sıçan
İskemi/Reperfüzyon
Uzak Organ
Karaciğer
Serbest Radikal
Antioksidan
Geraniol
Rat
Ischemia/Reperfusion
Remote Organ
Liver
Free Radical
Antioxidant
Sıçanlarda kısa süreli renal iskemi / reperfüzyon’a uzak doku hasarına karşı geraniol’ün koruycu etkisi
masterThesis
TEXT
10144536.pdf.pdf.txt
10144536.pdf.pdf.txt
text/plain
151400
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1639/3/10144536.pdf.pdf.txt
42f39cbf3baab87c3962d8aba374a9f7
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1639/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10144536.pdf.pdf
10144536.pdf.pdf
application/pdf
2949599
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1639/1/10144536.pdf.pdf
6a42f1d2ec5fe208717e56df7e4ad11f
MD5
1
11684/1639
oai:openaccess.ogu.edu.tr:11684/1639
2019-01-31 03:07:12.421
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1612
2019-01-31T01:07:32Z
com_11684_15
com_11684_2
col_11684_86
Olgun, Murat
Sönmez, Ali Cevat
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji
2019-01-30T08:15:50Z
2019-01-30T08:15:50Z
2017-10
2017
http://hdl.handle.net/11684/1612
Bu araştırma; 2012-2013 ve 2013-2014 ürün yıllarında Eskişehir’de Geçit Kuşağı Tarımsal Araştırma Enstitüsü deneme arazilerinde sulu ve kıraç koşullarda yürütülmüştür. Denemede dört farklı ekim sıklığı (350, 500, 650 ve 800 tohum/m²) uygulamasının altı ekmeklik buğday (Triticum aestivum L.) çeşidinin (Alpu 01, Atay 85, Bezostaya 1, Harmankaya 99, Sönmez 01 ve Sultan 95) verim, verim unsurları, kalite ve bazı fizyolojik özellikleri üzerine etkilerinin tespit edilmesi amaçlanmıştır.
Hem kıraç hemde sulu koşullarda Bezostaja 1 kalite yönünden Harmankaya 99 ise tane verim ve verim unsurları yönünden yüksek performans gösteren çeşitler olarak belirlenmiştir. Diğer taraftan kıraç koşullarda başak uzunluğu, bin tane ağırlığı, başakta tane sayısı ve ağırlığı, hasat indeksi, bitki boyu, bayrak yaprak alanı, başaklanma gün sayısı, bayrak yaprak klorofil içeriği ve tane protein oranı parametrelerinde; sulu koşullarda ise başak uzunluğu, bin tane ağırlığı, başakta tane sayısı ve ağırlığı, hasat indeksi, başaklanma gün sayısı, bayrak yaprak klorofil içeriği, hektolitre ağırlığı ve tane protein oranı parametrelerinde ekim sıklıkları arttıkça elde edilen değerlerde azalma meydana gelmiş olup en yüksek değerler 350 tohum/m² ekim sıklığı uygulamasından alınırken, en düşük değerler 800 tohum/m² uygulamasından elde edilmiştir. Kıraç koşullarda en yüksek tane verimi 650 tohum/m² den alınırken sulu koşullarda bu değer 500 tohum/m² den elde edilmiştir. Yine kıraç ve sulu koşulların her ikisinde de ekim sıklığı arttıkça tane veriminde kuadratik artışlar görülmüş olup optimum ekim sıklığı kıraç koşullarda 625 tohum/m², sulu koşullarda ise 510 tohum/m² olarak belirlenmiştir.
This study was carried out in Transitional Zone Agricultural Research Institute during crop growing seasons at 2012-2013 and 2013-2014. The aim of the reseach was to determine the effects of the application of four different sowing densities (350, 500, 650 and 800 seed/m²) on six bread wheat (Triticum aestivum L.) cultivars (Alpu 01, Atay 85, Bezostaya 1, Harmankaya 99, Sönmez 01 and Sultan 95) in rainfed and irrigated conditions for yield, yield components, some quality and physiological traits.
In this study Harmankaya 99 and Bezostaja 1 cultivars gave high performance for grain yield, yield components, physiological traits and quality in both rainfed and irrigated conditions. On the other hand, in rainfed conditions spike length, thousand grain weight, grain number and weight in spike, harvest index, plant height, flag leaf area, number of days of heading, flag leaf chlorophyll content and grain protein content; in irrigated conditions spike length, thousand kernel weight, grain number and weight in spike, harvest index, number of days of heading, flag leaf chlorophyll content, hectoliter weight and grain protein content values were decreased with increasing seeding rates. The highest values were given from 350 seeds/m² seeding rates while the lowest ones belonged to 800 seeds/m² seding rates. Quadratic increases were occured on yield with increasing sowing rate in both irrigated and rainfed conditions. Once the highest grain yields in irrigated and rainfed conditions were taken from 650 seeds/m² and 500 seeds/m² respectively; optimum seeding rates were determined as 625 seeds/m² in rainfed conditions and 510 seeds/m² in irrigated conditions.
Submitted by Kaner Ulusoy (kaneru26@gmail.com) on 2018-07-27T10:41:28Z
No. of bitstreams: 1
10170121.pdf: 4568178 bytes, checksum: dd283570c69ae8f4d14f7bf2b34bdeee (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2019-01-30T08:15:50Z (GMT) No. of bitstreams: 1
10170121.pdf: 4568178 bytes, checksum: dd283570c69ae8f4d14f7bf2b34bdeee (MD5)
Made available in DSpace on 2019-01-30T08:15:50Z (GMT). No. of bitstreams: 1
10170121.pdf: 4568178 bytes, checksum: dd283570c69ae8f4d14f7bf2b34bdeee (MD5)
Previous issue date: 2017-10
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/embargoedAccess
Ekmeklik Buğday
Ekim Sıklığı
Tane Verim
Ekmeklik Kalite
Bread Wheat
Seeding Density
Grain Yield
Bread Quality
Sulu ve kuru koşullarda yetiştirilen ekmeklik buğday çeşitlerinde farklı ekim sıklıklarının bazı fizyolojik, verim ve kalite özelliklerine etkisinin belirlenmesi
doctoralThesis
TEXT
10170121.pdf.txt
10170121.pdf.txt
text/plain
437757
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1612/3/10170121.pdf.txt
f1515ea6d84e7da78e43f4e5b9a02a6e
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1612/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
10170121.pdf
10170121.pdf
application/pdf
4568178
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1612/1/10170121.pdf
dd283570c69ae8f4d14f7bf2b34bdeee
MD5
1
11684/1612
oai:openaccess.ogu.edu.tr:11684/1612
2019-01-31 03:07:32.361
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1695
2019-06-22T00:00:31Z
com_11684_15
com_11684_2
col_11684_86
Canbek, Mediha
Durmuş, Başak
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2019-06-21T05:47:18Z
2019-06-21T05:47:18Z
2011-02
2011-02
Durmuş, B. (2011). Renal Ġskemi/Reperfüzyon Sonucu OluĢan Uzak Doku Hasarına KarĢı Gallik Asidin Olası Koruyucu Etkisi. (Yüksek lisans tezi). Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü, Eskişehir.
http://hdl.handle.net/11684/1695
Bu tez çalışmasında; sıçanlarda, deneysel böbrek iskemi/reperfüzyon (İ/R) hasarından dolayı karaciğerde oluşan oksidatif strese karşı gallik asitin olası koruyucu etkileri araştırıldı. 35 adet erkek Spraque dawley sıçan rasgele seçilerek; Grup I (Kontrol), Grup II (İ/R), Grup III (İ/R + 50mg.kg-1 gallik asit), Grup IV (İ/R + 100mg.kg-1 gallik asit) ve Grup V (İ/R + 200mg.kg-1 gallik asit) oluşturuldu. Ksilazin (10 mg.kg-1) ve ketamin (70 mg.kg-1) anestezisi altında Grup I dıĢındaki tüm gruplara sağ böbrek nefroktomisi yapıldı. Sonra Grup II‟ye SF ve Grup III, IV,V‟e de 1 hafta boyunca günde bir kez intraperitonel olarak gallik asit verildi. Ardından bu gruplara 45 dakika iskemi / 6 saat reperfüzyon uygulandı. Deney sonunda tüm gruplardan, kan örnekleri ve karaciğer dokuları alındı. Sonuçlar istatistiksel olarak değerlendirildi. Grup I‟e göre, Grup II‟de serum ALT ve AST değerlerinin ve karaciğer dokusuna ait SOD, CAT, Gpx aktivitelerinin arttığı; Grup III, IV ve V‟ de de CAT, SOD ve Gpx aktivitelerinin benzer olduğu görüldü. Histopatolojik analizlerde ise Grup II karaciğer dokusunda ileri derecede nekroz, yoğun nüklear infiltrasyon, vakuolizasyon ve yoğun kanama, gözlenmiĢ olup Grup V‟te bu bulgulara rastlanmadı. İmmunhistokimyasal olarak, Grup II‟de iNOS reaksiyonu çok yoğun iken, Grup V‟te bu yoğunluğun oluĢmadığı saptandı. Grup V‟teki histolojik ve biyokimyasal değişikler bu grupta İ/R hasarının büyük ölçüde önlendiğini gösterdi.
In this thesis was to investigate that possible protective effects of gallic acid in liver injury due to experimental renal ischemia-reperfusion (I/R) injury in rats.
A total of 35 male Sprague dawley rats were divided into 5 groups by randomized selection (n=7). Five groups were designed that Group I (Control), Group II (I/R), Group III (I/R+ 50 mg.kg-1 gallic acid), Group IV (I/R+ 100 mg.kg-1 gallic acid) and Group V (I/R+ 200 mg.kg-1 gallic acid). Right nephrectomies were performed under xylazine (10 mg.kg-1) and ketamine (70 mg.kg-1) anesthesia in all group rats except Group I. Substances were given intraperitoneal in Group II, III, IV and V rats every day along a week and after that 45 minutes of Ischemia and 6 hours of Reperfusion were applied to these groups rats. At the end of the experiment, blood samples and liver tissues were quickly taken from all of the group. All analysis results were evaluated statistically. Due to I/R injury in Group II, serum ALT and AST statistically increased levels. Belonging to Group II‟s the liver tissue SOD, CAT, Gpx isoenzyme activity was increased compared to Group I. Histopathologically, in Group II‟s the liver tissue was shown that infiltration, intense congestion, advanced necrozis and intense vakuolization. Although immunohistochemical evaluation in Group II at iNOS reaction was determined very density, this density was not found in Group V. Histopathological and biochemical changes in Group V show that distant organ injury due to renal I/R injury were prevented.
The results of this study have demonstrated that gallic acid (200 mg.kg-1 i.p.) prevents distant organ injury because of renal I/R injury.
Submitted by Meral Cem (mcem@ogu.edu.tr) on 2019-03-28T06:36:32Z
No. of bitstreams: 1
394810.pdf: 1787169 bytes, checksum: b5cc26b86e4988a9db482a399a561cfd (MD5)
Approved for entry into archive by Meral Cem (mcem@ogu.edu.tr) on 2019-06-21T05:47:18Z (GMT) No. of bitstreams: 1
394810.pdf: 1787169 bytes, checksum: b5cc26b86e4988a9db482a399a561cfd (MD5)
Made available in DSpace on 2019-06-21T05:47:18Z (GMT). No. of bitstreams: 1
394810.pdf: 1787169 bytes, checksum: b5cc26b86e4988a9db482a399a561cfd (MD5)
Previous issue date: 2011-02
tur
info:eu-repo/semantics/openAccess
İskemi/Reperfüzyon
Gallik asit
Karaciğer
Uzak organ
Antioksidan
Serbest radikal
Ischemia/Reperfusion
Gallic acid
Liver
Remote organ
Antioxidant
Free radical
Renal iskemi/reperfüzyon sonucu oluşan uzak doku hasarına karşı gallik asidin olası koruyucu etkisi
masterThesis
TEXT
394810.pdf.txt
394810.pdf.txt
text/plain
132891
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1695/3/394810.pdf.txt
bb60f6f79f4d2aa75d238c56aa8569b0
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1695/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
394810.pdf
394810.pdf
application/pdf
1787169
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1695/1/394810.pdf
b5cc26b86e4988a9db482a399a561cfd
MD5
1
11684/1695
oai:openaccess.ogu.edu.tr:11684/1695
2019-06-22 03:00:31.505
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1683
2019-06-22T00:00:57Z
com_11684_15
com_11684_2
col_11684_86
Ocak, Atila
Şentürk, Sibel
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2019-06-21T05:44:53Z
2019-06-21T05:44:53Z
2011-01
2011-01
Şentürk, S. (2011). Porsuk Çayı Kanal 1 Kolunda Bulunan Farklı Hidrofit Türlerde Makro ve Mikro Element Seviyelerinin İncelenmesi. (Yüksek lisans tezi). Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü, Eskişehir.
http://hdl.handle.net/11684/1683
Bu çalışmada Porsuk Çayı’na dökülen Kanal 1 suyundaki bazı hidrofit bitkilerinin (Cynodon dactylon L. Pers var. dactylon, Polygonum lapathifolium L., Sparganium erectum L. subsp. erectum, Veronica anagallis-aquatica L., Ceratophyllum demersum L.) çeşitli organlarındaki makro ve mikro elementlerin birikimleri (Al, Ca, Fe, K, Mg, Na, P, S, Si, Zn, B, Cd, Cr, Cu, Hg, Mn, Ni, Pb, Se) araştırılmıştır. Elde edilen sonuçlar değerlendirildiğinde, Porsuk çayına dökülen Kanal 1 suyunda izin verilebilir sınır değerlerin üzerinde bir ağır metal kirliliğinin olduğu saptanmıştır. Yapılan analizler sonucu Porsuk Çayının 1. Kanal lokalitesinden alınan su örnekleri Su Kirliliği Kontrolü Yönetmeliği’ne göre değerlendirildiğinde; içerdiği Cd, Al ve Na miktarları açısından IV. sınıf (çok kirlenmiş su), Hg mikarı açısından III. sınıf (kirli su), Cu ve Fe miktarı açısından II. sınıf (az kirlenmiş su) ve Pb, Cr, Ni, Zn, Mn, B ve S miktarı açısından ise I. sınıf (yüksek kaliteli su) su kalitesine sahip olduğu saptanmıştır. Araştırma bulguları ışığında Kanal 1’den alınan sediment örnekleri için Cr ve Ni seviyeleri kabul edilebilir sınır değerlerin üzerindedir ve S. erectum subsp. erectum L.’nin kökünde Fe, Cr, Ni ve Pb, V. anagallis-aquatica L.’nin kök ve çiçek bölgesinde Fe, Zn, Ag, Cr ve Pb , C. demersum L.’nin kök ve gövde bölgesinde Fe, Cr, Ni ve Pb , C. dactylon L.’nin kök ve yaprak bölgesinde Fe, Cr, Mn, Ni ve Pb ve P. lapathifolium L.’nin kök ve yaprak bölgesinde Fe, Cr, Ni ve Pb değerleri için hiperakümülatörlük özellik gösterdikleri saptanmıştır. Böylece S. erectum subsp. erectum L., P. lapathifolium L., C. dactylon L., V. anagallis-aquatica L. ve C. demersum L. bitkilerinin ağır metalleri absorbsiyon yeteneklerinden dolayı iyi birer hiperakümülatör bitki oldukları ve gelecekte çalışma alanında kurulması söz konusu olabilecek yapay sulak alanlarda kirli su ortamlarının temizlenmesinde bu bitkilerinin kullanılması su kalitesinin arttırılması açısından pozitif sonuçlar doğuracaktır.
In this study, makro and mikroelement (Al, Ca, Fe, K, Mg, Na, P, S, Si, Zn, B, Cd, Cr, Cu, Hg, Mn, Ni, Pb, Se) accumulation of some parts of the hydrophyts (Cynodon dactylon L. Pers var. dactylon, Polygonum lapathifolium L., Sparganium erectum L. subsp. erectum, Veronica anagallis-aquatica L., Ceratophyllum demersum L.) in Channel 1 of Porsuk stream were investigated. It was determined that, Channel 1 of Porsuk Stream has more than permissible pollution level because of high heavy metal value. As a results of analysis, water samples are IV. class (very polluted water) because of including Cd, Al and Na; III. class (polluted water) because of including Hg; II. class (low polluted water) because of including Cu and Fe and I. class (non-polluted water) because of including Pb, Cr, Ni, Zn, Mn, B, S according to the evaluation of Water Pollution Control Regulations. The findings of the present study Cr and Ni levels of sediment samples in Canal 1 are more than permissible level and Fe, Cr, Ni and Pb was found in root of S. erectum subsp. erectum L. ; Fe, Zn, Ag, Cr and Pb was found in root and flower of V. anagallisaquatica L. ; Fe, Cr, Ni and Pb was found in root and body of C. demersum L.; Fe, Cr, Mn, Ni and Pb was found in root and leaf of C. dactylon L.; Fe, Cr, Ni and Pb was found in root and leaf of P. lapathifolium L. hyperaccumulator feature was determined for these plants. S. erectum subsp. erectum L. , P. lapathifolium L., C. dactylon L., V. anagallisaquatica L. and C. demersum L.are acceptable hyperaccumulator plant due to heavy metal absorption capacity. These plants are used to clean polluted waters and improve the quality of water in terms of positive consequences establishment of constructed wetlands that may be incurred in the future.
Submitted by Meral Cem (mcem@ogu.edu.tr) on 2019-03-28T08:18:41Z
No. of bitstreams: 1
397100.pdf: 2483599 bytes, checksum: 90fd872341ac6c960cd3eb517faf2478 (MD5)
Approved for entry into archive by Meral Cem (mcem@ogu.edu.tr) on 2019-06-21T05:44:53Z (GMT) No. of bitstreams: 1
397100.pdf: 2483599 bytes, checksum: 90fd872341ac6c960cd3eb517faf2478 (MD5)
Made available in DSpace on 2019-06-21T05:44:53Z (GMT). No. of bitstreams: 1
397100.pdf: 2483599 bytes, checksum: 90fd872341ac6c960cd3eb517faf2478 (MD5)
Previous issue date: 2011-01
tur
Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Ağır metal
Eskişehir
Hiperakmülatör bitki
Porsuk çayı
Yapay sulak alan
Heavy metal
Hyperaccumulator plant
Porsuk stream
Constructed wetland
Porsuk çayı kanal 1 kolunda bulunan farklı hidrofit türlerde makro ve mikro element seviyelerinin incelenmesi
masterThesis
TEXT
397100.pdf.txt
397100.pdf.txt
text/plain
140046
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1683/3/397100.pdf.txt
d74744d413f83c81f4b02227dd27e749
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1683/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
397100.pdf
397100.pdf
application/pdf
2483599
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1683/1/397100.pdf
90fd872341ac6c960cd3eb517faf2478
MD5
1
11684/1683
oai:openaccess.ogu.edu.tr:11684/1683
2019-06-22 03:00:57.908
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1687
2019-06-22T00:01:06Z
com_11684_15
com_11684_2
col_11684_86
Kunduhoğlu, Buket
Ütkün, Saniye
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2019-06-21T05:45:46Z
2019-06-21T05:45:46Z
2011-01
2011-01
Ütkün, S. (2011). Portakal Suyunda Escherichia coli O157:H7 ve Listeria Monocytogenes İnaktivasyonunda Ultrasound ve Bazı Uçucu Yağların Kombine Kullanımı. (Yüksek lisans tezi). Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü, Eskişehir.
http://hdl.handle.net/11684/1687
Son on yılda yüksek besinsel ve duyusal özellik sunan güvenli ve dayanıklı gıda ürünlerine olan tüketici talebini karşılayabilmek amacıyla minimal işleme önemli bir modern gıda koruma metodu olarak kabul görmüştür. Meyve suların minimal işlemesi için araştırılan ısısal olmayan tekniklerler arasında özellikle düşük ısıda uygulanan “soniaksyon” araştırmacıların ve sanayinin artarak ilgisini çeker hale gelmiştir. Ancak ısısal olmayan yöntemler bozulma etmenlerinin ve patojenlerin azaltılmasında ilk engel olarak etkili iken, işlem sonrasında canlı kalan hücrelerin depolama süresince büyümesinin engellenmesi ve/veya kontrol edilmesinde antimikrobiyaller daha etkilidir. Artan tüketici bilinci ve sentetik katkı maddelerine olan endişelerden dolayı doğal katkı maddeleri ile korunmuş gıdalar populer olmuştur. Bu veriler ışığında bu çalışmada, ultrasound (20 kHz, 99.2 µm yoğunluğunda; 5 dk), farklı ortam sıcaklıkları (4, 25, 35, 40, 45 ve 50 ⁰C) ve uçucu yağların (EO: 200, 400 ve 800 µl/L; Eugenol, Linalool ve Cinnamaldehyde) birlikte kullanımlarının portakal suyundaki Escherichia coli O157:H7 ve Listeria monocytogenes gelişiminlerine etkileri araştırılmıştır. Ġnaktivasyon denemeleri, 45 ⁰C’ de ultrasoundun tek başına ve EOlarla beraber kullanımı ile E. coli O157:H7 hücre sayısında; sırasıyla 1,32 log birim (>5 dk), 4,48 (30 sn’de; Eugenol), 4,25 (30 sn’de; Linalool) ve 4,2 (4 dk’da; Cinnamaldehyde) log birimlik bir azalma meydana geldiğini göstermiştir. Ultrasoundun tek başına (45 ⁰C) ve EOlarla (800 µl/L) birlikte kullanımıyla, E. coli O157:H7 için D değeri sırasıyla 2,78 ve 1,66 dk (kullanılan üç EOın ortalaması) olarak belirlenmiştir. Ultrasoundun tek başına (45 ⁰C) ve Eugenol, Linalool ve Cinnamaldehyde ile birlikte kullanımı L. monocytogenes için de benzer mikrobiyal inaktivasyon sonuçları göstererek, sırasıyla 0,92 log birim (5 dk) ve 4,63 (2 dk), 4,38 (3 dk), 2,94 (5 dk) log birimlik azalmalar sağlamıştır. Sonikasyon 50 ⁰C’de yapıldığında L. monocytogenes inaktivasyonu artmış, ultrasoundun tek başına ve EOlarla (800 µl/L) beraber kullanımında D değerleri sırasıyla 3,44 dk ve 1,10 dk olarak belirlenmiştir. Ayrıca ultrasound ve EO ile işlem görmüş portakal sularının 4 ve 25 ⁰C’ de 2 ay depolaması sonrasında hiçbir mikrobiyal gelişim gözlenmemiştir.
During the last decade minimal processing has been well established as an essential strategy for modern food preservation in order to meet growing consumer demands for safe and durable food products offering high nutritional and sensory value. Among the non-thermal techniques investigated for minimal processing of fruit juices, “sonication” has attracted increasing interest by researchers and industry, particularly when applied with mild heat. But the non-thermal approach acts as an initial hurdle in reducing the spoiling and pathogen microflora, while the antimicrobials are effective hurdles within the storage time, as they inhibit and/or control the growth of surviving cells. Because of greater consumer awareness and concern about synthetic chemical additives, foods preserved with natural additives become popular. In the light of these data, in this study, the influence of combined effects of ultrasound (20 kHz, 99.2 µm intensity; 5 min), different heat treatment (4, 25, 35, 40, 45 and 50 °C) and essential oils (EOs; eugenol, linalool and cinnamaldeyde: at 200, 400 and 800 µl/L) on the inactivation and potential subsequent growth of Escherichia coli O157:H7 and Listeria monocytogenes in orange juice was investigated. Inactivation experiments showed that sonication alone and combined with EOs (800 µl/L) increased E. coli O157:H7 cell destruction by 1,32 log cycles (in >5 min) and 4,38 (in 30 sec; eugenol), 4,25 (in 30 sec; linalool) and 4,2 log cycles (in 4 min; cinnamaldeyde) at 45°C in orange juice, respectively. When sonication applied alone (at 45°C) and combined with EOs (800 µl/L), D value of E. coli O157:H7decreased from 2,78 min. to 1,66 min. (mean of three EOs) respectively. Similar microbial inactivation was obtained for L. monocytogenes by ultrasonic treatment alone (at 45°C) or combined with each eugenol, linalool and cinnamaldeyde (800 µl/L); 0,92 log cycles (in >5 min) and 4,63 (in 2 min), 4,38 (in 3 min) and 2,94 (in >5 min) log cycles, respectively. When sonication applied at 50 °C for L. monocytogenes, inactivation level was increased and, D values were determined as 3,44 min and 1,10 min for ultrasonic treatment alone and combined with EOs (800 µl/L), respectively. Additionally, there was not any microbial growth in orange juice samples treated with ultrasound combined with EOs (800 µl/L), during 2 months of the storage at 4 and 25 °C.
Submitted by Meral Cem (mcem@ogu.edu.tr) on 2019-03-28T08:29:30Z
No. of bitstreams: 1
398244.pdf: 4022467 bytes, checksum: 8f04f58e363a58b820ce7dafc18bac3b (MD5)
Approved for entry into archive by Meral Cem (mcem@ogu.edu.tr) on 2019-06-21T05:45:46Z (GMT) No. of bitstreams: 1
398244.pdf: 4022467 bytes, checksum: 8f04f58e363a58b820ce7dafc18bac3b (MD5)
Made available in DSpace on 2019-06-21T05:45:46Z (GMT). No. of bitstreams: 1
398244.pdf: 4022467 bytes, checksum: 8f04f58e363a58b820ce7dafc18bac3b (MD5)
Previous issue date: 2011-01
tur
Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Ultrasound
Uçucu yağlar
Portakal suyu
E. coli O157:H7
L. monocytogenes
Essential oils
Orange juice
Portakal suyunda escherichia coli O157:H7 ve listeria monocytogenes inaktivasyonunda ultrasound ve bazı uçucu yağların kombine kullanımı
masterThesis
TEXT
398244.pdf.txt
398244.pdf.txt
text/plain
235262
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1687/3/398244.pdf.txt
680e026ca85a75f1be29457109ca3547
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1687/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
398244.pdf
398244.pdf
application/pdf
4022467
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1687/1/398244.pdf
8f04f58e363a58b820ce7dafc18bac3b
MD5
1
11684/1687
oai:openaccess.ogu.edu.tr:11684/1687
2019-06-22 03:01:06.713
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1684
2019-06-22T00:00:58Z
com_11684_15
com_11684_2
col_11684_86
Yamaç, Mustafa
Atlı, Burcu
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2019-06-21T05:45:05Z
2019-06-21T05:45:05Z
2011-03
2011-03
Atlı, B. (2011). Fungal Fermentasyonla Statin Üretiminin Optimizasyonu. (Yüksek lisans tezi). Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü, Eskişehir.
http://hdl.handle.net/11684/1684
Bu çalışmada bazı makrofungusların 3-hidroksi-3-metil-glutaril Ko A redüktaz inhibitörü (lovastatin) üretimi taranmıştır. Taranan 136 izolattan 6 tanesinin lovastatin ürettiği belirlenmiştir. Lovastatin ürettiği belirlenen izolatlar arasından en yüksek üretime sahip izolatlar (OBCC 2002 ve Pleurotus ostreatus OBCC 1031) seçilerek lovastatin üretiminin optimizasyonları yapılmıştır. Pleurotus ostreatus OBCC 1031 ve OBCC 2002 izolatlarından lovastatin üretimi için katı faz ve derin kültür fermentasyonlarında Plackett-Burman istatiksel tasarımı ile lovastatin üretiminde en etkin bileşen/koşullar seçilerek cevap yüzey metoduyla önemli parametrelerin seviyelerinin optimizasyonu yapılmıştır. Bu çalışmada Plackett-Burman deney tasarımı analizi sonucunda katı faz fermentasyonunda lovastatin üretimini artırıcı yönde etkileyen en etkili bileşenlerin OBCC 2002 izolatı için arpa, partikül boyutu; OBCC 1031 izolatı için ise arpa, yeast ekstrakt ve partikül boyutu olduğu belirlenmiştir. Derin kültür fermentasyonunda ise OBCC 2002 izolatı için glikoz, pepton, karıştırma hızı, NaCl ve tiamin, OBCC 1031 izolatının da glikoz, yeast ekstrakt ve karıştırma hızı olduğu belirlenmiştir. En etkili bulunan besiyeri bileşen ve koşulları OBCC 2002 izolatının full faktöriyel deney tasarımıyla optimize edilen katı faz fermentasyonu dışındaki tüm durumlarda Box-Behnken deney tasarımı ile optimize edilmiştir. OBCC 2002 izolatının maksimum lovastatin üretimi (139.45 mg/g), 1-2 mm partikül boyutuna sahip % 70 nemlendirilen 5 gram arpada 28 ˚C’ de 6 günlük katı faz fermentasyonu ile gerçekleşmiştir. Bu değer aynı izolatın derin kültürde elde edilen lovastatin üretimi değerinden 10 kat fazladır. OBCC 1031 izolatının maksimum üretimi (114.82 mg/l) ise 28 ˚C’ de % 3 glikoz, % 0.5-1 yeast ekstrakt besiyeri içeriği ile oluşturulan statik derin kültür fermentasyonu ile gerçekleşmiştir.
In this study, 136 different macrofungi isolates were screened for 3-hydroxy-3methyl-glutaryl Co A reductase inhibitor (lovastatin) production. It was determined that only 6 isolates were able to produce lovastatin, among 136 macrofungi isolates. The highest production of lovastatin among macrofungi was obtained from the extracts of isolate OBCC 2002 and isolate Pleurotus ostreatus OBCC 1031. Plackett–Burman statistical design was used to select to factors that have positive effects on lovastatin production and subsequently optimization of these parameters for production of lovastatin by isolate OBCC 2002 and isolate Pleurotus ostreatus OBCC 1031 was studied by response surface methodology using submerged and solid-state fermentation. In this study, the statistical analysis of Plackett–Burman experimental results showed that glucose, peptone, NaCl, thiamine, agitation speed, barley, and particle size for OBCC 2002; glucose, yeast extract, agitation speed, barley, particle size for P. ostreatus OBCC 1031 are significant components for the lovastatin production. The more significant medium components and culture condition were optimized using of the Box-Behnken design in all situations except for solid state fermentation of OBCC 2002 isolate that was optimized by using a full factorial design. The maximum lovastatin production by isolate OBCC 2002 (139,45 mg/g) was carried out with the solid-state fermentation at 28 ˚C for 6 days by using barley 5 g with 1-2 mm particle size and 70 % humidity. This value was ten times higher than the amount of lovastatin production obtained by the submerged fermentation. For OBCC 1031 isolate, the maximum lovastatin production of 114,82 mg/l was obtained after 6 days of fermentation period in the optimized medium containing, 3 % glucose, 0.5-1 % yeast extract at 28 ˚C and static conditions.
Submitted by Meral Cem (mcem@ogu.edu.tr) on 2019-03-28T08:40:53Z
No. of bitstreams: 1
398212.pdf: 4122201 bytes, checksum: 3257a12b9f8b98fd96fa167160dec4eb (MD5)
Approved for entry into archive by Meral Cem (mcem@ogu.edu.tr) on 2019-06-21T05:45:05Z (GMT) No. of bitstreams: 1
398212.pdf: 4122201 bytes, checksum: 3257a12b9f8b98fd96fa167160dec4eb (MD5)
Made available in DSpace on 2019-06-21T05:45:05Z (GMT). No. of bitstreams: 1
398212.pdf: 4122201 bytes, checksum: 3257a12b9f8b98fd96fa167160dec4eb (MD5)
Previous issue date: 2011-03
tur
Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Makrofungi
Lovastatin
Katı faz fermentasyonu
Plackett-Burman tasarımı
Yüzey cevap metodu
Macrofungi
Lovastatin
Solid-state fermentation
Submerged fermentation
Plackett-Burman design
Response surface methodology
Fungal fermentasyonla statin üretiminin optimizasyonu
masterThesis
TEXT
398212.pdf.txt
398212.pdf.txt
text/plain
179530
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1684/3/398212.pdf.txt
0d4af34c5b6823ad6a829ed7d6f5a98d
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1684/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
398212.pdf
398212.pdf
application/pdf
4122201
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1684/1/398212.pdf
3257a12b9f8b98fd96fa167160dec4eb
MD5
1
11684/1684
oai:openaccess.ogu.edu.tr:11684/1684
2019-06-22 03:00:58.923
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1690
2019-06-22T00:00:29Z
com_11684_15
com_11684_2
col_11684_86
Ayhancı, Adnan
Çetik, Songül
TR 59869
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2019-06-21T05:46:22Z
2019-06-21T05:46:22Z
2011-01
2011-01
Çetik, S. (2011). İltihabi Barsak Hastalığında Likopenin Hematoprotektif Etkileri (Yüksek lisans tezi). Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü, Eskişehir.
http://hdl.handle.net/11684/1690
İltihabi barsak hastalığında (İBH) anemi sık rastlanan bir problemdir. İBH’ de anemi patogenezinde en sık demir eksikliği ve kronik hastalık anemisi görülmektedir. Bu nedenle İBH’ li hastalara antiinflamatuar ilaçların verilmesi ya da antioksidan maddeler kullanılarak hastalığın giderilmesi, demir ve vitamin replasmanı kadar önemlidir. Bu deneysel çalışmada antioksidan ve hücre koruyucu etkileri olduğu bilinen likopenin kolitte gelişen anemiyi önlemede muhtemel koruyucu etkisi test edildi. Çalışmada 112 adet Sprauge dawley ırkı erkek sıçanlar her grupta 7 hayvan olacak şekilde kontrol grubu hariç 15 gruba ayrıldı. Tüm deney gruplarına 0. günde 120 mg/kg TNBS intrarektal olarak verildi ve sıçanlarda akut kolit oluşturuldu. TNBS uygulamasından bir gün sonra i.p. olarak, 40 mg/kg L-NAME, 1 mg/kg zeytinyağı, 5 ve 10 mg/kg likopen dozları zeytinyağında (1:1) hazırlanarak, üç gün süre ile (her gün) verildi. Tüm sıçanlardan eter anestezisi altında intrakardiyak kan örnekleri alınarak eritrosit, lökosit ve trombositler sayıldı ve SPSS 9.0 paket programı ile verilerin istatistiksel analizleri yapıldı. 1. günde eritrosit sayısı TNBS grubu hariç diğer gruplarda düşerken lökosit sayısı inflamasyonu işaret edecek şekilde arttı. Trombosit sayısı ise TNBS grubu hariç diğer tüm gruplarda düştü. 2. günde eritrosit ve trombosit sayıları TNBS grubu hariç diğer tüm gruplarda artarken lökosit sayısı tüm gruplarda düştü. 3. günde günde eritrosit ve trombosit sayıları 10 mg/kg likopen grubu hariç diğer tüm gruplarda arttı. Lökosit sayısı ise 10 mg/kg likopen grubunda artış gösterirken diğer gruplarda 2. gün değerleri ile aynı kaldı. Deneysel akut kolit modelimizde likopenin, hemopoezde ve aneminin önlenmesinde etkili olduğunu söyleyebiliriz ancak ne ölçüde etkili olduğunu söyleyebilmek için kronik kolit modellerinin oluşturulması gerekir.
Anemia is a frequent extra intestinal complication of inflammatory bowel disease (IBD). It is generally a combination of iron deficiency and anemia of chronic disease (ACD). For this reason, prescribing anti-inflammatory drugs or remedying the disease through antioxidant agents is also important, in addition to replacement of iron and vitamins in the treatment of this disease. The present study aims to determine the possible protective effects of lycopene, which is known to have both cell-protective and antioxidative effects, upon anemia that develops in colitis. In the present study, 112 Sprague-dawley male rats were equally divided into 16 groups, one remaining as the control group. All the study groups were intrarectally administered 120 mg/kg of trinitrobenzene sulfonic acid (TNBS), as a result of which experimental colitis was induced. Just one day after TNBS administration, 40 mg/kg of L-NAME, 1 mg/kg of olive oil, 5 and 10 mg/kg of lycopene dissolved in olive oil (1:1) was intraperitoneally given to the rats in the study groups three days in a row. All the rats were sacrificed after being anesthetized with ether in order to their determine erythrocyte, leukocyte and thrombosis numbers via intracardiac blood samples. Subsequently, a statistical analysis of the data obtained was achieved through SPSS 9.0 software package. On the 1st day of the experiment while the number of erythrocytes decreased in all the groups with the exception of the TNBS group, the number of leucocytes showed an increase that was deemed as an indication of inflammation. As to the thrombosis levels, they showed a decrease in all study the groups excepting the TNBS group. On the 2nd day of the experiment, while the number of erythrocytes and thromboses was observed to have increased in all the groups excepting the TNBS group, the number of leucocytes decreased in all the study groups. On the 3rd day of the experiment, the number of erythrocytes and thromboses showed an increase in all the study groups excepting 10 mk/kg Lycopene group, in which the number of leucocytes increased. However, leucocytes in all the other groups remained at the same levels as they were on the 2nd. Based upon the data obtained in this experimental acute colitis model, we can assume that lycopene is effective in hemopoiesis, as well as in preventing anemia. However, in order to be able to determine to what extent lycopene exerts this influence, chronic colitis models should be carried out by further studies.
Submitted by Meral Cem (mcem@ogu.edu.tr) on 2019-04-02T10:30:16Z
No. of bitstreams: 1
394589.pdf: 773623 bytes, checksum: c3d8ad4e4530be15d58790e85389649f (MD5)
Approved for entry into archive by Meral Cem (mcem@ogu.edu.tr) on 2019-06-21T05:46:22Z (GMT) No. of bitstreams: 1
394589.pdf: 773623 bytes, checksum: c3d8ad4e4530be15d58790e85389649f (MD5)
Made available in DSpace on 2019-06-21T05:46:22Z (GMT). No. of bitstreams: 1
394589.pdf: 773623 bytes, checksum: c3d8ad4e4530be15d58790e85389649f (MD5)
Previous issue date: 2011-01
tur
Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
TNBS
Akut Kolit
Hematoksisite
L-NAME
Zeytinyağı
Likopen
Antioksidan
Sitoprotektivite
Rat.
Akut colit, hematoxicite
Olive oil
Lycopene
Antioxidant
Cytoprotectivity
İltihabi bnarsak hastalığında likopenin hematoprotektif etkileri
masterThesis
TEXT
394589.pdf.txt
394589.pdf.txt
text/plain
132089
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1690/3/394589.pdf.txt
ec38e302bbe57c4f4495176fb5480cdc
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1690/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
394589.pdf
394589.pdf
application/pdf
773623
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1690/1/394589.pdf
c3d8ad4e4530be15d58790e85389649f
MD5
1
11684/1690
oai:openaccess.ogu.edu.tr:11684/1690
2019-06-22 03:00:29.901
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1691
2019-06-22T00:00:30Z
com_11684_15
com_11684_2
col_11684_86
Ayhancı, Adnan
Özkal, Bilge
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2019-06-21T05:46:33Z
2019-06-21T05:46:33Z
2011-01
2011-01
Özkal, B. (2011). Likopen’ in Sitoprotektif Etkileri. (Yüksek lisans tezi). Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü, Eskişehir.
http://hdl.handle.net/11684/1691
İltihabi barsak hastalığı (IBD) ile karaciğer hastalıkları arasındaki ilişki uzun zamandan beri bilinmesine rağmen ülseratif kolitte karaciğer hasarının nasıl oluştuğu halen tam olarak bilinmemektedir. Ancak ülseratif kolitte barsak epitelinin geçirgenliğinin arttığı ve bu durumda endotoksin gibi bakteriyel antijenlerin lamina propriaya geçerek portal ven yoluyla karaciğere ulaştığı ve karaciğerde iltihabi bir reaksiyon ile sonuçlandığı düşünülmektedir. Bu çalışmada sıçanlara deneysel olarak 120 mg/kg trinitro benzosülfonik asit (TNBS) verilerek oluşturulan kolitte gelişen oksidatif stres ve olası karaciğer hasarına karşı sentetik bir nitrik oksit sentetaz enzimi (iNOS) inhibitörü olan N-nitro L-arjinin metil ester (L-NAME) ve antioksidan (AO) özellikleri bilinen Likopen’ in ne derece koruyucu etkileri olduğu araştırıldı.
Çalışmada 91 adet 220-250 gr ağırlığında Sprague Dawley ırkı erkek sıçanlar kullanıldı. Sıçanlar her grupta 7 hayvan olacak şekilde kontrol grubu hariç 12 gruba ayrıldı. Kontrol grubuna 1 ml serum fizyolojik intraperitonal (i.p) verildi. Diğer tüm gruplara sıfırıncı günde %50 etenolde çözülerek hazırlanmış 120 mg/kg TNBS intrarektal olarak verilip kolit oluşturuldu. 1. 2. ve 3. gruplar TNBS grupları olarak belirlendi. TNBS uygulamasından 1 gün sonra 4. 5. ve 6. gruptaki hayvanlara LNAME, 7. 8. ve 9. gruptaki hayvanlara 1 mg/kg zeytinyağı, 10. 11 ve 12. gruptaki hayvanlara ise 10 mg/kg Likopen, i.p olarak verildi. Sadece TNBS verilen hayvanlar 1. 2. ve 3. günlerde diğer gruplardaki hayvanlar ise 2. 3. ve 4. günlerde eter ile anestezi edilerek kan ve karaciğer doku örnekleri alındı.
Deneysel sonuçlarımız hem serum AST, ALT ve LDH düzeyleri göz önüne alındığında hem de karaciğer doku örneklerindeki histopatoloji bulguları değerlendirildiğinde Likopen’ in, kolit nedenli karaciğer hasarını önlemede zeytinyağından ve sentetik bir AO olan L-NAME’ den daha yararlı olduğunu ortaya koymuştur. Ayrıca kolitte karaciğer hasarını gidermede Likopen kullanıldığına dair bir litaretüre rastlanılmadı. Bu nedenle çalışmamız, kolit nedenli karaciğer hasarında Likopen’ in koruyucu etkisini araştıran özgün bir çalışmadır.
Although Inflammatory Bowel Disease (IBD) and liver diseases are known to be related, how exactly ulcerative colitis renders damage to the liver is still poorly understood. Nonetheless, permeability of the intestinal epithel tissue is known to increase in ulcerative colitis. Therefore, it is speculated that such bacterial antigens as endotoxin that can move across lamina propria can gain access to the liver by way of the portal vein tract, thus giving rise to an inflammatory reaction.
105 male rats belonging in the species of Sprague Dawley, whose weights varying between 220 and 250, were used in this study. These rats were divided into 12 groups, each consisting of 7 rats, with the exception of the control group. 1ml of serum physiologic was administrated intraperitoneally (i.p) to the rats in the control group, while all the other groups were administrated 120 mg/kg TNBS prepared by dissolving in %50 ethanol through the intrarectal tract on the very first day of the experiment. Groups 1, 2 and 3 were labelled as TNBS groups. 24 hours after the administration of TNBS, rats in groups 4, 5 and 6 were given L-NAME, the ones in groups 7, 8, 9 being given 1ml/kg olive oil. The remaining groups (10, 11 and 12) were given 10 mg/kg of Lycopene i.p those given only TNBS were anaesthetized with ether for blood and liver tissue samples on the first, second and third days of the experiment, while those in the other groups underwent the same application on the second, third and fourth days.
Evaluation of serum AST, ALT and LDH levels, as well as histopathologic findings of the liver tissue, seems to suggest that Lycopene has a protective effect upon liver damage due to colitis, and that Lycopene is more beneficial to preventing oxidative stress than are olive oil and L-NAME, an synthetic antioxidant substance. We could find no published study into the protective effect of Lycopene upon colitisinduced liver damage. Therefore, our study is the first of its kind in that we showed Lycopene to have a protective effect upon colitis-related liver damage.
Submitted by Meral Cem (mcem@ogu.edu.tr) on 2019-04-02T10:40:06Z
No. of bitstreams: 1
393849.pdf: 3635302 bytes, checksum: 860f51c81a9906b624096ddfe9edda66 (MD5)
Approved for entry into archive by Meral Cem (mcem@ogu.edu.tr) on 2019-06-21T05:46:33Z (GMT) No. of bitstreams: 1
393849.pdf: 3635302 bytes, checksum: 860f51c81a9906b624096ddfe9edda66 (MD5)
Made available in DSpace on 2019-06-21T05:46:33Z (GMT). No. of bitstreams: 1
393849.pdf: 3635302 bytes, checksum: 860f51c81a9906b624096ddfe9edda66 (MD5)
Previous issue date: 2011-01
tur
Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
TNBS
Kolit
Karaciğer
Likopen
L-NAME
Hücre koruyucu etki
Sıçan
Colitis
The liver
Lycopene
Cytoprotective effect
Rat
Likopen’in sitoprotektif etkileri
masterThesis
TEXT
393849.pdf.txt
393849.pdf.txt
text/plain
139517
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1691/3/393849.pdf.txt
25de151adabdd7fcf02d3c2bee729ae3
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1691/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
393849.pdf
393849.pdf
application/pdf
3635302
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1691/1/393849.pdf
860f51c81a9906b624096ddfe9edda66
MD5
1
11684/1691
oai:openaccess.ogu.edu.tr:11684/1691
2019-06-22 03:00:30.733
Dspace@ESOGU
openaccess@ogu.edu.tr
REFHSVRJTSBMSVNBTlNJCgpCdSBsaXNhbnPEsSBpbXphbGF5xLFwIGfDtm5kZXJlcmVrLCBnw7ZuZGVyaW5pemkgZMO8bnlhIMOnYXDEsW5kYSBiYXPEsWzEsSBoYWxkZSwgCmVsZWt0cm9uaWsgb3J0YW1kYSB2ZSBoZXJoYW5naSBiYXNrYSBiaXIga2FuYWxsYSB5ZW5pZGVuIG9sdcWfdHVybWFrLCAKw6dldmlyaXNpbmkgeWFwbWFrIChhxZ9hxJ/EsWRhIHRhbsSxbWxhbmTEscSfxLEgw7x6ZXJlKSB2ZS92ZXlhIGRhxJ/EsXRtYWsgacOnaW4gCkVza2nFn2VoaXIgT3NtYW5nYXppIMOcbml2ZXJzaXRlc2nigJluaW4gKEVTT0dVKSDDtnplbCBvbG1heWFuIGhha2xhcsSxbsSxIGthYnVsIGV0bWnFnyBvbHVyc3VudXouCgpFU09HVSwgZ8O2bmRlcmluaXppbiBpw6dlcmnEn2luaSBkZcSfaXN0aXJtZWRlbiBoZXJoYW5naSBiaXIgCm9ydGFtZGEgZmFya2zEsSBiacOnaW1sZXJkZSBrb3J1bWEgYW1hw6dsxLEgb2xhcmFrIMOnZXZpcmViaWxpci4gCsOWdGUgeWFuZGFuIEVTT0dVLCBnw7x2ZW5saWssIHllZGVrbGVtZSB2ZSBrb3J1bWEgYW1hY8SxeWxhIGJ1IGfDtm5kZXJpbmluIApiaXJkZW4gZmF6bGEga29weWFzxLFuxLEgZWxpbmRlIHR1dGFiaWxpci4gCgpHw7ZuZGVyaW5pbiBzaXplIGFpdCBvcmlqaW5hbCBiaXIgw6dhbGnFn21hIG9sZHXEn3VudSB2ZSBidSBsaXNhbnN0YSBiZWxpcnRpbGVuIApoYWtsYXLEsSBrYWJ1bCBldG1lIGhha2vEsW7EsXogb2xkdcSfdW51IGJlbGlydG1pxZ8gb2x1cnN1bnV6LiBBeW7EsSB6YW1hbmRhIGfDtm5kZXJpbml6aW4sIApiaWxkacSfaW5peiBrYWRhcsSxeWxhLCBraW1zZW5pbiDDtnpsdWsgaGFra8SxbsSxIMOnacSfbmVtZWRpxJ9pbmkgZGUgc3VubXXFnyBvbHVyc3VudXouCgpFxJ9lciBnw7ZuZGVyaSB0ZWxpZiBoYWtrxLFuYSBzYWhpcCBvbHVubWF5YW4gYmlyIG1hdGVyeWFsIGnDp2VyaXlvcnNhLCBvIHphbWFuIAp0ZWxpZiBoYWtrxLEgc2FoaWJpbmRlbiBidSBsaXNhbnMgaWNpbiBnZXJla2xpIG9sYW4gRVNPR1UgaGFrbGFyxLFuxLEga2FidWwgZXRtZWsgCmljaW4ga8Sxc8SxdHPEsXogaXppbiBhbGTEscSfxLFuxLF6xLEgdmUgYnUgdGFyeiDDvMOnw7xuY8O8IGtpxZ9pbGVyIHRhcmFmxLFuZGFuIHNhaGlwIG9sdW5hbiAKbWF0ZXJ5YWxsZXJpbiBnw7ZuZGVyaSBpw6dlcmnEn2kgdmV5YSBtZXRuaSBpw6dlcmlzaW5kZSBhw6dpa8OnYSB0YW7EsW1sYW5kxLHEn8SxbsSxIHZlIAprYWJ1bCBlZGlsZGnEn2luaSBzdW5hcnNpbml6LgoKRcSeRVIgR8OWTkRFUsSwIEVTT0dVIERJxZ5JTkRBIEJBxZ5LQSBCxLBSIEtVUlVMVcWeIFRBUkFGSU5EQU4gREVTVEVLTEVORU4gQsSwUiDDh0FMScWeTUFZQSAKREFZQUxJIMSwU0UsIEJVIFRBUlogQklSIEFOTEHFnk1BIFZFWUEgU8OWWkxFxZ5NRU7EsE4gR0VSRUtUxLBSRMSwxJ7EsCBExLDEnkVSIApaT1JVTkxVTFVLTEFSSSBZRVLEsE5FIEdFVMSwUkTEsMSexLBOxLBaxLAgU1VOQVJTSU5JWi4KCkVTT0dVIGlzbWluaXppIGfDtm5kZXJpbmluIHlhemFyxLEgdmV5YSBzYWhpYmkgb2xhcmFrIGHDp8Sxa8OnYSB0YW7EsW1sYXlhY2FrdMSxciB2ZSAKYnUgbGlzYW5zxLFuIGl6aW4gdmVyZGnEn2luaW4gZMSxxZ/EsW5kYSBoZXJoYW5naSBiaXIgZGXEn2nFn2lrbGlrIHlhcG1heWFjYWt0xLFyLgo=
oai:openaccess.ogu.edu.tr:11684/1682
2019-06-22T00:00:44Z
com_11684_15
com_11684_2
col_11684_86
Ocak, Atila
Şentürk, Sibel
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2019-06-21T05:44:37Z
2019-06-21T05:44:37Z
2011-01
2011-01
Şentürk, S. (2011). Porsuk Çayı Kanal 1 Kolunda Bulunan Farklı Hidrofit Türlerde Makro ve Mikro Element Seviyelerinin İncelenmesi. (Yüksek lisans tezi). Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü, Eskişehir.
http://hdl.handle.net/11684/1682
Bu çalışmada Porsuk Çayı’na dökülen Kanal 1 suyundaki bazı hidrofit bitkilerinin (Cynodon dactylon L. Pers var. dactylon, Polygonum lapathifolium L., Sparganium erectum L. subsp. erectum, Veronica anagallis-aquatica L., Ceratophyllum demersum L.) çeşitli organlarındaki makro ve mikro elementlerin birikimleri (Al, Ca, Fe, K, Mg, Na, P, S, Si, Zn, B, Cd, Cr, Cu, Hg, Mn, Ni, Pb, Se) araştırılmıştır. Elde edilen sonuçlar değerlendirildiğinde, Porsuk çayına dökülen Kanal 1 suyunda izin verilebilir sınır değerlerin üzerinde bir ağır metal kirliliğinin olduğu saptanmıştır. Yapılan analizler sonucu Porsuk Çayının 1. Kanal lokalitesinden alınan su örnekleri Su Kirliliği Kontrolü Yönetmeliği’ne göre değerlendirildiğinde; içerdiği Cd, Al ve Na miktarları açısından IV. sınıf (çok kirlenmiş su), Hg mikarı açısından III. sınıf (kirli su), Cu ve Fe miktarı açısından II. sınıf (az kirlenmiş su) ve Pb, Cr, Ni, Zn, Mn, B ve S miktarı açısından ise I. sınıf (yüksek kaliteli su) su kalitesine sahip olduğu saptanmıştır. Araştırma bulguları ışığında Kanal 1’den alınan sediment örnekleri için Cr ve Ni seviyeleri kabul edilebilir sınır değerlerin üzerindedir ve S. erectum subsp. erectum L.’nin kökünde Fe, Cr, Ni ve Pb, V. anagallis-aquatica L.’nin kök ve çiçek bölgesinde Fe, Zn, Ag, Cr ve Pb , C. demersum L.’nin kök ve gövde bölgesinde Fe, Cr, Ni ve Pb , C. dactylon L.’nin kök ve yaprak bölgesinde Fe, Cr, Mn, Ni ve Pb ve P. lapathifolium L.’nin kök ve yaprak bölgesinde Fe, Cr, Ni ve Pb değerleri için hiperakümülatörlük özellik gösterdikleri saptanmıştır. Böylece S. erectum subsp. erectum L., P. lapathifolium L., C. dactylon L., V. anagallis-aquatica L. ve C. demersum L. bitkilerinin ağır metalleri absorbsiyon yeteneklerinden dolayı iyi birer hiperakümülatör bitki oldukları ve gelecekte çalışma alanında kurulması söz konusu olabilecek yapay sulak alanlarda kirli su ortamlarının temizlenmesinde bu bitkilerinin kullanılması su kalitesinin arttırılması açısından pozitif sonuçlar doğuracaktır.
In this study, makro and mikroelement (Al, Ca, Fe, K, Mg, Na, P, S, Si, Zn, B, Cd, Cr, Cu, Hg, Mn, Ni, Pb, Se) accumulation of some parts of the hydrophyts (Cynodon dactylon L. Pers var. dactylon, Polygonum lapathifolium L., Sparganium erectum L. subsp. erectum, Veronica anagallis-aquatica L., Ceratophyllum demersum L.) in Channel 1 of Porsuk stream were investigated. It was determined that, Channel 1 of Porsuk Stream has more than permissible pollution level because of high heavy metal value. As a results of analysis, water samples are IV. class (very polluted water) because of including Cd, Al and Na; III. class (polluted water) because of including Hg; II. class (low polluted water) because of including Cu and Fe and I. class (non-polluted water) because of including Pb, Cr, Ni, Zn, Mn, B, S according to the evaluation of Water Pollution Control Regulations. The findings of the present study Cr and Ni levels of sediment samples in Canal 1 are more than permissible level and Fe, Cr, Ni and Pb was found in root of S. erectum subsp. erectum L. ; Fe, Zn, Ag, Cr and Pb was found in root and flower of V. anagallisaquatica L. ; Fe, Cr, Ni and Pb was found in root and body of C. demersum L.; Fe, Cr, Mn, Ni and Pb was found in root and leaf of C. dactylon L.; Fe, Cr, Ni and Pb was found in root and leaf of P. lapathifolium L. hyperaccumulator feature was determined for these plants. S. erectum subsp. erectum L. , P. lapathifolium L., C. dactylon L., V. anagallisaquatica L. and C. demersum L.are acceptable hyperaccumulator plant due to heavy metal absorption capacity. These plants are used to clean polluted waters and improve the quality of water in terms of positive consequences establishment of constructed wetlands that may be incurred in the future.
Submitted by Meral Cem (mcem@ogu.edu.tr) on 2019-04-03T06:02:39Z
No. of bitstreams: 1
397100.pdf: 2483599 bytes, checksum: 90fd872341ac6c960cd3eb517faf2478 (MD5)
Approved for entry into archive by Meral Cem (mcem@ogu.edu.tr) on 2019-06-21T05:44:37Z (GMT) No. of bitstreams: 1
397100.pdf: 2483599 bytes, checksum: 90fd872341ac6c960cd3eb517faf2478 (MD5)
Made available in DSpace on 2019-06-21T05:44:37Z (GMT). No. of bitstreams: 1
397100.pdf: 2483599 bytes, checksum: 90fd872341ac6c960cd3eb517faf2478 (MD5)
Previous issue date: 2011-01
tur
Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Ağır metal
Hiperakmülatör bitki
Eskişehir
Porsuk çayı
Yapay sulak alan
Heavy metal
Hyperaccumulator plant
Porsuk stream
Constructed wetland
Porsuk çayı kanal 1 kolunda bulunan farklı hidrofit türlerde makro ve mikro element seviyelerinin incelenmesi
masterThesis
TEXT
397100.pdf.txt
397100.pdf.txt
text/plain
140046
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1682/3/397100.pdf.txt
d74744d413f83c81f4b02227dd27e749
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1682/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
397100.pdf
397100.pdf
application/pdf
2483599
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1682/1/397100.pdf
90fd872341ac6c960cd3eb517faf2478
MD5
1
11684/1682
oai:openaccess.ogu.edu.tr:11684/1682
2019-06-22 03:00:44.403
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1675
2019-06-22T00:01:10Z
com_11684_15
com_11684_2
col_11684_86
Ocak, Atila
Sayarer, Melike
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2019-06-21T05:40:59Z
2019-06-21T05:40:59Z
2010-10
2010-10
Sayarer, M. (2010). Eskişehir Hekimdağ (Bozdağ) Florası’na Katkılar. (Yüksek lisans tezi). Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü, Eskişehir.
http://hdl.handle.net/11684/1675
Bu çalışma enlem ve boylam dereceleri dikkate alınarak hazırlanan Davis’ in grid kare sistemine göre B3 karesinde yer alan Hekimdağ (Bozdağ) florasını kapsamaktadır. Hekimdağ (Bozdağ), Eskişehir ilinin kuzeyinde yer almaktadır. Çalışma alanı 803 - 1394 m yükseklikler arasındadır. Çalışma alanına ait bitkilerin belirlenmesi için arazi çalışmaları 2009 - 2010 yılları arasında yapılmıştır. Araştırma alanından toplanan ve gözlemlenen 420 bitki örneğinin teşhis edilmesi
sonucunda 50 familyaya ait 176 cins ve bu cinslere ait 272 tür ve tür altı takson tespit edilmiştir. Bunlardan 16 takson B3 karesi için yeni kayıttır. Endemizm oranı % 10.33’tür. Taksonların fitocoğrafik bölgelere göre dağılımı; İran - Turan elementleri % 12.54, Avrupa - Sibirya elementleri % 12.54, Akdeniz elementleri % 9.60 şeklindedir. Araştırma alanında, içerdiği tür sayısına göre en büyük 5 familya sırasıyla Asteraceae 44 (% 16.20), Fabaceae 32 (% 11.80), Brassicaceae 21 (% 7.72), Lamiaceae 18 (% 6.61), Rosaceae 17 (% .30)’dir. Araştırma alanında en fazla tür ve türaltı takson içeren ilk 5 cins ise sırasıyla Astragalus 7 (% 2.60), Trifolium 6 (% 2.20), Centaurea 6 (% 2.20), Crocus 4 (%
1.50), Gagea 4 (% 1.50)’dir.
This study concerns the flora of the Hekimdag (Bozdag). The research area, according
to Grid Square System of Davis (1965) which has been established by considering the latitude and longitude degrees is in the B3 square. Hekimdag (Bozdag) is around the north side of the Eskisehir. The height of the research area is between 803 m - 1394 m The excursion fort the research to determine the plants of the research area has been studied in 2009 - 2010. 272 taxa belonging to 176 genera and 50 families were found after the identification of 420 plant specimens collected and observed from the research area.
16 taxa are new records for the B3 grid square. The rate of endemism is 10.33 %.
The distribution of taxa within the phytogeographical regions is as follows: Irano –
Turanian elements 12.54 %, Euro – Siberians 12.54 %, Mediterranean elements 9.60 %.
According to the number of species Asteraceae 44 (% 16.20), Fabaceae 32 (% 11.80),
Brassicaceae 21 (% 7.72), Lamiaceae 18 (% 6.61), Rosaceae 17 (% 6.30) are the largest five families. The largest five genera are Astragalus 7 (% 2.60), Trifolium 6 (% 2.20), Centaurea 6 (% 2.20), Crocus 4 (% 1.50), Gagea 4 (% 1.50).
Submitted by Meral Cem (mcem@ogu.edu.tr) on 2019-04-04T13:31:43Z
No. of bitstreams: 1
388607.pdf: 23096383 bytes, checksum: 8d3e7baf404ed3ffcf55be05bb9ddd8f (MD5)
Approved for entry into archive by Meral Cem (mcem@ogu.edu.tr) on 2019-06-21T05:40:59Z (GMT) No. of bitstreams: 1
388607.pdf: 23096383 bytes, checksum: 8d3e7baf404ed3ffcf55be05bb9ddd8f (MD5)
Made available in DSpace on 2019-06-21T05:40:59Z (GMT). No. of bitstreams: 1
388607.pdf: 23096383 bytes, checksum: 8d3e7baf404ed3ffcf55be05bb9ddd8f (MD5)
Previous issue date: 2010-10
tur
Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Flora
Hekimdağ
Bozdağ
Eskişehir
Türkiye
Turkey
Eskişehir Hekimdağ (Bozdağ) florası’na katkılar
masterThesis
TEXT
388607.pdf.txt
388607.pdf.txt
text/plain
189492
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1675/3/388607.pdf.txt
66eae6405c1f9b0f6966bb5499fafd3e
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1675/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
388607.pdf
388607.pdf
application/pdf
23096383
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1675/1/388607.pdf
8d3e7baf404ed3ffcf55be05bb9ddd8f
MD5
1
11684/1675
oai:openaccess.ogu.edu.tr:11684/1675
2019-06-22 03:01:10.471
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1674
2019-06-22T00:01:13Z
com_11684_15
com_11684_2
col_11684_86
Çabuk, Ahmet
Benli, Eda
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2019-06-21T05:40:48Z
2019-06-21T05:40:48Z
2010-11
2010-11
Benli, E. (2010). Trametes versicolor lakkazı ile 2,4-diklorofenolden klor uzaklaştırılması. (Yüksek lisans tezi). Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü, Eskişehir.
http://hdl.handle.net/11684/1674
Submitted by Meral Cem (mcem@ogu.edu.tr) on 2019-04-05T07:43:02Z
No. of bitstreams: 1
388939.pdf: 19807786 bytes, checksum: aeb280b18669bfe28be7b20a75d88bab (MD5)
Approved for entry into archive by Meral Cem (mcem@ogu.edu.tr) on 2019-06-21T05:40:48Z (GMT) No. of bitstreams: 1
388939.pdf: 19807786 bytes, checksum: aeb280b18669bfe28be7b20a75d88bab (MD5)
Made available in DSpace on 2019-06-21T05:40:48Z (GMT). No. of bitstreams: 1
388939.pdf: 19807786 bytes, checksum: aeb280b18669bfe28be7b20a75d88bab (MD5)
Previous issue date: 2010-11
tur
Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Klor uzaklaştırılması
Basidiyomiset
Lakkaz
Trametes versicolor
2,4-diklorofenol
Dechlorination
Basidiomycetes
Laccase
Trametes versicolor
2,4-dichlorophenol
Trametes versicolor lakkazı ile 2,4-diklorofenolden klor uzaklaştırılması
masterThesis
TEXT
388939.pdf.txt
388939.pdf.txt
text/plain
76
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1674/3/388939.pdf.txt
535699d0e6e86864c2ec58513f25bcae
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1674/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
388939.pdf
388939.pdf
application/pdf
19807786
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1674/1/388939.pdf
aeb280b18669bfe28be7b20a75d88bab
MD5
1
11684/1674
oai:openaccess.ogu.edu.tr:11684/1674
2019-06-22 03:01:13.532
Dspace@ESOGU
openaccess@ogu.edu.tr
REFHSVRJTSBMSVNBTlNJCgpCdSBsaXNhbnPEsSBpbXphbGF5xLFwIGfDtm5kZXJlcmVrLCBnw7ZuZGVyaW5pemkgZMO8bnlhIMOnYXDEsW5kYSBiYXPEsWzEsSBoYWxkZSwgCmVsZWt0cm9uaWsgb3J0YW1kYSB2ZSBoZXJoYW5naSBiYXNrYSBiaXIga2FuYWxsYSB5ZW5pZGVuIG9sdcWfdHVybWFrLCAKw6dldmlyaXNpbmkgeWFwbWFrIChhxZ9hxJ/EsWRhIHRhbsSxbWxhbmTEscSfxLEgw7x6ZXJlKSB2ZS92ZXlhIGRhxJ/EsXRtYWsgacOnaW4gCkVza2nFn2VoaXIgT3NtYW5nYXppIMOcbml2ZXJzaXRlc2nigJluaW4gKEVTT0dVKSDDtnplbCBvbG1heWFuIGhha2xhcsSxbsSxIGthYnVsIGV0bWnFnyBvbHVyc3VudXouCgpFU09HVSwgZ8O2bmRlcmluaXppbiBpw6dlcmnEn2luaSBkZcSfaXN0aXJtZWRlbiBoZXJoYW5naSBiaXIgCm9ydGFtZGEgZmFya2zEsSBiacOnaW1sZXJkZSBrb3J1bWEgYW1hw6dsxLEgb2xhcmFrIMOnZXZpcmViaWxpci4gCsOWdGUgeWFuZGFuIEVTT0dVLCBnw7x2ZW5saWssIHllZGVrbGVtZSB2ZSBrb3J1bWEgYW1hY8SxeWxhIGJ1IGfDtm5kZXJpbmluIApiaXJkZW4gZmF6bGEga29weWFzxLFuxLEgZWxpbmRlIHR1dGFiaWxpci4gCgpHw7ZuZGVyaW5pbiBzaXplIGFpdCBvcmlqaW5hbCBiaXIgw6dhbGnFn21hIG9sZHXEn3VudSB2ZSBidSBsaXNhbnN0YSBiZWxpcnRpbGVuIApoYWtsYXLEsSBrYWJ1bCBldG1lIGhha2vEsW7EsXogb2xkdcSfdW51IGJlbGlydG1pxZ8gb2x1cnN1bnV6LiBBeW7EsSB6YW1hbmRhIGfDtm5kZXJpbml6aW4sIApiaWxkacSfaW5peiBrYWRhcsSxeWxhLCBraW1zZW5pbiDDtnpsdWsgaGFra8SxbsSxIMOnacSfbmVtZWRpxJ9pbmkgZGUgc3VubXXFnyBvbHVyc3VudXouCgpFxJ9lciBnw7ZuZGVyaSB0ZWxpZiBoYWtrxLFuYSBzYWhpcCBvbHVubWF5YW4gYmlyIG1hdGVyeWFsIGnDp2VyaXlvcnNhLCBvIHphbWFuIAp0ZWxpZiBoYWtrxLEgc2FoaWJpbmRlbiBidSBsaXNhbnMgaWNpbiBnZXJla2xpIG9sYW4gRVNPR1UgaGFrbGFyxLFuxLEga2FidWwgZXRtZWsgCmljaW4ga8Sxc8SxdHPEsXogaXppbiBhbGTEscSfxLFuxLF6xLEgdmUgYnUgdGFyeiDDvMOnw7xuY8O8IGtpxZ9pbGVyIHRhcmFmxLFuZGFuIHNhaGlwIG9sdW5hbiAKbWF0ZXJ5YWxsZXJpbiBnw7ZuZGVyaSBpw6dlcmnEn2kgdmV5YSBtZXRuaSBpw6dlcmlzaW5kZSBhw6dpa8OnYSB0YW7EsW1sYW5kxLHEn8SxbsSxIHZlIAprYWJ1bCBlZGlsZGnEn2luaSBzdW5hcnNpbml6LgoKRcSeRVIgR8OWTkRFUsSwIEVTT0dVIERJxZ5JTkRBIEJBxZ5LQSBCxLBSIEtVUlVMVcWeIFRBUkFGSU5EQU4gREVTVEVLTEVORU4gQsSwUiDDh0FMScWeTUFZQSAKREFZQUxJIMSwU0UsIEJVIFRBUlogQklSIEFOTEHFnk1BIFZFWUEgU8OWWkxFxZ5NRU7EsE4gR0VSRUtUxLBSRMSwxJ7EsCBExLDEnkVSIApaT1JVTkxVTFVLTEFSSSBZRVLEsE5FIEdFVMSwUkTEsMSexLBOxLBaxLAgU1VOQVJTSU5JWi4KCkVTT0dVIGlzbWluaXppIGfDtm5kZXJpbmluIHlhemFyxLEgdmV5YSBzYWhpYmkgb2xhcmFrIGHDp8Sxa8OnYSB0YW7EsW1sYXlhY2FrdMSxciB2ZSAKYnUgbGlzYW5zxLFuIGl6aW4gdmVyZGnEn2luaW4gZMSxxZ/EsW5kYSBoZXJoYW5naSBiaXIgZGXEn2nFn2lrbGlrIHlhcG1heWFjYWt0xLFyLgo=
oai:openaccess.ogu.edu.tr:11684/1673
2019-06-22T00:00:08Z
com_11684_15
com_11684_2
col_11684_86
Çabuk, Ahmet
Çece, Şule
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2019-06-21T05:40:36Z
2019-06-21T05:40:36Z
2010-11
2010-11
Çece. Ş. (2010). Trametes versicolor Lakkazı ile 4-Klorofenol'den Klor Uzaklaştırılması. Yüksek lisans tezi). Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü, Eskişehir.
http://hdl.handle.net/11684/1673
Klorofenoller soğutucu, yangın geciktirici, boya çözücü, pestisit, herbisit ve kereste koruyucusu olarak çeşitli alanlarda kullanılan kimyasal maddelerdir. Yüksek toksisiteleri, kanser oluşturabilmeleri ve doğada kolay bozunamamaları nedeni ile önemli kirleticiler olarak bilinirler. Klorofenollerin herhangi bir yolla organizmaya alınması ksenobiyotik (zenobiyotik) etki yaratır. Bazı mikroorganizmalar klorofenolleri biyolojik olarak bozundurup kloru ayrıştırıp, organizmadan uzaklaştırabilirler. Bu çalışmada, Trametes versicolor (ATCC200801) mikroorganizması kullanılarak, buğday kepeği (3 g/100 ml) ilaveli patates dekstrozlu broth ortamında, lakkaz enzimi üretilmiştir. Yüksek aktiviteli lakkaz enzimi kullanılarak, pH, substrat konsantrasyonu, enzim miktarı, inkübasyon süresi ve ortam sıcaklığı parametrelerinin 4klorofenolden klor uzaklaştırılması işlemi üzerine olan etkisi incelenmiştir. Belirlenen optimum koşullarda 4- klorofenolün toksisitesindeki değişim Microtox cihazı ile takip edilmiştir. Ayrıca klor uzaklaştırıldıktan sonra 4-klorofenolün kimyasal yapısındaki değişiklikler FTIR analizleri ile belirlenmiştir. 4-klorofenolden klor uzaklaştırılması için uygun koşullar pH 4, başlangıç substrat konsantrasyonu 200 µM, süre 30 dk ve sıcaklık 40 oC ve enzim miktarı 4 ml olarak belirlenmiştir. Belirlenen optimum koşullarda oksijen tüketimi ve klor uzaklaştırılması arasındaki ilişki araştırılmıştır. Mikrotoksisite sonuçlarına göre 5. dakikada EC50 (yarım maksimal etkili konsantrasyon) değerlerinde toksisitesinde bir artış görülmüştür. 4-klorofenolün bozunduğunu belirten bulgular gözlenmiştir. Çalışmamızdan elde edilen bulgular Trametes versicolor (ATCC200801)’den elde edilen lakkaz enziminin, 4-klorofenolden klor uzaklaştırılması i şleminde etkin olarak kullanılabileceğini ortaya koymuştur (Örneğin: Atık suların arıtılmasında toprak temizleme işlemi gibi).
Chlorophenols that are often used in the production of refrigeration cooling gas systems, fire retardants, paints, solvents, pesticides, herbicides and wood preservatives, are known to be an important class of xenobiotics. Because of their high toxicity, strong resistance to degradation and ability to build up in the body, chlorophenols are considered cause for cancer. Some microorganisms are able to degrade chlorophenols and produce dechlorination of chlorophenolics. In this study, laccase enzyme was produced through PDB culture including pellicle and Trametes versicolor (ATCC200801). The effect of process parameters such as: pH, substrate concentration, enzyme concentration, reaction time and temperature on the degradation of 4-clorophenol was studied with laccase enzyme which had high activity for dechlorination of 4-chlorophenol. Correlation between oxygen consumption and dechlorination process was investigated in optimal media. Changes in toxicity versus the quantity of 4-chlorophenol were monitored using Microtox. Also, after the dechlorination of 4-chlorophenol, the changes in the chemical structure of 4chlorophenol were determined with FTIR analysis. Optimal conditions for dechlorination of 4-clorophenol have been found to be: pH 4.0, substrate concentration 200 µM, reaction time 30 min, temperature 40 °C and enzyme concentration 4 ml/L. During dechlorination studies, it was observed that the quantity of oxygen in the culture medium was decreased. Changes in the degree of toxicity of 4-chlorophenol was monitored using Microtox. Also, after the dechlorination of 4-chlorophenol, changes in chemical structure of 4-chlorophenol was determined with FTIR analysis. Based on the results obtained from the study, we suggest that laccase enzyme produced from Trametes versicolor (ATCC200801) has the ability to cause dechlorination of 4-chlorophenol. The microtoxicity results showed an increase in the half maximal effective concentration (EC50) in 5th min. The enzyme can be used as an effective reagent in the dechlorination processes (e.g., wastewater treatment soil remediation etc systems).
Submitted by Meral Cem (mcem@ogu.edu.tr) on 2019-04-05T07:51:58Z
No. of bitstreams: 1
388628.pdf: 891578 bytes, checksum: 666ce382fadce5d5192610088a9b765e (MD5)
Approved for entry into archive by Meral Cem (mcem@ogu.edu.tr) on 2019-06-21T05:40:36Z (GMT) No. of bitstreams: 1
388628.pdf: 891578 bytes, checksum: 666ce382fadce5d5192610088a9b765e (MD5)
Made available in DSpace on 2019-06-21T05:40:36Z (GMT). No. of bitstreams: 1
388628.pdf: 891578 bytes, checksum: 666ce382fadce5d5192610088a9b765e (MD5)
Previous issue date: 2010-11
tur
Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Basidiyomiset
Lakkaz
Trametes versicolor
Klor uzaklaştırılması
4-klorofenol
Basidiomycetes
Laccase, Trametes versicolor, dechlorination, 4chlorophenol.
Trametes versicolor lakkazı ile 4-klorofenol’den klor uzaklaştırılması
masterThesis
TEXT
388628.pdf.txt
388628.pdf.txt
text/plain
153292
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1673/3/388628.pdf.txt
0d8124eb8cacb91d04309fa6a2b7b144
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1673/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
388628.pdf
388628.pdf
application/pdf
891578
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1673/1/388628.pdf
666ce382fadce5d5192610088a9b765e
MD5
1
11684/1673
oai:openaccess.ogu.edu.tr:11684/1673
2019-06-22 03:00:08.384
Dspace@ESOGU
openaccess@ogu.edu.tr
REFHSVRJTSBMSVNBTlNJCgpCdSBsaXNhbnPEsSBpbXphbGF5xLFwIGfDtm5kZXJlcmVrLCBnw7ZuZGVyaW5pemkgZMO8bnlhIMOnYXDEsW5kYSBiYXPEsWzEsSBoYWxkZSwgCmVsZWt0cm9uaWsgb3J0YW1kYSB2ZSBoZXJoYW5naSBiYXNrYSBiaXIga2FuYWxsYSB5ZW5pZGVuIG9sdcWfdHVybWFrLCAKw6dldmlyaXNpbmkgeWFwbWFrIChhxZ9hxJ/EsWRhIHRhbsSxbWxhbmTEscSfxLEgw7x6ZXJlKSB2ZS92ZXlhIGRhxJ/EsXRtYWsgacOnaW4gCkVza2nFn2VoaXIgT3NtYW5nYXppIMOcbml2ZXJzaXRlc2nigJluaW4gKEVTT0dVKSDDtnplbCBvbG1heWFuIGhha2xhcsSxbsSxIGthYnVsIGV0bWnFnyBvbHVyc3VudXouCgpFU09HVSwgZ8O2bmRlcmluaXppbiBpw6dlcmnEn2luaSBkZcSfaXN0aXJtZWRlbiBoZXJoYW5naSBiaXIgCm9ydGFtZGEgZmFya2zEsSBiacOnaW1sZXJkZSBrb3J1bWEgYW1hw6dsxLEgb2xhcmFrIMOnZXZpcmViaWxpci4gCsOWdGUgeWFuZGFuIEVTT0dVLCBnw7x2ZW5saWssIHllZGVrbGVtZSB2ZSBrb3J1bWEgYW1hY8SxeWxhIGJ1IGfDtm5kZXJpbmluIApiaXJkZW4gZmF6bGEga29weWFzxLFuxLEgZWxpbmRlIHR1dGFiaWxpci4gCgpHw7ZuZGVyaW5pbiBzaXplIGFpdCBvcmlqaW5hbCBiaXIgw6dhbGnFn21hIG9sZHXEn3VudSB2ZSBidSBsaXNhbnN0YSBiZWxpcnRpbGVuIApoYWtsYXLEsSBrYWJ1bCBldG1lIGhha2vEsW7EsXogb2xkdcSfdW51IGJlbGlydG1pxZ8gb2x1cnN1bnV6LiBBeW7EsSB6YW1hbmRhIGfDtm5kZXJpbml6aW4sIApiaWxkacSfaW5peiBrYWRhcsSxeWxhLCBraW1zZW5pbiDDtnpsdWsgaGFra8SxbsSxIMOnacSfbmVtZWRpxJ9pbmkgZGUgc3VubXXFnyBvbHVyc3VudXouCgpFxJ9lciBnw7ZuZGVyaSB0ZWxpZiBoYWtrxLFuYSBzYWhpcCBvbHVubWF5YW4gYmlyIG1hdGVyeWFsIGnDp2VyaXlvcnNhLCBvIHphbWFuIAp0ZWxpZiBoYWtrxLEgc2FoaWJpbmRlbiBidSBsaXNhbnMgaWNpbiBnZXJla2xpIG9sYW4gRVNPR1UgaGFrbGFyxLFuxLEga2FidWwgZXRtZWsgCmljaW4ga8Sxc8SxdHPEsXogaXppbiBhbGTEscSfxLFuxLF6xLEgdmUgYnUgdGFyeiDDvMOnw7xuY8O8IGtpxZ9pbGVyIHRhcmFmxLFuZGFuIHNhaGlwIG9sdW5hbiAKbWF0ZXJ5YWxsZXJpbiBnw7ZuZGVyaSBpw6dlcmnEn2kgdmV5YSBtZXRuaSBpw6dlcmlzaW5kZSBhw6dpa8OnYSB0YW7EsW1sYW5kxLHEn8SxbsSxIHZlIAprYWJ1bCBlZGlsZGnEn2luaSBzdW5hcnNpbml6LgoKRcSeRVIgR8OWTkRFUsSwIEVTT0dVIERJxZ5JTkRBIEJBxZ5LQSBCxLBSIEtVUlVMVcWeIFRBUkFGSU5EQU4gREVTVEVLTEVORU4gQsSwUiDDh0FMScWeTUFZQSAKREFZQUxJIMSwU0UsIEJVIFRBUlogQklSIEFOTEHFnk1BIFZFWUEgU8OWWkxFxZ5NRU7EsE4gR0VSRUtUxLBSRMSwxJ7EsCBExLDEnkVSIApaT1JVTkxVTFVLTEFSSSBZRVLEsE5FIEdFVMSwUkTEsMSexLBOxLBaxLAgU1VOQVJTSU5JWi4KCkVTT0dVIGlzbWluaXppIGfDtm5kZXJpbmluIHlhemFyxLEgdmV5YSBzYWhpYmkgb2xhcmFrIGHDp8Sxa8OnYSB0YW7EsW1sYXlhY2FrdMSxciB2ZSAKYnUgbGlzYW5zxLFuIGl6aW4gdmVyZGnEn2luaW4gZMSxxZ/EsW5kYSBoZXJoYW5naSBiaXIgZGXEn2nFn2lrbGlrIHlhcG1heWFjYWt0xLFyLgo=
oai:openaccess.ogu.edu.tr:11684/1672
2019-06-22T00:00:35Z
com_11684_15
com_11684_2
col_11684_86
Şahin, Yalçın
Akbulut, Merve
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2019-06-21T05:40:24Z
2019-06-21T05:40:24Z
2010-10
2010-10
Akbulut, M. (2010). Trametes Versicolor Lakkazı ile 2-klorofenolden Klor Uzaklaştırılması. (Yüksek lisans tezi). Eskişehir Osmangazi Üniversitesi/Fen Bilimleri Enstitüsü, Eskişehir.
http://hdl.handle.net/11684/1672
Submitted by Meral Cem (mcem@ogu.edu.tr) on 2019-04-24T07:25:34Z
No. of bitstreams: 1
389902.pdf: 22353780 bytes, checksum: c17897c581a3b230ef43b9b938edfada (MD5)
Approved for entry into archive by Meral Cem (mcem@ogu.edu.tr) on 2019-06-21T05:40:24Z (GMT) No. of bitstreams: 1
389902.pdf: 22353780 bytes, checksum: c17897c581a3b230ef43b9b938edfada (MD5)
Made available in DSpace on 2019-06-21T05:40:24Z (GMT). No. of bitstreams: 1
389902.pdf: 22353780 bytes, checksum: c17897c581a3b230ef43b9b938edfada (MD5)
Previous issue date: 2010-10
tur
Eskişehir Osmangazi Üniversitesi, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Basidiyomiset
Lakkaz
Trametes versicolor
Klor uzaklaştırılması
Klorofenol
Basidiomycetes
Laccase
Dechlorination
2-Chlorophenol
Trametes versicolor lakkazı ile 2-klorofenolden klor uzaklaştırılması
masterThesis
TEXT
389902.pdf.txt
389902.pdf.txt
text/plain
79
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1672/3/389902.pdf.txt
d8332a0f6bcb32827dae5005f9550191
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1672/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
389902.pdf
389902.pdf
application/pdf
22353780
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1672/1/389902.pdf
c17897c581a3b230ef43b9b938edfada
MD5
1
11684/1672
oai:openaccess.ogu.edu.tr:11684/1672
2019-06-22 03:00:35.88
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/3222
2022-06-16T00:00:18Z
com_11684_15
com_11684_2
col_11684_86
Ocak, Atila
Arı, Süleyman
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2022-06-15T08:22:23Z
2022-06-15T08:22:23Z
2007
2007
http://hdl.handle.net/11684/3222
Bu çalışmada araştırma alanı olarak seçilen Büyükyayla, Eskişehir ilinin kuzeyinde yer almaktadır. Çalışma alanı enlem ve boylam çizgileri dikkate alınarak hazırlanan Davis’in grid (ağ) sistemine göre B3 karesi içinde yer almaktadır. Çalışma alanı 1010–1450 m. yükseklikler arasındadır. Büyükyayla bitkilerinin belirlenmesi için arazi çalışmaları 2005–2007 yılları arasında yapılmıştır.
Araştırma alanında 55 familyalarına ait, 170 cinse ait 232 tür ve tür altı takson belirlenmiştir. Belirlenen taksonlar içinde en fazla orana %11 ile Asteraceae familyası sahiptir. Bu familyayı %9.8 ile Fabaceae familyası ve %9 ile Liliaceae familyası izlemektedir. Florayı oluşturan türlerin fitocoğrafik bölgelere göre dağılımlarına bakıldığında, Mediterranean elementlerinin %7.7, İran-Turan elementlerinin %5.4 Euro-Siberian elementlerin %5’lik bir orana sahip olduğu görülmektedir.
Çalışma alanındaki endemik tür ve türaltı takson sayısı 16 olup endemizm oranı % 6.89'dur.
Alan vejetasyonunun büyük bir kısmını orman, step, sub-alpin çayır ve nemli dere vejetasyonu oluşturmaktadır. Bitki taksonlarının hayat formları incelendiğinde en fazla hemikriptofit, en az ise vasküler parazit bulunduğu saptanmıştır.
In this study, the choosen research area of the floristic composition of Büyükyayla ( B3:Eskişehir) is around the north side of the Eskişehir. The resourch area, according to Grid System of Davis (1965) which has been established by considering the latitude and longitude lines is in the B3 square. The height of the research area is between 1010m – 1450m. The excursion fort he research to determine the plants of the Büyükyayla has been studied in 2005 – 2007.
In the research are 232 species and subspecies taxon which belong 53 genera and 173 genus were determined. The Asteraceae family has the highest rate of 11 % in the determined taxon. After this familia there are Fabaceae family with the rate of 9.8 % and Liliaceae family with the rate of 9 %. When we check the distributions of the species, composed of flora according to phtogeographical areas; we see that Mediterrane Elements with the rate of 7,7 % is the first, it is followed by İrano – Turanian Elements with the rate of 5,4 % and Euro – Siberian Elements with the rate of 5,0 %
The number of the endemic species and subspecies taxon are 16 and the rate of the endemism is 6.89.
Besides, it was determined that 13 plant taxa took place in various risk kategories. Area vegetation is composed of largely by forest, steppe, sub-alpin meadow and stream vejetations. When the life forms of plant taxa were analysed, it was determined that the group of hemicryptophyte has the most number of plant taxa and the group of vascular parasite has the less number of plant taxa with.
The wide part of the vegetation of the area composed of forest, step, sub-alpin, grass and humid brook vegetation. When we examine the life forms of the taxons its been determined that hemicriptophyt parasites has the highest number and vascular parasites has the lowest number.
Submitted by Ramazan Karayel (g1216) on 2021-02-15T09:24:05Z
No. of bitstreams: 1
suleyman_ari_tez.pdf: 832808 bytes, checksum: e9558ce22261627a6577bc135f30caba (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-06-15T08:22:23Z (GMT) No. of bitstreams: 1
suleyman_ari_tez.pdf: 832808 bytes, checksum: e9558ce22261627a6577bc135f30caba (MD5)
Made available in DSpace on 2022-06-15T08:22:23Z (GMT). No. of bitstreams: 1
suleyman_ari_tez.pdf: 832808 bytes, checksum: e9558ce22261627a6577bc135f30caba (MD5)
Previous issue date: 2007
ESOGÜ, Fen Bilimleri Enstitüsü
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Flora
Büyükyayla ( B3: Eskişehir )
Türkiye
Büyükyayla (B3:Eskişeihir) florası üzerindeki sistematik bir çalışma
masterThesis
TEXT
suleyman_ari_tez.pdf.txt
suleyman_ari_tez.pdf.txt
text/plain
105944
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3222/3/suleyman_ari_tez.pdf.txt
89525b1333faa285c2a2710b1ad8d19a
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3222/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
suleyman_ari_tez.pdf
suleyman_ari_tez.pdf
application/pdf
832808
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3222/1/suleyman_ari_tez.pdf
e9558ce22261627a6577bc135f30caba
MD5
1
11684/3222
oai:openaccess.ogu.edu.tr:11684/3222
2022-06-16 03:00:18.601
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/3230
2022-06-16T00:00:54Z
com_11684_15
com_11684_2
col_11684_86
Kiraz, Nuri
Yamaç, Mustafa
Dağ, İlknur
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2022-06-15T08:33:11Z
2022-06-15T08:33:11Z
2007
2007
http://hdl.handle.net/11684/3230
Son yıllarda patojen maya ve küflerin yol açtığı fungal infeksiyonlar, bağışıklığı baskılanmış bireylerde yüksek derecede morbidite ve mortaliteye yol açmaktadır. Bu infeksiyonlar yayılıcı ve yüzeyel infeksiyonları kapsar. En sık etkenler Candida ve Aspergillus türleridir. Kullanılan ilaçların dar spektrumlu oluşu, toksisitesi, tolere edilebilme güçlüğü ve dirençli suşların ortaya çıkması nedeniyle tedavi genellikle zordur. Özellikle tek ilaç tedavisine cevap vermeyen hastalarda ya da dirençli suşların varlığında kombinasyon tedavisi düşünülebilir.
Mantarların insan hücresinden farklı olarak hücre duvar yapısı bulunmaktadır. Son yıllarda gündeme gelen ekinokandin grubu antifungaller hücre duvar sentezi üzerine etkilidirler. Bu grupta yer alan kaspofungin, klinik kullanıma yeni giren bir antifungaldir. Polien ve triazol grubu antifungal ilaçlar ise etki mekanizmaları farklı olmakla beraber ergosterol yapı üzerinden ekilidirler. Ekinokandin sınıfındaki antifungallerin duyarlılık testleri için standart bir metod hala geliştirilememiştir ve antifungal kombinasyonları ile ilgili in vitro test yöntemlerine yönelik ayrıntılı çalışmalara ihtiyaç bulunmaktadır.
Bu çalışmada, C. glabrata suşlarının in vitro duyarlılığını saptamada kullanılan broth mikrodilüsyon ve E-test yöntemleri arasındaki uyum kaspofungin için %90, amfoterisin B için %86, flukonazol için %92, vorikonazol için %84 ve itrakonazol için %58 olarak bulunmuştur. Ayrıca flukonazol ve itrakonazole dirençli izolatların tümünün kaspofungine duyarlı olduğu görülmüştür. Araştırmamızda kaspofungin’in (CAS); vorikonazol (VORI), flukonazol (FLU), itrakonazol (ITRA) ve amfoterisin B (AmB) ile ikili kombinasyonlarının C. glabrata izolatlarına karşı in vitro aktiviteleri de değerlendirilmiştir . İlaç etkileşimleri E-test (iki farklı yöntemle), disk difüzyon ve time-kill metodları kullanılarak çalışılmıştır. Çalışılan kombinasyonlar içinde CAS+AmB ve CAS+VORI’nin umut verici olduğu görülmüştür. Kullanılan yöntemler içinde E-testin kullanımı kolaydır ve antifungal kombinasyon testleri için kabul edilebilir olduğu düşünülmektedir. Elde ettiğimiz sonuçların antifungal tedavide faydalı olacağını düşünmekteyiz.
In recent years, fungal infections by reason of pathogenic yeast and molds lead to higher mortality and morbidity in immunsupressed patients. These infections are both superficial and invasive. Mostly seen-ones are species of Candida and Aspergillus. The treatment of them are generally difficult on account of occurrence of resistance agents, difficulty of being tolerability, toxicity, being broad spectrum of drugs used. Combination therapy can be specifically advised in the existence of resistant agents or patients whom one-drug treatment is negative.
Currently a class of antifungals known as Echinocandin is effective on the cell wall synthesis. One of these antifungal is Caspofungin, which has been started to use in clinics recently. Antifungal drugs named polien and triazoles are efficient on ergosterol structure though these drugs have different effects. A method has not been developed for the susceptibility test of the antifungals from class of echinocandin and detailed studies are needed for in vitro test methods related to antifungal combination.
In this study, broth microdilution and E-test methods are used to determine in vitro susceptibility of Candida glabrata strains. Agreement between two methods is 90% for caspofungin (CAS), %92 for fluconazole (FLU), 86% for amphotericin B (AmB), 84% for voriconazole (VORI), 58% itraconazole (ITRA). However, all fluconazole and itraconazole-resistant isolates were inhibited by caspofungin.
In this research, dual combinations of caspofungin with vorikonazol, itrakonazol, flukonazol and amphotericin B were evaluated against C. glabrata isolates. Time-kill, E-test and disk diffusion method were used to evaluate drug interactions of combinations CAS+AmB, CAS+VORI, CAS+ITRA, CAS+FLU, CAS+AmB and CAS+VORI are seen efficient within combination studied. The method of E-test is the easest among methods and it is acceptable for the antifungal combination test. We think that results obtained will be beneficial in the antifungal therapy.
Submitted by Ramazan Karayel (g1216) on 2021-02-15T12:09:03Z
No. of bitstreams: 1
ilknur_dag_tez.pdf: 2184818 bytes, checksum: 66184d7790c2949730062e0549b3cafe (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-06-15T08:33:11Z (GMT) No. of bitstreams: 1
ilknur_dag_tez.pdf: 2184818 bytes, checksum: 66184d7790c2949730062e0549b3cafe (MD5)
Made available in DSpace on 2022-06-15T08:33:11Z (GMT). No. of bitstreams: 1
ilknur_dag_tez.pdf: 2184818 bytes, checksum: 66184d7790c2949730062e0549b3cafe (MD5)
Previous issue date: 2007
ESOGÜ, Fen Bilimleri Enstitüsü
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Candida
Polien
Vorikonazol
Kaspofungin’in, Candida glabrata’nın klinik izolatlarına karşı vorikonazol, flukonazol, itrakonazol ve amfoterisin B ile kombinasyonlarının time-kill metodu, E-test (iki farklı yöntemle) ve disk difüzyon yöntemleriyle in vitro etkilerinin değerlendirilmesi
masterThesis
TEXT
ilknur_dag_tez.pdf.txt
ilknur_dag_tez.pdf.txt
text/plain
200707
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3230/3/ilknur_dag_tez.pdf.txt
772e7634b06795ec9827a20fbb71cc78
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3230/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
ilknur_dag_tez.pdf
ilknur_dag_tez.pdf
application/pdf
2184818
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3230/1/ilknur_dag_tez.pdf
66184d7790c2949730062e0549b3cafe
MD5
1
11684/3230
oai:openaccess.ogu.edu.tr:11684/3230
2022-06-16 03:00:54.017
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/3236
2022-06-16T00:01:10Z
com_11684_15
com_11684_2
col_11684_86
Kınacı, Gülcan
Aytaç, Zehra
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2022-06-15T11:55:40Z
2022-06-15T11:55:40Z
2007
2007
http://hdl.handle.net/11684/3236
Bu arastırma, 2002-2003 ve 2003-2004 yıllarında on kıslık kanola çesidinin
(Bienvenue, Ceres, Chang, Darmor, Express, Falcon, Hansen, Synergy, Samourai ve
Zorro) Eskisehir ekolojik kosullarındaki verimlerinin (tohum, yağ ve protein), verim
ögelerinin (bitki boyu, yan dal sayısı, bitkide kapsül sayısı, ana dalda kapsül sayısı,
kapsül uzunluğu, kapsülde tohum sayısı ve bin tane ağırlığı) ve kalite özelliklerinin
(ham yağ oranı, ham protein oranı) ortaya konulması amacıyla yürütülmüstür.
Arastırma sonucunda verim, verim özellikleri ve kalite özellikleri bakımından
çesitler arasında istatistiki anlamda önemli farklılıklar belirlenmistir. Đki yıllık sonuçlara
göre en yüksek tohum verimi, her iki yılda da 300 kg/da’ın üstünde değer veren
“Chang”, “Zorro” ve “Bienvenue” çesitlerinden elde edilmistir (sırasıyla 348,6 kg/da,
316,0 kg/da, 309,3 kg/da). Ham yağ veriminde, hem ortalama değerde hem de deneme
yıllarında 120 kg/da’ın üstünde yer alan çesitler yine Chang, Zorro ve Bienvenue’dür
(sırasıyla 139,2 kg/da, 128,9 kg/da, 127,7 kg/da). Ayrıca bu üç çesit yüksek protein
verimine sahip çesitler olmuslardır (sırasıyla 69,41 kg/da, 65,43 kg/da ve 65,37 kg/da).
Bunlardan Chang, yüksek verim kapasitesiyle ilk sırada yer alırken bunu izleyen Zorro,
çevre kosullarından oldukça az etkilenmesiyle dikkati çekmistir. Verim gücü
bakımından ilk iki sırada yer alan Chang ve Zorro’yu izleyen Bienvenue zor kosullarda
güvenilebilir bir çesit olma özelliği göstermistir.
This research was carried out to determine yield (seed yield, oil yield and protein
yield), yield components (plant height, number of branches, number of pods per plant,
number of pods on main stem, pod lenght, number of seeds per pod, 1000-seed weight)
and quality traits (crude oil content and crude protein content) of ten winter type
rapeseed cultivars (Bienvenue, Ceres, Chang, Darmor, Express, Falcon, Hansen,
Synergy, Samourai ve Zorro) under Eskisehir conditions in 2002-2003 ve 2003-2004.
Significant differences were found between cultivars with respect to yield, yield
components and quality traits. Especially Chang, Zorro and Bienvenue showed above 3
ton/ha of seed yield and 1.2 ton/ha oil yield both year. According to the mean values of
two years, the highest seed yield were obtained from “Chang” (3.49 t/ha), “Zorro” (3.16
t/ha) and “Bienvenue” (3,09 t/ha). These cultivars also showed highest values of oil and
protein contents. The highest oil and protein yield were obtained from “Chang” (1.39
t/ha and 0,69 t/ha), “Zorro” (1.29 t/ha and 0,65 t/ha) and “Bienvenue” (1.28 t/ha and
0.65 t/ha). Due to its high yield performance “Chang” was at the first place and
fallowed by “Zorro” wich was less effected from environmental conditions.
“Bienvenue” which was at the third place showed reliable performance even in
unfavourable conditions.
Submitted by Ramazan Karayel (g1216) on 2021-02-16T08:28:54Z
No. of bitstreams: 1
zehra_aytac_tez.pdf: 1284962 bytes, checksum: c57f7f5fdb3576114ad9c57d44a85aba (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-06-15T11:55:40Z (GMT) No. of bitstreams: 1
zehra_aytac_tez.pdf: 1284962 bytes, checksum: c57f7f5fdb3576114ad9c57d44a85aba (MD5)
Made available in DSpace on 2022-06-15T11:55:40Z (GMT). No. of bitstreams: 1
zehra_aytac_tez.pdf: 1284962 bytes, checksum: c57f7f5fdb3576114ad9c57d44a85aba (MD5)
Previous issue date: 2007
ESOGÜ;Fen Bilimleri Enstitüsü
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Kıslık Kanola
Adaptasyon
Verim
Verim özellikleri
Kalite
Bazı kıslık kanola (Brassica napus ssp.oleifera L.) çesitlerinin tarımsal özellikleri ve eskisehir kosullarına adaptasyonu
doctoralThesis
TEXT
zehra_aytac_tez.pdf.txt
zehra_aytac_tez.pdf.txt
text/plain
243728
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3236/3/zehra_aytac_tez.pdf.txt
462021ea770970e9b6816cbcad616d3c
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3236/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
zehra_aytac_tez.pdf
zehra_aytac_tez.pdf
application/pdf
1284962
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3236/1/zehra_aytac_tez.pdf
c57f7f5fdb3576114ad9c57d44a85aba
MD5
1
11684/3236
oai:openaccess.ogu.edu.tr:11684/3236
2022-06-16 03:01:10.836
Dspace@ESOGU
openaccess@ogu.edu.tr
REFHSVRJTSBMSVNBTlNJCgpCdSBsaXNhbnPEsSBpbXphbGF5xLFwIGfDtm5kZXJlcmVrLCBnw7ZuZGVyaW5pemkgZMO8bnlhIMOnYXDEsW5kYSBiYXPEsWzEsSBoYWxkZSwgCmVsZWt0cm9uaWsgb3J0YW1kYSB2ZSBoZXJoYW5naSBiYXNrYSBiaXIga2FuYWxsYSB5ZW5pZGVuIG9sdcWfdHVybWFrLCAKw6dldmlyaXNpbmkgeWFwbWFrIChhxZ9hxJ/EsWRhIHRhbsSxbWxhbmTEscSfxLEgw7x6ZXJlKSB2ZS92ZXlhIGRhxJ/EsXRtYWsgacOnaW4gCkVza2nFn2VoaXIgT3NtYW5nYXppIMOcbml2ZXJzaXRlc2nigJluaW4gKEVTT0dVKSDDtnplbCBvbG1heWFuIGhha2xhcsSxbsSxIGthYnVsIGV0bWnFnyBvbHVyc3VudXouCgpFU09HVSwgZ8O2bmRlcmluaXppbiBpw6dlcmnEn2luaSBkZcSfaXN0aXJtZWRlbiBoZXJoYW5naSBiaXIgCm9ydGFtZGEgZmFya2zEsSBiacOnaW1sZXJkZSBrb3J1bWEgYW1hw6dsxLEgb2xhcmFrIMOnZXZpcmViaWxpci4gCsOWdGUgeWFuZGFuIEVTT0dVLCBnw7x2ZW5saWssIHllZGVrbGVtZSB2ZSBrb3J1bWEgYW1hY8SxeWxhIGJ1IGfDtm5kZXJpbmluIApiaXJkZW4gZmF6bGEga29weWFzxLFuxLEgZWxpbmRlIHR1dGFiaWxpci4gCgpHw7ZuZGVyaW5pbiBzaXplIGFpdCBvcmlqaW5hbCBiaXIgw6dhbGnFn21hIG9sZHXEn3VudSB2ZSBidSBsaXNhbnN0YSBiZWxpcnRpbGVuIApoYWtsYXLEsSBrYWJ1bCBldG1lIGhha2vEsW7EsXogb2xkdcSfdW51IGJlbGlydG1pxZ8gb2x1cnN1bnV6LiBBeW7EsSB6YW1hbmRhIGfDtm5kZXJpbml6aW4sIApiaWxkacSfaW5peiBrYWRhcsSxeWxhLCBraW1zZW5pbiDDtnpsdWsgaGFra8SxbsSxIMOnacSfbmVtZWRpxJ9pbmkgZGUgc3VubXXFnyBvbHVyc3VudXouCgpFxJ9lciBnw7ZuZGVyaSB0ZWxpZiBoYWtrxLFuYSBzYWhpcCBvbHVubWF5YW4gYmlyIG1hdGVyeWFsIGnDp2VyaXlvcnNhLCBvIHphbWFuIAp0ZWxpZiBoYWtrxLEgc2FoaWJpbmRlbiBidSBsaXNhbnMgaWNpbiBnZXJla2xpIG9sYW4gRVNPR1UgaGFrbGFyxLFuxLEga2FidWwgZXRtZWsgCmljaW4ga8Sxc8SxdHPEsXogaXppbiBhbGTEscSfxLFuxLF6xLEgdmUgYnUgdGFyeiDDvMOnw7xuY8O8IGtpxZ9pbGVyIHRhcmFmxLFuZGFuIHNhaGlwIG9sdW5hbiAKbWF0ZXJ5YWxsZXJpbiBnw7ZuZGVyaSBpw6dlcmnEn2kgdmV5YSBtZXRuaSBpw6dlcmlzaW5kZSBhw6dpa8OnYSB0YW7EsW1sYW5kxLHEn8SxbsSxIHZlIAprYWJ1bCBlZGlsZGnEn2luaSBzdW5hcnNpbml6LgoKRcSeRVIgR8OWTkRFUsSwIEVTT0dVIERJxZ5JTkRBIEJBxZ5LQSBCxLBSIEtVUlVMVcWeIFRBUkFGSU5EQU4gREVTVEVLTEVORU4gQsSwUiDDh0FMScWeTUFZQSAKREFZQUxJIMSwU0UsIEJVIFRBUlogQklSIEFOTEHFnk1BIFZFWUEgU8OWWkxFxZ5NRU7EsE4gR0VSRUtUxLBSRMSwxJ7EsCBExLDEnkVSIApaT1JVTkxVTFVLTEFSSSBZRVLEsE5FIEdFVMSwUkTEsMSexLBOxLBaxLAgU1VOQVJTSU5JWi4KCkVTT0dVIGlzbWluaXppIGfDtm5kZXJpbmluIHlhemFyxLEgdmV5YSBzYWhpYmkgb2xhcmFrIGHDp8Sxa8OnYSB0YW7EsW1sYXlhY2FrdMSxciB2ZSAKYnUgbGlzYW5zxLFuIGl6aW4gdmVyZGnEn2luaW4gZMSxxZ/EsW5kYSBoZXJoYW5naSBiaXIgZGXEn2nFn2lrbGlrIHlhcG1heWFjYWt0xLFyLgo=
oai:openaccess.ogu.edu.tr:11684/2044
2021-03-12T01:00:17Z
com_11684_15
com_11684_2
col_11684_86
Bayramoğlu, Gökhan
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2021-03-11T08:10:16Z
2021-03-11T08:10:16Z
2007
2007
http://hdl.handle.net/11684/2044
Siklofosfamid kanser tedavisinde kullanılan bir ilaçtır ve normal hücrelerde
metabolitleri sebebiyle toksisiteye neden olur. Alkilleyici bir ajan olan
siklofosfamidin yüksek dozlarda kullanılması gereklidir. Ancak bu yaklasım
hematoksisite, ürotoksisite ve hepatotoksisite gibi yan etkilerden dolayı kullanımı
sınırlıdır. Bu yan etkilerden korunmak için kanser tedavisi esnasında bazı
antioksidan maddeler toksisiteyi engelleyebilir. Silimarin gibi antioksidan
maddeler hücre koruyucu özellige sahiptirler. Bu çalısmada; deney hayvanlarında
siklofosfamid (50, 100 ve 150 mg/kg dozlarda) ile olusturulmus toksisitenin
silimarin (100 ve 200 mg/kg dozlarda) ile olası koruyucu rolü arastırıldı.
Mevcut bu çalısmada;
• Lökosit, trombosit ve kemik iligi çekirdekli hücrelerinde,
• Serum Alanin amino transferaz (ALT), Aspartat amino transferaz
(AST) ve Laktat dehidrogenaz (LDH) enzimlerinde,
• Karaciger Malondialdehid (MDA) seviyesinde,
• Karaciger katalaz (CAT) ve glutatyon peroksidaz (GPx) enzimlerindeki
önemli degisiklikler arastırıldı.
Bu çalısmadan elde edilen sonuçlar silimarinin siklofosfamid kaynaklı
toksisiteyi azaltabilecegi tespit edildi.
Cyclophosphamide is a widely used antineoplastic drug, which could cause
toxicity of the normal cells due to its toxic metabolites. As a alkylating agent,
cyclophosphamide has been proposed for high-dose therapy, however
hematoxicity, hepatoxitcity and urotoxicity are dose-limited side effects. To avoid
these toxic side effects, some antioxidant agents should detoxify during the
cyclophosphamide chemotherapy for neoplastic disorders. Antioxidant agents like
silymarin has a cytoprotective action. In this study, the possible protective role of
silymarin (100 and 200 mg/kg body weight) towards the tissue defence system in
the toxicity induced by Cyclophosphamide (50, 100 and 150 mg/kg body weight)
was studied in the experimental rats.
The present this study, The significant (P<0, 05) alterations;
• in the numbers of leukocyte, thrombocyte, bone morrow nucleated
cells,
• in the levels of enzymic [Alanine amino transferase (ALT),
Aspartate amino transferase (AST) and Lactate dehydrogenase
(LDH)] of the serum
• in the level of malondialdehyde (MDA) of the liver tissue,
• in the levels of enzymic [catalase (CAT) and glutathione peroxidase
(GPx)] of the liver tissue were investigated in the cyclophosphamide
toxicity. Also morphological analysis urinary bladder was
performed by observing the hemorrhagic cyctitis.
Results indicated that administration of silymarin can significantly
reduce the toxic side of cyclophosphamide.
Submitted by Ramazan Karayel (g1216) on 2021-02-17T12:15:08Z
No. of bitstreams: 1
gokhan_bayramoglu_tez.pdf: 3171727 bytes, checksum: 7ed1c73e6784d922c0e7e52c1515b4d6 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2021-03-11T08:10:16Z (GMT) No. of bitstreams: 1
gokhan_bayramoglu_tez.pdf: 3171727 bytes, checksum: 7ed1c73e6784d922c0e7e52c1515b4d6 (MD5)
Made available in DSpace on 2021-03-11T08:10:16Z (GMT). No. of bitstreams: 1
gokhan_bayramoglu_tez.pdf: 3171727 bytes, checksum: 7ed1c73e6784d922c0e7e52c1515b4d6 (MD5)
Previous issue date: 2007
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Siklofosfamid
Oksitadif stres
Sıçan
Silimarin
Sıçanlarda siklofosfamid ile oluşturulmuş oksidatatif strese karşı silimarinin olası
doctoralThesis
TEXT
gokhan_bayramoglu_tez.pdf.txt
gokhan_bayramoglu_tez.pdf.txt
text/plain
130112
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/2044/3/gokhan_bayramoglu_tez.pdf.txt
fa7c187de14c2e3f115de4b8865668cf
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/2044/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
gokhan_bayramoglu_tez.pdf
gokhan_bayramoglu_tez.pdf
application/pdf
3171727
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/2044/1/gokhan_bayramoglu_tez.pdf
7ed1c73e6784d922c0e7e52c1515b4d6
MD5
1
11684/2044
oai:openaccess.ogu.edu.tr:11684/2044
2021-03-12 03:00:17.106
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/2051
2021-03-12T01:00:55Z
com_11684_15
com_11684_2
col_11684_86
Çabuk, Ahmet
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2021-03-11T08:16:01Z
2021-03-11T08:16:01Z
2005
2005
http://hdl.handle.net/11684/2051
Siyanür, endüstriyel aktivitelerin dogal bir ürünü olarak çevreye yayılır. EPA
(Environmental Protection Agency) tarafından tehlikeli bir madde ve toksik bir kirletici
olarak tanımlanmıstır. Bazı mikroorganizma gruplarının siyanür yıkım yetenegine
sahip oldukları bilinmekle birlikte Basidiomycetes grubu mikroorganizmaların siyanür
yıkım özellikleri hakkında sınırlı sayıda bilgi vardır.
Bu çalısmada, Trametes (Coriolus) versicolor (ATCC 2000801), Phanerochaete
chrysosporium (ME 446) ve Pleurotus sajor-caju gibi bazı Basidiomycetes üyeleri
arasından siyanür yıkım yetenekleri bakımından etkin tür seçilmistir. Denenen
funguslar arasında Trametes versicolor (ATCC 2000801) hücrelerinin digerlerine
kıyasla daha yüksek bir yıkım aktivitesine sahip oldugu görülmüstür. Seçilen bu etkin
türle; inkübasyon süresi, biyokütle miktarı, baslangıç siyanür konsantrasyonu, sıcaklık,
pH ve karıstırma hızı gibi parametreler optimize edilmistir. Belirlenen optimum
kosullar altında, amonyak, format ve formamit gibi siyanür yıkımı sonucu olusan bazı
ürünlerin varlıgı arastırılmıstır. Aynı zamanda, siyanür içeren atıklarda bulunabilecek
etanol, metanol ve fenol gibi kirleticilerin Trametes versicolor (ATCC 2000801)
hücrelerinin siyanür biyoyıkımı üzerine etkisi arastırılmıstır.
Optimum siyanür yıkım degeri; 42 saat inkübasyon süresi, 3.5 g biyokütle
miktarı, 125 mg/l baslangıç siyanür konsantrasyonu, 30 °C sıcaklık, pH 10.5 ve 150 rpm
çalkalama hızı kosullarında elde edilmistir.
Belirlenen optimum kosullar altında Trametes versicolor (ATCC 2000801),
hücreleri ile siyanür yıkımı sonucunda, çözeltide amonyak bulunmustur. Ancak format
ve formamit belirlenememistir. Ayrıca, siyanür içeren atıklarda kirletici olarak bulunan
etanol, etkin türle siyanür yıkım yetenegini azaltmıs fakat metanol ve fenol zayıf etki
göstermistir.
Elde edilen sonuçlara göre Trametes versicolor (ATCC 2000801)’un siyanürle
kirlenmis bölgelerin temizlenmesinde etkin olarak kullanılabilecegi düsünülmektedir.
Cyanide is released to the environment as a result of industrial activities and
natural processes. Cyanide has been defined as a hazardous substance and toxic
pollutant according to EPA (Environmental Protection Agency). In nature, some
microorganisms are responsible for the degradation of cyanide, but there is limited
information about the degradation characteristics of Basidiomycetes for cyanide.
In this study, was the selection of potent strain from the point of view cyanide
degradation in some Basidiomycetes strains including Trametes (Coriolus) versicolor
(ATCC 200801), Phanerochaete chrysosporium (ME 446) and Pleurotus sajor-caju.
The degradation activity of Trametes versicolor (ATCC 200801) was found to be more
than that of the other fungi examined. The parameters including incubation time,
amount of biomass, initial cyanide concentration, temperature, pH and agitation rate
were tested for Trametes versicolor (ATCC 200801). It was investigated that, some
cyanide degradation products such as ammonia, formate and formamide under the
determined optimum conditions. Also, the effects of cyanide-containing waste
contaminants such as ethanol, methanol and phenol on the biodegradation of cyanide by
Trametes versicolor (ATCC 200801) were studied.
The optimum cyanide degradation was obtained after 42 hours of incubation at
30 ºC. The optimum pH and agitation rate was measured as 10.5 and 150 rev.min-1,
respectively. The biomass was found as 3.5 g for the maximum degradation with an
initial cyanide concentration of 125 mg l-1.
Ammonia was found in the solution of the Trametes versicolor (ATCC 200801)
degradation of cyanide under the determined optimum conditions, no formate and
formamide were detected. Addition of the cyanide containing waste contaminants, like
ethanol reduced the cyanide degradation of the effective strain, but methanol and phenol
affected poorly.
We propose that, according to its ability to degrade cyanide, Trametes versicolor
(ATCC 200801) might be effective in the treatment of cyanide contaminated sites.
Submitted by Ramazan Karayel (g1216) on 2021-02-17T12:28:45Z
No. of bitstreams: 1
ahmet_cabuk_tez.pdf: 1128075 bytes, checksum: 1adecb81f1594a7e4f5af8d1ff12602b (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2021-03-11T08:16:01Z (GMT) No. of bitstreams: 1
ahmet_cabuk_tez.pdf: 1128075 bytes, checksum: 1adecb81f1594a7e4f5af8d1ff12602b (MD5)
Made available in DSpace on 2021-03-11T08:16:01Z (GMT). No. of bitstreams: 1
ahmet_cabuk_tez.pdf: 1128075 bytes, checksum: 1adecb81f1594a7e4f5af8d1ff12602b (MD5)
Previous issue date: 2005
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Beyaz çürükçül
Fungus
Siyanür
Beyaz çürükçül funguslarla siyanür biyodegrasyonu
doctoralThesis
TEXT
ahmet_cabuk_tez.pdf.txt
ahmet_cabuk_tez.pdf.txt
text/plain
127227
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/2051/3/ahmet_cabuk_tez.pdf.txt
22974ef6070973ef31e26eb17d354f06
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/2051/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
ahmet_cabuk_tez.pdf
ahmet_cabuk_tez.pdf
application/pdf
1128075
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/2051/1/ahmet_cabuk_tez.pdf
1adecb81f1594a7e4f5af8d1ff12602b
MD5
1
11684/2051
oai:openaccess.ogu.edu.tr:11684/2051
2021-03-12 03:00:55.98
Dspace@ESOGU
openaccess@ogu.edu.tr
REFHSVRJTSBMSVNBTlNJCgpCdSBsaXNhbnPEsSBpbXphbGF5xLFwIGfDtm5kZXJlcmVrLCBnw7ZuZGVyaW5pemkgZMO8bnlhIMOnYXDEsW5kYSBiYXPEsWzEsSBoYWxkZSwgCmVsZWt0cm9uaWsgb3J0YW1kYSB2ZSBoZXJoYW5naSBiYXNrYSBiaXIga2FuYWxsYSB5ZW5pZGVuIG9sdcWfdHVybWFrLCAKw6dldmlyaXNpbmkgeWFwbWFrIChhxZ9hxJ/EsWRhIHRhbsSxbWxhbmTEscSfxLEgw7x6ZXJlKSB2ZS92ZXlhIGRhxJ/EsXRtYWsgacOnaW4gCkVza2nFn2VoaXIgT3NtYW5nYXppIMOcbml2ZXJzaXRlc2nigJluaW4gKEVTT0dVKSDDtnplbCBvbG1heWFuIGhha2xhcsSxbsSxIGthYnVsIGV0bWnFnyBvbHVyc3VudXouCgpFU09HVSwgZ8O2bmRlcmluaXppbiBpw6dlcmnEn2luaSBkZcSfaXN0aXJtZWRlbiBoZXJoYW5naSBiaXIgCm9ydGFtZGEgZmFya2zEsSBiacOnaW1sZXJkZSBrb3J1bWEgYW1hw6dsxLEgb2xhcmFrIMOnZXZpcmViaWxpci4gCsOWdGUgeWFuZGFuIEVTT0dVLCBnw7x2ZW5saWssIHllZGVrbGVtZSB2ZSBrb3J1bWEgYW1hY8SxeWxhIGJ1IGfDtm5kZXJpbmluIApiaXJkZW4gZmF6bGEga29weWFzxLFuxLEgZWxpbmRlIHR1dGFiaWxpci4gCgpHw7ZuZGVyaW5pbiBzaXplIGFpdCBvcmlqaW5hbCBiaXIgw6dhbGnFn21hIG9sZHXEn3VudSB2ZSBidSBsaXNhbnN0YSBiZWxpcnRpbGVuIApoYWtsYXLEsSBrYWJ1bCBldG1lIGhha2vEsW7EsXogb2xkdcSfdW51IGJlbGlydG1pxZ8gb2x1cnN1bnV6LiBBeW7EsSB6YW1hbmRhIGfDtm5kZXJpbml6aW4sIApiaWxkacSfaW5peiBrYWRhcsSxeWxhLCBraW1zZW5pbiDDtnpsdWsgaGFra8SxbsSxIMOnacSfbmVtZWRpxJ9pbmkgZGUgc3VubXXFnyBvbHVyc3VudXouCgpFxJ9lciBnw7ZuZGVyaSB0ZWxpZiBoYWtrxLFuYSBzYWhpcCBvbHVubWF5YW4gYmlyIG1hdGVyeWFsIGnDp2VyaXlvcnNhLCBvIHphbWFuIAp0ZWxpZiBoYWtrxLEgc2FoaWJpbmRlbiBidSBsaXNhbnMgaWNpbiBnZXJla2xpIG9sYW4gRVNPR1UgaGFrbGFyxLFuxLEga2FidWwgZXRtZWsgCmljaW4ga8Sxc8SxdHPEsXogaXppbiBhbGTEscSfxLFuxLF6xLEgdmUgYnUgdGFyeiDDvMOnw7xuY8O8IGtpxZ9pbGVyIHRhcmFmxLFuZGFuIHNhaGlwIG9sdW5hbiAKbWF0ZXJ5YWxsZXJpbiBnw7ZuZGVyaSBpw6dlcmnEn2kgdmV5YSBtZXRuaSBpw6dlcmlzaW5kZSBhw6dpa8OnYSB0YW7EsW1sYW5kxLHEn8SxbsSxIHZlIAprYWJ1bCBlZGlsZGnEn2luaSBzdW5hcnNpbml6LgoKRcSeRVIgR8OWTkRFUsSwIEVTT0dVIERJxZ5JTkRBIEJBxZ5LQSBCxLBSIEtVUlVMVcWeIFRBUkFGSU5EQU4gREVTVEVLTEVORU4gQsSwUiDDh0FMScWeTUFZQSAKREFZQUxJIMSwU0UsIEJVIFRBUlogQklSIEFOTEHFnk1BIFZFWUEgU8OWWkxFxZ5NRU7EsE4gR0VSRUtUxLBSRMSwxJ7EsCBExLDEnkVSIApaT1JVTkxVTFVLTEFSSSBZRVLEsE5FIEdFVMSwUkTEsMSexLBOxLBaxLAgU1VOQVJTSU5JWi4KCkVTT0dVIGlzbWluaXppIGfDtm5kZXJpbmluIHlhemFyxLEgdmV5YSBzYWhpYmkgb2xhcmFrIGHDp8Sxa8OnYSB0YW7EsW1sYXlhY2FrdMSxciB2ZSAKYnUgbGlzYW5zxLFuIGl6aW4gdmVyZGnEn2luaW4gZMSxxZ/EsW5kYSBoZXJoYW5naSBiaXIgZGXEn2nFn2lrbGlrIHlhcG1heWFjYWt0xLFyLgo=
oai:openaccess.ogu.edu.tr:11684/3260
2022-06-17T00:01:16Z
com_11684_15
com_11684_2
col_11684_86
Yamaç, Mustafa
Gönen, Fatma
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2022-06-16T06:55:03Z
2022-06-16T06:55:03Z
2005
2005
http://hdl.handle.net/11684/3260
Bu çalısmada, Clavariadelphus truncatus, Tricholoma auratum, Ganoderma
carnosum, Lenzites betulina, Polyporus arcularius, Rhizopogon roseolus, Lepista nuda,
Trametes hirsuta, Ganoderma sp makrofunguslarının katı ve sıvı ortamlarda çinkoya
karsı toleransları ve biyosorpsiyon kapasiteleri arastırılmıstır.
Katı ortamda misel kuru agırlıgına göre en yüksek çinko konsantrasyonunda
(225 ppm Zn) C. truncatus %88 ve T. auratum %47 oranlarında tolerans göstermistir.
Sıvı ortamda en yüksek çinko konsantrasyonunda (150 ppm Zn) C. truncatus %84,5,
T. hirsuta % 46, T. auratum %31,15 ve G. carnosum %11,04 oranlarında toleranslı
oldukları bulunmustur. Çinko içeren sıvı ortamda G. carnosum izolatının büyüyen
miselleri ile biyosorpsiyon kapasitesi (150 ppm Zn) 138 mg/g kuru agırlık olarak
belirlenmistir.
Kuru ve yas misellerle 100 ppm çinko konsantrasyonunda yapılan biyosorpsiyon
tarama çalısmasında G. carnosum izolatına ait kuru misellerin Qmax degeri 38,04 mg/g
kuru agırlık ve yas miseller için Qmax 33,3 mg/g kuru agırlık olarak tayin edilmistir.
G. carnosum’un farklı hücre tipleri ile biyosorpsiyon denemelerinde dinlenen
hücrelerin 12.saatte Qmax degeri 31 mg/g kuru agırlık tayin edilmistir. Gerçeklestirilen
tolerans ve biyosorpsiyon tarama çalısmaları neticesinde G. carnosum izolatının en
yüksek konsantrasyonunda sıvı ortamda büyüyen miselleri en iyi (138 mg/g kuru agırlık)
sonucu vermistir. Deneyler 27 ºC, 150 rpm ve farklı çinko konsantrasyonlarında
yapılmıstır.
In this work, the tolerance of Clavariadelphus truncatus, Tricholoma auratum,
Ganoderma carnosum, Lenzites betulina, Polyporus arcularius, Rhizopogon roseolus,
Lepista nuda, Trametes hirsuta, Ganoderma sp, to the zinc in solid and liquid media,
and the biosorption capacity of mentioned macrofungi have been researched.
In solid media, according to the dry weight,in the highest zinc concentration
(225 ppm Zn), C. truncatus have tolerated with a percent of %88 and T. auratum with a
percent of %47. In liquid media, in the highest zinc concentration (150 ppm), it has
been found that C. truncatus was tolerant wite a ratio of % 84,5, T. hirsuta % 46, T.
auratum %31,15 and G. carnosum %11,04. In a liquid media including zinc the
growing mycelia of G. carnosum and the capacity of biosorption were defined as (150
ppm Zn) 138 mg/g dry weight.
In a work of biosorption screening, made in 100 ppm zinc concentration wite dry
and wet mycelia, the Qmax value of dry mycelia belonging to G. carnosum isolate was
found as 38,04 mg/g dry weight and for wet mycelia Qmax 33,3 mg/g dry weight.
The Qmax value of different cell types of G. carnosum and the resting cells of
biosorption experiments in the 12 th hour has been 31 mg/g dry weight.
As a result of biosorption and tolerance screening, the growing mycelia in liquid
media with the highest concentration of G. carnosum has shown the best results (138
mg/g dry weight). The experiments were performed in 27 °C, 150 rpm and different zinc
concentration.
Submitted by Ramazan Karayel (g1216) on 2021-02-22T07:11:17Z
No. of bitstreams: 1
fatma_gonen_tez.pdf: 480576 bytes, checksum: d4c9bbc631c32cf441cafa7821892f9f (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-06-16T06:55:03Z (GMT) No. of bitstreams: 1
fatma_gonen_tez.pdf: 480576 bytes, checksum: d4c9bbc631c32cf441cafa7821892f9f (MD5)
Made available in DSpace on 2022-06-16T06:55:03Z (GMT). No. of bitstreams: 1
fatma_gonen_tez.pdf: 480576 bytes, checksum: d4c9bbc631c32cf441cafa7821892f9f (MD5)
Previous issue date: 2005
ESOGÜ, Fen Bilimleri Enstitüsü
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Clavariadelphus Truncatus
Tricholoma Auratum
Bazı şapkalı makro fungusların ağır metal toleransı üzerine çalışmalar
masterThesis
TEXT
fatma_gonen_tez.pdf.txt
fatma_gonen_tez.pdf.txt
text/plain
128981
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3260/3/fatma_gonen_tez.pdf.txt
03ca55c217af8bcd5512e52ea41179d2
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3260/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
fatma_gonen_tez.pdf
fatma_gonen_tez.pdf
application/pdf
480576
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3260/1/fatma_gonen_tez.pdf
d4c9bbc631c32cf441cafa7821892f9f
MD5
1
11684/3260
oai:openaccess.ogu.edu.tr:11684/3260
2022-06-17 03:01:16.449
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/2141
2021-03-12T01:00:27Z
com_11684_15
com_11684_2
col_11684_86
Emeksiz Ayrancı, Dursun Figen
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2021-03-11T13:23:17Z
2021-03-11T13:23:17Z
2005
2005
http://hdl.handle.net/11684/2141
Son yıllarda toksik etkilerinin arttıgının gözlenmesi sonucu sindirim sistemi,
merkezi sinir sistemi ve üreme sistem basta olmak üzere tüm vücutta bor ve ürünlerinin
etkileri ile ilgili ülkemiz ve dünyada yogun çalısmalar baslatılmıstır. Bor ürünlerinden olan
Borik asit, hücre zarlarının fonksiyonlarını, hormonal ve mineral metabolizmayı
etkilemektedir. Toksik dozlarda, erkek deney hayvanlarında döllenme basarısının
bozulmasına, spermatogenezin durmasına, esey ve sertoli hücre kaybına yol açtıgı ileri
sürülmektedir. Borik asitin diger etkileri ise, ön midede hiperplazi indüksiyonu ile hepatik
ve subkutan dokularda tümoral gelisimlerdir.
Bu çalısmada agız yolu ile verilen toksik dozda akut borik asit uygulamasından
sonra sıçan testis, karaciger, böbrek ve beyin dokularında borik asidin yarattıgı
histopatolojik degisikliklerin ısık mikroskobu ile belirlenmesi amaçlanmıstır.
Çalısmada, ortalama 285 gr agırlıgında 12 haftalık 30 adet erkek albino Sprague-
Dawley sıçana, 1000 mg/kg/gün borik asit 7 gün süre ile oral olarak verilmistir. Kontrol
olarak, yaklasık aynı agırlıkta ve yastaki 12 adet erkek albino Sprague-Dawley sıçan
kullanılmıstır. Yedinci günün sonunda hayvanlardan testis, karaciger, böbrek ve beyin
dokuları izole edilmistir. Deney bitiminde, deney grubunun kontrol grubuna göre belirgin
vücut agırlıgı kaybı oldugu saptanmıstır. Aynı sekilde, deney grubu testis, karaciger ve
böbrek agırlıklarının da kontrollere göre azaldıgı görülmüstür. Alınan testis, karaciger,
böbrek ve beyin dokularında histopatolojik incelemeler yapılmıstır. Isık mikroskobu ile
yapılan incelemede parafin kesitlerde ve yarı ince kesitlerde, testis dokusunun vasküler
yatagında konjesyon ve alınan tüm dokularda degisik oranlarda hücresel dejenerasyon
görülmüstür.
Sonuç olarak, akut borik asit uygulamasının, yaygın toksik etki ile birlikte özellikle
testis dokusunda spermatogenez durmasına yol açarak histopatolojik degisikliklere neden
oldugu görülmüstür.
In the last years, many studies related to the effects of boric acid and its products
throughout one’s body and boron has been initiated to be done as a result of the fact that its
toxic effects have increased, mainly on gastrointestinal system, central nervous system and
reproductive system. Boric acid from boron products affects the functions of cell
membrane, hormonal and mineral metabolism. It has put forward that boric acid
administrated in toxic doses impairs fertility by causing inhibition of spermatogenesis, loss
of germ and sertoli cell in male rodents. The other effects of boric acid also includes
tumoral development in hepatic and subcutaneıus tissues as well as the induction of
hyperplasia in forestomach.
In this study, by means of light microscopy, the determination of histopathological
changes caused by boric acid in rat testicular, liver, kidney and brain tissue, after orally
administration of acute boric acid in toxic doses was aimed.
In the study, boric acid was administrated during 7 days 1000 mg/kg body
weight/day to 30 males of albino Sprague-Dawley rats, mean weight of 285 g and age of 12
weeks. As a control group, 12 male Sprague-Dawley rats, approximately same age and
weight, were used. In the end of the seventh day, the animals’ testis, liver and kidney tissues
were isolated. In the end of the test, it was determined that the test group had apparent loss
of body weight compared to control group. In the same way, it was determined that the
testis, liver and kidney weights of the animals decreased in the test group compared to the
control group. In the taked out testis, liver, kidney and brain tissues, histopathological
investigations were done. In the investigation by light microscopy, in paraphine crosssections,
it was observed that cellular degeneration in different proportions in all the taked
out tissues as well as the congestion in the vascular deposit in testicular tissue existed.
As a result, administration of acute boric acid causes to histopathological changes
by inhibiting spermiogenesis especially in testis tissue as well as widespread toxic effect.
Submitted by Ramazan Karayel (g1216) on 2021-02-22T08:58:35Z
No. of bitstreams: 1
Tez.pdf: 2877888 bytes, checksum: 0f77cc25f6e1f139845aa75e348f89ae (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2021-03-11T13:23:17Z (GMT) No. of bitstreams: 1
Tez.pdf: 2877888 bytes, checksum: 0f77cc25f6e1f139845aa75e348f89ae (MD5)
Made available in DSpace on 2021-03-11T13:23:17Z (GMT). No. of bitstreams: 1
Tez.pdf: 2877888 bytes, checksum: 0f77cc25f6e1f139845aa75e348f89ae (MD5)
Previous issue date: 2005
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Akut Toksisite
Bor
Borik asit
Doku
Testis
Akut borik asit uygulanan sıçanlarda testis, karaciğer, böbrek ve beyin dokuları üzerinde gözlenen histopatolojik değişimler
doctoralThesis
TEXT
Tez.pdf.txt
Tez.pdf.txt
text/plain
130525
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/2141/3/Tez.pdf.txt
9d406cb51731002c377ebc96069bc62a
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/2141/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
Tez.pdf
Tez.pdf
application/pdf
2877888
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/2141/1/Tez.pdf
0f77cc25f6e1f139845aa75e348f89ae
MD5
1
11684/2141
oai:openaccess.ogu.edu.tr:11684/2141
2021-03-12 03:00:27.877
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/3275
2022-06-17T00:01:03Z
com_11684_15
com_11684_2
col_11684_86
Mısırlıoğlu, İbrahim Mete
Semiz, Aslı
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2022-06-16T08:48:53Z
2022-06-16T08:48:53Z
2005
2005
http://hdl.handle.net/11684/3275
Bu çalısma Ocak 2005-Nisan 2005 tarihleri arasında yapılan arazi çalısmalarına
dayanarak, Bozdag ve Sündiken Dagları karasal gastropoda faunasını belirlemek
amacıyla yapılmıstır.
Bozdag ve Sündiken Dagları’nda belirlenen 21 farklı lokaliteden karasal
gastropoda örnekleri toplanmıs ve teshisleri yapılmıstır.
Çalısma sonucu, Pulmonata altsınıfına dahil 11 cinse ait 12 tür ve 5 alttür tespit
edilmistir. Ayrıca belirlenen türlerin özellikleri ve ekolojilerine iliskin gözlemler
verilmistir.
Çalısma bölgesinde bulunan alttür ve türler; Chondrula (Chondrula) microtragus
tricuspidata (KÜSTER, 1846), Chondrus (Chondrus) zebra tantalus (L. PFEIFFER,
1868), Helicopsis (Helicopsis) subcalcarata subcalcarata (NAEGELE, 1903), Helix
cincta anatolica (KOBELT, 1891), Helix (Pelasga) pathetica (MOUSSON, 1854),
Mastus etuberculatus (FRAUNFELD, 1867), Metafruticicola (Metafruticicola)
proclivis (E. MARTENS, 1889), Monacha solidior (MOUSSON, 1863),
Pseudochondrula seductilis (ROSSMASSLER, 1837), Tacheopsis nicaeensis
(FERUSSAC, 1820), Xerolenta obvia obvia (MENKE, 1828), Zebrina (Zebrina)
detrita (MÜLLER, 1774)’dır.
Tür yogunlugu açısından en yogun lokalite 5 tür bulunan Taslıburun Orman
Deposu Çevresidir. Belen Köyü, Kayı Köyü, Otluk Köyü, Çatacık Orman Dsletme
Müdürlügü Girisi, Mayıslar Köyü, Hekimdag Geçidi ve Kozkayı Köyleri’nde yer alan
lokalitelerden sadece 1’er tür bulunmustur.
Bu çalısmada tespit edilen Helix cincta anatolica, Mastus etuberculatus,
Pseudochondrula seductilis, Tacheopsis nicaeensis, Dç Anadolu Bölgesi’nden ilk kez
bildirilmektedir.
This study has been made to determine the terrestrial gastropoda fauna of
Bozdag and Sündiken Mountains, between January-April 2005.
Terrestrial gastropoda samples were collected and identified from the 21
localities which had been determined on Bozdag and Sündiken Mountains.
As a result of this study, 12 species and 5 subspecies belonging to 11 genus in
Pulmonata subclasis were determined. Also the characteristics and ecologies of the
species, have been given in the study.
Species and subspecies, exists in the study area, are Chondrula (Chondrula)
microtragus tricuspidata (KÜSTER, 1846), Chondrus (Chondrus) zebra tantalus (L.
PFEIFFER, 1868), Helicopsis (Helicopsis) subcalcarata subcalcarata (NAEGELE,
1903), Helix cincta anatolica (KOBELT, 1891), Helix (Pelasga) pathetica
(MOUSSON, 1854), Mastus etuberculatus (FRAUNFELD, 1867), Metafruticicola
(Metafruticicola) proclivis (E. MARTENS, 1889), Monacha solidior (MOUSSON,
1863), Pseudochondrula seductilis (ROSSMASSLER, 1837), Tacheopsis nicaeensis
(FERUSSAC, 1820), Xerolenta obvia obvia (MENKE, 1828), Zebrina (Zebrina)
detrita (MÜLLER, 1774).
From the point of the intensity of species, the most dense location is the
surroundings of Tasburun Forest Depot including 5 different species. There has found
only one species from localities in Belen Village, Kayı Village, Otluk Village, The
entrance of The Çatacık Forest Administrative Office, Mayıslar Village, Hekimdag
Passageway and Kozkayı Village.
In this study, Helix cincta anatolica, Mastus etuberculatus, Pseudochondrula
seductilis, Tacheopsis nicaeensis are recorded firstly from Central Anatolia.
Submitted by Ramazan Karayel (g1216) on 2021-02-22T09:41:18Z
No. of bitstreams: 1
aslı semız tez.pdf.pdf: 542725 bytes, checksum: 7aad3ae28ba3c7c1cafd696227c02ad4 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-06-16T08:48:52Z (GMT) No. of bitstreams: 1
aslı semız tez.pdf.pdf: 542725 bytes, checksum: 7aad3ae28ba3c7c1cafd696227c02ad4 (MD5)
Made available in DSpace on 2022-06-16T08:48:53Z (GMT). No. of bitstreams: 1
aslı semız tez.pdf.pdf: 542725 bytes, checksum: 7aad3ae28ba3c7c1cafd696227c02ad4 (MD5)
Previous issue date: 2005
ESOGÜ, Fen Bilimleri Enstitüsü
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Bozdağ
Anadolu
Karasal Gastropoda
Bozdağ ve Sündiken Dağları karasal Gastropoda türlerinin belirlenmesi
masterThesis
TEXT
aslı semız tez.pdf.pdf.txt
aslı semız tez.pdf.pdf.txt
text/plain
80877
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3275/3/asl%C4%B1+sem%C4%B1z+tez.pdf.pdf.txt
4580f8e36527c54019a6d39090599a54
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3275/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
aslı semız tez.pdf.pdf
aslı semız tez.pdf.pdf
application/pdf
542725
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3275/1/asl%C4%B1+sem%C4%B1z+tez.pdf.pdf
7aad3ae28ba3c7c1cafd696227c02ad4
MD5
1
11684/3275
oai:openaccess.ogu.edu.tr:11684/3275
2022-06-17 03:01:03.067
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/3288
2022-06-17T00:01:35Z
com_11684_15
com_11684_2
col_11684_86
Ocak, Atila
Alan, Sevim
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2022-06-16T10:28:20Z
2022-06-16T10:28:20Z
2005
2005
http://hdl.handle.net/11684/3288
Türkiye Florası’nda Calamintha Miller (Lamiaceae) cinsi 9 tür 12 takson ile temsil edilmektedir. Bu taksonlardan 5’i endemiktir. Calamintha cinsine ait türler sistematik, morfolojik, anatomik ve kimyasal yönden incelenmiş ve birbirleriyle olan yakınlık dereceleri saptanmaya çalışılmıştır.
Çalışılan taksonlar şunlardır: [Calamintha grandiflora (L.) Moench, Calamintha betulifolia Boiss. & Ball, Calamintha tauricola P. H. Davis end., Calamintha pamphylica Boiss. & Heldr. subsp. pamphylica end., Calamintha pamphylica Boiss. & Heldr. subsp. davisii (Quezel & Contandr.) P.H. Davis end., Calamintha piperelloides Stapf end., Calamintha sylvatica Bromf. subsp. sylvatica, Calamintha sylvatica Bromf. subsp. ascendens (Jordan) P. W. Ball, Calamintha nepeta (L.) Savi subsp. nepeta, Calamintha nepeta (L.) Savi subsp. glandulosa (Req.) P. W. Ball, Calamintha incana (Sm.) Boiss., Calamintha caroli-henricana Kit Tan & Sorger end.].
Morfolojik çalışmalarda türlerin ayrıntılı tanımları verilip, bitkilerin genel görünüşleri, yaprak, brakte, çiçek, kaliks, korolla ve meyva şekilleri ilave edilmiştir.
Elde edilen sonuçlara göre Calamintha türlerinin daha geniş varyasyon sınırları içeren ayrım anahtarı morfolojik sonuçlar bölümünde verilmiştir.
Anatomik çalışmalarda türlerin kök, çiçekli gövde ve yapraklarının iç yapısı aydınlatılmıştır.
Kimyasal çalışmalarda Calamintha türlerinin uçucu yağları su distilasyonu ile elde edilmiş ve türlerin % yağ verimleri tablo halinde verilmiştir.
The genus Calamintha (Lamiaceae) is represented in Turkey by 9 species and altogether 12 taxa of which 5 are endemic. In this study systematical, morphological, anatomical and phytochemical properties and relationships of the following have been invistigated: (Calamintha grandiflora (L.) Moench, Calamintha betulifolia Boiss. & Ball, Calamintha tauricola P. H. Davis end., Calamintha pamphylica Boiss. & Heldr. subsp. pamphylica end., Calamintha pamphylica Boiss. & Heldr. subsp. davisii (Quezel & Contandr.) P.H. Davis end., Calamintha piperelloides Stapf end., Calamintha sylvatica Bromf. subsp. sylvatica, Calamintha sylvatica Bromf. subsp. ascendens (Jordan) P. W. Ball, Calamintha nepeta (L.) Savi subsp. nepeta, Calamintha nepeta (L.) Savi subsp. glandulosa (Req.) P. W. Ball, Calamintha incana (Sm.) Boiss., Calamintha caroli-henricana Kit Tan & Sorger end.).
In morphological studies, detailed descriptions of each taxon are given and general appearance of plants, leaf, bract, flower, calyx, corolla and fruit shapes are illustrated.
An improved identification key for Calamintha of Turkey has been prepared.
Anatomy of the, roots, flowering stems and leaves of the study materials has been described.
Water distilled essential oil yields of each taxon have been determined and given on the table.
Submitted by Ramazan Karayel (g1216) on 2021-02-22T11:40:39Z
No. of bitstreams: 1
İçindekiler, tablolar dizini, özet, teşekkür.pdf: 7305573 bytes, checksum: 88ed44b58f186815e4970feef21feea1 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-06-16T10:28:19Z (GMT) No. of bitstreams: 1
İçindekiler, tablolar dizini, özet, teşekkür.pdf: 7305573 bytes, checksum: 88ed44b58f186815e4970feef21feea1 (MD5)
Made available in DSpace on 2022-06-16T10:28:20Z (GMT). No. of bitstreams: 1
İçindekiler, tablolar dizini, özet, teşekkür.pdf: 7305573 bytes, checksum: 88ed44b58f186815e4970feef21feea1 (MD5)
Previous issue date: 2005
ESOGÜ, fen Bilimleri Enstitüsü
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Labiatae (Lamiaceae)
Calamintha
Taksonomi
Morfoloji
Anatomi
Uçucu yağ
Türkiye'deki Calamintha Miller (Lamiaceae) genusu üzerinde taksonomik, morfolojik, anatomik ve kimyasal çalışmalar
doctoralThesis
TEXT
İçindekiler, tablolar dizini, özet, teşekkür.pdf.txt
İçindekiler, tablolar dizini, özet, teşekkür.pdf.txt
text/plain
232094
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3288/3/%C4%B0%C3%A7indekiler%2C+tablolar+dizini%2C+%C3%B6zet%2C+te%C5%9Fekk%C3%BCr.pdf.txt
fcbe4c7f0825fd00222d724f9b08b00b
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3288/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
İçindekiler, tablolar dizini, özet, teşekkür.pdf
İçindekiler, tablolar dizini, özet, teşekkür.pdf
application/pdf
7305573
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3288/1/%C4%B0%C3%A7indekiler%2C+tablolar+dizini%2C+%C3%B6zet%2C+te%C5%9Fekk%C3%BCr.pdf
88ed44b58f186815e4970feef21feea1
MD5
1
11684/3288
oai:openaccess.ogu.edu.tr:11684/3288
2022-06-17 03:01:35.993
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/3316
2022-06-17T06:32:09Z
com_11684_15
com_11684_2
col_11684_86
Tokur, Süleyman
Çoban, Orhan
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2022-06-17T06:32:09Z
2022-06-17T06:32:09Z
2005
2005
http://hdl.handle.net/11684/3316
Bu çalısma Ekim 2002 ile Agustos 2003 tarihleri arasında, Eskisehir ili sınırları
içinde yer alan Sivrihisar Balıkdamı bölgesinde yapılmıstır (B3). Çalısmada bölgede yer
alan epilitik ve epifitik algler floristik olarak incelenmistir.
Arastırma bölgesinde belirlenen 5 istasyondan epilitik ve epifitik alg örnekleri
toplanmıstır. Yapılan incelemede epilitik ve epifitik alg toplulukları içerisinde,
diatomelerin hem tür hem de hücre sayısı olarak oldukça önemli bir kısmını
olusturdukları saptanmıstır. Bu çalısmada Bacillariophyta’ya ait 42, Chlorophyta’ya ait
5, Cyanophyta’ya ait 1 ve Rhodophyta’ya ait 1, takson olmak üzere toplam 49 alg
taksonu tespit edilmistir. Cocconeis pediculus Ehr., Gomphonema truncatum Ehr.,
Navicula cuspidata Kütz., Cymbella affinis Kütz. ve Oscillatoria tenuis C.A. Agardh’ un
en çok gözlenen taksonlar oldukları belirlenmistir.
This study, was carried out between October 2002 and August 2003 on
Sivrihisar Balıkdamı zone which is in the border of Eskisehir. This Study, Epilitic and
epiftic algae which to be found in anea, have been examined as a floristic.
Epilitic and epifitic algae were obtained from five stations chosen investigation
zone. Acording to the results of the study, the diatoms have been found significant in
term of the numbers of type and cell among th epilitic and epifiticalgae communities. 49
taxa in total belonging to Bacillariphyta’s 42, Chlorophyta’s 5, Cyanophyta’s 1,
Rhodophyta’s 1 have been determined. Cocconeis pediculus Ehr., Gomphonema
truncatum Ehr., Navicula cuspidata Kütz., Cymbella affinis Kütz., Oscillatoria tenuis
C.A. Agardh. have been found as the most observed ones within all taxa determined.
Submitted by Ramazan Karayel (g1216) on 2021-02-22T12:00:22Z
No. of bitstreams: 0
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-06-17T06:32:09Z (GMT) No. of bitstreams: 0
Made available in DSpace on 2022-06-17T06:32:09Z (GMT). No. of bitstreams: 0
Previous issue date: 2005
ESOGÜ, Fen Bilimleri Esntitüsü
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Sivrihisar
Balık Damı
Balıkdamı (Sivrihisar-Eskişehir) bölgesi epilitik ve epifitik alglerinin flora yönünden araştırılması
masterThesis
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3316/1/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
1
11684/3316
oai:openaccess.ogu.edu.tr:11684/3316
2022-06-17 09:32:09.782
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/2057
2021-03-12T01:02:12Z
com_11684_15
com_11684_2
col_11684_86
Koyuncu, Onur
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2021-03-11T08:21:07Z
2021-03-11T08:21:07Z
2005
2005
http://hdl.handle.net/11684/2057
Bu çalısmada Geyve (Sakarya) ve çevresinin floristik ve etnobotanik özellikleri
belirlenmeye çalısılmıstır. Arastırma alanı Grid kareleme sistemine göre A3 karesindedir. Mart
2002-Eylül 2005 yılları arasında yapılan bu çalısma sonucunda arastırma alanında 107 familya ve
461 cinse ait 932 takson (tür ve türaltı) yer aldığı saptanmıstır.
Arastırma alanında, içerdiği takson sayısına göre en büyük 5 familya sırasıyla Asteraceae
118 (%12.23), Fabaceae 78 (%8.38), Lamiaceae 63 (%6.77), Brassicaceae 57 (%6.13) ve
Poaceae 49 (%5.27)’dir. Arastırma alanında en fazla tür ve türaltı takson içeren ilk 5 cins ise
sırasıyla Veronica 14 (%1.5), Trifolium 14 (%1.5), Orchis 14 (%1.5), Salvia 11, (%1.18) ve
Centaurea 10 (%1.07)’dır.
Çalısma alanındaki endemik tür ve türaltı takson sayısı 54 olup endemizm oranı %
5.79'dur. Florayı olusturan türlerin fitocoğrafik bölgelere göre dağılımı ise Avrupa-Sibirya
elementi 148 (%15.88), Akdeniz elementi 107 (%11.48) ve Đran-Turan elementi 57 (%6.12)' dir.
Arastırma bölgesinin etnobotanik yapısı incelendiğinde 47 familya ve 66 cinse ait 89 tür ve
türaltı taksonun yöre halkı tarafından yiyecek, yakacak, süsleme, süs bitkisi ve tıbbi amaçlarla
kullanıldığı tespit edilmistir. Arastırma bölgesinde Aesculus hippocastanum (At kestanesi)'un
gövde kabukları ağrı gidermede, Cerasus avium (Kiraz)'un meyva sapları siroz hastalığı
tedavisinde, Cupressus sempervirens (Servi)'in kozalakları öksürük tedavisinde, Cynodon dactylon
(Ayrık)'un stolonları ayak sisliklerinin giderilmesinde, Coryllus avellana (Yabani Fındık)'nın
gövde kabukları nefes darlığında, Zea mays (Mısır)'ın koçan püskülleri idrar ve iltihap söktürücü
olarak, Pistacia terebinthus subsp. palaestina (Menengiç)'nın gövde ve yapraklarının ayak
mantarlarının tedavisinde kullanıldığı ilk kez tespit edilmistir.
In this research the aim was to determine Geyve's (Sakarya) and its surrounding's
floristical and etnobotanical features. The research field is at A3 square according to Grid
system. In this research taking place between March 2000 - September 2005 and 932 taxa
belong to 107 families and 461 genera were identified.
Acording to the number of taxa, Asteraceae 118 (12.23%), Fabaceae 78 (8.38%),
Lamiaceae 63 (6.77%), Brassicaceae 57 (6.13%) and Poaceae 49 (5.27%) are the largest
families. The largest genera are Veronica 14 (1.5%), Trifolium 14 (1.5%), Orchis 14 (1.5%),
Salvia 11 (1.18%) and Centaurea 10 (1.07%).
The number of endemic taxa are 54 and endemism rate is 5.79%. The disturbution of
phytogeographic elements is as follows: Euro-Siberian 148 (15.88%), Mediterranean 107
(11.48%) and Irano-Turanian 57 (6.12%).
When the etnobotanical form of the investigation field is researched, it is found that
the 89 taxa belonged to 47 families and 66 genera are used for eating, burning, adornment
plant and in medicine. This research also cover the therapeutic treatments of several diseases
such as; stem barks of Aesculus hippocastanum (At kestanesi) hasbeen used as ache analgesic,
fruit stalks of Cerasus avium (Kiraz) has been used successfuly in medical treatment of
cough; the stolons of Cynodon dactylon (Ayrık) has been used to get ride of foot swollen,
stem cortexes of Coryllus avellana (Yabani Fındık) has been used to treat asthma, the corn
tassels of Zea mays (Mısır) has been used as diuretics and as inflammatory drug and the stems
and leaves of Pistacia terebinthus subsp. palaestina (Menengiç) has been used as antifungal
treatment of foot.
Submitted by Ramazan Karayel (g1216) on 2021-02-23T07:51:32Z
No. of bitstreams: 1
onur_koyuncu_tez.pdf: 37551009 bytes, checksum: f5e9e7dd84cdf5976532da456c733414 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2021-03-11T08:21:07Z (GMT) No. of bitstreams: 1
onur_koyuncu_tez.pdf: 37551009 bytes, checksum: f5e9e7dd84cdf5976532da456c733414 (MD5)
Made available in DSpace on 2021-03-11T08:21:07Z (GMT). No. of bitstreams: 1
onur_koyuncu_tez.pdf: 37551009 bytes, checksum: f5e9e7dd84cdf5976532da456c733414 (MD5)
Previous issue date: 2005
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Flora
Etnobotanik
Geyve
Sakarya
Türkiye
Geyve (Sakarya) ve çevresinin floristik ve etnobotanik açıdan incelenmesi
doctoralThesis
TEXT
onur_koyuncu_tez.pdf.txt
onur_koyuncu_tez.pdf.txt
text/plain
321286
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/2057/3/onur_koyuncu_tez.pdf.txt
3ed895f7ce6c60e4f4ceef8a58cd8d62
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/2057/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
onur_koyuncu_tez.pdf
onur_koyuncu_tez.pdf
application/pdf
37551009
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/2057/1/onur_koyuncu_tez.pdf
f5e9e7dd84cdf5976532da456c733414
MD5
1
11684/2057
oai:openaccess.ogu.edu.tr:11684/2057
2021-03-12 03:02:12.868
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/2062
2021-03-12T01:01:06Z
com_11684_15
com_11684_2
col_11684_86
Yücel, Semra
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2021-03-11T08:24:27Z
2021-03-11T08:24:27Z
2007
2007
http://hdl.handle.net/11684/2062
Ülkemizin çesitli illerinde bulunan 19 doğal mağaradan izole edilen toplam 290
aktinomiset izolatının çesitli mikroorganizmalara karsı antimikrobiyal aktiviteye sahip
madde üretim potansiyelleri arastırılmıstır.
Test mikroorganizması olarak; Gr pozitif ve Gr negatif bakteriler, maya ve küf
susları kullanılarak “Agar Piece” metodu ile antimikrobiyal aktivite belirlenmistir.
Gram pozitif bakterilere karsı elde edilen antimikrobiyal aktivitenin, gram
negatif bakteriler, mayalar ve küflere oranla daha fazla olduğu saptanmıstır. Test
mikroorganizmalarına karsı yüksek aktivite gösteren 7 izolatın, 3 farklı klinik bakteriye
karsı antimikrobiyal aktivitesi arastırılmıstır. Daha sonra aktinomiset izolatları numerik
taksonomi metodlarıyla tanılanmıstır.
Test mikroorganizmaları ve klinik bakteriler ile yapılan antimikrobiyal aktivite
belirleme ve numerik taksonomi ile izolatların tanılanması, çalısmalarının sonuçları
ısığında, M1492 kodlu Streptomyces izolatı sonraki asamalarda kullanılmak üzere
seçilmistir.
Soya unu kullanılarak hazırlanan üretim ortamında, kuru hücre ağırlığı, pH
değisimi, glukoz miktarı, antimikrobiyal aktivite tespitleri yapılmıstır. Aktif madde
üretiminin 3.gün basladığı ve 5.-6. günlerde en yüksek seviyeye ulastığı gözlenmistir.
Streptomyces M1492 tarafından üretilen metabolitler uygun çözücüler ile
ekstrakte edilerek ince tabaka kromatografisi ile ayrılmıs ve spotların biyoaktiviteleri
biyootoğrafi yöntemiyle belirlenmistir. Aktif maddenin etkisi Minimum Đnhibitör
Konsantrasyonu ve Minimum Bakterisidal Konsantrasyonu verileri ile
değerlendirilmistir.
Aktif maddenin sıcaklık toleransında uygulanan, 30 dk 60 ºC sıcaklığa karsı
dirençli, 5 dk 100 ºC sıcaklığa karsı ise duyarlı olduğu belirlenmistir.
In this study we investigate potantial of production which has antimicrobial
activity against the different microorganisms of Actinomycetes isolate that were isolated
from 19 natural cave in different in Turkey. Antimicrobial activity were determined by
using of piece agar method and bacteria, yeast, molds were used as test microorganisms.
Antimicrobial activity that was against to gram positive bacteria was more than
antimicrobial activity against to gram negative bacteria, yeast and mold. It was
investigated of antimicrobial activity against to 3 different kind of multidrug resistant
microorganisms of 7 isolat which has high activity against the test microorganisms.
Actinomycetes isolat was evaluated by numeric taxonomy. In according to reasons of
studying Streptomyces M1492 isolat was choosed for using on the other steps.
Dry cell weight, change of pH, quantity of glukoz and antimicrobial activity was
fixated in a production area which soy meal was used. Đt was observed that production
of active matter was started at 3 th day and it reached the highest point at 5-6 th day.
Metabolits which was produced by Streptomyces M1492 were exracted by
suitable solvent and it was seperated by TLC and bioactivation of spot was determined
by biyootograpy. Active production effectivation was valuated by MIC and MBC.
It was determined that active production is resistant 30 min 60 0C and it is
sensative to 5 min 100 0C.
Submitted by Ramazan Karayel (g1216) on 2021-02-23T11:11:18Z
No. of bitstreams: 1
semra_yucel_tez.pdf: 7906017 bytes, checksum: d8f65c8be714050033fa617d353f318d (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2021-03-11T08:24:27Z (GMT) No. of bitstreams: 1
semra_yucel_tez.pdf: 7906017 bytes, checksum: d8f65c8be714050033fa617d353f318d (MD5)
Made available in DSpace on 2021-03-11T08:24:27Z (GMT). No. of bitstreams: 1
semra_yucel_tez.pdf: 7906017 bytes, checksum: d8f65c8be714050033fa617d353f318d (MD5)
Previous issue date: 2007
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Aktinomiset
Antimikrobiyal Aktivite
İTK
Biyootografi
MİK
Mağaralardan izole edilen aktinomiset izolatlarının antimikrobiyal aktiviteleri üzerine çalışmalar
masterThesis
TEXT
semra_yucel_tez.pdf.txt
semra_yucel_tez.pdf.txt
text/plain
218736
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/2062/3/semra_yucel_tez.pdf.txt
1c05585ec021ea853450d2c89eaa0f72
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/2062/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
semra_yucel_tez.pdf
semra_yucel_tez.pdf
application/pdf
7906017
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/2062/1/semra_yucel_tez.pdf
d8f65c8be714050033fa617d353f318d
MD5
1
11684/2062
oai:openaccess.ogu.edu.tr:11684/2062
2021-03-12 03:01:06.35
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/3342
2022-06-18T00:00:24Z
com_11684_15
com_11684_2
col_11684_86
Özelmas, Ünal
Dinçer, Melek
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2022-06-17T11:29:53Z
2022-06-17T11:29:53Z
2007
2007
http://hdl.handle.net/11684/3342
Bu çalışmada, Ağustos 2005-Eylül 2006 tarihleri arasında Eskişehir ve civarından Ophisops elegans centralanatoliae ve Ophisops elegans macrodactylus alttürlerine ait 110 örnek toplanarak morfolojik olarak incelenmiştir. Renk özellikleri bakımından birbirinden farklı olan Ophisops elegans macrodactylus ile Ophisops elegans centralanatoliae alttürleri arasında karşılaştırma yapılarak, Eskişehir ve civarında bu iki alttürün varlığı araştırılmıştır. Karşılaştırma Ophisops elegans alttürlerinin ayrımında kullanılan önemli karakter olan vücut etrafı pul+ventral plak sayısı ile daha az öneme sahip temporalia sayısına dayanarak yapılmıştır.
Eskişehir ilinin Batı ve Kuzey kısımlarında Ophisops elegans macrodactylus alttürü yayılış gösterirken, Güney ve Doğu bölgelerinde Ophisops elegans centralanatoliae alttürünün yayılış gösterdiği ilk kez bu çalışma ile ortaya konmuştur.
In this study, 110 specimens belonging to Ophisops elegans centralanatoliae and Ophisops elegans macrodactylus subspecies were collected from Eskişehir province between August 2005-September 2006 and examined morphologically. A comparison was made between Ophisops elegans centralanatoliae and Ophisops elegans macrodactylus subspecies which differ from each other in terms of coloration properties, and the possible presence of these two subspecies in Eskişehir Province was investigated. The comparisons were performed according to scale + ventral plate number around the mid-body which is important in discrimination of Ophisops elegans subspecies, and the temporalia number which has less significance.
It was first demonstrated in this study that distribution area of Ophisops elegans macrodactylus extends to Eastern and Northern parts while the distribution area of Ophisops elegans centralanatoliae subspecies reaches to southern and eastern parts of of Eskişehir Province.
Submitted by Ramazan Karayel (g1216) on 2021-02-23T11:35:11Z
No. of bitstreams: 1
melek_dincer_tez.pdf: 2034425 bytes, checksum: a526f875e9fd5a7506ac3e40a1fb9c6a (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-06-17T11:29:53Z (GMT) No. of bitstreams: 1
melek_dincer_tez.pdf: 2034425 bytes, checksum: a526f875e9fd5a7506ac3e40a1fb9c6a (MD5)
Made available in DSpace on 2022-06-17T11:29:53Z (GMT). No. of bitstreams: 1
melek_dincer_tez.pdf: 2034425 bytes, checksum: a526f875e9fd5a7506ac3e40a1fb9c6a (MD5)
Previous issue date: 2007
ESOGÜ, Fen Bilimleri Enstitüsü
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Ophisops Elegans
Eskişehir ilinde Ophisops elegans'ın taksonomik durumu
masterThesis
TEXT
melek_dincer_tez.pdf.txt
melek_dincer_tez.pdf.txt
text/plain
49961
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3342/3/melek_dincer_tez.pdf.txt
7573b908a4dddb8e694eb3e2976ed604
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3342/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
melek_dincer_tez.pdf
melek_dincer_tez.pdf
application/pdf
2034425
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3342/1/melek_dincer_tez.pdf
a526f875e9fd5a7506ac3e40a1fb9c6a
MD5
1
11684/3342
oai:openaccess.ogu.edu.tr:11684/3342
2022-06-18 03:00:24.853
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/3350
2022-06-18T00:01:03Z
com_11684_15
com_11684_2
col_11684_86
İlhan, Semra
Özcan, Nalan
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2022-06-17T11:41:21Z
2022-06-17T11:41:21Z
2007
2007
http://hdl.handle.net/11684/3350
Son yıllarda çok düsük ve yüksek sıcaklık, pH, tuz ve basınç gibi ekstrem
ortamlarda yasayan çesitli mikroorganizmalara rastlanmıstır, bunlara ekstremofil olarak
adlandırılmıstır. Bu mikroorganizmalardan elde edilen ekstremozinlerin (enzimlerin)
ekstrem kosullarda kararlı olmaları endüstriyel amaçlı enzim üretiminde tercih
edilmelerini sağlamıstır. Bu çalısmada tuzlu topraklardan izole edilen 25 farklı taksona
ait 104 mikrofungus izolatı tarafından amilaz, lipaz ve proteaz sentezleme yetenekleri
incelenmistir. Ayrıca bu çalısmada, en iyi aktivite gösteren izolatlar tarafından bu
enzimlerin üretimi üzerine tuz konsantrasyonunun etkisi arastırılmıstır.
Arastırma sonucunda incelenen izolatların büyük bir kısmının proteaz (%80),
amilaz (%51) ve lipaz (%41) olmak üzere çesitli enzimatik aktivitelere sahip olduğu
belirlenmistir. Amilaz üretimi için P. chryosegenum; lipaz için A. versicolor ve proteaz
için A. niger en yüksek aktivite gösteren türlerdir.
Enzim üretimi yüksek olan türlerin enzim aktivitesi üzerine tuz konsantrasyonun
etkisi incelenmistir. %2,5-10 tuz konsantrasyonunda amilaz P.chrysogenum (2.10.3);
lipaz A. versicolor (4.10.1), P.chrysogenum (2.10.3) ve P. aurantiogriseum (7.5.2);
proteaz A. niger (6.10.6) ve A. flavipes (9.10.8) en iyi sonuç gösteren türlerdir.
Çalısmamızın sonucunda, tuz konsantrasyonunun artmasıyla izolatların enzim
üretim yeteneklerinin azaldığı görülmüstür.
In the recent years, various microorganisms which live in extreme circumstances
such as pH, salt, pressure, the low and high temperatures have been come across and
they have been named as extremophiles. Deterministic nature of extremozym
(enzymes) which are being extracted from such microorganisms provided them to be
preferred in the industrial orientated enzymes production. In this study amylase, lipase
and protease production by 104 microfungi isolates belonging to 25 different taxa,
isolated from salty soils has been investigated. Furthermore, the effect of salt
concentraction on production of such enzymes by the best activity- shown isolates has
been researched in this study.
Research results indicate that most of the isolates investigated have various
enzymatic activity such as lipase (%41), amylase (%51) and protease (%80). P.
chrysogenum for amylase production, A. versicolor for lipase and A. niger for protease
production appear to be the highest activity shown types.
The effect of salt concentraction on enzymes activity of the species that have
high enzyme production has also been studied. The species that show the best results in
the %2,5 -10 salt concentraction are as follows: amylase P. chrysogenum (2.10.3);
lipase A. versicolor (4.10.1), P. aurantiogriseum (7.5.2) and P. chrysogenum (2.10.3)
and protease A. niger (6.10.6) and A. flavipes (9.10.8).
Finally, ability of the enzyme production of the microfungi isolates was
observed to notably decrease, when the salt concentration increase in the medium.
Submitted by Ramazan Karayel (g1216) on 2021-03-01T08:02:02Z
No. of bitstreams: 1
nalan_ozcan_tez.pdf: 2777219 bytes, checksum: f12a16fb49003cf43120c329249ebb92 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-06-17T11:41:21Z (GMT) No. of bitstreams: 1
nalan_ozcan_tez.pdf: 2777219 bytes, checksum: f12a16fb49003cf43120c329249ebb92 (MD5)
Made available in DSpace on 2022-06-17T11:41:21Z (GMT). No. of bitstreams: 1
nalan_ozcan_tez.pdf: 2777219 bytes, checksum: f12a16fb49003cf43120c329249ebb92 (MD5)
Previous issue date: 2007
ESOGÜ, Fen Bilimleri Enstitüsü
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Mikrofungus
Ekstremofil
Ekstremozim
Enzim
Amilaz
Lipaz ve proteaz
Halotolerant funguslarda enzin taranması ve tuz konsantrasyonunun etkisi
masterThesis
TEXT
nalan_ozcan_tez.pdf.txt
nalan_ozcan_tez.pdf.txt
text/plain
126635
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3350/3/nalan_ozcan_tez.pdf.txt
f060492b67348d059eeabdb0bf2da232
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3350/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
nalan_ozcan_tez.pdf
nalan_ozcan_tez.pdf
application/pdf
2777219
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3350/1/nalan_ozcan_tez.pdf
f12a16fb49003cf43120c329249ebb92
MD5
1
11684/3350
oai:openaccess.ogu.edu.tr:11684/3350
2022-06-18 03:01:03.209
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/3364
2022-06-21T00:00:49Z
com_11684_15
com_11684_2
col_11684_86
Çolak, Güler
Töre Yaman, Sabahat
Çolak, Güler
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2022-06-20T05:46:43Z
2022-06-20T05:46:43Z
2005
2005
http://hdl.handle.net/11684/3364
Bu araştırmada çimlenme ve ilk fide büyüme evrelerindeki Lycopersicon
esculentum Mill.’de bazı gelişim parametreleri üzerine Ca(NO3)2 ve MgSO4
tuzluluğunun etkileri incelendi. Çalışmada fotoperyodik indüksiyona maruz bırakılan
Lycopersicon esculentum Mill. cv. H-2274 genotipinin tohumları ile fotoperyot ve
karanlık uygulanan Lycopersicon esculentum Mill. cv. 11D-230 genotipinin
tohumlarında Ca(NO3)2 ve MgSO4 tuzluluğunun çimlenme oranlarında neden olduğu
değişimler arasında istatistiksel anlamı olan bir farklılık gözlenemezken, H-2274
genotipinde karanlıkta inkübasyona alınan tohumlarda farklılığın p= 0.001 düzeyinde
MgSO4 lehine daha yüksek olduğu görüldü. Fotoperyot uygulanan 11D-230 genotipinin
hipokotil, kök ve kotiledon yaş ağırlıklarında, karanlık şartlarda 11D-230 genotipinin
hipokotil ve kök yaş ağırlıklarında ve karanlık şartlarda H-2274 genotipinin kotiledon
ve kök yaş ağırlıklarında Ca(NO3)2 ve MgSO4 tuzluluğunun neden olduğu değişimler
istatistiksel anlam oluşturmazken, H-2274 genotipinde fotoperyodik indüksiyon altında
Ca(NO3)2 uygulamalarıyla MgSO4 uygulamalarından daha yüksek hipokotil, kök ve
kotiledon yaş ağırlıkları elde edildi. H-2274 genotipinde karanlık şartlarda da Ca(NO3)2
uygulamaları ile daha yüksek hipokotil yaş ağırlıkları belirlendi. Genel morfometrik
değerlendirmelerde H-2274 genotipinin lateral kök gelişimlerinde Ca(NO3)2 ve MgSO4
tuzluluğunun neden olduğu değişimler arasında istatistiksel anlamı olan bir farklılık
izlenemezken, 11D-230 genotipinde Ca(NO3)2 uygulamalarıyla daha yüksek değerlerle
temsil edilen lateral kök gelişimlerine tanık olundu. Ele alınan diğer morfometrik
gözlemlerde de genotiplere göre farklılaşan düzeylerde değişimler söz konusu idi.
This study aims to investigate the effects of Ca(NO3)2 and MgSO4 upon some
developmental parameters in Lycopersicon esculentum Mill. during the germination and
first growth periods. No statistical significance could be determined between the
changes in the germination levels of the salinity of Ca(NO3)2 and MgSO4 in the seeds of
the genotype of Lycopersicon esculentum Mill. cv. 11D-230 exposed to darkness and
photoperiods and those of Lycopersicon esculentum Mill. cv. H-2274 exposed to
photoperiodic inductions. The difference in the seeds incubated in darkness was much
higher in H-2274 genotype in favour of MgSO4 (p=0.001). No statistical significance
could be determined for the levels of the change of the salinity of Ca(NO3)2 and MgSO4
in relation to the hypocotyl, root and cotyledons of 11D-230 genotype exposed to
photoperiods and darkness and on the other hand, the wetness weigh of the hypocotyl,
root and cotyledons of H-2274 genotype was much higher during photoperiod
inductions with the application of Ca(NO3)2 and MgSO4 applications. On morphometric
evalvations, there was no statistical significance between the changes caused by the
salinity of Ca(NO3)2 and MgSO4 regarding the lateral root development of H-2274
genotype. However, lateral root developments represented with higher values were
determined as a result of Ca(NO3)2 applications to 11D-230 genotype. As to the other
morphometric observations mentioned in the study, varying changes were observed
depending on the genotypes.
Submitted by Ramazan Karayel (g1216) on 2021-03-01T08:53:11Z
No. of bitstreams: 1
S. Tore YAMAN tez.pdf: 499292 bytes, checksum: 907433b03d51f07537308477e1bfb787 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-06-20T05:46:43Z (GMT) No. of bitstreams: 1
S. Tore YAMAN tez.pdf: 499292 bytes, checksum: 907433b03d51f07537308477e1bfb787 (MD5)
Made available in DSpace on 2022-06-20T05:46:43Z (GMT). No. of bitstreams: 1
S. Tore YAMAN tez.pdf: 499292 bytes, checksum: 907433b03d51f07537308477e1bfb787 (MD5)
Previous issue date: 2005
ESOGÜ, Fen Bilimleri Enstitüsü
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Çimlenme
Lycopersiocon
Esculentum
Çimlenme ve ilk fide büyüme evrelerindeki Lycopersicon esculentum Mill. 'de bazı gelişim parametreleri üzerine Ca (NO3)2 ve MgSO4 tuzluluğunun etkileri
masterThesis
TEXT
S. Tore YAMAN tez.pdf.txt
S. Tore YAMAN tez.pdf.txt
text/plain
203527
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3364/3/S.+Tore+YAMAN+tez.pdf.txt
5db7902a504a8044427b2e0258872ae4
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3364/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
S. Tore YAMAN tez.pdf
S. Tore YAMAN tez.pdf
application/pdf
499292
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3364/1/S.+Tore+YAMAN+tez.pdf
907433b03d51f07537308477e1bfb787
MD5
1
11684/3364
oai:openaccess.ogu.edu.tr:11684/3364
2022-06-21 03:00:49.035
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/3353
2022-06-18T00:01:08Z
com_11684_15
com_11684_2
col_11684_86
Çalışkan, Hakan
Aslan, Adem
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2022-06-17T11:48:35Z
2022-06-17T11:48:35Z
2006
2006
http://hdl.handle.net/11684/3353
Bu çalışma, Nisan 2004 ile Ağustos 2005 tarihleri arasında Eskişehir’de yakalanan 450 Sarcophagid örneğine dayanmaktadır. Bu çalışmada bir altfamilyaya ait (Sarcophaginae) 8 cins ve toplam 12 tür tespit edilmiştir. Bu türlerden; Helicophagella noverca, Liosarcophaga jacobsoni, Pandelleana protuberans ve Sarcophaga croatica Türkiye Sarcophagidae faunası için yeni kayıttır.
Çalışma alanında tespit edilen türlerin tanımları ve teşhisde kullanılan erkek genital parçalarının (phallus, cerci, ve V. sternit) çizimleri verilmiştir.
This study depends on 450 Sarcophagid specimens caught in Eskişehir between April 2004 and August 2005. In this study, 8 genus and 12 species belonging to one subfamilies (Sarcophaginae) were determined. From those species; Helicophagella noverca, Liosarcophaga jacobsoni, Pandelleana protuberans and Sarcophaga croatica which are new records for Turkey.
Together with the description of 12 Sarcophagidae species which are determined in the study area, the drawings of the male genilitia parts are given in the paper.
This study depends on 450 Sarcophagid specimens caught in Eskisehir between
April 2004 and August 2005. In this study, 8 genus and 12 species belonging to one
subfamilies (Sarcophaginae) were determined. From those species; Helicophagella
noverca, Liosarcophaga jacobsoni, Pandelleana protuberans and Sarcophaga croatica
which are new records for Turkey.
Together with the description of 12 Sarcophagidae species which are determined in
the study area, the drawings of the male genilitia parts are given in the paper.
Submitted by Ramazan Karayel (g1216) on 2021-03-03T07:33:19Z
No. of bitstreams: 1
Adem_Aslan_Tez.pdf: 5607708 bytes, checksum: 14ebda352469d76181c7f303315439a6 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-06-17T11:48:35Z (GMT) No. of bitstreams: 1
Adem_Aslan_Tez.pdf: 5607708 bytes, checksum: 14ebda352469d76181c7f303315439a6 (MD5)
Made available in DSpace on 2022-06-17T11:48:35Z (GMT). No. of bitstreams: 1
Adem_Aslan_Tez.pdf: 5607708 bytes, checksum: 14ebda352469d76181c7f303315439a6 (MD5)
Previous issue date: 2006
ESOGÜ, Fen Bilimleri Enstitüsü
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Eskişehir
Fauna
Eskişehir Sarcophagidae (Diptera) faunası üzerine çalışmalar
masterThesis
TEXT
Adem_Aslan_Tez.pdf.txt
Adem_Aslan_Tez.pdf.txt
text/plain
112955
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3353/3/Adem_Aslan_Tez.pdf.txt
221050b4303c5e17343580956bb1fc99
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3353/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
Adem_Aslan_Tez.pdf
Adem_Aslan_Tez.pdf
application/pdf
5607708
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3353/1/Adem_Aslan_Tez.pdf
14ebda352469d76181c7f303315439a6
MD5
1
11684/3353
oai:openaccess.ogu.edu.tr:11684/3353
2022-06-18 03:01:08.0
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1795
2021-03-04T01:00:28Z
com_11684_15
com_11684_2
col_11684_86
Tosun, Zehra
ESOGÜ, Fen Bilimleri Enstitüsü
2021-03-03T13:06:36Z
2021-03-03T13:06:36Z
2007
2007
http://hdl.handle.net/11684/1795
Bu çalısmada arastırma bitkilerinin kök, gövde ve yaprak enine kesitleri ile
yaprak yüzeysel kesitleri incelenmistir. Allium ampeloprasum L., A. scorodoprasum
L., A. szovitsii Regel ve A. stamineum Boiss. türlerinin gövde enine kesitlerinde
sklerankimatik bir halka bulunmaktadır. A. ampeloprasum L., A. scorodoprasum L.,
A. szovitsii Regel ve A. stamineum Boiss. türlerinin gövde enine kesitlerinin genel
görünüsleri yuvarlak-yuvarlağımsı oldukları görülmüstür. Gövdelerde iletim
demetleri dairesel, dağınık bir dizilis gösterip kapalı kolleteral tiptedirler. A.
ampeloprasum L. ve A. scorodoprasum L. türlerinin gövde enine kesitlerinde
merkezde parankimatik hücrelerden meydana gelmis bir öz bölgesi bulunmaktadır. A.
stamineum Boiss. ve A. szovitsii Regel türlerinde ise merkezde genis bir öz bosluğu
bulunmaktadır. Gövde enine kesitlerinde kambiyum tabakası bulunmadığı için
bitkilerin gövdeleri tek yıllık bitkilerin karakteristik anatomik özelliklerini
göstermektedir.
Arastırma bitkilerinin yaprakları bifasial tiptedir. A. ampeloprasum L., A.
scorodoprasum L., A. szovitsii Regel türlerinin yaprak enine kesitinde alt ve üst
epidermisin üzerinde kalınca bir kütikula tabakası bulunmaktadır. A. stamineum Boiss.
türünde ise sadece üst epidermiste kalın bir kütikulaya rastlanmıstır, alt epidermiste
ise kütikula oldukça ince bir tabaka halindedir. Yaprak yüzeysel kesitlerinde,
epiderma hücrelerinin boyuna uzamıs, birbirine paralel sıralar halinde
oldukları görülmüstür. Stomalar anomositik tiptedirler.
Arastırma bitkilerinin stoma frekansları yaprak üst epidermisinde en
yüksek, %59, A. scorodoprasum L. türünde; en düsük ise, %30, A. szovitsii Regel
türünde bulunmustur. Yaprak alt epidermisinde ise stoma frekansı en yüksek, %53,
A. ampeloprasum L. ve en düsük, %28, A. szovitsii Regel türlerinde saptanmıstır.
Ancak A. stamineum Boiss.’ un yaprak alt yüzeyinde stomaya rastlanmamıstır.
Sitotaksonomik Çalısmalar
Arastırma bitkilerinden A. ampeloprasum L. un 2n= 40 ve A. myrianthum
Boiss. bitkisinin ise 2n= 16 kromozomlu diploid bitkiler oldukları saptanmıstır.
A. ampeloprasum L. ve A. myrianthum Boiss. türlerinin kromozomları
oldukça büyük olup kromozom morfolojilerinin incelenmesi için 6 saat
kolsisin+buz ve 8-hidroksi kinolin+buz uygulaması yapılarak ancak
kromozomların birbirinden ayrılması sağlanabilmistir. Her iki türde de herhangi
bir mitoz anomalisine rastlanmamıstır.
In this study root, stem and leaf cross sections and leaf surface sections of the
research plants were studied. There exists a cykleranchymatic hoop on the body cross
sections of the Allium ampeloprasum L, A. scorodoprasum L, A. szovitsii Regel and A.
stamineum Boiss. species. The general appearances of the stem cross sections of the A.
ampeloprasum L, A. scorodoprasum L., A. szovitsii Regel and A. stamineum Boiss.
species were observed to be general round-roundish. The transmission bunches on the
stems shows circular, scattered arranging and they are in closed collateral types. There
is a core area consisting of the parenchymatic cells on the center of the stem cross
sections of the A. ampeloprasum L, A. scorodoprasum types. There is a wide core
space on the center of the A. stamineum Boiss. and L, A. szovitsii Regel species. Since
there is not a cambium layer on the stem cross sections, the stems of the plants shows
the characteristic anatomical features of the one year plants .
The leaves of the research plants are in bifasial type. There is a thick cuticle
layer on the bottom and upper epidermis of the leaf cross sections of the A.
ampeloprasum L., A. scorodoprasum L., A. szovitsii Regel species. On A. stamineum
Boisss. species only a thick cuticle has been seen on the upper epidermis and the cuticle
on bottom epidermis is in form of very thin layer. It was observed that the epidarma
cells on the leaf cross sections lengthened longitudinally and in row parallel to each
other.
The stoma frequencies of the research plants on leaf upper epidermis was found
highest % 59 in A. scorodoprasum L. species, and lowest %30 in A. szovitsii Regel
species. On leaf bottom epidermis stome frequency has been detected highest % 53 on
A . ampeloprasum L. and lowest %28 on A. szovitsii Regel species. But no stoma has
been found on the leaf bottom surface of the A. stamineum Boiss.
Cytotaxonomical Studies
It has been detected the research plants A. ampeloprasum is 2n=40 and A.
myrianthum Boiss. is 2n=16 chromosome diploid plants.
The chromosomes of the A. ampeloprasum L. and A. myrianthum Boiss. species are
extremely big only the discrimination of the chromosomes for the examination of their
morphologies have been provided after the application of kolsisin+ice and 8- hidroxy
kinolyn+ice for 6 hours. No mitosis anomaly has been detected on each specie.
Submitted by Ramazan Karayel (g1216) on 2021-03-03T08:02:23Z
No. of bitstreams: 1
ZEHRA_TOSUN_TEZ.pdf: 1878330 bytes, checksum: 0bd7ee96a90d7705a00351e402861929 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2021-03-03T13:06:36Z (GMT) No. of bitstreams: 1
ZEHRA_TOSUN_TEZ.pdf: 1878330 bytes, checksum: 0bd7ee96a90d7705a00351e402861929 (MD5)
Made available in DSpace on 2021-03-03T13:06:36Z (GMT). No. of bitstreams: 1
ZEHRA_TOSUN_TEZ.pdf: 1878330 bytes, checksum: 0bd7ee96a90d7705a00351e402861929 (MD5)
Previous issue date: 2007
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Geyve
Doğal Yayılış
Geyve ve çevresinde doğal yayılış gösteren bazı Allium L. türleri üzerinde morfolojik, anatomik ve sitotaksonomik çalışmalar
masterThesis
TEXT
ZEHRA_TOSUN_TEZ.pdf.txt
ZEHRA_TOSUN_TEZ.pdf.txt
text/plain
88742
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1795/3/ZEHRA_TOSUN_TEZ.pdf.txt
20abe51db72e307d88a3086c09fff7e3
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1795/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
ZEHRA_TOSUN_TEZ.pdf
ZEHRA_TOSUN_TEZ.pdf
application/pdf
1878330
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1795/1/ZEHRA_TOSUN_TEZ.pdf
0bd7ee96a90d7705a00351e402861929
MD5
1
11684/1795
oai:openaccess.ogu.edu.tr:11684/1795
2021-03-04 03:00:28.252
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/3392
2022-06-21T00:00:29Z
com_11684_15
com_11684_2
col_11684_86
Canberk, Mediha
Aral, Erinç
Uyanoğlu, Mustafa
ESOGÜ, Fen Bilimleri Enstitüsü, Biyofizik Anabilim Dal
2022-06-20T13:35:39Z
2022-06-20T13:35:39Z
2006
2006
http://hdl.handle.net/11684/3392
Dogada bulunan çok sayıda bitkisel materyal halk tarafından çesitli hastalıklarda
ilaç olarak kullanılmaktadır. Bunlardan birisi de kekik bitkisidir. Origanum (kekik)’
dan elde edilen uçucu yagların insan saglıgı üzerine çesitli etkileri bilimsel olarak ortaya
konmustur. Ancak, uçucu yagların vücudun önemli organlarından birisi olan karaciger
üzerine in vivo olarak etkisi ile ilgili arastırmalar bulunmamaktadır. Arastırmamızda
kekikten saflastırılan karvakrol isimli uçucu yagın, parsiyal hepatektomi yapılan
sıçanlarda karaciger rejenerasyonu üzerine etkisi arastırıldı. Ayrıca, arastırmamızda
karaciger rejenerasyonu üzerine olumlu etkileri bilinen silymarinin etkisi karvakrol ile
karsılastırılarak incelendi. Deneyimizde saglıklı Wistar albino sıçanlar kullanılarak 7
deney grubu olusturuldu. Grup 1 kontrol grubu iken, Grup 2, 3 ve 4 hayvanlarına
laparotomiden 60 dakika önce sırasıyla tek doz serum fizyolojik, karvakrol ve silymarin
enjeksiyonu; Grup 5, 6 ve 7 hayvanlarına yine laparotomiden 60 dakika önce sırasıyla
tek doz serum fizyolojik, karvakrol ve silymarin enjeksiyonu ile %68- 70 parsiyal
hepatektomi yapıldı. Cerrahi islemlerden 72 saat sonra karacigerlerin hepatektomi
öncesi ve sonrasında yas agırlıkları alınarak rejenerasyon oranları hesaplandı.
Karaciger kesitlerinin bir bölümüne Hematoksilin & Eosin (H&E) boyası uygulanarak
histolojik degerlendirmeler yapıldı ve mitotik indeks çıkarıldı. Kesitlere ayrıca
Proliferating Cell Nuclear Antigen (PCNA) ve Interleukin-6 (IL-6)
immunohistokimyasal boyaları uygulandı. Kan ve kemik iligi örneklerinde hücreler
sayıldı. Serum örneklerinde biyokimyasal olarak aspartate transaminase (AST) ve
alanine transaminase (ALT) karaciger enzimleri ile; ELISA testi yardımıyla Tumor
Necrosis Factor-A (TNF-A) ve Interleukin-6 (IL-6) sitokinlerinin seviyeleri belirlendi.
Serum örneklerindeki analiz sonuçları ve kesitlerden elde edilen veriler
istatistiksel olarak degerlendirilerek gruplar arasında karsılastırmalar yapıldı.
Arastırmamızda intraperitoneal olarak verilen karvakrol ve silymarinin karaciger
rejenerasyon oranını artırdıgı ayrıca, uygulamıs oldugumuz dozda karvakrolün
karaciger histolojik yapısında toksik bir etki olusturmadıgı sonucuna varıldı.
There is a large quantity of naturally occurring herbal materials that are
traditionally used by people for their curative properties regarding various diseases.
Origanum (kekik) is one of these herbs. There are several studies reporting various
effects of volatile oils upon human health extracted from kekik. However, no study has
so far investigated their effects on the liver. The present study aims to investigate
possible effects of purified carvacrol obtained from kekik upon the regenerative feature
of the liver subsequent to partial hepatectomy in rats. The carvacrol was tested in
comparison with silymarin, known for its positive effects upon liver regeneration.
Therefore, Wistar Albino rats were divided into seven groups. Group 1 was chosen as
the main control group, while Groups 2, 3 and 4 were chosen as the study groups. Each
of the study groups was given a single dosage of injection of physiological fluid,
carvacrol and silymarin respectively, 60 minutes prior to laparotomy. None of the livers
of the rats in these study groups was dissected. As to partial hepatectomy groups, they
underwent the same injection applications as the aforementioned study groups, in
addition to 68-70% of liver dissection. The rats were slaughtered 72 hours after partial
hepatectomy. Regeneration rates were calculated in consideration of wet weight before
and after hepatectomy. Sections of the liver that had been dyed with Hematoxyline &
Eosin (H&E) were histologically evaluated and a mitotic index was established for this.
Different sections of the same liver tissues were immunohistochemically dyed with
Proliferating Cell Nuclear Antigen (PCNA) and Interleukin-6 (IL-6). Cell count of
blood and bone marrow was performed. Aspartate transaminase (AST) and alanine
transaminase (ALT) levels were biochemically determined in serum samples. Tumour
Necrosis Factor-9 (TNF-9) and IL-6 levels were also determined using the ELISA test.
Results of analysis of serum samples and data obtained from the sections were
evaluated statistically and a comparison was achieved between the rat groups involved
in the study. It was concluded that intraperitonally administered carvacrol and
silymarin increased the rate of regeneration of the liver. It was also conlcluded that the
dosage given in the present study did not have a toxic effect upon histological structure
of the liver.
Submitted by Ramazan Karayel (g1216) on 2021-03-03T08:12:18Z
No. of bitstreams: 1
Mustafa_Uyanoglu_tez.pdf: 2425797 bytes, checksum: 0ecfe0a6069d0d2f1e49e5207e62cd0f (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-06-20T13:35:39Z (GMT) No. of bitstreams: 1
Mustafa_Uyanoglu_tez.pdf: 2425797 bytes, checksum: 0ecfe0a6069d0d2f1e49e5207e62cd0f (MD5)
Made available in DSpace on 2022-06-20T13:35:39Z (GMT). No. of bitstreams: 1
Mustafa_Uyanoglu_tez.pdf: 2425797 bytes, checksum: 0ecfe0a6069d0d2f1e49e5207e62cd0f (MD5)
Previous issue date: 2006
ESOGÜ, Fen Bilimleri Enstitüsü
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Karaciger Rejenerasyonu
Parsiyal Hepatektomi
Karvakrol
Silymarin
Sıçan
Parsiyal hepatektomi yapılmış sıçanlarda karvakrolün karaciğer üzerine etkileri
doctoralThesis
TEXT
Mustafa_Uyanoglu_tez.pdf.txt
Mustafa_Uyanoglu_tez.pdf.txt
text/plain
149760
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3392/3/Mustafa_Uyanoglu_tez.pdf.txt
dc396dfb6670eb3a8c25558d14b99906
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3392/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
Mustafa_Uyanoglu_tez.pdf
Mustafa_Uyanoglu_tez.pdf
application/pdf
2425797
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3392/1/Mustafa_Uyanoglu_tez.pdf
0ecfe0a6069d0d2f1e49e5207e62cd0f
MD5
1
11684/3392
oai:openaccess.ogu.edu.tr:11684/3392
2022-06-21 03:00:29.458
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/3644
2022-07-07T00:00:30Z
com_11684_15
com_11684_2
col_11684_86
İlhan, Semra
Filik İşcen, Cansu
ESOGÜ, Fen Bilimleri Enstitüsü, Biyoloji Ana Bilim Dalı
2022-07-06T06:08:22Z
2022-07-06T06:08:22Z
2006
2006
http://hdl.handle.net/11684/3644
Çalışmada Porsuk Havzasında yer alan ve yüksek organik madde içerikli atık su üreten tarıma dayalı sanayilerin atık sularının anaerobik arıtılabilirlikleri ve metan üretim potansiyellerinin araştırılması amaçlanmıştır. Biyokimyasal metan potansiyeli (BMP), farklı başlangıç kimyasal oksijen ihtiyacına (KOİ) sahip atık sularla bazal ortamlı ve bazal ortamsız olarak yapılmıştır. Sonuçlar bazal ortam ilavesinin çalışılan atık suların anaerobik arıtımı için önemli olduğunu ortaya çıkarmıştır. BMP sonuçlarına göre kek üretimi, peynir yapımı ve alkol damıtımı atık suyu (şlempe) endüstrilerinden çıkan atık suların anaerobik arıtıma en uygun atık sular olduğu belirlenmiştir. Anaerobik metan üretimi 12000 mg/l başlangıç KOİ değerinde kek üretimi atık suyu için 1062 ml CH4/g KOİ (12,7 l CH4/l atık su), 30000 mg/l başlangıç KOİ değerinde peynir altı suyu için 366 ml CH4/g KOİ (10,98 l CH4/l atık su), 27000 mg/l başlangıç KOİ değerinde şlempe için 222 ml CH4/g KOİ (6 l CH4/l atık su) olarak bulunmuştur.
Bu üç atık suyun, seri bağlı iki reaktörden (R1 ve R2) oluşan yukarı akışlı anaerobik dolgulu yatak reaktörde arıtım çalışmaları yapılmıştır. Kek üretimi atıksuyu ile süren 150 günlük çalışmalar sırasında organik yük 1,3-10,2 g KOİ/(l gün) aralığında ve hidrolik alıkonma süresi ise 120-26 saat arasında değiştirilmiştir. Organik yük 7,5 g KOİ/(l gün) olduğunda 29 saatlik alıkonma süresinde iki reaktörün toplamında %98-99 KOİ giderimi elde edilmiştir.
Şlempe ile yapılan çalışmalar 200 gün sürmüş ve R1 için organik yük 2,71-5,48 g KOİ/(l gün) aralığında ve R2 için 0,68-1,18 g KOİ/(l gün) aralığında değiştirilmiştir. Organik yük 4,8 g KOİ/(l gün) olduğunda 175 saatlik alıkonma süresinde iki reaktörün toplamında %97,1 KOİ giderimine ulaşılmıştır.
Peynir altı suyu ile yukarı akışlı anaerobik dolgulu yatakta arıtım çalışmaları 185 gün sürmüştür. R1’de organik yük 2-15 g KOİ/(l gün) aralığında ve R2’de 0,3-2,23 g KOİ/(l gün) aralığında değiştirilmiştir. Organik yük 12,71 g KOİ/(l gün) olduğunda 85 saatlik alıkonma süresinde iki reaktörün toplamında %98,9 KOİ giderimi elde edilmiştir.
Anaerobic treatability and methane production potential of high organic materials containing wastewaters from agricultural industry which located in the Porsuk River Basin have been investigated. Experiments on biochemical methane potential (BMP) have been carried out on the wastewaters with various initial chemical oxygen demand (COD) adding the basal medium and without it. The results have shown that basal medium addition were important for the examined wastewaters. According to BMP results; cake production, cheese making, and beet molasses alcohol distillery wastewaters have been deduced as the most suitable effluents for the anaerobical treatment. Anaerobical methane production potentials have been found for cake production wastewater at 12000 mg l-1 initial COD value as 1062 ml CH4/g COD (12,7 l CH4/l wastewater), for cheese making wastewater at 30000 mg l-1 initial COD value as 366 ml CH4/g COD (10,98 l CH4/l wastewater), and for alcohol distillery wastewater (vinasse) at 27000 mg l-1 initial COD value as 222 ml CH4/g COD (6 l CH4/l wastewater).
These three wastewaters have been treated in two upflow packed bed anaerobic reactors, that effluent of the first reactor (R1) is the feed of the second one (R2). During 150 days operation time with the cake production wastewater organic load has changed between 1,310,2 g COD/(l day), hydrolic retention time between 120-26 hours. At 7,5 g COD/(l day) organic load and 29 h retention time, 98-99% total COD removal in two reactors has been observed.
Experiments with alcohol distillery wastewater have continued 200 days and organic loads have changed between 2,71-5,48 g COD/(l day) for the R1 and 0,68-1,18 g COD/(l day) for R2. At 4,8 g COD/(l day) organic load and 175 hours retention time, 97,1% total COD removal in two reactors has been achieved.
Feeding cheese making wastewater to upflow packed bed anaerobic reactors has lasted for 185 days. Organic loads have changed between 2-15 g COD/(l day) for R1 and 0,3-2,23 g COD/(l day) for R2. At 4,8 g COD/(l day) organic load and 85 hours retention time, 98,9% total COD removal in two reactors has gained.
Submitted by Mustafa Meteoğlu (g0682) on 2021-03-03T08:29:50Z
No. of bitstreams: 0
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-07-06T06:08:22Z (GMT) No. of bitstreams: 0
Made available in DSpace on 2022-07-06T06:08:22Z (GMT). No. of bitstreams: 0
Previous issue date: 2006
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Kek Üretim Atık Suyu
Şlempe
Peynir Altı Suyu
Yukarı Akışlı Anaerobik Dolgulu Yatak Reaktör
Biyokimyasal Metan Potansiyeli (BMP)
Eskişehir'de yer alan tarıma dayalı sanayilere ait yüksek organik madde içerikli atık suların anaerobik arıtılabilirliklerinin ve metan üretim potansiyellerinin araştırılması
doctoralThesis
TEXT
184073.pdf.txt
184073.pdf.txt
text/plain
215365
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3644/3/184073.pdf.txt
204f867b9e182b63d71b429f02b92628
MD5
3
ORIGINAL
184073.pdf
184073.pdf
application/pdf
1025334
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3644/2/184073.pdf
dfa7d1163b8bbfce9f0fcffb6d89bde6
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3644/1/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
1
11684/3644
oai:openaccess.ogu.edu.tr:11684/3644
2022-07-07 03:00:30.014
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1798
2021-03-04T01:00:34Z
com_11684_15
com_11684_2
col_11684_86
Tokur, Süleyman
Yaylacı, Ömer Koray
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2021-03-03T13:11:34Z
2021-03-03T13:11:34Z
2006
2006
http://hdl.handle.net/11684/1798
Bu araştırmada Geyve (A3: Sakarya)’de doğal yayılış gösteren Liliaceae
familyasından Bellevalia clusiana Griseb., Ornithogalum pyrenaicum L., Muscari
comosum (L.) Miller, Scilla autumnalis L. ve Caryophyllaceae familyasından Silene
gallica L., türlerinin bazı morfolojik ve sitotaksonomik özellikleri incelenmiştir.
Bu çalışmada, Bellevalia cinsinin endemik türlerinden olan Bellevalia.
clusiana’nın, Ornithogalum pyrenaicum, Muscari comosum, Scilla autumnalis ve Silene
gallica türlerinin kromozom sayımları ve karyotip analizleri yapılmış ayrıca bazı
morfolojik özellikleri incelenmiştir.
Karyotipik çalışmalarda Bellevalia clusiana, Ornithogalum pyrenaicum, Muscari
comosum ve Scilla autumnalis türlerine ait soğanların çimlendirilmesiyle elde edilen
kök uçları kullanılmıştır. Silene gallica’nın kök uçları ise türün tohumlarının
çimlendirilmesiyle elde edilmişlerdir. Somatik hücrelerin bulunduğu kök uçlarına ön
tespit 8-Hidroksikinolin, tespit % 100 saf glasial asetik asit ve hidroliz 1 N HCl gibi
işlemlerden sonra aseto orsein boyama metodu uygulanmıştır. Bölünmenin en fazla
olduğu kök ucu primer meristem hücrelerinde, metafaz kromozomları sayısal ve
morfolojik yönden incelenmiştir.
Bu çalışmada, yurdumuzda doğal yayılış gösteren Liliaceae (Liliopsida) ve
Caryophyllaceae (Magnoliopsida) familyalarına dahil beş türün bazı sitotaksonomik
özellikleri belirlenmiştir. Elde edilen sonuçlara göre; Bellevalia clusiana 2n=16,
Ornihogalum pyrenaicum 2n=24, Muscari comosum 2n=18, Scilla autumnalis 2n=14,
Silene gallica 2n=24’tür. Türlerin kromozom sayıları bundan önce bazı araştırıcılar
tarafından Türkiye dışında da yayılış gösteren bu türlerde tespit edilen kromozom
sayıları ile uyum göstermektedir.
Bellevalia clusiana türünde kromozomların metasentrik (I. kromozom),
subtelosentrik (II. kromozom) ve submetasentrik sentromer durumlu (III. ve IV.
kromozomlar) oldukları belirlenmiştir. Ornithogalum pyrenaicum türünde de kromozomların metasentrik (I., VII.,
VIII., XI. ve XII. kromozomlar), submetasentrik (II., IV., V., IX. ve X. kromozomlar)
subtelosentrik sentromer (III. ve VI. kromozomlar) durumludurlar.
Submitted by Görkem Çınar (18262273360) on 2021-03-03T10:20:02Z
No. of bitstreams: 1
Ömer Koray_Yaylacı_tez.pdf: 605987 bytes, checksum: 812bb7ab962b5bc2f090ac926360ce63 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2021-03-03T13:11:34Z (GMT) No. of bitstreams: 1
Ömer Koray_Yaylacı_tez.pdf: 605987 bytes, checksum: 812bb7ab962b5bc2f090ac926360ce63 (MD5)
Made available in DSpace on 2021-03-03T13:11:34Z (GMT). No. of bitstreams: 1
Ömer Koray_Yaylacı_tez.pdf: 605987 bytes, checksum: 812bb7ab962b5bc2f090ac926360ce63 (MD5)
Previous issue date: 2006
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Sitotaksenemik
Doğal Yayılış
Geyve ( A3:Sakarya )’de doğal yayılış gösteren bazı bitkiler üzerinde sitotaksonomik çalışmalar
masterThesis
TEXT
Ömer Koray_Yaylacı_tez.pdf.txt
Ömer Koray_Yaylacı_tez.pdf.txt
text/plain
77411
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1798/3/%C3%96mer+Koray_Yaylac%C4%B1_tez.pdf.txt
9959025e1858f82769e37296d715698f
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1798/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
Ömer Koray_Yaylacı_tez.pdf
Ömer Koray_Yaylacı_tez.pdf
application/pdf
605987
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1798/1/%C3%96mer+Koray_Yaylac%C4%B1_tez.pdf
812bb7ab962b5bc2f090ac926360ce63
MD5
1
11684/1798
oai:openaccess.ogu.edu.tr:11684/1798
2021-03-04 03:00:34.002
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1914
2021-03-10T01:06:55Z
com_11684_15
com_11684_2
col_11684_86
Kulcanay Şahin, İlknur
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2021-03-09T13:10:11Z
2021-03-09T13:10:11Z
2005
2005
http://hdl.handle.net/11684/1914
Diabet; vasküler komplikasyonları nedeniyle doku dolasımını olumsuz etkileyen ve bunun
bir sonucu olarak doku hasarına neden olan bir hastalıktır. Diabetin neden oldugu bu doku hasarı;
böbrek ve göz gibi önemli organları etkiledigi gibi cildi de etkilemektedir. yi regüle edilememis
diabette gözlenen kan sekeri yüksekligi, ciltte yapılan operasyonları (örnegin; skin flaps) olumsuz
etkilemektedir. Dolayısıyla da, kan sekerinin düzenlenmesine ilave olarak, ciltteki kan
dolasımının da arttırılması gerekliligi ortaya çıkmaktadır. Uzun yıllardan beri agrı, kasıntı,
nöropati vb. rahatsızlıkların tedavisinde kullanılagelen TENS (Transcutaneus Electrical Nevre
Stimulation) yöntemi; yara iyilesmesi ve ciltteki kan dolasımının yetersizligi gibi problemlerde de
kullanılmaktadır.
Çalısmamızda Streptozotocin ( STZ ) ile tek doz 60 mg/kg olarak, intraperitoneal (i.p)
yolla deneysel diyabetik hale getirilen Wistar Albino sıçanlarda, flep nekrozunun azaltılması
üzerinde TENS’ in etkileri arastırılmıstır.
Deneylerde agırlıkları 200-240 g olan 40 adet erkek sıçan kullanılmıstır. Sıçanlar 10’ ar
bireylik 4 gruba (K, A, B, C) ayrılmıs ve bu gruplardan ikisi (K ve C) sadece sodyum sitrat
tamponu verilmis olan saglıklı kontrol guruplarını olustururken, diger iki gurup (A ve B) sodyum
sitrat tamponu içinde çözünmüs STZ ile akut diyabetik hale getirilmis grupları olusturmaktadır.
STZ tatbikinden 24 saat sonra, kuyruklardan intravenöz yolla alınan kanların glukoz seviyeleri
glukometre cihazı ile tespit edilmis ve kan seker seviyesi 250 mg/dL’ nin üzerinde olanlar
diyabetik olarak kabul edilmistir.
Saglıklı ve diyabetli bireyleri karsılastırabilmek için TENS, bu dört gruptan sadece B ve C’
ye uygulanmıs olup, diger iki gurup kontrol amaçlı olarak degerlendirilmeye alınmıstır. Tüm
guruplardaki sıçanların sırt bölgelerinden, intraperitonal ketamin anestezisi (100 mg/kg) altında
kaldırılmıs olan 2x7 cm’ lik deri flebinin tekrar yerlestirilmesi yoluyla nekrotik doku olusumuna
bakılmıstır. Sadece gurup B ve C’deki sıçanların yaralarına günde 1 saat olmak üzere yedi gün
boyunca TENS (0.2 ms’ lik, monopolar, 80 Hz frekansında, 20 mA’ lık akım ) uygulanmıs ve
yedinci günün sonunda tüm gruplarda nekroz ölçümü yapılarak biyopsi alınmıstır. Daha sonra
biyopsi örneklerinin histopatolojik incelemeleri tamamlanmıstır.
Sonuç olarak TENS akımının, saglam bireylerde flebin nekroz alanını anlamlı olarak
azalttıgı gözlemlenmistir. Ancak, deneysel olarak STZ ile diyabetli hale getirilmis sıçanlarda
anlamlı sayılabilecek bir fleb iyilesmesi gözlemlenmemistir. Yine çalısmamızda TENS
uygulanmıs diyabetik sıçanlarda inflamasyonun azaldıgı saptanmıstır.
Diabetes is a type of disease which negatively influences the circulation of blood at the
tissues and eventually causes the tissue damage because of its vascular complications. A tissue
damage caused by diabetes has negative effects on some of the important organs such as eyes and
kidneys, as well as has effects on skin. Elevated blood-glucose levels can be seen in poorly
regulated diabetes has negative effects on the skin operations e.g. skin flaps. Thus, as an addition
to the regulation of the blood-glucose levels it emerges that it is necessary to increase the skin
perfusion in order to overcome negative effects encountered in skin operations. Having been used
for the treatment of pain, pruritus and neuropathies for so many years, TENS (Transcutaneus
Electrical Nevre Stimulation) is still in use of enhancement of wound healing and skin perfusion
deficiency.
In this study, healing effects of the TENS on the necrosis of skin flaps in STZ – induced
diabetic Albino Wistar rats (60 mg/kg, i.p) have been investigated. Forty male Wistar albino rats
weighing between 200-240 g were used in the study. The rats were separated in four groups
including 10 individuals in each group (K, A, B, C). While K and C groups were consisting of
sodium citrate buffer treated nondiabetic rats, which was a control group, the other two groups A
and B were including acute diabetic rats treated with STZ solved in sodium citrate buffer, which
caused them to be diabetic. Twenty-four hours after STZ treatment, blood glucose levels have
been determined by the glucometer, using the intravenous blood samples obtained from the tails.
The rats, whose blood glucose levels were over 250 mg/dl at 24 hours after STZ administration,
were accepted as diabetic.
In order to be able to compare the healthy and diabetic individuals, TENS was only applied
to the groups B and C, and the other two were used as control groups as it was mentioned above.
To investigate the necrotic tissue forming in each group, necrotic tissues formed by raising
caudally based dorsal flaps measuring 2x7 cm and then returning to it’s bed under intravenous
ketamine anesthesia (100 mg /kg). TENS (monopolar pulses of 0.2 ms duration, 80 hz frequency
and 20 mA intensity) was only applied to the rat’s flaps in groups B and C for one hour a day for
seven days. At the end of the seventh day the necrosis at the distal ends of the flaps were
measured and biopsies were taken for histopathologic evaluation. In conclusion, the study showed
that TENS significantly decreases the flap necrosis in nondiabetic individuals . But no positive
effects of the TENS application on the flap survival in the experimentally diabetic rats was
determined. In our study it has also been determined that inflamation decreased in TENS-induced
diabetic rats.
Submitted by Ramazan Karayel (g1216) on 2021-03-03T10:35:13Z
No. of bitstreams: 1
Ilknur_Kulcanay_Sahin_tez.pdf: 28745186 bytes, checksum: 32ab778e6851dad4d39250abe1df3a73 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2021-03-09T13:10:11Z (GMT) No. of bitstreams: 1
Ilknur_Kulcanay_Sahin_tez.pdf: 28745186 bytes, checksum: 32ab778e6851dad4d39250abe1df3a73 (MD5)
Made available in DSpace on 2021-03-09T13:10:11Z (GMT). No. of bitstreams: 1
Ilknur_Kulcanay_Sahin_tez.pdf: 28745186 bytes, checksum: 32ab778e6851dad4d39250abe1df3a73 (MD5)
Previous issue date: 2005
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Diabetes Mellitus
Streptozotosin
TENS
Deri Flepleri
Sıçan
Streptozotocin ile akut diyabet oluşturulmuş erkek sıçanlarda, yara iyileşmesinde elektrik akımının etkisinin araştırılması
doctoralThesis
TEXT
Ilknur_Kulcanay_Sahin_tez.pdf.txt
Ilknur_Kulcanay_Sahin_tez.pdf.txt
text/plain
170086
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1914/3/Ilknur_Kulcanay_Sahin_tez.pdf.txt
adca2b0bcb4c5192e1878ff47ce41a98
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1914/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
Ilknur_Kulcanay_Sahin_tez.pdf
Ilknur_Kulcanay_Sahin_tez.pdf
application/pdf
28745186
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1914/1/Ilknur_Kulcanay_Sahin_tez.pdf
32ab778e6851dad4d39250abe1df3a73
MD5
1
11684/1914
oai:openaccess.ogu.edu.tr:11684/1914
2021-03-10 03:06:55.367
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/1913
2021-03-10T01:00:17Z
com_11684_15
com_11684_2
col_11684_86
Platin, Sevil
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2021-03-09T13:09:36Z
2021-03-09T13:09:36Z
2004
2004
http://hdl.handle.net/11684/1913
Çagımızda endüstri ürünlerinin üretimi ve tüketimi hızla artmıstır. Bunun
yanında olusan endüstriyel atıkların birikimi ve bunların doga üzerine olan etkileri ciddi
problemlere yol açmaktadır.
Tekstil atık suları içerdikleri çok degisik kimyasallardan ve özellikle de boyar
maddelerden dolayı arıtılması zor olan endüstriyel atık sulardan birisidir. Renk atıksu
içerisindeki en önemli kirleticidir ve mutlak suretle bu ortamlara ulasmadan önce rengin
giderilmesi gerekir. Atık sudan rengin giderimi çözünmüs renksiz organik maddelerin
gideriminden daha fazla önemlidir. Çünkü suda çok az miktarda bile boya bulunması
rengi arttırır ve nehirlerin, göllerin ve diger su kaynaklarının ısık geçirgenligini ve
gazların çözünürlügünü etkiler.
Tekstil endüstrisinde kullanılan boyarmaddelerin mikroorganizmalarla
parçalanabilirligi üzerine arastırmalar yapılmıs ve bu boyarmaddeleri dekolorize
edebilme veya parçalayabilme potansiyeline sahip olan birçok mikroorganizmanın var
oldugu ortaya konmustur. Beyaz çürükçül funguslar boyarmaddelerin yıkımı ve
renginin giderimi ve endüstriyel atıkların arıtımı çalısmalarında biyolojik sistem olarak
kullanılmaktadır.
Bu çalısmada Tekstil boyalarının (Blue 49, Orange 12, Orange 13, Red 31,
Black 5, RBBR) renk giderimini etkileyen parametreler Phanerochaeta chrysosporium,
Trametes versicolor ve Pleurotus sajor-caju için optimize edilmistir. pH , inokulum
miktarı, çalkalama hızı, boya konsantrasyonu ve sıcaklıgın renk giderimi için önemli
oldugu bulunmustur.
Yapılan çalısmalar sonucunda elde ettigimiz optimum kosullarda Phanerochaeta
chrysosporium, Trametes versicolor ve Pleurotus sajor-caju için pH 4,5, inokulum
miktarı 25 mg/l, çalkalama hızı 150 rpm, boya konsantrasyonu 25 mg/l ve 50 mg/l ve
sıcaklık 30 °C olarak bulunmustur.
In this century, the amount of industrial produces and their consumption has
increased tremendously. Along with this increase, accumulation of industrial waste and
its effect on nature has caused serious problems.
Textile waste water, including various chemicals and especially dye, is one of
the most difficult industrial wastes which could be refined. Color is the most important
pollutant in waste water and it should be decolorized before it reaches the above
mentioned resources. Decolorization is more important than purifying colorless organic
substances from waste water. Even a small amount of dye found in water increases the
color of rivers, lakes and other water resources, and reduces the penetration of light and
effects the solubility of gases.
Many researches about fragmentation of dye used in textile industry by
microorganisms have been conducted, and it has been found out that there are many
microorganisms which have the potential to fragment and decolorize dye. White rot
fungus are used as a biological system in ruining and decolorizing of dye and refining
industrial wastes.
In this study, the parameters Phanerochaeta chrysosporium, Trametes versicolor
and Pleurotus sajor-caju to decolorize textile dye (Blue 49, Orange 12, Orange 13, Red
31, Black 5, RBBR) are optimized. It has been found out that pH, amount of inoculums,
shaking velocity, dye concentration and heat are important in decolorization.
As a result of the study, the following values have been found under optimum
conditions for Phanerochaeta chrysosporium, Trametes versicolor and Pleurotus sajorcaju,
pH 4.5, amount of inoculums 25 mg/l, shaking velocity 150 rpm, dye
concentration 25 mg/l and 50 mg/l and heat 30°C.
Submitted by Ramazan Karayel (g1216) on 2021-03-03T10:42:10Z
No. of bitstreams: 1
Beyaz Çürükçül Funguslar İle Tekstil Boyarmaddelerin Renginin Giderimi.pdf: 2884105 bytes, checksum: 8f677c86440017a227c48ad74a5fb87d (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2021-03-09T13:09:36Z (GMT) No. of bitstreams: 1
Beyaz Çürükçül Funguslar İle Tekstil Boyarmaddelerin Renginin Giderimi.pdf: 2884105 bytes, checksum: 8f677c86440017a227c48ad74a5fb87d (MD5)
Made available in DSpace on 2021-03-09T13:09:36Z (GMT). No. of bitstreams: 1
Beyaz Çürükçül Funguslar İle Tekstil Boyarmaddelerin Renginin Giderimi.pdf: 2884105 bytes, checksum: 8f677c86440017a227c48ad74a5fb87d (MD5)
Previous issue date: 2004
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Beyaz Çürükçül Funguslar
Phanerochaeta Chrysosporium
Trametes versicolor ve Pleurotus sajor-caju
Renk Giderimi
Tekstil Boyaları
Beyaz çürükçül funguslar ile tekstil boyarmaddelerin renginin giderimi
doctoralThesis
TEXT
Beyaz Çürükçül Funguslar İle Tekstil Boyarmaddelerin Renginin Giderimi.pdf.txt
Beyaz Çürükçül Funguslar İle Tekstil Boyarmaddelerin Renginin Giderimi.pdf.txt
text/plain
185713
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1913/3/Beyaz+%C3%87%C3%BCr%C3%BCk%C3%A7%C3%BCl+Funguslar+%C4%B0le+Tekstil+Boyarmaddelerin+Renginin+Giderimi.pdf.txt
9f6bf951b4b5cbee550ac6bce54efe4b
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1913/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
Beyaz Çürükçül Funguslar İle Tekstil Boyarmaddelerin Renginin Giderimi.pdf
Beyaz Çürükçül Funguslar İle Tekstil Boyarmaddelerin Renginin Giderimi.pdf
application/pdf
2884105
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/1913/1/Beyaz+%C3%87%C3%BCr%C3%BCk%C3%A7%C3%BCl+Funguslar+%C4%B0le+Tekstil+Boyarmaddelerin+Renginin+Giderimi.pdf
8f677c86440017a227c48ad74a5fb87d
MD5
1
11684/1913
oai:openaccess.ogu.edu.tr:11684/1913
2021-03-10 03:00:17.947
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/3844
2022-07-27T00:00:28Z
com_11684_15
com_11684_2
col_11684_86
Çalışkan, Hakan
Kiper, Ulaş
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2022-07-26T07:13:07Z
2022-07-26T07:13:07Z
2006
2006
http://hdl.handle.net/11684/3844
Bu çalışma Mayıs 2004 ile Ağustos 2005 tarihleri arasında, Eskişehir’ de yakalanan
319 adet Tipulidae örneğine dayanmaktadır. Bu çalışmada; 2 cinse ait (Tipula ve
Nephrotoma), 16 tür belirlenmiştir.
Çalışma alanında belirlenen 16 Tipulidae türünün tanımları ile birlikte teşhislerinde
kullanılan erkek genitalia parçalarının çizimleri verilmiştir.
This study depends on 319 Craneflies (Tipulidae) samples found in Eskişehir between
April 2005 and August 2005. As a result of this study, 2 genus and 16 species belonging to
two subgenus (Tipula and Nephrotoma) are found.
Together with the description of 16 Tipulidae species which are determined in the
study area, the drawings of the male genilitia parts’ are given in the paper.
Submitted by ÖNDER GÜNGÖR (g1063) on 2021-03-03T11:07:32Z
No. of bitstreams: 1
ulas_kiper_tez_pdf.pdf: 1849049 bytes, checksum: aa4b8cd65d7f16f3c4179f22fa34e936 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-07-26T07:13:07Z (GMT) No. of bitstreams: 1
ulas_kiper_tez_pdf.pdf: 1849049 bytes, checksum: aa4b8cd65d7f16f3c4179f22fa34e936 (MD5)
Made available in DSpace on 2022-07-26T07:13:07Z (GMT). No. of bitstreams: 1
ulas_kiper_tez_pdf.pdf: 1849049 bytes, checksum: aa4b8cd65d7f16f3c4179f22fa34e936 (MD5)
Previous issue date: 2006
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Diptera
Nematocera
Tipulidae
Sistematik
Fauna
Türkiye
Eskişehir
Eskişehir Tipulidae (Diptera) faunası üzerine çalışmalar
masterThesis
TEXT
ulas_kiper_tez_pdf.pdf.txt
ulas_kiper_tez_pdf.pdf.txt
text/plain
127205
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3844/3/ulas_kiper_tez_pdf.pdf.txt
64382f3c86ec2f3031f8d05d084da320
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3844/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
ulas_kiper_tez_pdf.pdf
ulas_kiper_tez_pdf.pdf
application/pdf
1849049
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3844/1/ulas_kiper_tez_pdf.pdf
aa4b8cd65d7f16f3c4179f22fa34e936
MD5
1
11684/3844
oai:openaccess.ogu.edu.tr:11684/3844
2022-07-27 03:00:28.844
Dspace@ESOGU
openaccess@ogu.edu.tr
REFHSVRJTSBMSVNBTlNJCgpCdSBsaXNhbnPEsSBpbXphbGF5xLFwIGfDtm5kZXJlcmVrLCBnw7ZuZGVyaW5pemkgZMO8bnlhIMOnYXDEsW5kYSBiYXPEsWzEsSBoYWxkZSwgCmVsZWt0cm9uaWsgb3J0YW1kYSB2ZSBoZXJoYW5naSBiYXNrYSBiaXIga2FuYWxsYSB5ZW5pZGVuIG9sdcWfdHVybWFrLCAKw6dldmlyaXNpbmkgeWFwbWFrIChhxZ9hxJ/EsWRhIHRhbsSxbWxhbmTEscSfxLEgw7x6ZXJlKSB2ZS92ZXlhIGRhxJ/EsXRtYWsgacOnaW4gCkVza2nFn2VoaXIgT3NtYW5nYXppIMOcbml2ZXJzaXRlc2nigJluaW4gKEVTT0dVKSDDtnplbCBvbG1heWFuIGhha2xhcsSxbsSxIGthYnVsIGV0bWnFnyBvbHVyc3VudXouCgpFU09HVSwgZ8O2bmRlcmluaXppbiBpw6dlcmnEn2luaSBkZcSfaXN0aXJtZWRlbiBoZXJoYW5naSBiaXIgCm9ydGFtZGEgZmFya2zEsSBiacOnaW1sZXJkZSBrb3J1bWEgYW1hw6dsxLEgb2xhcmFrIMOnZXZpcmViaWxpci4gCsOWdGUgeWFuZGFuIEVTT0dVLCBnw7x2ZW5saWssIHllZGVrbGVtZSB2ZSBrb3J1bWEgYW1hY8SxeWxhIGJ1IGfDtm5kZXJpbmluIApiaXJkZW4gZmF6bGEga29weWFzxLFuxLEgZWxpbmRlIHR1dGFiaWxpci4gCgpHw7ZuZGVyaW5pbiBzaXplIGFpdCBvcmlqaW5hbCBiaXIgw6dhbGnFn21hIG9sZHXEn3VudSB2ZSBidSBsaXNhbnN0YSBiZWxpcnRpbGVuIApoYWtsYXLEsSBrYWJ1bCBldG1lIGhha2vEsW7EsXogb2xkdcSfdW51IGJlbGlydG1pxZ8gb2x1cnN1bnV6LiBBeW7EsSB6YW1hbmRhIGfDtm5kZXJpbml6aW4sIApiaWxkacSfaW5peiBrYWRhcsSxeWxhLCBraW1zZW5pbiDDtnpsdWsgaGFra8SxbsSxIMOnacSfbmVtZWRpxJ9pbmkgZGUgc3VubXXFnyBvbHVyc3VudXouCgpFxJ9lciBnw7ZuZGVyaSB0ZWxpZiBoYWtrxLFuYSBzYWhpcCBvbHVubWF5YW4gYmlyIG1hdGVyeWFsIGnDp2VyaXlvcnNhLCBvIHphbWFuIAp0ZWxpZiBoYWtrxLEgc2FoaWJpbmRlbiBidSBsaXNhbnMgaWNpbiBnZXJla2xpIG9sYW4gRVNPR1UgaGFrbGFyxLFuxLEga2FidWwgZXRtZWsgCmljaW4ga8Sxc8SxdHPEsXogaXppbiBhbGTEscSfxLFuxLF6xLEgdmUgYnUgdGFyeiDDvMOnw7xuY8O8IGtpxZ9pbGVyIHRhcmFmxLFuZGFuIHNhaGlwIG9sdW5hbiAKbWF0ZXJ5YWxsZXJpbiBnw7ZuZGVyaSBpw6dlcmnEn2kgdmV5YSBtZXRuaSBpw6dlcmlzaW5kZSBhw6dpa8OnYSB0YW7EsW1sYW5kxLHEn8SxbsSxIHZlIAprYWJ1bCBlZGlsZGnEn2luaSBzdW5hcnNpbml6LgoKRcSeRVIgR8OWTkRFUsSwIEVTT0dVIERJxZ5JTkRBIEJBxZ5LQSBCxLBSIEtVUlVMVcWeIFRBUkFGSU5EQU4gREVTVEVLTEVORU4gQsSwUiDDh0FMScWeTUFZQSAKREFZQUxJIMSwU0UsIEJVIFRBUlogQklSIEFOTEHFnk1BIFZFWUEgU8OWWkxFxZ5NRU7EsE4gR0VSRUtUxLBSRMSwxJ7EsCBExLDEnkVSIApaT1JVTkxVTFVLTEFSSSBZRVLEsE5FIEdFVMSwUkTEsMSexLBOxLBaxLAgU1VOQVJTSU5JWi4KCkVTT0dVIGlzbWluaXppIGfDtm5kZXJpbmluIHlhemFyxLEgdmV5YSBzYWhpYmkgb2xhcmFrIGHDp8Sxa8OnYSB0YW7EsW1sYXlhY2FrdMSxciB2ZSAKYnUgbGlzYW5zxLFuIGl6aW4gdmVyZGnEn2luaW4gZMSxxZ/EsW5kYSBoZXJoYW5naSBiaXIgZGXEn2nFn2lrbGlrIHlhcG1heWFjYWt0xLFyLgo=
oai:openaccess.ogu.edu.tr:11684/3422
2022-06-22T00:02:20Z
com_11684_15
com_11684_2
col_11684_86
Canbek, Mediha
Koparal, Tansu
Bostancıoğlu, Rakibe Beklem
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2022-06-21T10:34:49Z
2022-06-21T10:34:49Z
2008
2008
http://hdl.handle.net/11684/3422
Kanser, çağımızda oldukça yaygın olarak karsılastığımız ciddi bir problemdir.
Bu hastalığın tedavisinde, kemoterapi sıklıkla basvurulan bir yöntemdir. Metal
kompleksleri içeren kemoterapotik ilaçların bu hastalığın tedavisinde olumlu sonuçlar
verdiği düsünülmektedir.
Bu tezde kullandığımız maddeler bazı kanser türlerinin tedavisinde
kullanılabilecek ilaç hammaddeleri olabilir. Bu maddeler bazı binaftol türevlerinden
hareketle elde edilmis metal kompleksleridir. Bunların sağlam ve kanserli hücreler
üzerindeki sitotoksik ve apoptotik etkisi, in vitro olarak hücre kültürü teknikleriyle
arastırılmıstır. Bu amaçla sağlıklı çin hamster akciğer (V79 379 A) ve kanserli insan
akciğer hücreleri (A549), [(CuL)(NO3)2] ve [(NiL)(CIO4)2] maddelerinin belirli
dozlarına maruz bırakıldıktan sonra, hücrelerin sitotoksisitesi; mitokondrial aktiviteye
dayalı MTT testi ile ölçülmüstür. Sonuçlar her iki maddenin de hücreler üzerinde
sitotoksik etki yaptığını göstermistir.
Bu maddelerin apoptotik etkisi ise DAPI boyama yöntemi ile incelenmistir. Test
maddeleri, özellikle [(NiL)(CIO4)2] hücrelerde apoptozise neden olmustur.
Cancer is a serious problem that we quite frequently confronted with for a long
tıme. Chemotheraphy is a rather frequently consulted method in cure of this illness. It is
thought that, medicines which contain metal complexes affect this illness positively.
The materials that are used in this study are metal complexes, obtained from
derivatives of binaftol and we think that these materials can be used as drug materials in
curing certain kinds of cancers. In this thesis, cytotoxic and apoptotic effects of these
metal complexes were investigated with techniques of cell cultures on healthy and
cancer cells as in vitro. Accordingly, at first Chinese hamster lung cell (V79 379 A) and
lung cancer cell of human (A549) were exposed to approprite dose of [(CuL)(NO3)2]
and [(NiL)(CIO4)2] materials and, then cell cytotoxicity is measured with MTT test
which is accepted as indicator of mitochondrial activity. The results showed that both
materials cause cytotoxicity on healthy and cancer cells.
Apoptotic effect of these materials is detected with DAPI staining method. Test
materials, especially [(NiL)(CIO4)2], cause apoptosis on cells.
Submitted by Ramazan Karayel (g1216) on 2021-03-04T08:12:14Z
No. of bitstreams: 1
beklem_bostancioglu_ tez.pdf: 45751814 bytes, checksum: a752dead16cf7c356512c618199e1c4f (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-06-21T10:34:49Z (GMT) No. of bitstreams: 1
beklem_bostancioglu_ tez.pdf: 45751814 bytes, checksum: a752dead16cf7c356512c618199e1c4f (MD5)
Made available in DSpace on 2022-06-21T10:34:49Z (GMT). No. of bitstreams: 1
beklem_bostancioglu_ tez.pdf: 45751814 bytes, checksum: a752dead16cf7c356512c618199e1c4f (MD5)
Previous issue date: 2008
ESOGÜ, Fen Bilimleri Enstitüsü
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Metal Kompleksleri
MTT
Apoptozis
DAPI Boyama
Bazı binaftol türevlerinden hareketle elde edilen metal komplekslerinin sağlam ve kanserli hücreler üzerindeki apoptotik etkilerinin belirlenmesi
masterThesis
TEXT
beklem_bostancioglu_ tez.pdf.txt
beklem_bostancioglu_ tez.pdf.txt
text/plain
429625
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3422/3/beklem_bostancioglu_+tez.pdf.txt
d265d1816e3b6ec32b2b4634a635cb98
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3422/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
beklem_bostancioglu_ tez.pdf
beklem_bostancioglu_ tez.pdf
application/pdf
45751814
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3422/1/beklem_bostancioglu_+tez.pdf
a752dead16cf7c356512c618199e1c4f
MD5
1
11684/3422
oai:openaccess.ogu.edu.tr:11684/3422
2022-06-22 03:02:20.826
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/3424
2022-06-22T00:00:19Z
com_11684_15
com_11684_2
col_11684_86
İlhan, Semra
Saçkesen, Mustafa
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2022-06-21T11:24:28Z
2022-06-21T11:24:28Z
2007
2007
http://hdl.handle.net/11684/3424
Anaerobik funguslar gerek ruminantların ve gerekse tek mideli herbivorların
birçoğunun sindirim sisteminde simbiyotik olarak yasarlar. Konakçı hayvanın
funguslar için uygun sıcaklık, anaerobik ortam ve besin kaynağı sağlamasına karsılık
funguslar konakçı hayvan tarafından alınan bitkilerin hücre duvarlarındaki
polisakkaritleri sellobiyoz ve glikoza çevirerek simbiyotik halkayı tamamlarlar. Orpin
tarafından kesiflerinden bu yana 6 cins içerisinde 19 tür tanımlanmıstır. Neocallimastix,
Piromyces ve Caecomyces cinsleri monosentrik, Orpinomyces, Anaeromyces ve
Cyllamyces cinsleri ise polisentrik yasam gösterirler.
Bu çalısmada, bir tanesi rumen sıvısı diğerleri çesitli herbivorlara ait dıskı olmak
üzere 25 örnek üzerinde çalısılmıstır. Đzolasyon islemi sonucunda elde edilen 6 izolatın
Neocallimastix cinsine ait olduğu anlasılmıstır. Bu izolatların zoosporları ve vegetatif
halleri görüntülenmistir.
Anaerobic fungi inhabit the gastro-intestinal tract of ruminants and the most
non-ruminant herbivores. Host animals provide nutrient and anaerobic environment
whilst anaerobic fungi are involved in biodegradation of plant particles ingested by the
host animals. Since their first identification by Orpin, 6 genera and 19 species have
been characterized so far. While Neocallimastix, Piromyces and Caecomyces are
monocentric fungi, species of the genera Orpinomyces, Anaeromyces and Cyllamyces
show polycentric development.
In this study, it was investigated 25 samples. From these samples one was
Rumen fluid and the others were feaceses from various herbivors. As a result of
isolation processes, 6 isolates obtained belonged to Neocallimastix genus. The
zoospores and vegetative forms of these isolates were monitored.
Submitted by Ramazan Karayel (g1216) on 2021-03-04T08:24:02Z
No. of bitstreams: 1
mustafa_sackesen_tez.pdf: 8414828 bytes, checksum: b016607cf29eb8f55dc55ee93dceb332 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-06-21T11:24:28Z (GMT) No. of bitstreams: 1
mustafa_sackesen_tez.pdf: 8414828 bytes, checksum: b016607cf29eb8f55dc55ee93dceb332 (MD5)
Made available in DSpace on 2022-06-21T11:24:28Z (GMT). No. of bitstreams: 1
mustafa_sackesen_tez.pdf: 8414828 bytes, checksum: b016607cf29eb8f55dc55ee93dceb332 (MD5)
Previous issue date: 2007
ESOGÜ, Fen Bilimleri Enstitüsü
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Anaerobik Fungus
İzolasyon
İdentifikasyon
Neocallimastigales
Ruminantlardan anaerobik fungus izolasyonu ve identifikasyonu
masterThesis
TEXT
mustafa_sackesen_tez.pdf.txt
mustafa_sackesen_tez.pdf.txt
text/plain
127619
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3424/3/mustafa_sackesen_tez.pdf.txt
b469ea31202699d3bc5a2b1450177bf3
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3424/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
mustafa_sackesen_tez.pdf
mustafa_sackesen_tez.pdf
application/pdf
8414828
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3424/1/mustafa_sackesen_tez.pdf
b016607cf29eb8f55dc55ee93dceb332
MD5
1
11684/3424
oai:openaccess.ogu.edu.tr:11684/3424
2022-06-22 03:00:19.999
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/3666
2022-07-07T00:00:24Z
com_11684_15
com_11684_2
col_11684_86
Şahin, Yalçın
Emiroğlu, Özgür
ESOGÜ, Fen Bilimleri Enstitüsü, Biyoloji Anabilim Dalı
2022-07-06T11:37:29Z
2022-07-06T11:37:29Z
2008
2008
http://hdl.handle.net/11684/3666
Mart 2006-Şubat 2007 tarihleri arasında Uluabat Gölü’nde Esox lucius
Linnaeus, 1758, Carassius gibelo (Bloch, 1782), Scardinius erythophthalmus
(Linnaeus, 1758) populasyonlarının biyolojik özellikleri saptanmaya çalışılmıştır.
Bu amaçla ile Uluabat Gölü’nden yakalanan Esox lucius , Carassius gibelo,
Scardinius erythophthalmus örneklerinin morfometrik özellikleri belirlenerek yaş-eşey
kompozisyonları, boy ve ağırlık dağılımları, yaş-boy ilişkileri, yaş-ağırlık ilişkileri, von
Bertalanffy’in büyüme denklemleri, boy ağırlık ilişkileri, mevsimsel kondisyon
faktörleri, Gonodo Somatik Đndeksleri ve üreme periyotları belirlenmiştir.
In this study bioechological features of Esox lucius Linnaeus, 1758, Carassius
gibelio (Bloch, 1782) ve Scardinius erythophthalmus (Linnaeus, 1758) populatıon has
been confirmed between March 2006-February 2007 in Uluabat Lake.
Age-sex compositions, height and weight distibutions, age-height relationsships,
age-weight relationships, von Bertalanffy’s growth balances, height and weight
relationships, seasonal condition factors, Gonodo somatic indexes and reproduction
periods of Esox lucius, Carassius gibelio, ve Scardinius erythophthalmus samples
caught in Uluabat Lake are modified by determining the morphometrical of features of
these species.
Submitted by ÖNDER GÜNGÖR (g1063) on 2021-03-04T08:54:46Z
No. of bitstreams: 1
ozgur_emiroglu_tez.pdf: 1475764 bytes, checksum: 2cc3904a50997a1a7ce1c312e386497e (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-07-06T11:37:29Z (GMT) No. of bitstreams: 1
ozgur_emiroglu_tez.pdf: 1475764 bytes, checksum: 2cc3904a50997a1a7ce1c312e386497e (MD5)
Made available in DSpace on 2022-07-06T11:37:29Z (GMT). No. of bitstreams: 1
ozgur_emiroglu_tez.pdf: 1475764 bytes, checksum: 2cc3904a50997a1a7ce1c312e386497e (MD5)
Previous issue date: 2008
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Uluabat Gölü
Esox Lucius
Carassius Gibelo
Scardinius Erythophthalmus
Uluabat gölü (Bursa) Esox lucius Linnaeus, 1758, Carassius gibelio (Bloch, 1782) ve Scardinius erythophthalmus (Linnaeus, 1758) populasyonlarının biyoekolojik özelliklerinin incelenmesi
doctoralThesis
TEXT
ozgur_emiroglu_tez.pdf.txt
ozgur_emiroglu_tez.pdf.txt
text/plain
243200
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3666/3/ozgur_emiroglu_tez.pdf.txt
4310717a7304fce78926106381cd1df5
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3666/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
ozgur_emiroglu_tez.pdf
ozgur_emiroglu_tez.pdf
application/pdf
1475764
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3666/1/ozgur_emiroglu_tez.pdf
2cc3904a50997a1a7ce1c312e386497e
MD5
1
11684/3666
oai:openaccess.ogu.edu.tr:11684/3666
2022-07-07 03:00:24.704
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/3676
2022-07-08T00:00:33Z
com_11684_15
com_11684_2
col_11684_86
Çalışkan, Hakan
Özkan, Murat
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2022-07-07T05:42:55Z
2022-07-07T05:42:55Z
2005
2005
http://hdl.handle.net/11684/3676
Bu çalışma, Haziran 2004 ile Temmuz 2005 tarihleri arasında Eskişehir’de yakalanan 660 syrphid örneğine dayanmaktadır. Bu çalışmada iki altfamilyaya ait (Syrphinae ve Milesiinae) 20 cins ve toplam 26 tür tespit edilmiştir.
Çalışma alanında tespit edilen türlerin tanımları ve teşhis anahtarları verilmiştir. Türlerin baş, anten, mesonotum, kanat, abdomen ve bacaklarına ait bazı karakteristik ayırtedici kısımların şekilleri verilmiştir.
This study depends on 660 syrphid samples found in Eskişehir between June 2004 and July 2005. In this study, 20 genus and 26 species belonging to two subfamilies (Syrphinae ve Milesiinae) were found.
Species’ which are determined in working area descriptions and determination keys are given. Relating to species head, antennae, mesonotum, wing, abdomen and legs some characteristic distinguishing parts of shape are also given.
Submitted by Mustafa Meteoğlu (g0682) on 2021-03-05T11:02:52Z
No. of bitstreams: 1
TEZ.pdf: 2804289 bytes, checksum: e05fec02cb2b70f6de9508b856cb7bf2 (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-07-07T05:42:55Z (GMT) No. of bitstreams: 1
TEZ.pdf: 2804289 bytes, checksum: e05fec02cb2b70f6de9508b856cb7bf2 (MD5)
Made available in DSpace on 2022-07-07T05:42:55Z (GMT). No. of bitstreams: 1
TEZ.pdf: 2804289 bytes, checksum: e05fec02cb2b70f6de9508b856cb7bf2 (MD5)
Previous issue date: 2005
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Syrpied
Eskişehir Syrphidae (Diptera) faunası üzerine çalışmalar
masterThesis
TEXT
TEZ.pdf.txt
TEZ.pdf.txt
text/plain
184938
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3676/3/TEZ.pdf.txt
ff80870b4f46f772ddd26fcca40338a3
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3676/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
TEZ.pdf
TEZ.pdf
application/pdf
2804289
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3676/1/TEZ.pdf
e05fec02cb2b70f6de9508b856cb7bf2
MD5
1
11684/3676
oai:openaccess.ogu.edu.tr:11684/3676
2022-07-08 03:00:33.176
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/3917
2022-07-28T00:00:35Z
com_11684_15
com_11684_2
col_11684_86
Arslan, Naime
Kökmen, Seval
ESOGÜ, Fen-Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2022-07-27T11:59:03Z
2022-07-27T11:59:03Z
2006
2006
http://hdl.handle.net/11684/3917
Bu çalışma Ağustos 2004 ve Temmuz 2005 tarihleri arasında Uluabat
(Apolyont) Gölü Oligochaeta faunası’nın tespiti ve mevsimsel dağılışlarını incelemek
amacıyla belirlenen 12 istasyondan Ağustos 2004 ve Temmuz 2005 tarihleri arasında
her ay (Aralık 2004, Ocak-Şubat 2005 aylarında olumsuz hava koşulları nedeniyle
örnek elde edilememiştir) olmak üzere taban örnekleri toplanmış, Oligochaeta dışındaki
gruplar ordo-familya düzeyine kadar, Oligochaeta bireyleri ise mümkün olan en alt
taksonomik seviyeye kadar teşhisleri yapılmış; örnek alımları esnasında aynı zamanda
su örnekleri de alınarak suyun bazı fiziko-kimyasal ve mikrobiyolojik analizleri de
(çözünmüş oksijen, pH, sıcaklık, tuzluluk, Biyolojik oksijen ihtiyacı, Kimyasal Oksijen
İhtiyacı, NO3-N, NO2-N, NH4-N) yapılmıştır.
Çalışma süresince belirlenen 12 istasyondan aylık olarak toplanan örneklerin
incelenmesi sonucunda Tubificidae familyasından Tubifex tubifex, Limnodrilus
hoffmeisteri, Limnodrilus profundicola, Potamothrix hammoniensis, Psammoryctides
albicola, Rhyacodrilus coccineus; Naidinae alt familyasından Paranais frici, Uncinais
uncinata, Stylaria lacustris, Nais communis, Nais variabilis, Nais pardalis, Nais
barbata, Pristina aequiseta, Dero digitata; Lumbriculidae familyasından Trichodrilus
sp. olmak üzere 19 tür tespit edilmiş olup aynı zamanda Lumbricidae ve
Branchiobdellidae familyalarına ait bireyler de tespit edilmiş olup, özellikle de toprak
formlarının oluşturduğu Lumbricidae familyasına ait örneklerin deforme ve-veya ergin
birey olmaları yüzünden tür seviyesine kadar teşhisleri yapılamamıştır.
Branchiobdellidae familyasına ait bireyler genellikle diğer omurgasız grupları üzerinde,
özellikle de Astacus leptodactylus karapaksı, üyeleri veya antenleri üzerinde parazit
olarak bulunmaktadır. Çalışmamızda elde edilen Branchiobdellidae bireyi serbest olarak
tespit edilmiştir ve tür düzeyine kadar teşhisi henüz yapılmamıştır.
Çalışmamızda en yüksek m2
deki birey sayısı 11. istasyonda Kasım 2004
örnekleminde (19956 birey/m2
), en düşük birey sayısı ise 3. istasyon Haziran 2005
örnekleminde (0 birey/ m2
) tespit edilmiştir. Buna ilaveten, istasyonların ortalama
olarak m2
deki birey sayılarına bakıldığında ise sırayla 10. istasyon (3457 birey/m2
), 9.
istasyon (3368 birey/m2
) ve 11. istasyonun (2869 birey/m2
) geldiği görülmektedir.
Uluabat Gölü’nün Shannon-Weiner Index (SWI=H’) çeşitliliğine bakıldığında
ise 0-1.49 (Kasım 2004 örneklemi- 11. istasyon) arasında değiştiği gözlenmiştir.
Bray-Curtis kümeleme analizinden de elde edilen sonuçlara göre çalışma
alanında 6. ve 12. istasyonlar ile 8.,11. ve daha sonra 10. istasyonlar kendi içlerinde
diğer istasyonlara göre daha yüksek bir benzerlik göstermektedir.
Tespit edilen türlerin abundansları ile fiziko-kimyasal-mikrobiyolojik
parametreler arasında herhangi bir ilişki olup olmadığı önce “Canonical
Correspondence Analyses ”(CANOCA)” yöntemi ile incelenmiş daha sonra bu ilişkinin
derecelerinin belirlenmesi için ise Pearson Korelasyon Katsayısı yöntemi
kullanılmıştır.
CANOCA analizinde 12. istasyonun diğer istasyonlardan farklı olarak burada
tespit edilen türlerin abundanslarının özellikle yoğun sucul bitkiler ile ilişkili olduğu
daha sonra ise çözünmüş oksijenin III. seviyesi ve NO2-N’nin I. seviyesi ile ilişkili
olduğu gözlenmiş; tür bazında ise Potamothrix hammoniensis, Tubifex tubifex ve
Psammoryctides albicola’nın abundansları ile orta derecedeki vejetasyonun, sıcaklığın
I. düzeyinin, Biyolojik oksijen ihtiyacının II. düzeyinin, PO3’ün I. düzeyinin ve fekal
koliform’un I . düzeyinin arasında bir ilişki olduğu tespit edilmiştir.
Pearson korelasyon sonuçlarına göre ise Potamothrix hammoniensis abundası ile
biyolojik oksijen ihtiyacı ve PO3 arasında pozitif bir korelasyon olduğu (*p<0.05);
Tubifex tubifex’in abundansı ile biyolojik oksijen ihtiyacı arasında yüksek bir pozitif
korelasyon olduğu (*p<0.05); Psammoryctides albicola yoğunluğu ile özellikle sıcaklık
arasında bir pozitif korelasyon olduğu tespit edilmiştir.
In this study, determination and seasonal distribution of Uluabat Lake
Oligochaeta fauna was investigated between August 2004 and July 2005 because of
bad-weather condition samples couldn’t have been taken in December 2004, January
2005 and February 2005. During the study period, Oligochaeta specimens were
collected from 12 determined stations and also some physical and chemical properties
of water such as DO, PH, temperature, salinity, turbidity, BOD, KOI, NO3-N, NO2-N,
NH4-N and total phosphorus were measured monthly (except December, January and
February) between August 2004 and July 2005.
As a result of examining the samples collected monthly from 12 stations during
the study, of reported 16 Tubifex tubifex, Limnodrilus hoffmeisteri, Limnodrilus
profundicola, Potamothrix hammoniensis, Psammoryctides albicola, and Rhyacodrilus
coccineus are belong to family Tubificidae, Paranais frici, Uncinais uncinata, Stylaria
lacustris, Nais communis, Nais variabilis, Nais pardalis, Nais barbata, Pristina
aequiseta, Dero digitata to subfamily Naidinae, and Trichodrilus sp. to family
Lumbriculidae. Moreover, the specimens to families Lumbricidae and
Branchiobdellidae were also recorded. The samples to family Lumbricidae constituted
by soil form especially were not diagnosed due to they are immature and were be
deformed.
The individuals of family Branchiobdellidae were found as parasitic on other
invertebrates and carapace, extremities and antenna of crayfish, Astacus leptodactylus.
In this study, only one specimen of Branchiobdellidae was found as soliter, and it was
not diagnosed to species level still.
In our study, the highest specimen number (19956 specimens/m2
) was reported
at station 11 during samplings in November 2004, and the lowest value was also found
at station 3 in June 2004 as 0 individual per m2
. In addition, as the number of specimens
per m2 3457 specimens were recorded at station 10, it was followed by the station 9 with
3368 specimens, and the station 11 with 2869 specimens.
Shannon-Wiener diversity index values (SWI=H') among the sampling stations
did not show significant difference, and these values ranged between 0 and 1.49
(November 2004, sampling station 11).
Relationship between the abundance of identified species and physcicochemical-microbiological parameters was analyzed by “Canonical Correspondence
Analyses ”(CANOCA)”. The degree of the relationship was determined by Pearson
Correlation coeffiency.
Submitted by ÖNDER GÜNGÖR (g1063) on 2021-03-05T12:41:42Z
No. of bitstreams: 0
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-07-27T11:59:03Z (GMT) No. of bitstreams: 0
Made available in DSpace on 2022-07-27T11:59:03Z (GMT). No. of bitstreams: 0
Previous issue date: 2006
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Kimyasal Oksijen İhtiyacı
Canonical Correspondence Analyses
Psammoryctides Albicola Yoğunluğu
Biyolojik Oksijen İhtiyacı
Uluabat (Apolyont) Gölü Olıgochaeta (Annelıdae) limnofaunası
masterThesis
TEXT
183500.pdf.txt
183500.pdf.txt
text/plain
250568
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3917/3/183500.pdf.txt
15bb3732b16214b1e1001d2a804ec5b7
MD5
3
ORIGINAL
183500.pdf
183500.pdf
application/pdf
5134823
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3917/2/183500.pdf
630286a6bdc75b5c72a17c62acf6fb58
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3917/1/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
1
11684/3917
oai:openaccess.ogu.edu.tr:11684/3917
2022-07-28 03:00:35.097
Dspace@ESOGU
openaccess@ogu.edu.tr
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
oai:openaccess.ogu.edu.tr:11684/3920
2022-07-28T00:00:59Z
com_11684_15
com_11684_2
col_11684_86
İlhan, Semra
Çolak, Ferdağ
ESOGÜ, Fen-Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2022-07-27T12:02:54Z
2022-07-27T12:02:54Z
2006
2006
http://hdl.handle.net/11684/3920
Antibiyotikler mikroorganizmalar taraf ndan üretilen, yüksek seyreltmelerde di er
mikroorganizmalar n büyümesine antagonistik etki yapan maddeler olarak tan mlanmaktad r.
Çoklu ilaç direncine sahip bakteriler birden fazla antibiyoti e dirençli olanlard r ve
mikroorganizmalar n dirençli hale geldikleri antibiyotiklerden art k etkilenmezler.
Çal mam zda çe itli habitatlardan 414 endospor olu turan basil izole edilmi tir. Bu
izolatlar n aktif metabolit aç s ndan tarama i lemi iki a amada gerçekle tirilmi tir. Birinci
a amada piece agar yöntemi kullan lm ve ikinci a amada ise klinik izolatlara kar
gösterdi i aktivite piece agar ve disk difüzyon yöntemine göre yap lm t r. %kinci taramada
izolatlar n % 23’ü en az ndan bir klinik izolata kar aktivite göstermi tir.
Seçilen izolatlar VITEK sistem ile identifiye edildi inde 4’ü Bacillus subtilis, 4’ü B.
cereus, 2’si B. amyloliquefaciens, Ya asidi profillerine (FAME) göre identifiye edildi inde
7’si B. cereus, 1’i B. amyloliquefaciens, 2’si Paenibacillus macerans olarak tan mlanm t r.
S cakl k, çalkalama h z , pH, karbon kayna , azot kayna ve mineral madde tipinin
seçilen izolat n geli imi ve antibakteriyal ve antifungal metabolit üretimi üzerine etkisi
responce surface modeline göre incelenmi tir. 200 rpm çalklama h z nda, 35-42 °C’de ve pH
7 de en fazla hücre geli imi ve metabolit üretimi görülmü tür. Modele göre karbon
kayna n n en önemli faktör oldu u bulunmu tur.
Endasimbiyotik stain (P. macerans) taraf ndan üretilen metabolitler etil asetat ile
ekstrakte edilerek ince tabaka kromotografisi ve kolon kromoto rafisi ile safla t r lm t r.
Aktif maddenin etkisi minimum inhibisyon konsantrasyonu ve minimum sidal
konsantrasyonu ile de erlendirilmi tir.
Antibiotics have been defined as substances produced by microorganisms that,
in high dilution, are antagonistic to the growth or life of other microorganisms. Multi
drug resistant bacteria are those that are resistant to more than one antibiotic, meaning
that the microorganisms are no longer affected by the antibiotics to which they have
become resistant.
In this study a total of 414 endospor forming bacilli were isolated from different
habitats. Screening for biological active metabolite was carried out two stage. In first
screening, 221 active isoltes were obtained using piece agar method, in terms of their
general inhibition effects to some test bacteria, yeast and molds. Second screening of
the isolates was carried out disc diffusion and piece agar method in terms of their
general inhibition aganist to some multidrug resistant microorganisms. 23% of the
isolates shown inhibition effects aganist at least one multi drug resistant
microorganisms.
Ten endospor forming bacillus strains selected were identified as 4 Bacillus
subtilis, 4 B. cereus and 2 B. amyloliquefaciens by VITEC system and as 7 B. cereus, 1
B. amyloliquefaciens and 2 Paenibacillus macerans according to faty acids profiles
(FAME).
A surface responce model was used to study the effect of pH, temperature,
agitation, carbon source, nitrojen source and mineral matter source on growth of P.
macerans and its antifungal and antibacterial metabolite production. 200 rpm agitation,
temperature 35-42°C’de and pH 7 favoured cell growth and prouction metabolite.
According to the model it was found that carbon source was the most important factor.
The metabolites produced by the endosymbiotic strain (P. macerans) were
extracted with ethyl acetate. Active metabolite was isolated and purified by thin layer
chromotogrphy and column chromotography. The effect of active substans on test
microorganisms was evaluated by minimum inhibition consentration ve minimum cidal
concentration.
Submitted by ÖNDER GÜNGÖR (g1063) on 2021-03-05T13:15:20Z
No. of bitstreams: 1
Ferdag Colak-tez.pdf: 13577851 bytes, checksum: 263a932406c70e8a6db4b0e0e3465d4a (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2022-07-27T12:02:54Z (GMT) No. of bitstreams: 1
Ferdag Colak-tez.pdf: 13577851 bytes, checksum: 263a932406c70e8a6db4b0e0e3465d4a (MD5)
Made available in DSpace on 2022-07-27T12:02:54Z (GMT). No. of bitstreams: 1
Ferdag Colak-tez.pdf: 13577851 bytes, checksum: 263a932406c70e8a6db4b0e0e3465d4a (MD5)
Previous issue date: 2006
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Bacillus
Antimikrobiyal Aktivite
Fame
Surface Responce
Vıtek
Kk
Çeşitli habitatlardan izole edilen endosporlu Basillerin antimikrobiyal aktivite açısından taranarak metabolitlerin saflaştırılması
doctoralThesis
TEXT
Ferdag Colak-tez.pdf.txt
Ferdag Colak-tez.pdf.txt
text/plain
245705
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3920/3/Ferdag+Colak-tez.pdf.txt
e0aaa1b92fba967c95ddaa197f8e7d33
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3920/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
Ferdag Colak-tez.pdf
Ferdag Colak-tez.pdf
application/pdf
13577851
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/3920/1/Ferdag+Colak-tez.pdf
263a932406c70e8a6db4b0e0e3465d4a
MD5
1
11684/3920
oai:openaccess.ogu.edu.tr:11684/3920
2022-07-28 03:00:59.679
Dspace@ESOGU
openaccess@ogu.edu.tr
REFHSVRJTSBMSVNBTlNJCgpCdSBsaXNhbnPEsSBpbXphbGF5xLFwIGfDtm5kZXJlcmVrLCBnw7ZuZGVyaW5pemkgZMO8bnlhIMOnYXDEsW5kYSBiYXPEsWzEsSBoYWxkZSwgCmVsZWt0cm9uaWsgb3J0YW1kYSB2ZSBoZXJoYW5naSBiYXNrYSBiaXIga2FuYWxsYSB5ZW5pZGVuIG9sdcWfdHVybWFrLCAKw6dldmlyaXNpbmkgeWFwbWFrIChhxZ9hxJ/EsWRhIHRhbsSxbWxhbmTEscSfxLEgw7x6ZXJlKSB2ZS92ZXlhIGRhxJ/EsXRtYWsgacOnaW4gCkVza2nFn2VoaXIgT3NtYW5nYXppIMOcbml2ZXJzaXRlc2nigJluaW4gKEVTT0dVKSDDtnplbCBvbG1heWFuIGhha2xhcsSxbsSxIGthYnVsIGV0bWnFnyBvbHVyc3VudXouCgpFU09HVSwgZ8O2bmRlcmluaXppbiBpw6dlcmnEn2luaSBkZcSfaXN0aXJtZWRlbiBoZXJoYW5naSBiaXIgCm9ydGFtZGEgZmFya2zEsSBiacOnaW1sZXJkZSBrb3J1bWEgYW1hw6dsxLEgb2xhcmFrIMOnZXZpcmViaWxpci4gCsOWdGUgeWFuZGFuIEVTT0dVLCBnw7x2ZW5saWssIHllZGVrbGVtZSB2ZSBrb3J1bWEgYW1hY8SxeWxhIGJ1IGfDtm5kZXJpbmluIApiaXJkZW4gZmF6bGEga29weWFzxLFuxLEgZWxpbmRlIHR1dGFiaWxpci4gCgpHw7ZuZGVyaW5pbiBzaXplIGFpdCBvcmlqaW5hbCBiaXIgw6dhbGnFn21hIG9sZHXEn3VudSB2ZSBidSBsaXNhbnN0YSBiZWxpcnRpbGVuIApoYWtsYXLEsSBrYWJ1bCBldG1lIGhha2vEsW7EsXogb2xkdcSfdW51IGJlbGlydG1pxZ8gb2x1cnN1bnV6LiBBeW7EsSB6YW1hbmRhIGfDtm5kZXJpbml6aW4sIApiaWxkacSfaW5peiBrYWRhcsSxeWxhLCBraW1zZW5pbiDDtnpsdWsgaGFra8SxbsSxIMOnacSfbmVtZWRpxJ9pbmkgZGUgc3VubXXFnyBvbHVyc3VudXouCgpFxJ9lciBnw7ZuZGVyaSB0ZWxpZiBoYWtrxLFuYSBzYWhpcCBvbHVubWF5YW4gYmlyIG1hdGVyeWFsIGnDp2VyaXlvcnNhLCBvIHphbWFuIAp0ZWxpZiBoYWtrxLEgc2FoaWJpbmRlbiBidSBsaXNhbnMgaWNpbiBnZXJla2xpIG9sYW4gRVNPR1UgaGFrbGFyxLFuxLEga2FidWwgZXRtZWsgCmljaW4ga8Sxc8SxdHPEsXogaXppbiBhbGTEscSfxLFuxLF6xLEgdmUgYnUgdGFyeiDDvMOnw7xuY8O8IGtpxZ9pbGVyIHRhcmFmxLFuZGFuIHNhaGlwIG9sdW5hbiAKbWF0ZXJ5YWxsZXJpbiBnw7ZuZGVyaSBpw6dlcmnEn2kgdmV5YSBtZXRuaSBpw6dlcmlzaW5kZSBhw6dpa8OnYSB0YW7EsW1sYW5kxLHEn8SxbsSxIHZlIAprYWJ1bCBlZGlsZGnEn2luaSBzdW5hcnNpbml6LgoKRcSeRVIgR8OWTkRFUsSwIEVTT0dVIERJxZ5JTkRBIEJBxZ5LQSBCxLBSIEtVUlVMVcWeIFRBUkFGSU5EQU4gREVTVEVLTEVORU4gQsSwUiDDh0FMScWeTUFZQSAKREFZQUxJIMSwU0UsIEJVIFRBUlogQklSIEFOTEHFnk1BIFZFWUEgU8OWWkxFxZ5NRU7EsE4gR0VSRUtUxLBSRMSwxJ7EsCBExLDEnkVSIApaT1JVTkxVTFVLTEFSSSBZRVLEsE5FIEdFVMSwUkTEsMSexLBOxLBaxLAgU1VOQVJTSU5JWi4KCkVTT0dVIGlzbWluaXppIGfDtm5kZXJpbmluIHlhemFyxLEgdmV5YSBzYWhpYmkgb2xhcmFrIGHDp8Sxa8OnYSB0YW7EsW1sYXlhY2FrdMSxciB2ZSAKYnUgbGlzYW5zxLFuIGl6aW4gdmVyZGnEn2luaW4gZMSxxZ/EsW5kYSBoZXJoYW5naSBiaXIgZGXEn2nFn2lrbGlrIHlhcG1heWFjYWt0xLFyLgo=
oai:openaccess.ogu.edu.tr:11684/2118
2021-03-12T01:01:40Z
com_11684_15
com_11684_2
col_11684_86
Şahin, Yalçın
Koyuncu, Volkan
ESOGÜ, Fen Edebiyat Fakültesi, Biyoloji Anabilim Dalı
2021-03-11T13:02:10Z
2021-03-11T13:02:10Z
2007
2007
http://hdl.handle.net/11684/2118
Ağustos 2004 - Eylül 2005 yılları arasında Uluabat Gölündeki 250 adet Scardinius
erythrophthalmus L.,1758 yakalanmıs ve büyüme parametreleri incelenmistir.
Đncelenen örneklerde erkek ve disi bireylerin I-V yasları arasında dağılım gösterdiği
tespit edilmistir. Đncelenen örneklerin %65.2’sinin disi %34.8’inin erkek bireylerden olustuğu
saptanmıstır.. Disi bireylerde total boy 105-281 cm.,ağırlık 17-332 gr., erkek bireylerde total
95 - 260 cm., ağırlık 15-295 gr. arasında tespit edilmistir. von Bertalanffy’nin büyüme
denklemine göre hesaplanan yas-boy, yas- ağırlık iliskileri disilerde;
Lt=28,1292 (1-e0,36 (t+0,40) ), Wt=391,92 (1-e0,36 (t+0,40))2,92,
erkeklerde ise;
Lt=26,483(1-e0,38(t+0,38) ), Wt=381,12 (1-e0,38(t+0,38))3,15
olarak saptanmıstır
Boy ağırlık iliskisi logaritmik olarak, disilerde;
Log W= -2,41174873 + 2,9261226212.Log L
Erkeklerde ise;
Log W= -2,58884768 + 3,1508353319.Log L
olarak saptanmıstır.
Total of 250 samples belonging to Scardinius erythrohthalmus were obtanied from
lake Uluabat betwen Agust 2004 and December 2005. Exeminated samples were determined
the ages of fameles and males respectively ranged between I-V .age groups.
The percentage of females were %65.2, males %34.8 out of 250 fish samples. As the
gonads about 35 of the samples had not reached to a full development level, sex determination
process could not be done. Length-weight relationships of females were 105-281 cm. and 17-
332 gr.; as for males were 95 - 260 cm. and 15-295 gr. respectively.
Von Bertalanffy equation used in determination of age length and age weight relations
were;
Lt=28,1292 (1-e0,36 (t+0,40) ), Wt=391,92 (1-e0,36 (t+0,40))2,92, in females and
Lt=26,483(1-e0,38(t+0,38) ), Wt=381,12 (1-e0,38(t+0,38))3,15 in males.
Length-weight relations for females are;
Log W= -2,41174873 + 2,9261226212.Log L
and for males;
Log W= -2,58884768 + 3,1508353319.Log L
Submitted by Ramazan Karayel (g1216) on 2021-03-08T07:13:40Z
No. of bitstreams: 1
volkan_koyuncu_tez.pdf: 1162101 bytes, checksum: 0cf0288be11898b362064919e3514f0e (MD5)
Approved for entry into archive by Kaner Ulusoy (kaneru26@gmail.com) on 2021-03-11T13:02:10Z (GMT) No. of bitstreams: 1
volkan_koyuncu_tez.pdf: 1162101 bytes, checksum: 0cf0288be11898b362064919e3514f0e (MD5)
Made available in DSpace on 2021-03-11T13:02:10Z (GMT). No. of bitstreams: 1
volkan_koyuncu_tez.pdf: 1162101 bytes, checksum: 0cf0288be11898b362064919e3514f0e (MD5)
Previous issue date: 2007
tur
ESOGÜ, Fen Bilimleri Enstitüsü
info:eu-repo/semantics/openAccess
Scardinius Erythrophthalmus
Kızılkanat
Uluabat Gölü
Büyüme Parametleri
Uluabat gölünde (Bursa) yaşayan Scardinius erythrophthalmus L.,1758 (kızılkanat balığı) populasyonunun büyüme parametrelerinin araştırılması
masterThesis
TEXT
volkan_koyuncu_tez.pdf.txt
volkan_koyuncu_tez.pdf.txt
text/plain
47776
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/2118/3/volkan_koyuncu_tez.pdf.txt
cc92709a4c5730224b3cd7e239539792
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1643
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/2118/2/license.txt
6cf488a9029cb3848b3e960b25b3caf3
MD5
2
ORIGINAL
volkan_koyuncu_tez.pdf
volkan_koyuncu_tez.pdf
application/pdf
1162101
http://openaccess.ogu.edu.tr:8080/xmlui/bitstream/11684/2118/1/volkan_koyuncu_tez.pdf
0cf0288be11898b362064919e3514f0e
MD5
1
11684/2118
oai:openaccess.ogu.edu.tr:11684/2118
2021-03-12 03:01:40.341
Dspace@ESOGU
openaccess@ogu.edu.tr
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
MToxMDB8Mjpjb2xfMTE2ODRfODZ8Mzp8NDp8NTp4b2Fp